Certolizumab

Certolizumab

Certolizumab pegol treats several inflammatory conditions and holds a place on the World Health Organisation's List of Essential Medicines. The medication helps patients who struggle with Penyakit Crohn, rheumatoid arthritis, psoriatic arthritis and ankylosing spondilitis. It targets specific inflammation pathways in the body.

This anti-TNF medication prevents body damage caused by these conditions. The FDA gave its approval to treat Crohn's disease in 2008, especially when patients didn't respond well to standard therapy. 

Most patients see their symptoms improve within 6-12 weeks after they start treatment. Certolizumab works quickly and shows lasting effects on symptoms while stopping joint damage in rheumatoid arthritis patients. This article covers everything patients should know about Certolizumab—from its classification and proper usage to side effects and precautions.

What is Certolizumab?

Certolizumab pegol represents a fragment of a monoclonal antibody that targets tumour necrosis factor alpha (TNF-α). The drug stands out as the only PEGylated anti-TNF biologic that doctors can prescribe for both rheumatoid arthritis and Crohn's disease.

Certolizumab Uses

Doctors prescribe Certolizumab injection to treat several inflammatory conditions:

• Moderate to severe Crohn's disease that doesn't respond to standard treatments
• Moderate to severe rheumatoid arthritis
• Active psoriatic arthritis
• Ankylosing spondylitis
• piring psorias
• Spondyloarthritis aksial non-radiografi
• Polyarticular juvenile idiopathic arthritis in children of 2 years and older

How and When to Use Certolizumab Tablet

Patients receive certolizumab as a lyophilised powder or prefilled syringe through subcutaneous injection. The treatment begins with 400 mg (two 200 mg injections) at weeks 0, 2, and 4. The maintenance dose varies by condition—patients take either 200mg every two weeks or 400mg monthly.

Side Effects of Certolizumab Tablet

Pasien umumnya mengalami:

• Infeksi pernapasan
• Ruam kulit
• Infeksi saluran kemih

More serious concerns include:

• Meningkatnya risiko infeksi
• Gejala gagal jantung
• Reaksi alergi

Kewaspadaan

The medication requires careful consideration with certain conditions.

• Patients must undergo tuberculosis testing before starting treatment.  
• Vaksin hidup harus dihindari selama perawatan. 
• pasien dengan multiple sclerosis, heart disease, or hepatitis should notify their doctor before using Certolizumab.

How Certolizumab Tablet Works

Certolizumab medication, a biological DMARD, locks onto TNF-alpha with remarkable precision. This action stops inflammation signals from damaging your joints and tissues. The drug works better at blocking both soluble and membrane-bound TNF forms than other similar medications. Certolizumab doesn't trigger certain immune responses that might cause extra side effects because it lacks the Fc portion found in complete antibodies.

Can I take Certolizumab with Other Medicines?

You can take Certolizumab injection with:

• Standard DMARDs like methotrexate
• Steroid medicines like prednisolone
• Pain relievers like paracetamol
• Anti-inflammatory drugs (NSAIDs)

You should never combine Certolizumab with:

• Other biological DMARDs 
• TNF blockers
• Live vaccines like the BCG vaccine
• COVID-19 mRNA vaccine

Informasi Dosis

• Patients with Crohn's disease receive 400 mg every four weeks after their starting doses. 
• Patients with rheumatoid arthritis, psoriatic arthritis, or ankylosing spondylitis can take either 200 mg every other week or 400 mg monthly. 
• Doctors prescribe weight-based dosing for children with polyarticular juvenile idiopathic arthritis. 
• Take any missed dose right away when you remember, then continue your original schedule.

Kesimpulan

Certolizumab brings new hope to people who struggle with inflammatory conditions. This powerful medication helps patients with Crohn's and rheumatoid arthritis when other treatments don't work. Most patients see their condition getting better within 6-12 weeks after they start the therapy.

Certolizumab works well, but patients need to think about several things before they begin treatment. They must get tested for TB and tell their doctor about any health issues they have. The medication stands out from other TNF blockers because it has a unique PEGylated structure. The right dosing schedule leads to the best results. 

Each patient's response to Certolizumab is different. Your doctor watches your progress and changes your treatment as needed. The main goal stays the same—less inflammation and a better quality of life. This medication helps thousands of people manage their conditions and take control of their daily activities again.

Pertanyaan Umum (FAQ)

1. Is certolizumab high risk?

Certolizumab comes with the most important risks you should discuss with your doctor. Research shows that certolizumab might cause serious adverse events more often than other similar medications. 

2. How long does certolizumab take to work?

The first improvements usually show up within 2-4 weeks after treatment begins. However, patients typically see full benefits around 6-12 weeks after starting Certolizumab. Your patience matters even if you don't see immediate results.

3. Apa yang terjadi jika saya melewatkan satu dosis?

Your next scheduled dose timing matters:

• Within one week—wait for your scheduled dose
• More than one week away—take the missed dose now and continue your regular schedule

4. Apa yang terjadi jika saya overdosis?

Medical attention becomes crucial right away if you overdose. Call the emergency number right away. Don't wait to see symptoms before getting help.

5. Who cannot take certolizumab?

Certolizumab might not be right for you if you:

• Have an active infection
• Haven't tried other treatments
• Have had severe allergic reactions to certolizumab

6. When should I take certolizumab?

Your Certolizumab injection schedule starts at weeks 0, 2, and 4. After that, maintenance doses happen every two or four weeks based on your condition. The time of day doesn't matter much as long as you stick to your schedule.

7. How many days to take certolizumab?

Certolizumab works as a long-term treatment. Symptoms can return if you stop, even after feeling better. Stopping too early often causes disease flare-ups.

8. When to stop certolizumab?

Your doctor should always guide your decision to stop Certolizumab. Stop immediately if you develop serious infections, allergic reactions, or severe side effects. Your doctor might also pause your treatment before surgery.

9. Is it safe to take certolizumab daily?

Certolizumab requires specific dosing schedules and should not be taken daily. Doctors typically prescribe either 200 mg every two weeks or 400 mg monthly. Your risk of side effects increases without extra benefits if you take it more frequently than prescribed. The best results come from following your doctor's recommended schedule.

10. What is the best time to take certolizumab?

Certolizumab injection works effectively regardless of when you take it during the day. Your focus should be on consistency. Choose a time that fits into your everyday routine—early hours could be better if you are likely to forget later on, or nights might be more suitable. Success in treatment comes from maintaining a consistent schedule.

11. What to avoid when taking certolizumab?

Patients using Certolizumab 200 mg should avoid:

• Live vaccines (including flu nasal spray, measles, mumps, rubella)
• Excessive alcohol consumption that could increase liver problems
• Contact with people who have active infections, especially during the initial months of therapy
• Unpasteurised dairy products and undercooked meats that could contain harmful bacteria

Remember to tell your doctor about any new medicines, supplements or significant lifestyle changes during your treatment.