අඩලිමුමාබ්

අඩලිමුමාබ්

Adalimumab is a fully human, recombinant monoclonal antibody that targets and blocks tumour necrosis factor-alpha (TNF-α), which helps reduce inflammation throughout the body. People with රූමටික ආතරයිටිස්, psoriatic arthritis, ankylosing spondylitis, Crohn's disease, and ulcerative colitis often experience relief when they use adalimumab injections. The medication controls these autoimmune conditions effectively but cannot cure them completely. This article will explain everything about adalimumab, including its uses, dosage and precautions before taking this medicine.

What is Adalimumab?

Adalimumab is a fully human monoclonal antibody. The medication targets tumour necrosis factor (TNF), a protein responsible for inflammation. This effective medication treats various inflammatory conditions.

Adalimumab Uses

This medication treats inflammation of:

• Joints—rheumatoid arthritis, juvenile idiopathic arthritis
• Skin—plaque දී සමේ, hidradenitis suppurativa
• Spine—ankylosing spondylitis
• Gut—Crohn's disease, ulcerative colitis
• Eyes—non-infectious uveitis

How and When to Use Adalimumab Tablet

Adalimumab comes in pre-filled syringes or injection pens that go under the skin. Your condition and age determine the dosage. Adults with rheumatoid arthritis usually need 40 mg every two weeks.

Side Effects of Adalimumab Tablet

The common side effects are: 

• එන්නත් කරන ස්ථානයේ ප්රතික්රියා
• හිසරදය
• ශ්වසන ආසාදන
• Severe infections (rare)
• අසාත්මිකතා

පූර්වාරක්ෂාව

• Keep your patient alert card with you. 
• ප්‍රතිකාර අතරතුර සජීවී එන්නත් ලබා ගැනීමෙන් වැළකී සිටිය යුතුය. 
• Avoid unpasteurised dairy, soft cheeses, undercooked meats, and raw eggs during treatment.
• Your doctor needs to know about any infections or ගර්භනී.

How Adalimumab Tablet Works

This medicine finds and attaches itself to a protein called tumour necrosis factor-alpha (TNF-alpha). When TNF-alpha attaches to cell receptors, it triggers inflammation in your body. The Adalimumab drug stops this protein from attaching to your cell's receptors and blocks the inflammation signal.

Adalimumab's unique approach targets only TNF-alpha and doesn't affect other cytokines. This targeted approach helps lower joint swelling, skin inflammation, and gut issues.

Can I take Adalimumab with Other Medicines?

You need to be cautious about certain combinations:

• Absolutely avoid: Other TNF blockers like etanercept, biological DMARDs such as anakinra, and live vaccines
• Use with caution: Methotrexate, corticosteroids, and standard painkillers

Your doctor needs to know about all medicines you take, including over-the-counter ones. Note that adalimumab might affect how certain drugs with narrow safety ranges (like warfarin) work in your body.

මාත්‍රා තොරතුරු

ඔබේ තත්වය මාත්‍රාව තීරණය කරයි:

• Adults with rheumatoid arthritis, psoriatic arthritis or ankylosing spondylitis need 40 mg every two weeks 
• Crohn's disease treatment starts with 160mg, then 80mg two weeks later, followed by 40mg every other week 
• Psoriasis treatment begins with 80mg, then 40mg a week later, followed by 40mg every other week

Your doctor will adjust these doses based on your treatment response.

නිගමනය

Adalimumab is a breakthrough treatment for patients who suffer from inflammatory conditions of all types. This medication can't cure these diseases, but it works well to manage symptoms and improve life quality for millions of people worldwide. You can think of it as a specialised key that brings relief by targeting just one inflammatory protein in your body.

Your body's response to this treatment will be unique. Your doctor will create a dosage schedule that fits your condition—you might need it weekly or every other week.

This therapy has some potential side effects, but it gives hope to people who struggled with limited treatment options before. Biosimilar versions have made this treatment more available to patients worldwide. Adalimumab helps thousands of people take back control of their health and daily activities—one targeted injection at a time.

නිතර අසනු ලබන ප්රශ්න

1. Is adalimumab high risk?

The medicine can weaken your ප්රතිශක්තිකරණ පද්ධතිය and make you more vulnerable to infections. The risk of infections is higher if you are above 65. The medication also comes with a small risk of certain cancers, especially lymphoma in younger patients. People with existing heart conditions might see their cardiac problems get worse. 

2. How long does adalimumab take to work?

The improvements appear somewhere between 2 to 12 weeks after you begin treatment. How fast you respond depends on your condition and other health factors. You need to stay patient because some conditions take more time to show progress than others.

3. මට මාත්‍රාවක් මග හැරුණොත් කුමක් සිදුවේද?

Take the missed dose as soon as you remember. After that, you can stick to your usual injection schedule. But if your next dose is coming up soon, ask your specialist what to do. Don't try to catch up by taking a double dose.

4. මම අධික මාත්‍රාවක් ගත්තොත් මොකද වෙන්නේ?

Contact your doctor right away if you suspect an overdose or have severe symptoms. Be sure to bring your medication packaging with you to help medical staff provide the correct treatment. Do not wait for symptoms to improve on their own.

5. Who cannot take adalimumab?

Adalimumab isn't suitable if you:

• Have had allergic reactions to adalimumab before
• Have active infections or fever
• Live with heart failure
• ඇති හෙපටයිටිස් බී
• Have nervous system conditions like බහු විධ
• Had surgery recently or have one scheduled soon

6. When should I take adalimumab?

Your doctor's instructions about timing are crucial. Rheumatoid arthritis treatment typically needs injections every other week. Treatment for Crohn's disease starts with higher doses, then moves to maintenance injections every two weeks. Psoriasis treatment begins with an 80mg dose and continues every fortnight.

7. When to stop adalimumab?

Always talk to your doctor before stopping adalimumab. You might need temporary breaks during infections or before surgery. Patients in remission can sometimes reduce their dosage gradually. The medication might need to be paused before certain vaccines.

8. How many days to take adalimumab?

Adalimumab has an effect as a long-term therapy. You should keep taking it even when your symptoms get better to maintain control of your condition. Most patients see improvements within a few weeks after they begin the therapy. Your doctor will decide how long you should continue based on your response and specific condition.

9. Is it safe to take adalimumab daily?

Daily usage isn't recommended. Your doctor will typically prescribe adalimumab:

• Every two weeks (40mg) to treat conditions like rheumatoid arthritis 
• Starting with higher doses (160mg), then 80mg after two weeks, followed by 40mg every fortnight for Crohn's disease 
• Weekly for patients who need stronger treatment 

Taking more frequent doses won't improve your results and might increase your risk of side effects.

10. What is the best time to take adalimumab?

Medical guidelines don't specify a "best time." What matters most is sticking to a routine. Choose a day and time that suits your schedule to help you remember your injection routine more easily.

11. What to avoid when taking adalimumab?

ඈත් වී සිටින්න:

• Live vaccines (BCG, MMR, rotavirus and nasal flu spray) 
• Medicines that increase infection risk 
• Herbal remedies without your doctor's approval 
• Unpasteurised dairy, soft cheeses, undercooked meats, and raw eggs 
• Crowded places where infection risks run high