Li-Fraumeni Syndrome

Li-Fraumeni syndrome (LFS) is a rare hereditary condition that increases a person’s risk for a wide spectrum of tumours. In LFS, the tendency to develop cancer is inherited, meaning that it can be passed from an affected parent to a child. Several types of cancer like soft-tissue sarcomas, breast cancer, osteosarcomas, brain tumours, etc. are commonly associated with Li-Fraumeni syndrome.

Causes and Symptoms

Li-Fraumeni syndrome is caused by changes in a gene known as TP53. Genes carry important information that tell our body’s cells how to function. The TP53 gene controls how cells grow and divide. One of its main jobs is to prevent cancers from forming. Normally, your cells carry two working copies of TP53. One is inherited from your mother and one from your father. Cells from people with Li-Fraumeni syndrome carry one working copy of TP53 and one copy that is altered. This alteration causes the gene to not work properly and is called a mutation. When the remaining working copy of TP53 becomes damaged within a cell, this can lead to a cancer.

The main symptom of Li-Fraumeni syndrome (LFS) is an increased risks to develop cancer. When a person has LFS, the risk to develop cancer is 50% by age 30 and 90% by age 60.

Diagnosis and Treatment

A careful and detailed review of a person’s medical and family history is important when attempting to make a diagnosis of Li-Fraumeni syndrome. Your doctor may construct a pedigree, or a multi-generation family tree, that shows which members of the family have developed cancer, the types of cancer, and their ages when the cancer first occurred to determine this condition.
To confirm that a person has LFS, a genetic test must be completed. First, a blood or saliva sample is obtained from an affected individual with cancer. DNA is isolated from the sample and the two copies of the TP53 gene are evaluated by direct DNA sequencing. Sequencing is a process by which a person’s genetic code is compared to a “normal” reference code.

There is no treatment that can cure Li-Fraumeni syndrome. However, there are options available to reduce your risk of developing cancer. These options include:

• Increased cancer screening
• Risk-reducing surgery
• Lifestyle changes

Talking to a doctor with expertise in Li-Fraumeni syndrome can help you determine the best medical management and risk-reduction options for your situation.

Why choose CARE?

Ultra Modern Technology

CARE Hospitals is one of the best Oncology Hospitals in India. We, at CARE Hospitals, make it our top priority to ensure that the most technologically advanced treatment options are available to patients who come to us for cancer treatments. Our Oncology department utilizes modern technology such as the LINAC (Linear Accelerator), PET CT Scan, to treat and diagnose various types of cancers.

Expert Team of Doctors

At CARE Hospitals, we create an environment of excellence in diagnosis, treatment and academics. Considered the best cancer specialists in India, our highly experienced team of doctors, nurses and staff works with tireless dedication towards improving patient health and ensuring the best possible clinical outcomes. Our standard of care demands that treatment plans not only are patient-centric and multidisciplinary, but also personalised for each patient.

High Success Rate

Cancer care is complex, prolonged and intense – both for the patients and the team that treats them. We, at CARE Hospitals, take pride in rendering treatment that has a high success rate. Our goal for our patients in the long term, is to ensure that the cancer doesn’t relapse.

Our Locations

Banjara Hills

The CARE Group’s flagship CARE Hospitals, located in Banjara Hills – a prime location in Hyderabad, was set up in the year 2000. Today, the multispecialty hospital has 435 beds, including 120 critical care beds, with an annual inflow of 1,80,000 outpatients and 16,000 in-patients.

Address 
Road No 1
Banjara Hills
Hyderabad – 500034

Email 
info@carehospitals.com

Phone
+91-40-30418888
Emergency
105711

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Banjara Hills(Outpatient)

The Group’s flagship CARE Hospitals, Banjara Hills, Hyderabad — a super specialty hospital — began patient care delivery at the CARE Outpatient Centre in October 2012. Located in the heart of the city, a km away from the in-patient hospital, it is India’s largest integrated outpatient centre with 65 beds.

Address 
Road No 10
Banjara Hills
Hyderabad – 500034

Email 
info@carehospitals.com

Phone
+91-40-39310444
Emergency
105711

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Nampally

CARE Hospitals, Nampally, Hyderabad, is the first hospital established by the CARE Hospitals Group in 1997. The hospital began as a 100-bed Heart Institute, focusing on cardiac care with a core team of 20 cardiologists, one operating theatre and one catheterization laboratory. The hospital was expanded and upgraded in the year 1998 and again in 2000 and is now a 266 bed facility.

Address 
Exhibition Grounds Road
Nampally
Hyderabad – 500001

Email 
info@carehospitals.com

Phone
+91-40-30417777
Emergency
+91-40-30417777

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Musheerabad

Guru Nanak CARE Hospitals, Musheerabad, Hyderabad, is a 101-bed multispecialty hospital, equipped with the best of both medical staff and infrastructure. With round-the-clock facilities and the best medical expertise, the hospital offers patients specialized care in over 45 specialties.

Address 
1-4-908/7/1
Musheerabad
Hyderabad – 500020

Email 
info@carehospitals.com

Phone
+040-30219000/9111/9123
Emergency
+040-30219000/9111/9123

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Market Street

CARE Hospitals, Secunderabad, was established on 1st June 1998. It has earned the reputation of being the best family hospital in the neighborhood and has treated hundreds of patients successfully over the years.

Address 
Near Clock Tower
Market Street
Secunderabad – 500003

Email 
info@carehospitals.com

Phone
+91-40-30114500
Emergency
+91-40-30114500

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Hi-tech City

The new 275-beds CARE Hospitals near Hi-tech City, is strategically located in Hyderabad’s silicon hub and is one of the most modern facilities in the region. It offers personalized care to the software population in a 3,10,000 sq ft area with 13 floors.

Address 
Old Mumbai Highway
Near Cyberabad Police Commissionerate
Hyderabad-500032

Email 
info@carehospitals.com

Phone
+91-40-33623500–3999
Emergency
1800 108 3999

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Ramnagar

CARE Hospitals, Ramnagar, Visakhapatnam, is an integral part of the CARE Hospitals Group and has been delivering quality healthcare since 1999. It continues to uphold the CARE Group’s mission of providing guidance, care and relief to all patients. Care with compassion and emphasis on putting the patient’s interests above one’s own are the hallmarks of the Group.

Address 
A S Raja Complex
Waltair Main Road, Ramnagar
Visakhapatnam – 530002

Email 
info@carehospitals.com

Phone
+91-891-3041444
Emergency
+91 891 2522622

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Maharanipeta

CARE Hospitals, Visakhapatnam, made a name as a premier Heart Institute after its inception in 1999. On 11th December 2009, the hospital became part of the CARE Hospitals Group, and was re-launched by Mr. N. Sambasiva Rao, Commissioner of Police, Visakhapatnam.

Address 
17-1-1, KGH Road
Maharanipeta
Visakhapatnam – 530002

Email 
info@carehospitals.com

Phone
+91-0891-3067000
Emergency
+91 891 3067044/22

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Railway New Colony

The new CARE Hospitals at Railway New Colony introduces a bouquet of services for residents of the smart city. This is the third CARE Hospitals Group facility in the city. Like the other two hospitals in Vizag, the facility is well designed with comfortable seating arrangements in the OPD.

Address 
43-9-201, SLV Arcade
Opp Sreekanya Theatre
Railway New Colony
Visakhapatnam – 530016

Email 
info@carehospitals.com

Phone
+91-0891-2554811, 2754811, 2784811
Emergency
+91-0891-2554811

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Ramkrishna CARE Hospitals

Ramkrishna CARE Hospitals is the leading corporate multispecialty hospital in Raipur, with 215 beds. The preferred hospital for the people of Chhattisgarh and the adjoining states, Ramkrishna CARE Hospitals strives to integrate new ideas and research with humane care and compassion. With the installation of a cath lab and commencement of cardiothoracic surgery, Ramkrishna CARE Hospitals is set to develop into a centre of cardiovascular care and an institution of excellence in the state of Chhattisgarh.

Address 
Aurobindo Enclave,
Pachpedhi Naka,
Dhamtari Road
Raipur – 492001

Email 
info@carehospitals.com

Phone
+91-771-3003300/ 1 / 2
Emergency
+91 771 3003364 /457/364

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Aditya CARE Hospitals

CARE Hospitals, Bhubaneswar, was inaugurated on 24th September 2007; full-fledged services started from October 2007 onwards. The 98-bed largest, private, multi-superspecialty corporate hospital in the city, it has experienced doctors, well-trained paramedical professionals and state-of-the-art equipment. CARE Hospitals has incorporated the latest techniques in patient care to stay abreast of the changing scenario in medical science while providing quality health care at an affordable price.

Address 
Plot No 329/1929 (P),
Chandrasekharpur
Bhubaneswar – 751016

Email 
info@carehospitals.com

Phone
+91-674-3053200
Emergency
+91 9937299112

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Bhubaneswar – (Prachi Enclave)

The CARE Hospitals Group’s first greenfield hospital, and its second facility in the city, is now operational at Prachi Enclave, Chandrasekharpur, Bhubaneswar, Odisha. A state-of-the-art multi superspecialty hospital it offers services in the core specialties of Cardiac Sciences, Neuro Sciences, Renal Sciences, Medical and Surgical Gastroenterology and Orthopedics, as well as high-end Critical Care and Emergency medicine and all major specialties.

Address 
Plot No. 324, Unit No. 42,
Prachi Enclave , Chandrasekharpur,
Bhubaneswar – 751016

Email 
info@carehospitals.com

Phone
0674-3021999
Emergency
+91-7077711777

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Nagpur

CARE Hospitals, Nagpur, has been acclaimed as a hospital par excellence for its contribution to healthcare in Nagpur city and the surrounding regions. This 105-bed hospital, commissioned on 19 November 2006, has earned a reputation for being the best provider of quality healthcare of international standards at affordable rates.

Address 
3 Farmland, Panchsheel Square
Ramdaspeth, Wardha Road
Nagpur – 440012

Email 
info@carehospitals.com

Phone
+91-712-3982222
Emergency
+91 9423623456

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Galaxy CARE Hospitals

Galaxy CARE was recently upgraded to a multispecialty 125-bed facility. New services such as a Cath Lab have been added. The Laboratory, General Ward and Endocrinology Departments have come up on an entirely new fourth floor. With its modern infrastructure and vibrant colours that are more than matched by the energy and enthusiasm of the team.

Address 
25-A Karve Road
Pune – 411004

Email 
info@carehospitals.com

Phone
+91-20-30244100
Emergency
+91 20 30244100/2/3

Location Map