I-thyroid peroxidase (TPO) iyi-enzyme evame ukutholakala endlaleni yegilo, edlala indima ebalulekile ekukhiqizeni ama-hormone egilo. Ukuhlolwa kwe-TPO kuthola amasosha omzimba ngokumelene ne-TPO egazini. Uma othile enokuxilongwa kwe-thyroid disorder, udokotela wakhe angase atuse ukuhlolwa kwe-anti-TPO antibody kanye nolunye ukuhlolwa kokuhlolwa kwe-thyroid ukuze abone imbangela eyinhloko. Abesifazane abakhulelwe abanezimo zegilo ezizimele bangase futhi belulekwe ukuthi bahlole i-TPO antibody.

Kuyini ukuhlolwa kwe-Anti TPO?

Amasosha omzimba e-Anti TPO atholwa egazini ngokuhlolwa kwezokwelapha okwaziwa ngokuthi i-anti TPO ab test. Lokhu kuhlolwa, okuphinde kubizwe ngokuthi i-Thyroid Peroxidase Autoantibody test, kukala amazinga amasosha omzimba egilo emzimbeni, okungaba inkomba yezimo zezempilo ezinzima kakhulu. Kuwusizo ikakhulukazi kubantu abanamazinga e-TSH aphakeme, ngisho noma amazinga abo amahhala e-T4 engaphakathi kwebanga elivamile. Abantu bangacelwa ukuthi bahlole lezi zivivinyo uma bebonisa izimpawu ezijwayelekile, okuhlanganisa:

• I-Goitre noma indlala yegilo ekhulisiwe, ebonakala ngokuvuvuka kwentamo, okuvame kakhulu ezinganeni ezinesisindo esiphansi.
• Ukuwohloka kwemisipha, okuholela ekulahlekelweni kwethoni yemisipha.
• Ukukhula kwesisindo ngenxa yokuphazamiseka kokungena i-metabolism.
• Ukukhathala, okubonisa ukuntuleka kwamandla emzimbeni.

Ukuhlolwa kwe-thyroid anti TPO kufeza izinhloso eziningi, okuhlanganisa:

Inhloso eyinhloko yokuhlolwa kwe-anti-TPO antibody ukuhlola nokuqapha ukuphazamiseka kwe-autoimmune yegilo, ikakhulukazi i-Hashimoto's thyroiditis kanye nesifo sika-Graves.

• Ukuze unqume ukuthi isiguli sine-goiter engeyona i-autoimmune noma isimo se-autoimmune yegilo.
• Ukuhlonza i-hypothyroidism, isimo esibonakala ngokuncipha kwe-thyroxine synthesis ye-hormone.
• Ukuhlola amathuba okuphindeka ngemva kokwelashwa kwe-Graves' disease.
• Ukuthola i-idiopathic myxedema, ebonakala nge-atrophic (enciphile noma encishisiwe ngosayizi) yegilo ndlala kanye nama-autoantibodies amahle ngokumelene nendlala yegilo.
• Ukuze uthole ukuthi ngabe umuntu uke wadlula ukwelashwa komdlavuza wegilo.
• Ukuhlola ingozi engaba khona ku-fetus kwabesifazane abakhulelwe abanesifo se-thyroid.

Kufanele ngikuthole nini lokhu kuhlolwa kwe-Anti TPO?

Ukuze unqume ukuhlonzwa kwesimo se-autoimmune esithinta indlala yegilo, ngokuvamile akudingekile ukuhlolwa kwe-antibody yegilo. Kodwa-ke, odokotela bangathola ukuhlolwa kwe-antibody ye-thyroid kuwusizo kulezi zimo ezilandelayo:

• I-Hyperthyroidism ngaphandle kwesizathu esicacile: Kwezinye izimo, ukuba khona kwegilo elisebenza ngokweqile kungase kubonise isifo sikaGraves, esingaqinisekiswa ngokuhlolwa komzimba nokuhlolwa kwehomoni yegilo. Ezimweni ezingavamile, ukuhlolwa kwe-TRAB noma izinqubo zokuthwebula izithombe, njenge-ultrasound ne-radionuclide thyroid scans, zingasiza ekuxilongeni noma ekukhipheni i-Graves' Disease.
• I-subclinical hypothyroidism: Ukuhlolwa kwamasosha omzimba e-TPO kungasiza ekunqumeni ukuthi umuntu one-TSH ephezulu kanye namazinga e-FT4 ajwayelekile ekugcineni uzokhula abe ne-hypothyroidism enzima futhi ehlala njalo noma ahlale e-subclinical, kungabikho zimpawu ezibonakalayo.
• I-Goitre: Ezimweni lapho indlala yegilo ikhule ngendlela engavamile, abanye ochwepheshe bezokwelapha batusa ukuhlolwa kwe-TPOAb, noma ngabe amazinga e-hormone yegilo avamile.
• Ukuqapha ukwelashwa okulandelayo komdlavuza we-thyroid: Amazinga e-TgAb angase ahlolwe lapho othile enza ukuhlolwa okulandelwayo kwe-thyroglobulin ngemva kokwelashwa, njengoba okunye ukuhlola kwe-thyroglobulin kungase kuthinteke ukuba khona kwabo.

Kwenzekani ngesikhathi sokuhlolwa kwe-Anti TPO?

Inqubo yokuthola isampula yegazi ihlanganisa ukufaka inaliti emithanjeni etholakala engalweni engenhla. Ibhande lokunwebeka linamathiselwe engalweni engenhla ngaphambi kokudweba isampula ukuze kwandiswe ukujikeleza kwegazi emithanjeni futhi kube lula ukukhishwa kwesampula. Isixazululo se-antiseptic sisetshenziswa esikhumbeni endaweni yokubhoboza. Isiguli kungenzeka sihlabeke kancane njengoba inaliti ingena esikhunjeni. Isikhathi sokudonswa kwegazi ngokuvamile singaphansi komzuzu owodwa.

Inqubo yokuhlolwa kwe-Anti TPO

Imihlahlandlela ejwayelekile yokuhlolwa kwe-Anti-TPO imi kanje:

• Ukuthola umthambo, i-phlebotomist ingase icele isiguli ukuthi senze isibhakela noma sisonge ibhande engalweni.
• Bazosebenzisa ikhambi elibulala amagciwane ukuze bahlanze indawo okuzokhishwa kuyo igazi.
• Ukuqoqa isampula yegazi elidingekayo ukuze kuhlaziywe, bazosebenzisa inaliti eyinyumba.
• Ngemuva kokuthi igazi selikhishiwe, isampula izofakwa ku-vial noma ishubhu lokuqoqa.
• Ngemva kwenqubo, i-phlebotomist izofaka ibhandishi endaweni ebhoboziwe ukuvimbela ukopha okwengeziwe futhi isebenzise ibhola likakotini ukumisa noma yikuphi ukopha.

Indawo ebhoboziwe ingase ibe nokungakhululeki okuncane noma ubuhlungu ngenxa yokwelashwa. Nokho, lezi zimpawu kufanele zibe ezejwayelekile futhi zibe okwesikhashana.

Ukusetshenziswa kokuhlolwa kwe-Anti TPO

Nakhu okunye ukusetshenziswa okuyinhloko kokuhlolwa kwe-anti-TPO:

• Ukuxilongwa kwe-Autoimmune Thyroid Disorders: Ukuhlolwa kwe-anti-TPO kuvame ukusetshenziselwa ukuxilonga izifo zegilo ezizimele, njenge-Hashimoto's thyroiditis kanye nesifo sika-Graves.
• Ukuqapha Ukuphazamiseka Kwe-Thyroid: Ukuhlolwa kungasetshenziswa futhi ukuqapha ukuqhubeka kwezifo ze-autoimmune thyroid kanye nempumelelo yokwelashwa.  
• Ukuhlola ingozi: Amazinga aphezulu e-anti-TPO antibody kubantu abanomsebenzi ojwayelekile we-thyroid angase abonise ingozi eyengeziwe yokuthuthukisa ukungasebenzi kahle kwe-thyroid esikhathini esizayo. 
• Ukuhlolwa Kokungazali: Kwezinye izimo, ama-anti-TPO amasosha omzimba angase ahlotshaniswe nawo ubunyumba kwabesifazane. Ukuhlolwa kwalamasosha omzimba kungaba yingxenye yokuhlolwa kwezinkinga zokungazali, njengoba ukungasebenzi kahle kwegilo kungase kuthinte inzalo.
• Ukuphatha Ukukhulelwa: Abesifazane abakhulelwe abanomlando wokuphazamiseka kwegilo noma ama-anti-TPO amasosha omzimba angaba sengozini yokuthola ukungasebenzi kahle kwe-thyroid noma i-postpartum thyroiditis. 

Ukulungiselela kanjani ukuhlolwa kwe-Anti TPO?

Ngokuvamile, akukho ukulungiselela okuthile okudingekayo ekuhlolweni. Nokho, kufanele kulandelwe imibandela embalwa evamile:

Yazisa udokotela nganoma yimiphi imithi enqunyiwe nenganqunyelwe, kuhlanganise ne-Ayurvedic Medicines, njengoba lokhu kungase kuguqule okutholwe kokuhlolwa kwe-TPO.
Ezimweni eziningi, ukuzila ukudla akudingekile ukuze kuhlolwe i-TPO. Nokho, kutuswa ukuba uthintane nodokotela uma umuntu eseqenjini elithile lokudla.

Kubalulekile ukugwema noma yikuphi ukucindezeleka okungadingekile noma ukukhathazeka okuhlobene nokuhlolwa, njengoba lokhu kungase kuthinte umphumela wokuhlolwa, kuphumele ekuxilongweni okungalungile. 

Imiphumela yokuhlolwa kwe-Anti TPO

Ibanga elijwayelekile le-Anti-TPO lingahluka ngokuphawulekayo ngokusekelwe kuhlelo lokuhlola, ilabhorethri eqhuba ukuhlolwa, nokunye okuguquguqukayo. Ngokuvamile, ububanzi be-Anti-TPO buncane kuno-9.0 IU/mL, futhi noma yini engaphezu kwalolu banga ibhekwa njengengavamile.

Isiphetho

Ukuhlolwa kwamasosha omzimba e-TPO kumane kungenye yokuhlolwa okuningana okuhlobene ne-thyroid, futhi ukuze kutholakale ukuxilongwa okunembile nokukhetha inkambo engcono kakhulu yesenzo, ukuchazwa kwayo kufanele kwenziwe ngokuhambisana nezinye izivivinyo zokusebenza kwe-thyroid (njenge-TSH, T3, ne-T4) kanye nokuhlolwa komtholampilo.

Ithimba lodokotela bezifo eziphezulu kanye nochwepheshe lihlinzeka ngezinsizakalo zokuxilonga ku CARE Izibhedlela. Sinikeza izinhlobonhlobo zokuhlolwa kwaselabhorethri yomtholampilo kanye namaphrofayela asetshenziselwa ukuqinisekisa ukuxilonga, ukulindela ukuhlonzwa kusenesikhathi, ukuhlola izimo, kanye/noma ukuqapha impilo yeziguli.

Imibuzo Evame Ukubuzwa

Q1. Liyini izinga elijwayelekile le-anti-TPO?

Izimpendulo. Izinga elivamile le-antibody ye-TPO licatshangelwa lapho inani lamasosha omzimba emzimbeni lingaphansi kuka-9 IU/mL. Asikho isizathu sokukhathazeka ezimweni ezinjalo.

Q2. Kwenzekani uma i-anti-TPO iphezulu?

Izimpendulo. Izinga le-antibody elingaphezu kuka-9 IU/mL liyinkomba ye-autoimmune thyroid disorder, okuhlanganisa nesifo sika-Hashimoto noma isifo se-Graves, futhi kufanele zelashwe ngendlela efanele.

Q3. Ngingayehlisa kanjani i-anti-TPO yami ngokwemvelo?

Izimpendulo. Ukunciphisa amazinga e-anti-TPO ngokwemvelo:

• Zivumele uphumule.
• Yehlisa noma yeka ukusebenzisa ama-NSAID angalimaza ulwelwesi lwesisu futhi uqale ukudla okuqeda ukudla.
• Gwema izinto ezibangela imvelo.
• I-Selenium ingenye yamavithamini abalulekile okuye kwaboniswa ukuthi asebenza kahle kakhulu ekwehliseni amasosha omzimba egilo.