Into ebizwa ngokuthi i-C-reactive protein (CRP) ikhiqizwa isibindi ukuphendula ukuvuvukala. Le phrotheni ingeyesigaba samaprotheni abizwa ngokuthi i-Acute Phase Reactants, akhishwa yi- izivikeli mzimba lapho ibona ukuvuvukala. Amazinga e-CRP aphakeme angase abonise nokuba khona kokuvuvukala emithanjeni ye-coronary, ngaleyo ndlela kwandise ingozi yesifo senhliziyo. Nakhu ukuqonda okuningiliziwe kokuhlolwa kwe-CRP.

Yini i-C-reactive Protein Test (CRP)?

Ukuhlolwa kwe-CRP kukala ukugcwala kwephrotheni eyaziwa ngokuthi i-CRP egazini, ekhiqizwa isibindi. Amazinga egazi e-CRP angase anyuswe lapho umuntu ehlangabezana ukuvuvukala noma ukutheleleka. I-protein C esebenzayo isetshenziselwa ukuqapha ukutheleleka njengoba amazinga e-CRP evame ukukhuphuka ngaphambi kokuqala kwezimpawu ezifana nobuhlungu noma imfiva futhi ehle njengoba umuntu elulama.

Inhloso yokuhlolwa kwegazi kwe-CRP

Ukuhlolwa kwe-C-reactive protein ngokuvamile ku-odwa ngokuthi abahlinzeki bezempilo ukusiza ekukhombeni noma ekukhishweni kwezimo ezithile, njenge:

• Ukutheleleka - Abantu ababonisa izimpawu zokuvuvukala ezifana nemfiva, ukugodola, isicanucanu, ububomvu noma ukuvuvukala, ukuhlanza, ukuphefumula okusheshayo, noma ukushaya kwenhliziyo okusheshayo.
• Ukwelashwa Kwe-Sepsis - Lesi simo esingase sibe yingozi empilweni kwenzeka lapho amasosha omzimba esabela ekuthelelekeni nge-microorganism ye-bacteria, okuholela ekuvuvukeni kwesistimu.
• Ukuqapha ukuthuthukiswa kwezifo ezizimele, kuhlanganise rheumatoid arthritis kanye neLupus (Systemic Lupus Erythematosus).
• Ukunquma ukwelashwa kwezifo ezivuthayo ezingapheli.
• Ukuhlola ezinye izinhlobo ze-arthritis

Ukuhlolwa kwegazi kwe-CRP kusetshenziselwa ukuqapha iziguli ngemva kokuhlinzwa noma izinqubo ezihlaselayo, okuhloswe ngazo ukunquma ukuthi ziye zahlakulela ukutheleleka ngesikhathi sokululama. Njengoba ukuhlolwa kwe-CRP kungakwazi ukuxilonga isifo esithile noma ukukhomba indawo yokuvuvukala emzimbeni, abahlinzeki bezempilo bavame uku-oda ukuhlolwa okwengeziwe lapho amazinga e-CRP ephakeme.

Ubani owenza ukuhlolwa kwe-CRP?

Ama-Phlebotomists angabahlinzeki bezempilo abayinhloko abanomthwalo wemfanelo wokudonsa igazi; kodwa-ke, noma yimuphi uchwepheshe wezempilo oqeqeshiwe njengodokotela noma abahlengikazi angakwazi ukwenza lo msebenzi. Amasampula egazi aqoqiwe abe esethunyelwa elabhorethri, lapho ososayensi belabhorethri yezokwelapha banesibopho sokulungisa amasampula kanye nokwenza ukuhlaziya besebenzisa imishini eyaziwa ngokuthi abahlaziyi.

Ukusetshenziswa kokuhlolwa kwe-CRP 

Ukuhlolwa kwe-CRP kusetshenziselwa ukuthola noma ukuqapha ukuvuvukala kuzo zombili izimo ezibucayi nezingamahlalakhona, Faka:

• Ukutheleleka okubangelwa amagciwane noma amagciwane
• Izifo zamathumbu okuvuvukala njenge-Crohn's disease kanye ne-ulcerative colitis
• Izifo ze-autoimmune ezifana ne-lupus, i-rheumatoid arthritis, ne-vasculitis
• Izimo zokuphefumula njengesifuba somoya

Ukuhlolwa kwe-CRP kungasetshenziswa ochwepheshe bezokwelapha ukuze bahlole ukusebenza kokwelashwa kokuvuvukala okungapheli noma ukubasiza banqume indlela engcono yokwelapha iziguli ezine-sepsis, ukusabela okungathí sina futhi okungase kube yingozi ekuthelelekeni okungene egazini.

Kwenziwa Kanjani Ukuhlolwa Kwe-CRP?

Ukuhlolwa kwe-CRP kungenziwa esikhungweni sezempilo, esibhedlela sendawo, emtholampilo, noma kulebhu ekhethekile yokuxilonga. Inqubo ngokuvamile ihilela ukukhetha umthambo, ngokuvamile otholakala eduze kwendololwane, nokunamathisela ibhande lokunwebeka engalweni engenhla ukuvumela umthambo ukuthi uvuvuke. Kube sekusetshenziswa i-alcohol swab ukuhlanza isikhumba. Kufakwa inaliti emthanjeni, kukhishwe igazi. Ngemva kwalokho, ibhande lokunwebeka liyasuswa, bese kukhishwa inaliti. Yonke inqubo ngokuvamile ayithathi imizuzu engaphezu kwemihlanu.

Izingozi

Ukuhlolwa kwegazi kungenye yezindlela ezivame kakhulu nezibalulekile zokuhlola nokuhlolwa kwezokwelapha. Ngokuvamile buncane ubungozi obuhlobene nokuhlolwa kwegazi. Abanye abantu bangase bezwe ubuhlungu obuncane noma imihuzuko endaweni lapho inaliti ifakwe khona, kodwa lezi zimpawu zivame ukunyamalala ngokushesha okukhulu.

Ikalwani I-CRP?

Ukuhlolwa kwegazi kwe-CRP kuhlaziya isampula yegazi lomuntu ukuze kutholakale ubukhona nobukhulu bokuvuvukala. Imiphumela yokuhlolwa kwe-CRP inikeza abahlinzeki bezempilo ulwazi mayelana nesimo esiwumsuka. Nokho, ukuhlolwa akubonisi umthombo wokuvuvukala noma imbangela yakho eyisisekelo. Ukuhlolwa okuzwela kakhulu kwe-CRP (h-CRP) kungasetshenziswa ukuhlola ingozi yesifo senhliziyo, ngisho nakubantu ababonakala benempilo enhle. Iyakwazi ukuthola amazinga aphansi kakhulu e-CRP kunokuhlola okujwayelekile kwe-CRP.

Kusho ukuthini izinga eliphansi le-CRP?

Izinga le-CRP elingaphansi kuka-0.9 mg/dL lithathwa njengelijwayelekile, ngakho abukho ububanzi "obuphansi kunokuvamile". Uma amazinga akho e-CRP ehlile kusukela kumphumela ophezulu wangaphambilini, kuphakamisa ukuthi ukuvuvukala emzimbeni wakho kungase kuncishiswe, noma ukuthi ukwelashwa kokuvuvukala kuyasebenza.

Imiphumela ye-CRP 

Imiphumela yokuhlolwa ingase ithathe izinsuku ezimbalwa ukuze itholakale. Abahlinzeki bezempilo banganikeza incazelo yemiphumela. Ukugcwala kweprotheyini e-C-reactive (CRP) egazini ngokuvamile kukalwa ngo-mg/L noma mg/deciliter. 

Ukwenyuka okuncane kokuhlushwa kwe-CRP, phakathi kuka-0.3 mg/dL no-1 mg/dL, akusho ngempela ukuba khona kwesifo esidinga ukwelashwa. Imiphumela yokuhlolwa ephezulu yileyo ene-concentration engu-8 mg/L noma engaphezu kuka-10 mg/L. Uhlu lwemiphumela yokuhlolwa kwephrotheni esebenzayo ka-C lungahluka kuye ngokuthi ilabhorethri eqhuba uhlolo.

Ngingadinga nini ukuhlolwa kwe-C-reactive protein (CRP)?

Ukuhlolwa kwe-CRP kungase kunqunywe udokotela uma isiguli sibonisa izimpawu zokutheleleka okukhulu kwebhaktheriya, njenge:

• Fever
• Ama-Chills
• I-nausea nokuhlanza
• Ukuphefumula okusheshayo
• Ukushaya kwenhliziyo okusheshayo

Isho Ukuthini Imiphumela Engajwayelekile?

Uhlu lwemiphumela yalokhu kuhlolwa luncike elabhorethri kanye nendlela esetshenzisiwe. Ngokuvamile, ukuhlushwa kwe-CRP okungaphansi kuka-9 mg/L kubhekwa kumabanga avamile we-C asebenzayo amaprotheni. Uma ukuhlushwa kwe-CRP egazini kudlula leli zinga, kungase kubonise impendulo yokuvuvukala entweni. Ukuze kutholakale umthombo wokuvuvukala, kungase kudingeke ukuhlolwa okwengeziwe.

Umphumela wokuhlola we-CRP owedlula ama-milligram angu-10 ngedesilitha ngayinye (mg/dL) ngokuvamile ubonakala njengokwenyuka okukhulu. Lo mphumela ungase ubonise noma yiziphi izimo ezilandelayo:

• Ukutheleleka ngegciwane
• Acute izifo ezibangelwa amagciwane
• I-vasculitis yesistimu
• Ukulimala okukhulu

Uma imiphumela yokuhlolwa kwegazi ye-CRP ingaphezu kuka-50 mg/L, kuthathwa njengokuphakama okukhulu. Ezimweni eziningi, ukufundwa okuphezulu kuhlotshaniswa nokutheleleka kwebhaktheriya acute.

Yini okufanele uyenze uma une-CRP ephezulu?

Odokotela babhekisela ezingeni eliphezulu le-C-reactive protein njenge-biomarker. Nakuba i-biomarker iyisici okufanele icatshangelwe lapho uhlola impilo yomuntu, akuyona inkomba eyodwa yokuxilongwa okuthile. Ukuze welashwe amazinga aphezulu we-C-reactive protein, ukudla ukudla okunothe ngefayibha yokudla, izithelo, nemifino kungasiza ekunciphiseni ukugxila kwe-CRP. Uma umuntu esengozini enkulu yokuba nesifo senhliziyo nemithambo yegazi, futhi imiphumela yokuhlolwa ikhombisa amazinga e-CRP aphakeme, umhlinzeki wezokunakekelwa kwempilo angase atuse izidakamizwa zokwehlisa i-cholesterol, njengama-statins. I-Vitamin C iphinde isetshenziselwe ukunciphisa amazinga e-CRP egazini labantu abasengozini enkulu yesifo senhliziyo.

Isiphetho

Ukuhlolwa kwegazi kwe-CRP kuklanyelwe ukuhlola izinga lokuvuvukala emzimbeni womuntu. Izinga eliphakeme le-CRP lingase libonise isimo sezokwelapha esicashile noma ingozi eyengeziwe isifo senhliziyo. Iziguli ezinamazinga e-CRP aphakeme kufanele zithintane nodokotela ukuze anqume inkambo engcono kakhulu yokunciphisa amathuba okuba nezinkinga zempilo ezimbi kakhulu.

Imibuzo Evame Ukubuzwa

Q1. Kwenzekani uma amazinga e-CRP ephezulu? 

Izimpendulo. Amazinga aphezulu e-CRP angase abonise inkinga enkulu yezempilo ehambisana nokuvuvukala. Umzimba usebenzisa ukuvuvukala njengendlela yokuvikela izicubu zawo futhi usheshise ukuphulukiswa ngemva kwengozi, ukutheleleka, noma ukugula.

Q2. Ingabe ukuhlolwa kwe-CRP kungathola izifo ezibangelwa amagciwane? 

Izimpendulo. Ukuhlolwa kwe-CRP kuyasiza ekuhlonzeni nasekuhloleni amazinga e-CRP aphakeme abangwa izifo ezibangelwa amagciwane. Kungasiza ukuthola izifo ezihlukahlukene zegciwane ezibangela ukuvuvukala futhi zikhuphule amazinga e-CRP.

Q3. Kungani kufanele umuntu ahlolelwe i-CRP? 

Izimpendulo. Labo abahlangabezana nanoma yiziphi izimpawu ezilandelayo zokutheleleka ngebhaktheriya bangadinga lokhu kuhlolwa:

• Fever
• I-nausea nokuhlanza
• Ukuphefumula okusheshayo
• Ukushaya kwenhliziyo okusheshayo

Q4. Ingabe ukuhlolwa kunezinye izingozi? 

Izimpendulo. Ukuhlolwa kwegazi mancane kakhulu amathuba okuba kudale umonakalo. Nakuba imihuzuko emincane noma ubuhlungu endaweni yokufaka inaliti kungenzeka, imiphumela emibi eminingi ayivamile.

Izikhombo:

https://my.clevelandclinic.org/health/diagnostics/23056-c-reactive-protein-crp-test