I-GGT inwetshwa njenge-Gamma-Glutamyl Transferase, i-enzyme ku- isibindiama-bile ducts, amanyikwe, kanye izinso. Ukuhlolwa kwegazi kwe-GGT kuwukuhlola okuvamile okwenziwa odokotela besibindi ukuze bahlole impilo yesibindi. Masidale ukuqonda okungcono kokuhlolwa kwe-GGT kanye nezinye izici zayo ezihlukahlukene.

Kuyini ukuhlolwa kwe-GGT?

Ukuhlolwa kwegazi kwe-GGT kwenziwa ukuhlola ukulimala kwesibindi noma isifo. Uma kukhona ukuvuvukala noma ukulimala ezithweni zakho, amazinga e-GGT egazini ayanda. Ngakho-ke, odokotela bazoncoma lokhu kuhlolwa uma izimpawu noma ezinye izivivinyo ziphakamisa ukuthi kunezinkinga zesibindi noma ukuvaleka kwemigudu ye-bile. I-GGT ephakeme ayinikezi ukuxilongwa okuqondile - kodwa inikeza uphawu olubalulekile oluyisixwayiso oludingekayo ukuze kuhlolwe okwengeziwe.

Inhloso yokuhlolwa kwe-GGT

Kunezinjongo ezimbalwa ezibalulekile zomtholampilo okungacebiseka ngazo ukuhlolwa kwegazi le-GGT:

• Ukuthola ukulimala kwamangqamuzana esibindi kusenesikhathi: I-GGT iyisici esibucayi kakhulu sesifo se-bile duct, ngaphambi kokuba ezinye izimpawu zibonakale. Ivumela ukuxilongwa okusheshayo kanye nokwelashwa kusenesikhathi ngaphambi kokuba kwenzeke umonakalo omkhulu.
• Ukuhlolela ukuphuza utshwala ngokweqile: Amazinga e-GGT avame ukukhuphuka ngisho nalapho uphuzwa utshwala obusesilinganisweni, okwenza kube usizo ukuhlonza ukusetshenziswa kabi kotshwala.
• Ukuze kuhlukaniswe imbangela yamazinga aphezulu e-alkaline phosphatase (ALP): I-GGT isiza ukucacisa uma i-ALP ephezulu ibangelwa izinkinga zesibindi ne-biliary noma okunye ngenxa yesifo samathambo.
• Ukuqapha inqubekelaphambili ngokwelashwa esifweni sesibindi esikhona: Ukwehla kokuthambekela kwamazinga we-serial GGT kubonisa ukuphulukiswa kancane kancane kwesibindi esivuvukele.

Kudingeka Nini Ukuhlolwa Kwe-GGT?

Umhlinzeki wokunakekelwa kwezempilo angase a-ode ukuhlolwa kwe-GGT uma unezimpawu noma izimo zezempilo ezingase zibandakanye ukungasebenzi kahle kwesibindi noma ukulimala komgudu wenyongo. Abantu ababonisa izimpawu zokuphazamiseka kwesibindi okungenzeka:

• Ukulahlekelwa kwesifiso, ukwehla kwesisindo ngendlela engaqondakali
• I-nausea, ukuhlanza, nokungaphatheki kahle kwesisu
• jaundice - Isikhumba esiphuzi kanye namehlo amhlophe
• Ukukhathala okujwayelekile okungapheli

Abantu abanezimo zempilo ezisengozini enkulu:

• Isifo sesibindi esaziwayo - isifo sofuba, i-cirrhosis, isibindi esinamafutha
• Umlando we-gallstones noma ukungasebenzi kahle kwe-bile duct
• I-pancreatitis noma izicubu ze-pancreatic
• Ukuchayeka ezidakamizwa/izithasiselo ezinobuthi esibindini
• Ukuhlolwa kwegazi okungavamile kokusebenza kwesibindi

Inqubo yokuhlola ye-GGT

Awekho amalungiselelo akhethekile adingekayo kulokhu kuhlolwa. Izincomo ezijwayelekile ngaphambi kokudonsa igazi ziyasebenza:

• Gwema konke ukuphuza utshwala okungenani amahora angama-24 ngaphambi kokuthatha igazi ukuze uvimbele ukuphakama okungamanga kwamazinga e-GGT. Ngezinye izikhathi, kungase kunconywe ukuba uyeke ukuzithiba.
• Yazisa isazi se-phlebotomist mayelana nayo yonke imithi yamanje kadokotela nengekho kadokotela ethathwayo. Umhlinzeki wezempilo ngezinye izikhathi angase acebise ukuthi kumiswe okwesikhashana umuthi othile uma kwaziwa ukuthi unomthelela emazingeni e-GGT. Iziguli kufanele zilandele ngokuqinile iseluleko sezokwelapha futhi ziyeke imithi kuphela uma zicelwa ngokucacile ukugwema izinkinga.
• Yidla ngokujwayelekile njengokudla okuvamile. Ukuzila ukudla akudingekile ngaphambi kokuthola ukuhlolwa kwe-GGT.

Inqubo yokuhlola ihlanganisa:

• Ukuhlolwa kwegazi okulula okwenziwa esikhungweni sokuxilonga/esibhedlela
• Isampula legazi eliqoqwe emthanjeni; I-anesthesia yendawo ayidingeki
• Ibhande lokunwebeka eliboshwe ukuze lihlukanise umthambo
• Ukufakwa kwe-Antiseptic endaweni yokubhoboza
• Umthamo wegazi ongu-2-6 mL odonswa kumashubhu anamathiselwe
• Ukuzwa kancane kokumpintsha ngesikhathi sokufakwa inaliti
• Kufakwa umfutho owenziwe ngesandla kuze kuphele ukopha, bese kufakwa ibhandishi uma kudingeka

Kusho ukuthini Amazinga E-GGT Ajwayelekile

Amazinga ajwayelekile e-GGT akhombisa ukuthi isibindi sakho, amapayipi enyongo namanyikwe asebenza kahle. Kubantu abadala, ububanzi bereferensi ngokuvamile buphakathi kuka-5 kuya ku-40 U/L. Nokho, amanani avamile angase ahluke kancane kuye ngokuthi ilabhorethri.

Isho Ukuthini Imiphumela Yokuhlolwa Kwe-GGT Engavamile?

Amazinga e-GGT aphezulu kunokujwayelekile asho:

• Ukulimala kwamangqamuzana esibindi, okungenzeka kakhulu ngenxa yesifo sesibindi esinamafutha, i-cirrhosis, i-viral hepatitis noma ukusetshenziswa kabi kotshwala
• Ama-bile ducts avinjelwe ngokuvamile ngenxa yamatshe enyongo
• Pancreatitis
• Amazinga aphakeme kancane angabonakala ngokukhuluphala, isifo sikashukela noma ukusetshenziswa kwezidakamizwa ezithile. Izinga elingaphezu kuka-100 U/L libonisa ukungasebenzi kahle kwe-hepatic noma i-bile duct okudinga ukuxilongwa ngokushesha.

Amazinga e-GGT angaphansi kobubanzi obujwayelekile awavamile kodwa angasho:

• Ukungondleki okungapheli
• Amazinga aphansi amaprotheni e-plasma

Kubantu abaningi abanempilo, amazinga e-GGT ehle kancane awabalulekile ngokwezempilo. Nokho, amanani aphansi kakhulu angaphansi kuka-3 U/L angabonisa isidingo sokuhlola okwengeziwe.

Isho Ukuthini Imiphumela Ye-GGT Engavamile?

Ukuhlolwa kwe-GGT okungajwayelekile akuhloli noma yisiphi isimo ngokwako, kodwa kunikeza ubufakazi obusekelayo. Udokotela wakho uzotolika umphumela wakho we-GGT ehambisana nezimpawu, okutholakele ekuhlolweni ngokomzimba, umlando wezokwelapha kanye neminye imiphumela yokuhlolwa efanelekile. Ukuhlolwa kokulandelela kungase kudingeke ukuze kutholakale ukuxilongwa okunembile.

Isiphetho

I-gamma-glutamyl transferase noma ukuhlolwa kwegazi kwe-GGT kusebenza njengethuluzi elibalulekile lokuhlola nokuxilonga isifo sesibindi. Ngokuvamile kuyingxenye yokuhlolwa okujwayelekile kwangaphambi kokuqashwa kanye nomshuwalense wezempilo. Nakuba ukushintshashintsha okumaphakathi kwamanani e-GGT kuyinto evamile, izinga eliphezulu le-GGT kufanele litshele ukunakekelwa kwezokwelapha ukuze kuhlolwe ukungasebenzi kahle kwesibindi noma ukuvaleka kwemigudu yenyongo. Ukugcina isisindo esijwayelekile nokugwema utshwala kuhlala kuwukhiye ekugcineni amanani e-GGT ehlolwa.

Imibuzo Evame Ukubuzwa

1. Liyini izinga elijwayelekile lokuhlolwa kwe-GGT?

Imikhawulo ejwayelekile evamile yabantu abadala yilena- 

• Owesilisa: 6 kuya ku-55 U/L; 
• Owesifazane: 5 kuya ku-38 U/L, kodwa okunye ukuhlukahluka kukhona kuwo wonke amalabhorethri.

2. Kwenzekani uma ukuhlolwa kwe-GGT kukhombisa ukuthi unayo?

I-GGT ephakeme ivamise ukukhombisa ukulimala kwamangqamuzana esibindi ngenxa yesifo sesibindi esinamafutha, izifo zesibindi, ukuchayeka kobuthi, ubuthi, njll., okudinga ukuhlolwa okwengeziwe.

3. Kwenzekani uma ukuhlolwa kwe-GGT kungenayo?

Nakuba ukushintshashintsha kwesikhashana kungase kwenzeke, amazinga ehla ngokuqhubekayo ngaphansi kwemikhawulo enempilo ayivelakancane kakhulu futhi kunikeza uphenyo lwezokwelapha ngokuntuleka kokudla okunomsoco noma izifo eziwumsuka.

4. Uyini umsebenzi we-GGT?

Inendima ebalulekile ekulawuleni izindlela ze-antioxidant glutathione futhi isiza ukugawula imithi ethile nobuthi.

5. Kuthatha isikhathi esingakanani ukwenza ukuhlolwa kwe-GGT?

Ukuqoqwa kwesampula kuthatha imizuzu embalwa kuphela. Imiphumela yokuhlolwa itholakala phakathi nosuku noma ezimbili, kuye ngendawo yokuxilonga.

6. Ngingakwazi ukunciphisa i-GGT?

Ukuguqulwa kwendlela yokuphila kusiza ukwenza amanani aphezulu ajwayelekile - ukuncipha, ukugwema utshwala/ubuthi nemithi. Ukwelapha izimo zokwelapha ezihambisana nakho nakho kuyazuzisa. Uma amazinga aphezulu kakhulu, ukwelashwa okuqondile kuqondiswe esifweni sesibindi esingaphansi.