I-enzyme ebizwa ngokuthi i-lipase, ekhiqizwa ama-pancreas ethu, isiza ekugayweni kwe-lipids yokudla emathunjini. I-Lipase isiza ekumunceni umzimba kwamafutha futhi ikhishwa amanyikwe, indlala ende, eyisicaba ephakathi komgogodla nesisu. I-pancreas ikhiqiza i-lipase eningi kunokujwayelekile uma ivuvukele noma ilimele. Amazinga e-lipase aphezulu ngokungavamile noma aphansi angase abonise a inkinga ye-pancreatic. Ukuhlolwa okwaziwa ngokuthi ukuhlolwa kwegazi kwe-Lipase kuvumela udokotela ukuthi anqume amazinga e-lipase emzimbeni.

Kuyini ukuhlolwa kwe-Lipase?

Ukuhlolwa kwe-lipase kunquma izinga le-lipase egazini. Umgomo wokuhlolwa kwe-lipase ukuthola ukuphazamiseka kwe-pancreatic, okuvamise ukuba yi-acute pancreatitis. I-pancreas iyisitho esingaphansi kwesisu esikhiqiza amahomoni abalulekile nama-enzyme. Lapho umuntu ene-pancreatitis eyingozi, amanyikwe ayavuvukala futhi avuvukele. Ukuhlolwa kwe-lipase kuvame ukusetshenziselwa ukukhomba i-pancreatitis engapheli, ukugula okuhlala isikhathi eside okungalimaza unomphela ama-pancreas. Ukuhlolwa kwe-lipase kungenziwa futhi ukukhomba ezinye izifo eziningana zezokwelapha, njenge:

• Ukuvinjwa kwamathumbu noma ukulimala
• Ubuhlungu obukhulu besisu noma emuva
• I-Peritonitis
• Ama-cysts ama-Pancreatic
• Isifo se-Celiac, esibangelwa amaprotheni gluten
• I-cystic fibrosis

Kufanele ngiluthole nini ukuhlolwa kwe-Lipase?

Izimo ezithile zempilo zivame ukutholwa kusetshenziswa okutholwe kulokhu kuhlola. Ukuhlolwa kwe-lipase kungasetshenziswa nabasebenzi bezokwelapha ukulandelela ukukhula kwezifo ezithile uma sezikhonjiwe. Kodwa-ke, ngokuvamile, benza ukuhlolwa ukuze bafinyelele ukuxilongwa kokuqala. Uma isiguli sibonisa izimpawu ezingase zibonise isimo esingavamile se-pancreatic, ikakhulukazi lezo ezisikisela i-acute pancreatitis, udokotela angase atuse ukuhlolwa kwe-lipase.

Izimpawu ze-pancreatitis eyingozi zingabandakanya:

• Ubuhlungu esiswini
• Ukuqunjelwa kwesisu noma ukungakhululeki
• Ukuqhephuka nezinzwa
• Fever
• Ukushaya kwenhliziyo okusheshayo
• Izitulo eziphaphathekile
• I-jaundice, ebonakala ngokuba phuzi kwesikhumba namehlo

Ukusetshenziswa kokuhlolwa kwe-Lipase

Lokhu kuhlolwa kusetshenziswa ngokuyinhloko kanye nokuhlolwa kwe-amylase kwe- ukuxilongwa kanye nokuqapha kwe-pancreatitis. Kungasiza futhi ekuxilongeni izifo eziningana, okuhlanganisa i-Cystic Fibrosis, isifo se-Celiac, nesifo sikaCrohn. Amazinga e-lipase angajwayelekile angakhombisa ukuba khona kwezinye izifo ezahlukahlukene ezingathinta i-pancreatitis. Uma sitholwa kusenesikhathi, lesi simo singalawuleka ngendlela efanele. Ukuhlonzwa kusenesikhathi kwamazinga e-lipase nakho kusiza ukuvimbela ukulimala kwezinye izingxenye zomzimba.

Yiziphi izinhlobo ezahlukene zokuhlolwa kwe-Lipase? 

Ukuhlolwa kwe-lipase ukuhlolwa kwezokwelapha okulinganisa amazinga e-lipase, i-enzyme ekhiqizwa amanyikwe, egazini. Amazinga e-lipase aphakeme angakhombisa izimo ezahlukahlukene ezithinta amanyikwe. Kunezinhlobo ezahlukene zokuhlolwa kwe-lipase, okuhlanganisa:

• Ukuhlolwa kwe-Serum Lipase: Lolu uhlobo oluvame kakhulu lokuhlolwa kwe-lipase futhi lukala inani le-lipase ku-serum yegazi.
• Ukuhlolwa kwe-Pancreatic Lipase Immunoreactivity (PLI): Lokhu kuhlolwa kukala ngokuqondile izinga le-pancreatic lipase, eliqondiswe kakhulu ekusebenzeni kwe-pancreatic.
• Ukuhlolwa kwe-Urine Lipase: Enye i-lipase ingase ikhishwe ngomchamo, futhi lokhu kuhlola kukala amazinga e-lipase emchameni.
• Ukuhlolwa kwe-Amidase: Lokhu kuhlolwa kukala umsebenzi we-pancreatic lipase kuma-molecule wamafutha futhi kusetshenziselwa ukuhlola ukusebenza kwe-pancreatic.
• Ukuhlolwa Kwamafutha E-Fecal: Nakuba kungekona ukuhlolwa okuqondile kwe-lipase, ukuhlolwa kwamafutha e-fecal ngezinye izikhathi kusetshenziselwa ukuhlola umsebenzi we-pancreatic ngokungaqondile ngokulinganisa inani lamafutha esitulweni. I-pancreatic lipase idlala indima ekugayweni kwamafutha, ngakho ukushoda kungaholela ekwandeni kwamafutha esitokisini.

Yiziphi izingozi zokuhlolwa kwe-Lipase?

Izingozi ezihlobene nokuhlolwa kwe-lipase zincane, futhi noma yikuphi ukungaphatheki kahle okuhlangenwe nakho ngokuvamile kufushane futhi kuncane ngesikhathi sokudonsa igazi, okuyinto evamile ekuhlolweni kwegazi okuningi. Izingozi ezingaba khona zihlanganisa izinselele ekutholeni isampula, okungase kuholele ezintini yenaliti eziningi. Ukuquleka ngenxa yokubona igazi, okwaziwa ngokuthi i-vasovagal response, kungenye ingozi engase ibe khona. Ukwengeza, kungase kube nengozi ye-hematoma (ukwakheka kwegazi ngaphansi kwesikhumba), ukutheleleka endaweni yokufaka inaliti, ubuhlungu besikhashana noma ukushaywa, kanye nemihuzuko. Naphezu kwalezi zingozi ezingaba khona, ngokuvamile azivamile futhi zincane.

Ungalungiselela kanjani ukuhlolwa kwe-Lipase?

Uma kukhulunywa ngenqubo yokuhlolwa kwe-lipase, kuncane kakhulu ukulungiswa okudingekayo. Njenganoma yikuphi ukuhlolwa kwezokwelapha, kubalulekile ukulandela iseluleko neziqondiso zochwepheshe nodokotela. Isiguli kufanele sizile ukudla amahora angu-8 kuye kwayi-12 ngaphambi kokuhlolwa kwe-lipase, njengoba eyalelwe udokotela. Ukuze kuqinisekiswe imiphumela yokuhlolwa enembile futhi kugwenywe noma yikuphi ukuphazamiseka, iziguli kufanele zazise udokotela wazo kusengaphambili nganoma yikuphi izidakamizwa noma izithasiselo zokudla bayathatha. Udokotela angase futhi aluleke ngokuphuza imithi ethile ngaphambi kokuhlolwa.'

Inqubo yokuhlolwa kwe-Lipase

Ngokuvamile, umthambo osengalweni, ngokuvamile osemgodini wendololwane, usetshenziselwa ukudonsa igazi ukuze kuhlolwe i-lipase.

I-phlebotomist ethatha isampula yegazi izohlanza indawo ezungeze umthambo nge-swab oyinyumba futhi ingase ifake i-tourniquet engalweni engenhla. Inalithi encane isetshenziselwa ukudonsa igazi ngokubhoboza isikhumba nokungena emthanjeni. Igazi eliqoqiwe lingena epayipini elixhunywe enalitini. Kujwayelekile ukuthi uzwe ukulunywa okuncane noma ubuhlungu lapho i-phlebotomist ifaka noma ikhipha inaliti.

Amanani wemiphumela yokuhlolwa kwe-Lipase

Imiphumela yokuhlolwa kwe-lipase ingase ihluke kuye ngezici ezifana neminyaka yesiguli, ubulili, umlando wezempilo, indlela yokuhlola, nezinye izici ngazinye. Kubalulekile ukuxoxa ngemiphumela nodokotela ngenxa yalokhu kuhluka. Umphumela ofanayo wokuhlola ungase ubonise inkinga kumuntu oyedwa kodwa hhayi komunye.

Imiphumela yokuhlolwa kwe-Lipase ngokuvamile yethulwa ngamayunithi ilitha ngalinye (U/L). Izinga le-lipase eliphakathi kuka-10 kuya ku-140 U/L libhekwa njengebanga elivamile kubantu abangaphansi kweminyaka engu-60, kuyilapho ububanzi obungu-24 kuya ku-151 U/L bubhekwa njengento evamile kubantu abaneminyaka engu-60 nangaphezulu.

Inkinga ye-pancreatic iboniswa ngokuba khona kwamanani aphezulu kune-lipase emzimbeni. Kungenzeka ukuthi abantu babe ne-acute pancreatitis uma igazi labo linamazinga e-lipase aphindwe izikhathi ezi-3 kuye kweziyi-10 kunalawo ajwayelekile.

Isiphetho

Ukuhlolwa kwe-lipase akuvamisile futhi mancane amathuba okuthi kube nemiphumela engemihle emibi. Odokotela bangakwazi ukubona i-pancreatitis eyingozi nezinye izimo zezempilo ze-pancreatic besebenzisa okutholakele kokuhlolwa. Ukuhlonzwa kusenesikhathi kanye nokwelashwa kwe-pancreatitis ebukhali kungakuvimbela ukuthi kubi kakhulu. Ukuhlolwa kwe-lipase kubiza kakhulu CARE Izibhedlela futhi iyatholakala kuzo zombili iziguli ezilaliswa esibhedlela nasezikhungweni zokuxilonga.

Imibuzo Evame Ukubuzwa

Q1. Kusho ukuthini izinga le-Lipase eliphezulu?

Izimpendulo. Ukuba khona kwamazinga e-lipase aphezulu kunokujwayelekile egazini kubonisa inkinga ewumsuka wamanyikwe. Amazinga e-lipase egazi aphakeme ngokuphindwe izikhathi ezi-3 kuye kweziyi-10 kunohlu olujwayelekile lwe-lipase ayizinkomba ze-pancreatitis eyingozi. Ukwengeza, amazinga e-lipase aphezulu angase abonise ukwehluleka kwezinso, isifo sesibindi, noma inkinga yesisu.

Q2. Ingabe i-high Lipase ibucayi?

Izimpendulo. Amazinga e-lipase aphakeme egazini angase abonise isifo esihlobene nama-pancreas. Amazinga kwesinye isikhathi aphakeme ngokuphindwe ka-5 kuye kwayi-10 kunenani eliphakeme lokubhekisela ku-pancreatitis eyingozi. Amazinga aphezulu e-lipase angase abe uphawu lwenkinga yezokwelapha evimbela amanyikwe ukuthi akhiqize i-lipase ngokujwayelekile. Izimo ezingaba khona zihlanganisa:

• Ama-gallstones
• Isifo se-Celiac
• I-Cholecystitis.
• Gastroenteritis
• Umdlavuza we-Pancreatic

Q3. Ingabe i-Lipase ephezulu iyelapheka?

Izimpendulo. Amanani aphakeme we-lipase ku-pancreatitis angancishiswa ngokuxilongwa nokwelashwa ngokushesha. Uketshezi olufakwa emthanjeni kanye nemithi yokubhekana nezinkinga eziwumsuka nokunciphisa ukungakhululeki kuyizindlela zokwelapha ezingenzeka. Ukugcina izindinganiso ezijwayelekile ze-lipase kanye nokudla okulinganiselayo kungasiza ekuvimbeleni i-pancreatitis eyingozi.

Q4. Yini ekhulisa amazinga e-Lipase?

Izimpendulo. Ukudla okunama-carbohydrate amaningi kuvame ukuba yisizathu samazinga aphezulu noma aphakeme e-lipase. Ukwengeza, ukucindezeleka, uphuzo oludakayo, nendlela yokuphila yokunganyakazi kungase kube nomthelela kubo.

Q5. Yiziphi izimpawu ze-lipase ephezulu?

Izimpendulo. Uma isiguli sibonisa izimpawu zesifo se-pancreatic, okuhlanganisa umkhuhlane, isicanucanu, indle enamafutha, ubuhlungu beqolo noma besisu obuhlabayo, ukuphelelwa ukudla, nokuncipha kwesisindo ngendlela engaqondakali, udokotela angase atuse ukuhlolwa kwe-lipase.

Q6. Ungawehlisa kanjani amazinga e-Lipase?

Izimpendulo. Ukuze unciphise inani le-lipase emzimbeni, umuntu angase adinge ukuthola uketshezi olufakwa emthanjeni noma imithi yokuphatha ubuhlungu nokwelapha ezinye izimo zezokwelapha. Ukudla ukudla okunomsoco kanye nokuyeka utshwala kungasiza ekunciphiseni ingozi ye-pancreatitis eyingozi ngenkathi kugcina amazinga e-lipase ezinzile.