I-Hyperproteinemia

I-Hyperproteinemia yenzeka njengoba amazinga amaprotheni egazi edlula ibanga elijwayelekile lika-6.0-8.3 g/dL. Lesi simo singase sizwakale siyinkimbinkimbi, kodwa siwuphawu oluyisixwayiso olubalulekile lokuthi umzimba wakho udinga usizo lwezokwelapha.

Amazinga aphezulu amaprotheni angakhomba izinkinga eziningana zempilo. Abantu abadala kufanele balondoloze uhla lwe-albhamuin luka-3.5 kuya ku-5.0 g/dl kanye nebanga le-globulin eliphakathi kuka-2.0 kuya ku-3.5 g/dl. Ibhalansi yamaprotheni omzimba, elinganiswa ngesilinganiso se-A/G, kufanele ihlale phakathi kuka-0.8 no-2.0. Ukuphelelwa amanzi emzimbeni okulula kungabangela i-hyperproteinemia, kodwa izimo ezimbi kakhulu njengokuvuvukala okungapheli, izifo, kanye nezinhlobo ezithile ze umdlavuza kungabuye kubangele.

Umsebenzi wamangqamuzana egazi omzimba uhlushwa yilokhu kuphazamiseka kwe-metabolic, okuholela ekwandeni kwamazinga ezinhlobo zomoya-mpilo osebenzayo. Ukuhlolwa kwezokwelapha kuba semqoka njengoba i-hyperproteinemia ivame ukwembula ukukhathazeka okujulile kwezempilo. I-Myeloma eminingi kanye ne-Waldenström macroglobulinemia ziphakathi kwezindlela ezidinga ukunakekelwa kwezokwelapha ngokushesha. Lesi sihloko sihlanganisa konke iziguli okufanele zazi mayelana nezimpawu ze-hyperproteinemia, izimbangela, izindlela zokuxilonga, nezinketho zokwelapha.

Iyini i-Hyperproteinemia?

Umzimba wakho udinga amaprotheni ukuze usebenze kahle. Amazinga aphezulu amaprotheni egazini lakho angabonisa izinkinga zempilo.

I-Hyperproteinemia yenzeka lapho i-plasma yegazi iqukethe amazinga amaprotheni aphezulu ngokungavamile. Ibanga elijwayelekile le-serum protein lihlala phakathi kuka-6.0 kuya ku-8.3 g/dL. Lokhu kuphazamiseka kwe-metabolic ngokuvamile kwenza izifo ezinzima zibe nzima kakhulu futhi kuthinte umbono wesiguli kabi.

Izimpawu ze-Hyperproteinemia

Abantu abavamile ukubona izimpawu ezivela kumaprotheni aphezulu egazi kuphela. Iziguli zingase zibe nalezi zimpawu:

• Ukukhathala okukhulu noma ukukhathala
• Ukwehla kwesisindo ngaphandle kwencazelo
• Ubuhlungu noma ukuphuka emathanjeni
• Ukutheleleka okuphindaphindiwe
• Imizwa yokuba ndikindiki kanye nokuluma

Izinkinga ze-Hyperproteinemia

Amazinga amaprotheni egazi angakhuphuka ngenxa yezizathu eziningana:

• Ukuphelelwa amanzi emzimbeni kunciphisa i-plasma yegazi, kuyilapho amaprotheni ehlala engashintshi
• Ukuvuvukala okungapheli okuvela ezimeni ezifana ne-rheumatoid arthritis kwandisa i-globulin
• Izifo ezibangelwa amagciwane, kuhlanganise i-hepatitis B, i-hepatitis C, i-HIV/AIDS
• I-Myeloma eminingi idala ukukhiqizwa okungajwayelekile kwamaprotheni
• Isifo sesibindi sithinta indlela amaprotheni asetshenziswa ngayo

Ingozi ye-Hyperproteinemia

I-Hyperproteinemia isebenza njengenkomba esikhundleni sesifo. Ucwaningo lukhombisa ukuthi lungaphazamisa ibhalansi yemvelo yamaseli akho egazi.

Izinkinga ze-Hyperproteinemia

Amazinga aphezulu amaprotheni angabangela izinkinga ezinkulu uma engelashwa:

• Your izinso zilimale kusuka ku-protein engapheli
• Ukuwohloka kwamathambo kwenzeka, ikakhulukazi uma une-myeloma eminingi
• Izinkinga zenhliziyo ukuthuthukisa ukuvuvukala okuqhubekayo

Sifo

Odokotela badinga indlela ehlelekile yokuthola nokuphatha i-hyperproteinemia. Basebenzisa lezi zivivinyo ezithile ukuxilonga i-hyperproteinemia:

• Ukuhlolwa Kwegazi - Isamba sokuhlolwa kwamaprotheni sikala amazinga amaprotheni ewonke, kuyilapho i-serum protein electrophoresis (SPEP) isiza ukukhomba amaprotheni athile kanye nomthombo wawo.
• Ukuhlolwa Komchamo - Udokotela angabona amaprotheni angavamile emchameni ngokusebenzisa umchamo weprotheyini electrophoresis
• I-Bone Marrow Biopsy - Lokhu kuhlolwa kubheka amaseli omnkantsha ukuze kuhlolwe izimo ezifana ne-myeloma eminingi
• I-Imaging Studies - Izilonda zamathambo noma ukulimala kwesitho kubonakala kuma-X-ray, ama-CT scan noma ama-MRIs

Ukwelashwa

Uhlelo lokwelapha luqondise umsuka wembangela:

• Ukubuyisela kabusha amanzi emzimbeni - Ukuphuza amanzi amaningi kusiza ukwenza umthamo wegazi ube ngokwejwayelekile uma ukuphelelwa amanzi emzimbeni kubangela inkinga
• Imithi - Odokotela bangase banikeze izidakamizwa ezilwa nokuvuvukala, i-corticosteroids noma ama-immunosuppressants ngokusekelwe esimweni
• I-Plasmapheresis - Odokotela basebenzisa le nqubo ukususa amaprotheni amaningi egazini
• Ukwelapha Izimo Ezithize - Ukwelashwa kuyahlukahluka kusuka kuma-antibiotics kuya kwezifo imiphumela emibi yokwelashwa ngamakhemikhali ngomdlavuza.

Uzoyibona Nini Udokotela

Iya kudokotela ngokushesha uma:

• Umzimba wakho unokuvuvukala noma ukuncipha kwesisindo okungalindelekile
• Ulokhu uthola izifo noma uzizwa ukhathele
• Unomlando wezinso noma izinkinga kwesibindi
• Izimpawu zakho ziba zimbi kakhulu noma kuvela ezintsha ezikukhathazayo

Prevention

Ezinye izimbangela zihlala zingagwemeki, kodwa lawa masu angasiza:

• Gcina umzimba wakho ugcwele amanzi
• Namathela ezinhlelweni zokwelashwa ezinqunyiwe ezimweni ezikhona
• Hlela ukuhlolwa okuvamile ukuze uthole izinkinga kusenesikhathi
• Khetha a Ukudla okunazo zonke kanye nendlela yokuphila enempilo

Isiphetho

I-Hyperproteinemia iwuphawu oluyisixwayiso kunesimo esizimele. Umzimba wakho udinga amaprotheni ukuze asebenze ngendlela evamile, kodwa amazinga angaphezu kuka-8.3 ​​g/dL adinga ukunakekelwa kwezokwelapha. Amazinga aphezulu amaprotheni ewodwa awavamile ukubangela izimpawu eziqondile. Ungase uzwe ukukhathala, ukuncipha, nobuhlungu bethambo obungakhomba kokuthile okudinga ukuhlolwa kodokotela.

Ukuhlolwa kwegazi kusiza odokotela bathole lesi simo. I-Serum protein electrophoresis ikhomba amaprotheni athile aphakamisa la mazinga. Ukuhlolwa komchamo kanye nezifundo zezithombe nakho kusiza ukuthola izinkinga zezimpande. Ukwelashwa kuncike ekutheni kudalwa yini - kusukela ekuphuzeni nje uketshezi oluthe xaxa ukuze kukhishwe amanzi emzimbeni kuya ekwelapheni okukhethekile komdlavuza.

Ukuqapha impilo yakho kuba okubalulekile uma unezici zobungozi noma izimo ezithinta ukukhiqizwa kwamaprotheni. Inani elifanele lokudla kwamanzi lisiza ukugcina ibhalansi efanele yamaprotheni egazi. Ukuhlala unamanzi kuvimbela izimo ezihlobene nokuphelelwa amanzi emzimbeni. Ukuvakasha kodokotela njalo kungabona izitayela ezikhathazayo kusenesikhathi.

Ukwazi nge-hyperproteinemia kukunikeza amandla okubona izixwayiso zezempilo ezingaba khona. Lokhu kungalingani kwamaprotheni egazi kusebenza njengesistimu ye-alamu yomzimba wakho futhi kuyakutshela uma kukhona okudinga ukunakwa. Ukunakekelwa kwezokwelapha okusheshayo nokulandela uhlelo lwakho lokwelashwa kuthuthukisa kakhulu imiphumela yanoma yiziphi izimo ezitholakala ngesikhathi sokuxilongwa.

Imibuzo Evame Ukubuzwa

1. Iyini imbangela eyinhloko yamaprotheni amaningi egazini?

Amazinga amaprotheni egazi akhuphuka kakhulu ngenxa yokuphelelwa amanzi emzimbeni. Ezinye izici eziningi zingaphakamisa amazinga amaprotheni okuhlanganisa ukuvuvukala okungapheli, izifo ezifana ne-hepatitis B, i-hepatitis C noma i-HIV, i-myeloma eminingi, nezimo zesibindi ezihlukahlukene. Izindlela zokwelapha zincike ezindleleni zomsebenzi.

2. Ingabe ukuphelelwa amanzi emzimbeni kubangela i-hyperproteinemia?

Yebo. Lapho umzimba ulahlekelwa uketshezi, umthamo we-plasma yegazi uyancipha, futhi ukugxila kwamaprotheni kuyanda. Ukuphelelwa amanzi emzimbeni ngokuvamile kubangela ukwanda okungazelelwe kwamazinga amaprotheni. Ukuphuza uketshezi olwanele ngokuvamile kuyixazulula inkinga ngokushesha.

3. Yiliphi ibanga elivamile le-hyperproteinemia?

Ingqikithi yamaprotheni egazi kufanele yehle phakathi kwamagremu angu-6.0 no-8.3 ngedesilitha ngayinye (g/dL). I-Hyperproteinemia yenzeka lapho ukufundwa kudlula leli banga. Ububanzi obujwayelekile be-albumin busukela ku-3.5 kuye ku-5.0 g/dL, futhi iglobulin ngokuvamile ikala phakathi kuka-2.0 kuya ku-3.5 g/dL.

4. Aphezulu kangakanani amaprotheni egazini?

Amazinga amaprotheni angaphezu kuka-8.3 ​​g/dL abonisa ukuphakama. Kodwa ukubaluleka komtholampilo kuyahlukahluka ngokusekelwe kulokho amaprotheni athile akhuphuka kanye nezindlela zawo.

5. Ingabe isibindi esinamafutha singabanga amaprotheni amaningi egazini?

Yebo. Ucwaningo lubonisa ukuthi isifo sesibindi esinamafutha angenalo utshwala (NAFLD) sihlotshaniswa namazinga aphezulu amaprotheni C. Iziguli ze-NAFLD zibonise amazinga aphezulu amaprotheni C uma kuqhathaniswa nalabo abane-hepatitis yegciwane elingapheli.

UDkt. Vivek Chaurasia

I-MBBS, MD (Imithi Yangaphakathi)
Izibhedlela ze-CARE CHL, e-Indore

Ukuze Ubhukhe Isikhathi, shayela:

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