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Alfuzosin

I-Alfuzosin isiza izigidi zamadoda ukuthi zilawule izimpawu zomchamo ezihambisana ne-prostate ngempumelelo. Ithebhulethi evamile ye-Alfuzosin iza ngamandla angu-10 mg futhi idinga umthamo owodwa kuphela wansuku zonke. Lesi sihloko sichaza yonke into iziguli okudingeka ziyazi mayelana nokusetshenziswa kwe-Alfuzosin, imihlahlandlela efanele yemithamo, imiphumela engemihle engaba khona, kanye nezinyathelo zokuphepha ezibalulekile zokuqinisekisa ukwelashwa okuphephile nokusebenzayo.

Iyini i-Alfuzosin?

I-Alfuzosin imithi kadokotela eyingxenye yezidakamizwa ezibizwa ngokuthi i-alpha-1 blockers. Yagunyazwa okokuqala ukuthi isetshenziswe ngokwezokwelapha ngo-1988, isiphenduke inketho yokwelapha ebalulekile yabesilisa abane-benign prostatic hyperplasia (BPH), ukukhuliswa okungewona umdlavuza kwendlala yesinye okuvamise ukuphatha amadoda amadala.

Izici ezibalulekile ze-Alfuzosin zifaka:

  • Imuncwa kalula ohlelweni lokugaya ukudla ngo-49% we-bioavailability uma ithathwa nokudla
  • Icutshungulwa kakhulu esibindini
  • Inesigamu sempilo yokuqeda cishe amahora ayishumi
  • Ikhishwa ngokuyinhloko nge-bile kanye nendle
  • I-11% kuphela yemithi ibonakala ingashintshile emchamweni
shayela nathi
bhuka i-aphoyintimenti

Ukusetshenziswa kwethebhulethi ye-Alfuzosin

Inhloso eyinhloko yamaphilisi e-alfuzosin ukwelapha i-benign prostatic hyperplasia (BPH), ukugula lapho indlala yendlala yesinye ikhula khona kodwa ihlale ingenawo umdlavuza. 

Amaphilisi e-Alfuzosin 10 mg asiza ekudambiseni izimpawu ezimbalwa ezivamile ze-BPH:

Ithuthukisa umsebenzi wezocansi, okuhlanganisa ukuqina okungcono kwe-erection kanye nokunciphisa ukungakhululeki ngesikhathi sokuphuma. Umuthi usebenza ngokuphumuza imisipha ethile ku-prostate kanye nesinye, esiza ukwandisa ukugeleza komchamo ngaphandle kokunciphisa i-prostate gland ngokwayo.

Ungayisebenzisa Kanjani Ithebhulethi ye-Alfuzosin

Ukuphathwa ngendlela efanele kwamaphilisi e-alfuzosin kubalulekile ukuze kuzuzwe izinzuzo eziphelele zokwelapha. 

Iziguli kufanele zilandele lezi ziqondiso ezibalulekile lapho zithatha amaphilisi e-alfuzosin:

  • Thatha ithebhulethi eyodwa ye-10 mg kanye ngosuku nengilazi yamanzi egcwele
  • Njalo phuza imithi ngemva kokudla okufanayo usuku ngalunye
  • Geza ithebhulethi iphelele ngaphandle kokuyichoboza, ukuyihlukanisa, noma ukuyihlafuna
  • Gcina isimiso sansuku zonke esingashintshi
  • Ukuthatha i-alfuzosin ngokudla kubaluleke kakhulu njengoba izinga lokumunca lehla ngo-50% uma lithathwa esiswini esingenalutho.
  • Ungalokothi uthathe umthamo ophindwe kabili ukuze ubuyisele ogejiwe.

Imiphumela Emibi Yethebhulethi ye-Alfuzosin

Njengayo yonke imithi, iziguli ezithatha amaphilisi e-alfuzosin zingase zibe nemiphumela ethile engemihle, kusukela kokuncane kuye kokuqina. Imiphumela engemihle evamile iziguli ezibhekana nazo ihlanganisa:

  • Isiyezi noma ikhanda elikhanyayo
  • bekhanda
  • Ukukhathala noma ukukhathala
  • Ukuminyana emakhaleni noma izimpawu ezinjengamakhaza
  • Ukungaphatheki kahle kwesisu

Ezinye iziguli zingase zibe nemiphumela emibi kakhulu edinga ukunakwa ngokushesha. Lokhu kubandakanya:

  • Ukungezwani okukhulu nezimpawu ezifana nezinkinga zokuphefumula, ukuvuvukala kobuso/umphimbo, noma ukuqubuka kwesikhumba
  • Ukwehla okungazelelwe kwe-BP lapho usukuma (i-orthostatic hypotension)
  • ubuhlungu besifuba noma ukushaya kwenhliziyo okungajwayelekile
  • Ukumiswa komthondo isikhathi eside, okubuhlungu okuhlala amahora angaphezu kwama-4 (priapism)

Ukuqapha

Ukucatshangelwa kokuphepha kudlala indima ebalulekile lapho uthatha amaphilisi e-alfuzosin:

  • Izimo Zezokwelapha: 
    • Iziguli ezinezinkinga zesibindi akufanele zithathe i-alfuzosin uma zinokukhubazeka kwesibindi okumaphakathi kuya kokunzima.
    • Labo abanezinkinga zezinso badinga ukuqapha ngokucophelela, ikakhulukazi uma ukukhululeka kwezinso kungaphansi kuka-30 mL/min. 
    • Abantu abanezimo zenhliziyo, ikakhulukazi labo abanomlando wokwelulwa kwe-QT, badinga ukunakwa okukhethekile njengoba i-alfuzosin ingase ithinte isigqi senhliziyo.
  • Ukungezwani komzimba: Abantu abangezwani nalo muthi noma okuqukethwe kwawo kufanele babonane nodokotela wabo ngaphambi kokuwuthatha.
  • Ukukhulelwa Nokuncelisa: Abesifazane abakhulelwe, abahlela ukukhulelwa, noma abancelisayo kufanele batshele udokotela wabo kusengaphambili. 
  • Ukuhlinzwa Kwamehlo: Uma umuntu ehlinzekwe iso kusengaphambili, kufanele atshele udokotela wakhe ngakho ngaphambi kokuthatha i-alfuzosin, njengoba kungase kwandise ingozi ye-intraoperative floppy iris syndrome ngesikhathi noma ngemva kwalokho. i-glaucoma or ukuhlinzwa kwe-cataract.

Isebenza kanjani ithebhulethi ye-Alfuzosin

Indlela yokusebenza ngemuva kwamaphilisi e-alfuzosin yembula indlela eyinkimbinkimbi lo muthi osiza ngayo ukuphatha izimpawu zomchamo. Njengomphikisi we-alpha-1 adrenergic, i-alfuzosin isebenza ngokukhomba ama-receptors athile atholakala endaweni ephansi yomchamo, ikakhulukazi ezindaweni ze-prostate kanye nentamo yesinye.

Isenzo esiyinhloko somuthi senzeka ngokubopha okukhethekile kuma-alpha-1 adrenergic receptors. Uma ecushwe ngokwemvelo, lawa ma-receptors abangela ukufinyela kwemisipha emgudwini womchamo. Ngokuvimbela lawa ma-receptors, i-alfuzosin isiza ukufeza:

  • Ukuphumula kwemisipha ebushelelezi ku-prostate
  • Ukuncipha kwengcindezi entanyeni yesinye
  • Ukugeleza komchamo okuthuthukisiwe ku-urethra
  • Ukuthululwa kwesinye okuthuthukisiwe
  • Ukunciphisa ukumelana nokugeleza komchamo

Ngingakwazi Ukuthatha I-Alfuzosin Ngeminye Imithi?

Ukusebenzisana Kwezidakamizwa Okukhulu:

  • Imithi elwa namagciwane (njenge-ketoconazole kanye itraconazole)
  • Imithi elwa namagciwane ye-HIV (njenge-ritonavir)
  • Ukushaya kwegazi kunemithi noma amaphilisi
  • Imithi ye-HIV (njenge-ritonavir)
  • Imithi yokungasebenzi kahle kwe-erectile (PDE-5 inhibitors)
  • I-Nitroglycerin 
  • Eminye imithi ye-alpha-blocker (njenge-doxazosin, i-prazosin, ne-tamsulosin)
  • I-CYP3A4 enzyme inhibitors enamandla

Ulwazi Lomthamo

Umuthi ojwayelekile wokudosa we-alfuzosin udinga ukunakwa okucophelelayo kusikhathi nezindlela zokuphatha ukuze kuqinisekiswe ukusebenza kahle okuphelele. Odokotela ngokuvamile banquma ithebhulethi eyodwa yokukhululwa okunwetshiwe engu-10 mg okufanele iphuzwe kanye ngosuku.

Isiphetho

Ukwelashwa okuphumelelayo nge-alfuzosin kuncike ekusetshenzisweni kwemithi efanele kanye nokunaka imihlahlandlela yokuphepha ngokucophelela. Iziguli kufanele zikhumbule ukuphuza umthamo wazo wansuku zonke nokudla, zibheke imiphumela engemihle engaba khona, futhi zigcine ukuxhumana njalo nodokotela bazo. Ukuhlolwa njalo kwezokwelapha kusiza ukuqinisekisa ukuthi umuthi uyaqhubeka nokusebenza ngempumelelo kuyilapho kunciphisa izingozi. Irekhodi elifakazelwe le-alfuzosin ekwelapheni izimpawu ze-BPH likwenza kube inketho ebalulekile kwabesilisa abafuna ukukhululeka ezinkingeni zomchamo ezihlobene nendlala yesinye.

Imibuzo Evame Ukubuzwa

1. Ingabe i-alfuzosin iphephile?

Ucwaningo lwezokwelapha lubonise ukuthi i-alfuzosin ngokuvamile ibekezelelwa kahle iziguli eziningi. Umuthi ukhombise iphrofayili yokuphepha evumayo, futhi u-6.1% kuphela weziguli ezibika isiyezi njengomphumela ovame kakhulu. Ukusabela okubi okuningi kuthambile futhi kungokwesikhashana, ngokuvamile kuxazululeka phakathi nezinsuku ezimbalwa zokuqala ukwelashwa.

2. Ubani okufanele aphuze i-alfuzosin?

Abesilisa abadala okutholwe ukuthi bane-benign prostatic hyperplasia (BPH) abathola izimpawu zokuchama ezimaphakathi kuya kwezinzima bangamakhandidethi afanelekile ekwelapheni i-alfuzosin. Umuthi uzuzisa kakhulu:

  • Amadoda angaphezu kweminyaka engama-50 anokuxilongwa okuqinisekisiwe kwe-BPH
  • Iziguli ezinenkinga yokuchama
  • Labo abafuna ukuphathwa isikhathi eside kwezimpawu ze-prostate

3. Ubani ongakwazi ukuthatha i-alfuzosin?

I-Alfuzosin ayilungele amaqembu amaningana eziguli:
Abesifazane nezingane

  • Amadoda anezinkinga ezinzima zesibindi
  • Iziguli ezinokukhubazeka okukhulu kwezinso
  • Labo abathatha imithi ethile efana ne-ketoconazole noma i-ritonavir
  • Abantu abanomlando we-orthostatic hypotension

4. Ngingakwazi ukuthatha i-alfuzosin nsuku zonke?

Yebo, i-alfuzosin 10 mg yenzelwe ukusetshenziswa kwansuku zonke. Umuthi usebenza kahle kakhulu uma uphuzwa njalo ngesikhathi esifanayo usuku ngalunye nokudla. Ukudla okuvamile kwansuku zonke kusiza ukugcina amazinga aqinile emithi emzimbeni, kunikeze ukukhululeka kwezimpawu okuqhubekayo.

5. Ngingathatha isikhathi esingakanani i-alfuzosin?

Iziguli zingathatha i-alfuzosin isikhathi eside ngaphansi kokuqondisa kodokotela. Umuthi usiza ukulawula izimpawu ze-BPH kodwa ayelaphi isimo. Ukuhlolwa njalo nodokotela kuqinisekisa ukusebenza ngempumelelo okuqhubekayo nokuphepha kokwelashwa.

6. Ingabe i-alfuzosin iyingozi ezinso?

I-Alfuzosin idinga ukuqapha ngokucophelela ezigulini ezinezinkinga ezinkulu zezinso. Nakuba ingeyona ingozi ngokuqondile ezinso, imithi ingase inqwabelane emzimbeni uma ukusebenza kwezinso kungasebenzi. Iziguli ezinenkinga yezinso kufanele zixoxe ngesimo sazo nodokotela wazo.

7. Kungani i-alfuzosin ithathwa ebusuku?

Ukuthatha i-alfuzosin ebusuku kusiza ukunciphisa umthelela wemiphumela engemihle engaba khona njengesiyezi ngesikhathi sokuvuka. Umthamo wakusihlwa ngokudla uqinisekisa ukumuncwa okuphelele futhi kusiza iziguli ukuthi zilawule noma yimiphi imiphumela emibi yokuqala ngesikhathi zilele.

8. Ingabe i-alfuzosin iphephile esibindini?

Abantu abanezifo zesibindi ezimaphakathi kuya kwezinzima akufanele bathathe i-alfuzosin ngoba ingase iholele ekwenyukeni kwamazinga ezidakamizwa emzimbeni. Isibindi siwucubungula lo muthi, futhi ukungasebenzi kahle kwesibindi kungaholela ekugxilweni okuphezulu komuthi, okungaba ngcono imiphumela emibi.