Anastrozole

Anastrozole

I-Anastrozole, isidakamizwa esinamandla esisetshenziselwa ukwelapha izinhlobo ezithile zomdlavuza wamabele, isishintshe kakhulu iziguli eziningi. Lo muthi, ovame ukunikezwa njengamaphilisi e-anastrozole, ubonise imiphumela emangalisayo ekusizeni ukuphatha i-hormone-receptor-positive. umdlavuza webele kwabesifazane be-postmenopausal. Kulesi sihloko, sizongena emininingwaneni ye-anastrozole nokusetshenziswa kwayo. Sizohlola ukuthi iyini i-anastrozole, isebenza kanjani, kanye nendlela efanele yokusebenzisa amaphilisi e-anastrozole 1 mg. 

Yini i-Anastrozole?

I-Anastrozole umuthi onamandla osetshenziswa ekwelapheni umdlavuza webele. Ingokwesigaba sezidakamizwa ezibizwa ngokuthi ama-nonsteroidal aromatase inhibitors. Amaphilisi e-Anastrozole amiselwe ngokuyinhloko kwabesifazane abangemva kokuya esikhathini abanomdlavuza webele we-hormone receptor-positive. Lo muthi usebenza ngokwehlisa inani le-estrogen elikhiqizwa emzimbeni, elingabambezela noma limise ukukhula kwezinhlobo ezithile zamangqamuzana omdlavuza webele athembele ku-estrogen ukuze akhule.

I-Anastrozole yaziwa ngokusebenza kwayo futhi ifakwe ohlwini Lwemithi Ebalulekile Lwenhlangano Yezempilo Yomhlaba (i-WHO). Itholakala njengemithi ejwayelekile futhi inqunywe kabanzi, nezigidi zemithi kadokotela zigcwaliswa minyaka yonke.

Ukusetshenziswa kwethebhulethi ye-Anastrozole

Ezinye zezindlela ezijwayelekile zokusetshenziswa kwe-anastrozole yilezi:

• Amaphilisi e-Anastrozole anendima ebalulekile ekwelapheni umdlavuza webele we-hormone receptor-positive kwabesifazane abangemva kokuya esikhathini. 
• Amaphilisi e-Anastrozole ayakhethwa njengokwelashwa kwe-adjuvant ngemva kokuhlinzwa noma ngemisebe yomdlavuza webele wesigaba sokuqala. 
• I-Anastrozole 1 mg nayo iyafaneleka njengenketho yokwelashwa yomugqa wokuqala yomdlavuza webele othuthukile noma we-metastatic kwabesifazane abangemva kokuya esikhathini. 
• Ezimweni lapho i-tamoxifen ingazange isebenze kahle, amaphilisi e-anastrozole angase asetshenziselwe ukwelapha umdlavuza webele osuke waba mubi kakhulu.
• Ngokwehlisa amazinga e-estrogen, i-anastrozole isiza ukuvimbela ukukhula kwezimila ezincike kule hormone.

Isetshenziswa kanjani i-Anastrozole Tablet

• Amaphilisi e-Anastrozole athathwa kanye ngosuku, ngokudla noma ngaphandle kokudla. 
• Kubalulekile ukulandela imiyalelo kadokotela wakho kahle. Ungashintshi umthamo we-anastrozole noma ubude besikhathi sokwelashwa ngaphandle kokubonisana nodokotela wakho. 
• Uma uphuthelwa umthamo, thatha ngokushesha lapho ukhumbula. Kodwa-ke, ungalokothi uphindaphinde imithamo ukuze unxephezele ophuthiwe. 
• Gcina amaphilisi e-anastrozole ekamelweni lokushisa, kude nokushisa, umswakama, nokukhanya okuqondile. 
• Gcina imithi lapho izingane zingakwazi ukufinyelela khona futhi ulahle noma yimuphi umuthi ophelelwe yisikhathi ngendlela efanele.

Imiphumela Emibi Yethebhulethi ye-Anastrozole

I-Anastrozole ingabangela imiphumela emibi ehlukahlukene, nakuba kungebona bonke abahlangabezana nayo. Imiphumela emibi evamile ihlanganisa: 

• Ukushisa nokujuluka
• Ubuhlungu bemisipha noma obuhlangene
• Ukuzizwa ugula (nausea)
• Ukuphathwa yikhanda 
• Ukushintsha kwesikhumba, njengokuqubuka noma ukoma
• Ukuncipha kwamathambo (osteoporosis) 
• Inkinga yokulala
• Ukugcinwa kwe-Fluid
• Umfutho wegazi ophezulu

Imiphumela emibi ejwayelekile ifaka phakathi: 

• Ukopha noma ukoma esithweni sangasese
• Ukulahlekelwa kwesifiso
• Izinguquko ekunambithekeni
• Izinwele ezincane 
• Isizungu noma ukuquleka
• Uhudo
• Ukuphuka kwamathambo
• Ukungezwani komzimba okukhulu, okuhlanganisa umkhuhlane, izinkinga zokuphefumula, ama-lymph node avuvukile, ukuvuvukala kobuso, amehlo, izindebe, nomlomo, noma ukulunywa

Ukuqapha

• Ukuqaphela izidakamizwa: Ngaphambi kokuthatha i-anastrozole, kuyadingeka ukwazisa udokotela wakho nganoma yikuphi ukungezwani nemithi noma izithako zayo. Xoxa ngayo yonke imithi yamanje, okuhlanganisa incwadi kadokotela, i-over-the-counter, amavithamini, nezithako zemithi. Imithi ethile equkethe i-estrogen, njengokwelashwa esikhundleni se-hormone noma ukulawula ukuzalwa, ingase ihlanganyele ne-anastrozole. Udokotela wakho angase adinge ukulungisa umthamo wakho noma akugade eduze ukuze uthole imiphumela engemihle.
• Isimo Sezempilo: Yazisa udokotela wakho nganoma yiziphi izimo zempilo ezikhona, ikakhulukazi i-cholesterol ephezulu, i-osteoporosis, isibindi, noma isifo senhliziyo. 
• Ukukhulelwa Nokuncelisa: I-Anastrozole ihloselwe kuphela abesifazane abangemuva kokuya esikhathini futhi ingase ilimaze umbungu osakhula. Uma ukhulelwe noma uncelisa, tshela udokotela wakho ngaphambi kokuqala le mithi.
• Ukuqapha I-Vitamin D: Ukusetshenziswa kwe-Anastrozole kungase kuhlotshaniswe ne-carpal tunnel syndrome. Bika noma yikuphi ukuba ndikindiki noma ukuntweza esandleni noma eminweni yakho kudokotela wakho ngokushesha. Ngaphezu kwalokho, yakho i-vitamin D amazinga angase adinge ukugadwa, futhi ungase udinge izithasiselo.

Isebenza kanjani ithebhulethi ye-Anastrozole

I-Anastrozole, imithi enamandla esigabeni se-aromatase inhibitors, ithonya ukwelashwa komdlavuza webele. Ivimbela i-enzyme aromatase, edlala indima edingekayo ekukhiqizeni i-estrogen. Kwabesifazane abangemva kokuya esikhathini, iningi le-estrogen liphuma kuma-androgens, liguqukela ekubeni ama-estrogen ezicubu ezihlukahlukene, okuhlanganisa nezindlala ze-adrenal, isikhumba, imisipha namafutha. Amaphilisi e-Anastrozole avimbela lokhu kuguqulwa, okuholela ekwehleni kwamazinga e-estrogen.

Ngingakwazi Ukuthatha I-Anastrozole Ngeminye Imithi?

I-Anastrozole inokusebenzisana okumbalwa neminye imithi, kodwa ukwazisa udokotela wakho ngayo yonke imithi eqhubekayo kubalulekile. Lokhu kubandakanya: 

• I-Axitinib
• Ama-estrogens ahlanganisiwe
• I-Estradiol
• Amakhambi amakhambi noma izithasiselo 
• I-Hormone replacement therapy (HRT) 
• I-Lomitapide
• Imithi ekhulula izimpawu zokunqamuka kokuya esikhathini 
• Tamoxifen

Ulwazi Lomthamo

Umthamo ojwayelekile we-anastrozole yithebhulethi eyodwa engu-1 mg kanye ngosuku. Lolu hlobo lomthamo lusebenza kukho konke ukusetshenziswa okugunyaziwe kwe-anastrozole, okuhlanganisa nokwelashwa kwe-adjuvant yomdlavuza webele wangaphambi kwesikhathi kanye nokwelashwa komdlavuza webele othuthukile. Umuntu angaba namaphilisi e-anastrozole ngokudla noma ngaphandle kokudla, kodwa kubalulekile ukuwaphuza ngesikhathi esifanayo usuku ngalunye ukuze alondoloze amazinga angaguquki emzimbeni.

Ukwelashwa kwe-adjuvant yomdlavuza webele wesigaba sokuqala (Isigaba 1) kwabesifazane be-postmenopausal, i-anastrozole inqunywa iminyaka emihlanu, nakuba ubude besikhathi obufanele bungaziwa. Ezimweni zomdlavuza webele osezingeni eliphezulu, ukwelashwa ngokuvamile kuyaqhubeka kuze kube yilapho kwenzeka ukukhula kwesimila.

Isiphetho

I-Anastrozole inomthelela omkhulu ekwelashweni komdlavuza webele, enikeza ithemba kwabesifazane abaningi abangemva kokuya esikhathini abanomdlavuza webele we-hormone receptor-positive. Ukwehlisa amazinga e-estrogen emzimbeni kusiza ukubambezela noma kumise ukukhula kwezinhlobo ezithile zamangqamuzana omdlavuza webele. Ukusebenza kwayo kuwo womabili umdlavuza webele osebancane kanye nasezingeni eliphezulu kuwenza ube yithuluzi elibalulekile ekulweni nalesi sifo. Nokho, njenganoma yimuphi umuthi, kubalulekile ukukala izinzuzo ngokumelene nemiphumela emibi futhi ulandele isiqondiso sikadokotela wakho eduze. Okuhlangenwe nakho kwawo wonke umuntu nge-anastrozole kungase kuhluke, futhi lokho okusebenza kangcono kumuntu oyedwa kungase kungabi kuhle komunye. 

Imibuzo Evame Ukubuzwa

1. Ubani okungafanele athathe i-anastrozole?

I-Anastrozole ayinconywa kwabesifazane abangaphambi kokuya esikhathini noma labo abakhulelwe noma ibele. Abantu abangezwani ne-anastrozole noma izithako zayo kufanele bakugweme. Abanenkinga yesibindi noma i-cholesterol ephezulu kufanele babonane nodokotela wabo ngaphambi kokusetshenziswa.

2. Ingabe i-anastrozole ayilungile ezinsweni zami?

Kunobufakazi obulinganiselwe obuxhumanisa i-anastrozole nezinkinga zezinso. Kodwa-ke, icala le-sclerosing glomerulonephritis labikwa ngesikhathi sokusetshenziswa kwe-anastrozole, okuphakamisa umphumela ongase ube khona. Iziguli kufanele zixoxisane nodokotela wazo nganoma yikuphi ukukhathazeka mayelana nempilo yezinso.

3. Ingabe i-anastrozole ayilungile enhliziyweni yami?

Nakuba ezinye izifundo zingabonisi ukwanda okuphawulekayo engozini yenhliziyo nemithambo yegazi nge-anastrozole, ezinye ziphakamisa isixhumanisi esingase sibe khona ekuhlulekeni kwenhliziyo nokufa kwenhliziyo nemithambo yegazi uma kuqhathaniswa ne-tamoxifen. Iziguli ezinezifo zenhliziyo ezikhona kufanele ziqashwe ngeso elibukhali ngesikhathi sokwelashwa.

4. Kuphephile isikhathi esingakanani ukuthatha i-anastrozole?

Ubude obunconyiwe bokwelashwa kwe-anastrozole iminyaka emihlanu kumdlavuza webele wesigaba sokuqala. Nokho, ubude besikhathi obufanele bungase buhluke futhi buncike ezimweni zomuntu ngamunye. Ezinye iziguli zingase ziqhubeke nokwelashwa isikhathi eside ngaphansi kokuqondisa kodokotela.

5. Yikuphi ukudla okufanele ngikugweme lapho ngithatha i-anastrozole?

Alukho uhlu oluthile lokudla okufanele lugwenywe ngokuqinile lapho uthatha i-anastrozole. Kodwa-ke, ukunciphisa noma ukugwema izithako eziqukethe i-phytoestrogens, njengemikhiqizo yesoya, i-flaxseed, namakhambi e-herbal, kuyancomeka. Amaprotheni e-whey angase futhi athinte ukusebenza komuthi.

6. Ingabe i-anastrozole ibangela ukukhuluphala?

Ucwaningo aluzange lubonise ukuhluka okuphawulekayo ekuzuzeni isisindo phakathi kwe-anastrozole ne-placebo noma i-tamoxifen. Kodwa-ke, abanye besifazane bangase babe nezinguquko zesisindo ngenxa yezici ezifana nokunqamuka kokuya esikhathini, ukucindezeleka, noma ukunciphisa umzimba ngesikhathi sokwelashwa. Ukuvivinya umzimba njalo nokudla okulinganiselayo kungasiza ekulawuleni isisindo.