Bilastine

Bilastine

I-rhinitis yokungezwani ithinta izigidi zabantu emhlabeni wonke. Izingane zakha ingxenye enkulu nakakhulu yalabo abathintekile. Abantu abalwa nalokhu kungezwani komzimba nezimo ezihlobene ezifana i-urticaria (ukuvuvukala) bangasebenzisa i-bilastine ukwelapha i-rhinitis yabo yokungezwani, isifuba, kanye nokulunywa okuhlobene nokungezwani komzimba, namehlo avuvukele. Abantu abadala kanye nentsha eneminyaka engu-12 noma ngaphezulu badinga ithebhulethi eyodwa ye-bilastine engu-20 mg nsuku zonke. Izingane ezineminyaka engu-6 kuya ku-12 zithatha umthamo ophansi we-10 mg. 

Ucwaningo lufakazela ukuthi i-bilastine isiza ukuthuthukisa izimpawu zamakhala nezamehlo ezigulini ezine-rhinoconjunctivitis eguquguqukayo futhi inciphisa amasondo nokuluma ezigulini ze-urticaria. Ukuhlukaniswa komuthi kusho ukuthi awenzi i-metabolism enkulu emzimbeni noma ahlanganyele nohlelo lwe-CYP450. Lesi sici siholela ekusebenzisaneni okungafuneki okumbalwa neminye imithi.

Yini Bilastine?

I-Bilastine isidakamizwa se-antihistamine sesizukulwane sesibili. Lo muthi awuweli kalula umgoqo wegazi nobuchopho, okusho ukuthi awuvamile ukubangela ukozela uma uqhathaniswa nama-antihistamine amadala. Umuthi uvimba ama-histamine receptors ngempumelelo futhi umise izimpawu zokungezwani komzimba ngaphambi kokuba ziqale.

Yiziphi I-Bilastine 20 mg Ukusetshenziswa?

Okulandelayo okunye okuvamile ukusetshenziswa kwethebhulethi ye-bilastine:

• I-rhinitis ye-allergenic yesizini (hay fever)
• I-perennial allergic rhinitis (i-allergies yonyaka wonke)
• I-urticaria (ukuqubuka okubuhlungu noma ukuqubuka)

Ungazisebenzisa Kanjani Futhi Nini Izibhebhe Ze-Bilastine

Umthamo onconyiwe yithebhulethi eyodwa ye-20 mg nsuku zonke. Ukudla kungaba nomthelela ekusebenzeni komuthi, ngakho-ke thatha ihora ngaphambi kokudla noma amahora amabili ngemuva kokudla. Vele ugwinye ithebhulethi yonke ngamanzi.

Bilastine Side Effects 

Iningi leziguli liphatha ibilastine kahle. Naphezu kwalokho, abanye abantu bangase bahlangabezane:

• bekhanda
• Ukozela (kwenzeka kancane kancane kunama-antihistamine amadala)
• Ukukhathala
• isiyezi

Ukuqapha

Iziguli ezinezinkinga ezinkulu zezinso akufanele zithathe i-bilastine. Umuthi ungase uhlanganyele neminye imithi, ngakho-ke gwema izinhlanganisela ezingathinta ukusebenza kwe-bilastine. Noma ubani onezimo zenhliziyo kufanele akhulume nodokotela wakhe ngaphambi kokuqala le mithi.

Isebenza kanjani i-Bilastine Tablet

I-Bilastine ivimba imiphumela ye-histamine ngokubopha okukhethekile kuma-H1 receptors. Ama-Allergens abangela ukukhululwa kwe-histamine kuma-mast cells, futhi i-bilastine ivimbela leli khemikhali ukuthi linamathele kuma-receptors abangela ukulunywa nokuvuvukala. Umuthi ufinyelela ekugxilweni okuphezulu egazini phakathi kwamahora angu-1-1.5. Imiphumela yayo ihlala amahora angama-24, futhi i-60-70% ye-receptor antagonism ihlala isebenza ngemuva kwalesi sikhathi.

Ngingakwazi Ukuthatha I-Bilastine Neminye Imithi?

Imithi eminingi isebenza ngokuphepha nge-bilastine ngoba ayithinti uhlelo lwe-enzyme ye-cytochrome P450. Kufanele uqaphele nge:

• Ama-P-glycoprotein inhibitors afanayo i-ketoconazole, i-erythromycin, i-diltiazem, i-cyclosporine, ne-ritonavir
• Amajusi okudla nezithelo anganciphisa kakhulu ikhono le-bilastine lokusebenza. Umuthi uncike ohlelweni lwezokuthutha lwe-OATP1A2 ukuze umunce. Ijusi yeGrapefruit inciphisa ukumuncwa kwayo.

Ulwazi Lomthamo

Abantu abadala kanye nentsha engaphezu kweminyaka eyi-12 kufanele bathathe ithebhulethi eyodwa yama-20 mg nsuku zonke. Izingane ezineminyaka engu-6-12 ubudala zidinga 10 mg kanye ngosuku. Thatha i-bilastine esiswini esingenalutho-okungenani ihora elingu-1 ngaphambi kokudla noma amahora angu-2 ngemva kokudla.

Isiphetho

I-Bilastine inikeza impumuzo ebaluleke kakhulu kubantu ababhekene ne-rhinitis ne-hives. Le antihistamine yesizukulwane sesibili ihlukile emithini emidala. Ayiweli neze ebuchosheni bakho futhi ibangele ukozela okuncane ngenkathi ivimba lawo ma-histamine receptors acasulayo.

Isikhathi esifanele senza i-bilastine isebenze kangcono. Umzimba wakho uwumunca kahle kakhulu uma uwuthatha esiswini esingenalutho. Kufanele uyithathe ihora ngaphambi kokudla noma ulinde amahora amabili ngemuva kokudla. Amanzi asebenza kangcono ngalo muthi. Amajusi ezithelo anganciphisa ukusebenza komuthi, futhi ijusi yamagilebhisi iyinkinga kakhulu.

Abanye abantu bangase baphathwe yikhanda noma bazizwe bekhathele ngezikhathi ezithile. Iningi leziguli liphatha kahle le antihistamine. I-Bilastine inika abantu ithuba elihle lokuthola impumuzo yokungezwani komzimba ngaphandle kobuthongo obungapheli obabangelwa ama-antihistamine amadala. Udokotela wakho angakusiza ukuthi unqume ukuthi i-bilastine ingasiza yini lapho ukungezwani komzimba ngezikhathi ezithile noma ukuqubuka okungazelelwe kuvela.

Imibuzo Evame Ukubuzwa

1. Ingabe i-bilastine iwumuthi onobungozi obukhulu?

I-Bilastine inerekhodi elihle kakhulu lokuphepha kanye nezingozi ezincane. Umuthi usebenza kahle ngisho nangemithamo eyi-10-11 ephakeme kunaleyo enqunyiwe. Nokho, iziguli ezinomlando wokwelulwa kwe-QT kudingeka ziqaphele.

2. Kuyini ukusetshenziswa okuyinhloko kwethebhulethi ye-bilastine?

Odokotela basebenzisa i-bilastine ukuze baphathe i-rhinitis ye-allergenic yonyaka kanye ne-urticaria engapheli (i-hives). Umuthi usiza ukukhulula ukuthimula, amehlo alumelayo, a ikhala yisisu, kanye nokuqubuka kwesikhumba ngenxa ye-allergies.

3. Yisiphi isikhathi esingcono kakhulu sokuthatha i-bilastine ekuseni noma kusihlwa?

Kufanele uthathe i-bilastine esiswini esingenalutho, ihora elilodwa ngaphambi kokudla noma amahora amabili ngemuva kokudla. Imithamo yasekuseni ngokuvamile isebenza kangcono kakhulu, kodwa ukuyiphuza ngesikhathi esifanayo usuku ngalunye kubaluleke kakhulu.

4. Amaphilisi e-bilastine athatha isikhathi esingakanani ukusebenza?

Umuthi uqala ukusebenza amahora angu-1-1.5 ngemva kokuwuphuza. Uzobona izimpawu zakho zokungezwani komzimba ziba ngcono maduze nje.

5. Ingabe i-bilastine ilungele isibindi?

I-Bilastine ayiphazamisi kakhulu isibindi njengoba ingashintshiwe lapho. Ngakho iziguli ezinezinkinga zesibindi azidingi ukulungiswa komthamo.

6. Kwenzekani uma ngiphuthelwa umthamo?

Thatha umthamo ogejiwe ngokushesha nje lapho ukhumbula. Nokho, yeqe uma sekusondele isikhathi somthamo wakho olandelayo. Akufanele neze uthathe imithamo emibili ngesikhathi esisodwa.

7. Kwenzekani uma ngiphuza ngokweqile?

Ungase uphathwe ikhanda, uzizwe unesiyezi noma ube nesicanucanu ngenxa yokusebenzisa ngokweqile. Thola usizo lwezempilo ngokushesha.

8. Ubani ongakwazi ukuthatha i-bilastine?

Gwema ukuthatha i-bilastine uma une-allergies kuyo noma izithako zayo. Kudingeka futhi ukunakekelwa okukhethekile uma unezinkinga ezinkulu zezinso noma izinkinga ezithile zesigqi senhliziyo. Khuluma nodokotela wakho kusengaphambili ezimweni ezinjalo.

9. Zingaki izinsuku zokuthatha ithebhulethi yebilastine?

Kufanele uthathe i-bilastine kuze kube yilapho izimpawu zakho zokungezwani komzimba zihamba uma une-allergies yonyaka. Umuthi ungamiswa futhi uqalwe kabusha lapho izinkinga zibuya. Abantu abangezwani nomzimba unyaka wonke badinga ukuqhubeka nokwelashwa ngesikhathi bechayeka ezibangeni. Ucwaningo lubonisa i-bilastine ihlala iphephile ngisho noma uyithatha ngokuqhubekayo kuze kube yizinyanga eziyi-12.

10. Ungamisa nini i-bilastine?

Abantu abangezwani nezinto ezithile ngezikhathi ezithile bangayeka ukwelashwa ngemva kokuba izimpawu seziphelile. Iziguli eziningi zidinga ama-antihistamine kuphela lapho zithola izimpawu. Iseluleko sikadokotela wakho mayelana nobude besikhathi sokwelashwa kufanele silandelwe esikhundleni sokuma wedwa.

11. Ingabe kuphephile ukuthatha i-bilastine nsuku zonke?

Yebo! Ucwaningo luqinisekisa ukuthi i-bilastine iphephile ukusetshenziswa kwansuku zonke. Ucwaningo lwesikhathi eside lubonise ukuthi umuthi ubekezelelwe kahle kakhulu nemiphumela engemihle embalwa. Ukusebenzisa njalo akuholeli ekwakhiweni kokubekezelelana.

12. Yini okufanele uyigweme lapho uthatha i-bilastine?

• Ukudla (thatha ihora eli-1 ngaphambi noma amahora ama-2 ngemuva kokudla)
• Ijusi yezithelo, ikakhulukazi ijusi yamagilebhisi 
• Utshwala obuningi (bungakwenza wozele kakhulu)
• Eminye imithi efana ne-ketoconazole, i-erythromycin, noma i-diltiazem uma unenkinga yezinso

13. Siyini isixwayiso sebilastine?

I-Bilastine ingase ithinte isigqi senhliziyo ezimweni ezingavamile. Kufanele uqaphele uma unezimo zenhliziyo noma ukushaya kwenhliziyo okungajwayelekile. Abantu abanobunzima Izinkinga zezinso kufanele uhlale kude nemithi ethile ngenkathi uthatha i-bilastine.

14. Ingabe i-bilastine inamandla kune-cetirizine?

I-Bilastine inamathela kuma-H1 receptors izikhathi ezi-3-6 kangcono kune-cetirizine. Ucwaningo lukhombisa ukuthi i-bilastine ikwenza ungozeli kakhulu kune-cetirizine ngenkathi usebenza kahle. Iphinde ibangele ubuhlungu bekhanda kanye nezinkinga zesisu ezimbalwa uma kuqhathaniswa ne-cetirizine.

15. Ingabe i-bilastine iphephile ekukhulelweni?

Odokotela bangase banikeze i-bilastine ngesikhathi sokukhulelwa kuphela uma izinzuzo zidlula izingozi ezingase zibe khona. Ngakho-ke, khuluma nodokotela wakho ngaphambi kokuyithatha.

16. Kungani ibilastine ingathathwa ngokushesha ngemva kokudla?

Ukudla kunciphisa inani le-bilastine elimunca umzimba wakho ngo-30%. Amajusi ezithelo avimba isistimu yezokuthutha ye-OATP1A2 i-bilastine edinga ukumuncwa kahle. Ukuthatha i-bilastine esiswini esingenalutho kukusiza ukuthi uthole izinzuzo zayo ezigcwele.