I-Buspirone

I-Buspirone

Ingabe wake wazizwa ugajwe ukukhathazeka noma unenkinga yokushintshashintsha kwemizwelo? I-Buspirone, umuthi osebenza ngezindlela eziningi, uthole ukunakwa ngekhono layo lokuphatha lezi zinselele ezivamile zempilo yengqondo. Lesi sidakamizwa sinikeza ithemba kwabaningi ababhekana nokuphazamiseka kokukhathazeka nezinye izindaba ezihlobene nemizwa, sinikeza indlela yokuthuthukisa izinga labo lempilo.

Ake sihlole ukusetshenziswa kwamaphilisi e-buspirone nokuthi asebenza kanjani emzimbeni. Sizofaka ulwazi olubalulekile mayelana nesilinganiso se-buspirone 10 mg, imiphumela yayo emibi, kanye nezinyathelo zokuphepha okufanele sizikhumbule. Kungakhathaliseki ukuthi ucabangela ukusebenzisa i-buspirone ngokwakho noma othandekayo, lo mhlahlandlela uhlose ukukunikeza ukuqonda okucacile kwalo muthi owusizo.

Iyini i-Buspirone?

I-Buspirone iyisidakamizwa se-anxiolytic esisetshenziselwa ukwelapha ukuphazamiseka kokukhathazeka, ikakhulukazi okuvamile ukuphazamiseka kokukhathazeka (GAD). Ingokwesigaba sezidakamizwa ze-azapirone futhi isebenza ngokulinganisa amazinga e-dopamine ne-serotonin ebuchosheni. Ngokungafani ne-benzodiazepines, i-buspirone ayibangeli ukuthembela ngokomzimba noma izimpawu zokuhoxa. Umuthi waqala ukwenziwa ngo-1968 futhi wathola imvume ye-FDA ngo-1986.

I-Buspirone isebenza njenge-agonist ingxenye (izinto ezilingisa izenzo ze-neurotransmitter) kuma-serotonin 5HT1a receptors, okukholakala ukuthi iwumthombo oyinhloko wemiphumela yayo yomtholampilo. Lesi sidakamizwa sinobudlelwane obubuthakathaka be-serotonin 5HT2 receptors nama-dopamine D2 autoreceptors. Imiphumela ye-anxiolytic ye-buspirone ngokuvamile ithatha amasonto amabili kuya kwamane ukuze ibonakale, okuyenza ingakufanelekeli ukukhululeka okukhulu kokukhathazeka.

Ukusetshenziswa kweBuspirone

• Amaphilisi e-Buspirone asetshenziselwa ngokuyinhloko ukwelapha isifo sokukhathazeka okujwayelekile (GAD). Lo muthi uthole ukugunyazwa yi-United States Food and Drug Administration ukuze ulawule ukuphazamiseka kokukhathazeka futhi unikeze ukukhululeka kwesikhashana ezimpawini zokukhathazeka. 
• I-Buspirone inqunywe njengokwelashwa komugqa wesibili lapho iziguli zingaphenduli kahle noma zingakwazi ukubekezelela imiphumela emibi noma izinkinga ze-serotonin reuptake inhibitors (SSRIs) ekhethiwe.
• Amaphilisi e-Buspirone asetshenziselwe ukukhulisa ukwelashwa kokucindezeleka kwe-unipolar. 
• Ukwengeza, i-buspirone ibonise ukuphumelela okuthile ekunciphiseni imiphumela emibi yocansi ehambisana nokusetshenziswa kwe-SSRI.
• Kwezinye izimo, odokotela bangase banikeze i-buspirone ukuze isetshenziswe ngaphandle kwelebula ekwelapheni ukuphazamiseka kokukhathazeka kwezingane.

Indlela yokusebenzisa i-Buspirone Tablets

• Amaphilisi e-Buspirone ngokuvamile athathwa ngomlomo kabili ngosuku, ngokudla noma ngaphandle kokudla. 
• Kuyadingeka ukugcina ukungaguquguquki endleleni yakho yokwelapha. Ukuze usize ukugcina isimiso esingaguquki, cabanga ukusebenzisa izikhumbuzi zemithi njengama-alamu noma izinhlelo zokusebenza ze-smartphone.
• Udokotela wakho uzokuqala ngedosi ephansi, kancane kancane ekwandisa njalo ezinsukwini ezi-2 kuya kwezingu-3. Umthamo omkhulu wansuku zonke ufinyelela ku-60 mg, kodwa iziguli eziningi zithola impumuzo ngo-20 kuya ku-30 ​​mg nsuku zonke.
• Kubalulekile ukulandela imiyalelo kadokotela wakho kahle. Ungashintshi umthamo wakho noma imvamisa ngaphandle kokubonisana nodokotela wakho. 
• Kufanele ugcine le mithi ekamelweni lokushisa esitsheni esiqinile ukuze ugweme ukukhanya kwelanga.
• Uma uphuthelwa umthamo, yithathe ngokushesha nje lapho ukhumbula khona ngaphandle uma sekusondele isikhathi somthamo wakho olandelayo ohleliwe. Kuleso simo, yeqa okugejiwe futhi uqhubeke nesimiso sakho esivamile.
• Kungase kuthathe amasonto ambalwa ukubona imiphumela egcwele ye-buspirone, ngakho-ke ukubekezela kubalulekile.

Imiphumela Emibi ye-Buspirone Tablets

Amaphilisi e-Buspirone angabangela imiphumela engemihle ehlukahlukene, kusukela kokuncane kuye kokubi. Imiphumela emibi evamile ihlanganisa: 

• isiyezi
• Ukulala
• Ukwesaba
• bekhanda
• Izinkinga zokugaya
• I-paresthesia noma i-numbness
• Umlomo omile
• Ukukhathala
• Lightheadedness
• tinnitus
• Imiphumela yocansi
• Izinguquko zesisindo 
• Umbono ophundlekile
• Uhudo
• I-nausea
• Ukuminyana emakhaleni nomphimbo obuhlungu
• Imiphumela yocansi

Ezimweni ezingavamile, ukusetshenziswa kwe-buspirone kungaholela ezindabeni ezimbi kakhulu ezifana nalezi: 

• Ukucindezeleka 
• I-Serotonin Syndrome: Kwezinye izimo, i-buspirone ingabangela isimo esisongela ukuphila esibizwa ngokuthi i-serotonin syndrome uma ithathwa iyodwa noma neminye imithi ekhulisa amazinga e-serotonin. Izimpawu ze-serotonin syndrome zihlanganisa ukubona izinto ezingekho, ukushaya kwenhliziyo okusheshayo, nokuqina kwemisipha.

Ukuqapha

Lapho uthatha i-buspirone, kubalulekile ukuqaphela izinyathelo ezithile zokuphepha, njenge: 

• Izimo Zezokwelapha: Abantu abanezinkinga zezinso noma zesibindi, i-bipolar disorder, noma isifo sikaParkinson kufanele baqaphele. 
• Ukukhulelwa Nokuncelisa: Abesifazane abakhulelwe, abazama ukukhulelwa, nabancelisayo kufanele babonane nodokotela wabo ngaphambi kokusebenzisa i-buspirone. Kubalulekile ukwabelana nodokotela wakho ngomlando wakho wezempilo ophelele.
• Izinyathelo Zokuqapha Isiyezi: I-Buspirone ingase ibangele isiyezi noma ukozela, kuthinte ikhono lakho lokushayela imoto noma ukusebenzisa imishini. Gwema ukuphuza utshwala ngenkathi usebenzisa le mithi, njengoba ingaqinisa le miphumela. 
• Umlando Wezokwelapha: Yazisa udokotela wakho uma usebenzisa eminye imithi, kuhlanganise nemikhiqizo ethengiswayo noma izithasiselo zemithi. I-Buspirone ingasebenzisana nemithi ethile, ikakhulukazi i-monoamine oxidase inhibitors, okubangela imiphumela emibi kakhulu. 

Ungayeki ngokuzumayo ukuthatha i-buspirone ngaphandle kokubonisana nodokotela wakho, njengoba lokhu kungase kubangele izimpawu zokuhoxiswa.

Isebenza kanjani i-Buspirone Tablet

Amaphilisi e-Buspirone asebenza ngokulinganisa amazinga e-serotonin ne-dopamine ebuchosheni. Ngokungafani neminye imithi yokukhathazeka, i-buspirone ingeyesigaba sezidakamizwa ze-azaspirodecanedione futhi isebenza njenge-serotonin 5-HT1A receptor agonist. Ithinta kakhulu ukukhathazeka kobuchopho nokwesaba ngokusebenzisana nama-subtypes amabili amakhulu we-5-HT1A receptor.

Isidakamizwa sisebenza njenge-agonist egcwele kuma-presynaptic 5-HT1A receptors ku-dorsal raphe, ekuqaleni okubangela ukuvinjelwa kokukhululwa kwe-serotonin. Ngokuhamba kwesikhathi, lokhu kuholela ekudambiseni ama-autoreceptors, okuholela ekwandeni kwesasasa le-serotonergic neuron kanye nokukhululwa kwe-serotonin okuthuthukisiwe. I-Buspirone isebenza njenge-agonist ngokwengxenye kuma-postsynaptic 5-HT1A receptors ku-hippocampus kanye ne-cortex, ekhuthaza i-hyperpolarisation ekuphenduleni i-serotonin ekhululiwe.

Le ndlela yokusebenza eyingqayizivele ichaza ukuqala ukubambezeleka kwemiphumela yokukhathazeka ye-buspirone, ngokuvamile ethatha amaviki angu-2 kuya kwangu-4 ukuze ibonakale.

Ngingakwazi Ukuthatha I-Buspirone Neminye Imithi?

I-Buspirone ingasebenzisana nemithi ehlukahlukene, ngakho-ke kubalulekile ukwazisa udokotela wakho ngayo yonke imithi oyiphuzayo. Ezinye izinhlanganisela zezidakamizwa zingakhuphula ubungozi bakho bemiphumela emibi noma ziguqule ukusebenza kwe-buspirone, njenge:

• Utshwala 
• Ama-antibiotics afana ne-linezolid, i-erythromycin, noma phumlani
• Ama-antidepressants afana ne-nefazodone
• Izidakamizwa ze-Antifungal ezifana itraconazole 
• Ama-Antipsychotics
• Imithi yomfutho wegazi ophakeme, njenge-diltiazem noma i-verapamil
• I-Monoamine oxidase inhibitors (MAOIs)
• Ukukhetha i-serotonin reuptake inhibitors (ama-SSRIs) 
• I-Serotonin-norepinephrine reuptake inhibitors (SNRIs)
• Ama-Triptans afana ne-sumatriptan ne-eletriptan

Ulwazi Lomthamo

Amaphilisi e-Buspirone atholakala ngamandla ahlukahlukene, okuhlanganisa ama-milligrams angu-5, ama-7.5 milligrams, ama-milligram angu-10, ama-milligram angu-15, nama-milligram angu-30. 

Umthamo wokuqala onconyiwe wokwelapha ukuphazamiseka kokukhathazeka okujwayelekile ngu-15 mg nsuku zonke, ngokuvamile uhlukaniswa imithamo emibili noma emithathu. Udokotela wakho angase andise umthamo ngo-5 mg njalo ezinsukwini ezi-2 kuya kwezingu-3 kuze kube yilapho umphumela oyifunayo ufinyelelwa. Umthamo omkhulu wansuku zonke ngu-60 mg, nakuba iziguli eziningi zithola impumuzo ngo-20 kuya ku-30 ​​mg ngosuku.

Kubalulekile ukulandela imiyalelo kadokotela wakho ngokunembile futhi ungashintshi umthamo wakho ngaphandle kokubonisana. Ukungaguquguquki ekuthatheni i-buspirone kubalulekile, ngakho gcina isimiso esijwayelekile.

Isiphetho

Amaphilisi e-Buspirone anikeza umsebe wethemba kulabo abanenkinga yokukhathazeka, ikakhulukazi ukuphazamiseka kokukhathazeka okujwayelekile. Lo muthi unendlela eyingqayizivele yokusebenza, ukulinganisa amakhemikhali obuchopho ukuze kudambise izimpawu zokukhathazeka ngaphandle kwengozi yokuncika ngokuvamile ehlotshaniswa nezinye izidakamizwa ezilwa nokukhathazeka. Njenganoma yimuphi umuthi, i-buspirone iza nesethi yayo yemiphumela emibi kanye nezinyathelo zokuphepha. Kubalulekile ukuba nezingxoxo ezivulekile nodokotela wakho mayelana nomlando wakho wezokwelapha kanye nanoma yimiphi eminye imithi oyiphuzayo. Ngokulandela iseluleko sikadokotela wakho nokuba nesineke, isidakamizwa i-buspirone singaba ithuluzi elibalulekile lokukusiza ulawule ukuphazamiseka kokukhathazeka futhi uthuthukise izinga lakho lempilo. Khumbula, uhambo lwawo wonke umuntu nempilo yengqondo luhlukile, futhi ukuthola ukwelashwa okufanele kuthatha isikhathi nokusebenzisana nodokotela wakho.

Imibuzo Evame Ukubuzwa

1. Ingabe i-buspirone isebenza ngokushesha?

I-Buspirone ayisebenzi ngaso leso sikhathi. Ngokuvamile kuthatha amaviki angu-2 kuya kwangu-4 ngaphambi kokuthi ubone ukuthuthuka kwezimpawu zakho zokukhathazeka. Lo mphumela ulibazisekile ungenxa yendlela i-buspirone ethinta ngayo amakhemikhali obuchopho. Kubalulekile ukuqhubeka nokuthatha imithi njengoba uyalelwe, ngisho noma ungazizwa ungcono ngaso leso sikhathi.

2. Ingabe i-buspirone ikwenza uzizwe kanjani?

I-Buspirone ingathinta abantu ngendlela ehlukile. Abanye bangase bazizwe bengakhathazeki kakhulu futhi bekhululekile, kanti abanye bangase babe nemiphumela engemihle efana nesiyezi noma ukozela. Akubangeli umuzwa 'ophezulu' ohlotshaniswa nemithi ethile yokukhathazeka. Umthelela ogcwele we-buspirone emoyeni uvamise ukukhula kancane kancane emavikini ambalwa.

3. Ingabe i-Buspirone iyisidakamizwa?

Cha, i-buspirone ayiyona i-narcotic. Kungokwesigaba semithi ebizwa ngokuthi i-anxiolytics. Ngokungafani nezidakamizwa, i-buspirone inengozi ephansi yokuncika. Lo muthi awuhlukaniswa njengento elawulwayo. Lesi sakhiwo sikwenza kube ukukhetha okuncanyelwayo kokwelashwa kokukhathazeka isikhathi eside.