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I-Carbimazole

I-Carbimazole idlala indima ebalulekile ekulawuleni izimo ze-thyroid ngokwehlisa i-hormone eyeqile ekhiqizwa indlala yegilo. Lesi sidakamizwa siwela ngaphansi kwe-thionamides futhi sisebenza njengokwelashwa okuyinhloko kwe-hyperthyroidism.

Lesi sihloko sihlanganisa imininingwane ebalulekile mayelana namaphilisi e-carbimazole. Ichaza ukusetshenziswa kwayo, isilinganiso esifanele sokuthatha, imiphumela engemihle engaba khona, namathiphu okuphepha.

Iyini i-Carbimazole?

I-Carbimazole ingeyeqembu elaziwa ngokuthi 'imithi elwa ne-thyroid', esiza ukuphatha indlala yegilo esebenza ngokweqile. Ngemva kokuba umzimba uwumunce, uyashintsha ube methimazole. Leli fomu elisebenzayo livimba i-peroxidase yegilo emazingeni e-iodinating tyrosine ku-thyroglobulin, enciphisa ukukhiqizwa kwe-hormone ye-T3 ne-T4.

Ukusetshenziswa kwe-Carbimazole Tablet

Odokotela batusa i-carbimazole ukwelapha hyperthyroidism futhi ulawule ama-hormone egilo ngokweqile aholela ekwehleni kwesisindo, ukushintshashintsha kwemizwelo, nokucasuka. I-Carbimazole isiza ukuzinzisa ukusebenza kwendlala ngaphambi kokuhlinzwa kwegilo. Iziguli zivame ukuzithatha nama-beta blockers ukuze zilawule izimpawu ezinjengokushaya kwenhliziyo okusheshayo.

Ungazisebenzisa Kanjani Futhi Nini Izibhebhe zeCarbimazole

  • Ungathatha amaphilisi e-carbimazole ngokudla noma ngaphandle kokudla ngokuwagwinya egcwele amanzi. 
  • Udokotela wakho angase ahlukanise umthamo wakho wansuku zonke ube izingxenye ezingu-2-3 usuku lonke. 
  • Imithamo kufanele ihlukaniswe ngokulinganayo—ekuseni, ntambama nasebusuku uma uyithatha kathathu ngosuku. 
  • Abantu abadala ngokuvamile baqala ngo-20mg kuya ku-60mg nsuku zonke.

Imiphumela Emibi Yethebhulethi yeCarbimazole

Okulandelayo eminye imiphumela emibi evamile:

Ezimweni ezingavamile kodwa ezinzima, i-carbimazole ingacindezela umnkantsha futhi ibangele i-neutropenia. Lesi simo sehlisa inani lamangqamuzana amhlophe egazi futhi senze kube nzima ukulwa nezifo.

Ukuqapha

Kufanele uyeke ukuthatha i-carbimazole ngokushesha uma ubona izimpawu zokutheleleka njengomphimbo obuhlungu, imfiva or izilonda emlonyeni. Usizo lwezokwelapha luyadingeka uma uba nezimpawu zenkinga yesibindi njengesikhumba esiphuzi noma amehlo. Abesifazane abakhulelwe badinga ukunakwa okukhethekile nge-carbimazole njengoba idlula ku-placenta futhi ingaba nomthelela empilweni yezingane zabo.

Indlela Amathebulethi eCarbimazole Asebenza ngayo

I-Carbimazole isebenza njenge-prodrug eshintsha ibe yindlela esebenzayo ngemva kokuyithatha. Umzimba wakho uwuguqula ngokushesha ube yi-methimazole emgudwini wokugaya ukudla noma ngemva nje kokumuncwa. Le nhlanganisela esebenzayo ivimba i-peroxidase yegilo futhi inciphisa ukukhiqizwa komzimba wakho kwamahomoni egilo i-T3 ne-T4.

Ngeke ubone imiphumela esheshayo evela kulo muthi. Iningi leziguli libona ukuthuthuka kwezimpawu zabo ngemuva kwamasonto angama-1-3, yize imiphumela egcwele ingathatha izinyanga eziyi-1-2.

Ngingathatha I-Carbimazole Neminye Imithi?

Eminye imithi yakho ingasebenzisana ne-carbimazole:

Kufanele utshele udokotela wakho ngayo yonke imithi oyiphuzayo, okuhlanganisa nezithako zemithi ngoba zingathinta indlela i-carbimazole esebenza ngayo.

Ulwazi Lomthamo

Abantu abadala ngokuvamile baqala ngo-20-60mg usuku ngalunye. Umthamo wokuqala uhlukaniswa ube izingxenye ezingama-2-3 usuku lonke. Umthamo wakho wesondlo uzoba ngu-5-15mg nsuku zonke uma isimo sakho sizinzile. Izingane zithola imithamo ehlukene ngokuya ngeminyaka yazo nesisindo.

Ukwelashwa kwakho kuzohlala okungenani izinyanga eziyisithupha, mhlawumbe kufike ezinyangeni eziyi-18. Ukuhlolwa kwegazi okuvamile kusiza udokotela wakho ukuthi aqaphe umsebenzi wakho wegilo futhi alungise umthamo wakho njengoba kudingeka.

Isiphetho

I-Carbimazole ibalulekile ekwelapheni i-hyperthyroidism futhi isiza abantu abaningi. Kuyasiza ekudambiseni izimpawu ezinjengokushintsha kwemizwa, ukwehla kwesisindo kungazelelwe, kanye nokushaya kwenhliziyo okusheshayo ngokunciphisa amazinga e-hormone yegilo. Awukwazi ukuqaphela ukuthuthukiswa okusheshayo kwezimpawu zakho. Kuzothatha amaviki ambalwa ukubona noma yikuphi ukuthuthukiswa. Izinzuzo ezigcwele ngokuvamile zithatha cishe izinyanga ezimbili. Ukuphatha isimo sakho se-thyroid kufinyeleleka kakhulu ngokubekezela nokunakekelwa okufanele.

Imibuzo Evame Ukubuzwa

1. Ingabe i-carbimazole isengozini enkulu?

Uma ucabanga ngokwelashwa kwe-carbimazole udinga ukukala izinzuzo zayo ngokumelene nezingozi ezingase zibe khona. Masifunde ngalo muthi ukukusiza ukuthi uwuqonde kangcono.

2. Iyini ukusetshenziswa okuyinhloko kwethebhulethi ye-carbimazole?

Odokotela basebenzisa i-carbimazole ukwelapha i-hyperthyroidism ngokunciphisa ukukhiqizwa kwehomoni yegilo. Odokotela bayinikeza lapho indlala yegilo yesiguli isebenza kakhulu futhi ibangela izimpawu ezinjengokuncipha kwesisindo kanye ukukhathazeka.

3. Yisiphi isikhathi esingcono kakhulu sokuphuza i-carbimazole ekuseni noma kusihlwa?

Ukuvumelana kwesikhathi kubaluleke ngaphezu kwehora elithile othatha ngalo i-carbimazole. Isiphakamiso sikadokotela wakho singase sincike kumithamo yasekuseni njengoba lokhu kudala umkhuba olula ongawulandela.

4. Amaphilisi e-carbimazole athatha isikhathi esingakanani ukusebenza?

Uzoqaphela ukuthuthuka phakathi kwamaviki angu-2-4 ngokujwayelekile. Umuthi udinga amaviki angu-6-8 ukuze usebenze ngokuphelele njengoba wenza amazinga e-hormone akho abejwayelekile kancane kancane.

5. Kwenzekani uma ngiphuthelwa umthamo?

Kufanele uyithathe uma ukhumbula, ngaphandle uma umthamo wakho olandelayo uzofika maduze. Vele uqalise kabusha uhlelo lwakho olujwayelekile - ungalokothi uthathe umthamo ophindwe kabili.

6. Ingabe i-carbimazole iphephile ezinso?

Isibindi sigaya lo muthi ukuze izinso zakho zihlale zingathintwa i-carbimazole ngokuvamile. 

7. Kwenzekani uma ngiphuza ngokweqile?

Ukweqisa ngokweqile kungadala izimpawu ze-hypothyroidism ezihlanganisa ukukhathala, ukuzwela amakhaza, nokuzuza kwesisindo. Ukwelashwa kuyadingeka ngokushesha.

8. Ubani ongakwazi ukuthatha i-carbimazole?

Iziguli ezinokuphazamiseka okukhulu kwegazi, ukusabela okubi kwangaphambilini noma izinkinga kwesibindi kufanele igweme i-carbimazole. Udokotela wakho udinga ukuhlola ngokucophelela uma ukhulelwe.

9. Zingaki izinsuku zokuphuza ithebhulethi ye-carbimazole?

Ukwelashwa kwakho kungase kuthathe izinyanga eziyi-12-18, ngokusekelwe endleleni ophendula ngayo kanye nokuqina kwesimo sakho. Ukuhlolwa kwegazi kusiza udokotela wakho ukuthi aqaphe ukuqhubeka kwakho njalo.

10. Nini ukuyeka i-carbimazole?

Ukwelashwa okuphelele kwe-carbimazole ngokuvamile kuthatha izinyanga eziyi-12-18. Udokotela wakho angase atuse ukuyeka ngemva kwezinyanga ezingu-12 uma amazinga akho e-TSH eba ngokwejwayelekile futhi udinga kuphela umthamo ophansi we-5mg noma ngaphansi nsuku zonke. 

11. Ingabe kuphephile ukuphuza i-carbimazole nsuku zonke?

Yebo. I-Carbimazole iphephile ukusetshenziswa lapho udokotela eqaphe ukwelashwa. Iziguli ezisabela kahle zingaqhubeka nokwelashwa ngokuphephile ngaphezu kweminyaka emi-2, ikakhulukazi uma zidinga imithamo emincane. 

12. Yini okufanele uyigweme lapho uthatha i-carbimazole?

Suka kulokhu:

  • Ukudla okunothe nge-iodine njengokhula lwasolwandle, i-shellfish nosawoti one-iodine
  • Iziphuzo eziqukethe i-caffeine njengoba zingase zibe zimbi nakakhulu i-hyperthyroidism
  • Imikhiqizo ye-soy ehlanganisa i-tofu nobisi lwe-soy

Umzimba wakho udinga ukudla okunothe nge-selenium njengamaqanda, isipinashi, ne-oatmeal ukuze ufinyelele amazinga avamile egilo ngokushesha.

13. Siyini isixwayiso se-carbimazole?

Ukuphepha kwakho kuncike ekubhekeni izimpawu zokutheleleka. Yeka ukuthatha i-carbimazole ngokushesha uma ubona imfiva, umphimbo obuhlungu, noma izilonda emlonyeni. Kufanele futhi ubheke isikhumba esiphuzi/amehlo noma umchamo omnyama ongaveza izinkinga zesibindi. Abesifazane abakhulelwe badinga ukunakekelwa okwengeziwe njengoba i-carbimazole idlula ku-placenta.

14. Kungani i-carbimazole inikezwa kanye ngosuku?

Ukuthatha imithi kanye ngosuku kwenza impilo ibe lula ezigulini. Ucwaningo lubonisa ukuthi i-30mg kanye ngosuku iphatha ngempumelelo i-hyperthyroid Isifo samathuna. Lolu hlelo olulula lusiza iziguli ukuthi zinamathele ohlelweni lwazo lokwelashwa futhi luthuthukise amazinga empumelelo. Izakhiwo zomuthi ziwuvumela ukuthi uhlale usebenza usuku lonke ngisho nomthamo owodwa.