I-Certolizumab

I-Certolizumab

I-Certolizumab pegol yelapha izimo ezimbalwa zokuvuvukala futhi ibambe indawo ohlwini Lwemithi Ebalulekile Yenhlangano Yezempilo Yezwe. Umuthi usiza iziguli ezinenkinga Isifo sikaCrohn, rheumatoid arthritis, i-psoriatic arthritis kanye ne-ankylosing i-spondylitis. Iqondise izindlela ezithile zokuvuvukala emzimbeni.

Lo muthi we-anti-TNF uvimbela ukulimala komzimba okubangelwa yilezi zimo. I-FDA yanikeza imvume yayo yokwelapha isifo sika-Crohn ngo-2008, ikakhulukazi lapho iziguli zingaphenduli kahle ekwelashweni okujwayelekile. 

Iziguli eziningi zibona izimpawu zazo ziba ngcono emasontweni angu-6-12 ngemva kokuqala ukwelashwa. I-Certolizumab isebenza ngokushesha futhi ibonisa imiphumela ehlala njalo ezimpawu ngenkathi imisa ukulimala okuhlangene ezigulini ze-rheumatoid arthritis. Le ndatshana ihlanganisa konke iziguli okufanele ziyazi nge-Certolizumab-kusukela ekuhlukaniseni nasekusetshenzisweni kwayo ngendlela efanele kuya emiphumeleni engemihle kanye nezindlela zokuphepha.

Iyini i-Certolizumab?

I-Certolizumab pegol imele ucezu lwe-monoclonal antibody eqondise i-tumor necrosis factor alpha (TNF-α). Umuthi ugqama njengokuwukuphela kwe-PEGylated anti-TNF biologic odokotela abangayinikeza kokubili isifo samathambo nesifo sika-Crohn.

Ukusetshenziswa kwe-Certolizumab

Odokotela banquma umjovo we-Certolizumab ukwelapha izimo eziningana zokuvuvukala:

• Isifo sika-Crohn esimaphakathi kuya esibi esingaphenduli ekwelashweni okujwayelekile
• I-arthritis ye-rheumatoid emaphakathi kuya kokuqina
• I-Active psoriatic arthritis
• I-ankylosing spondylitis
• ipuleti psoriasis
• I-non-radiographic axial spondyloarthritis
• I-Polyarticular juvenile idiopathic arthritis ezinganeni ezineminyaka engu-2 nangaphezulu

Ungayisebenzisa Kanjani Futhi Nini Ithebhulethi ye-Certolizumab

Iziguli zithola i-certolizumab njengempushana e-lyophilised noma isirinji efakwe ngaphambili ngomjovo ongaphansi kwesikhumba. Ukwelashwa kuqala ngo-400 mg (imijovo emibili ye-200 mg) emasontweni angu-0, 2, no-4. Umthamo wesondlo uyahlukahluka ngokuya ngesimo-iziguli zithatha noma i-200mg njalo emavikini amabili noma i-400mg njalo ngenyanga.

Imiphumela Emibi Yethebhulethi ye-Certolizumab

Iziguli zivame ukuzwa:

• Izifo zokuphefumula
• Ukukhwabanisa isikhumba
• Izifo ezithinta u-Urinary

Okunye okukhathazayo okubalulekile kuhlanganisa:

• Ukwanda kwengozi yokutheleleka
• Izimpawu zokuhluleka kwenhliziyo
• Ukuphendula kwe-allergen

Ukuqapha

Umuthi udinga ukucatshangelwa ngokucophelela nezimo ezithile.

• Iziguli kufanele zihlolwe isifo sofuba ngaphambi kokuqala ukwelashwa.  
• Imithi yokugoma ephilayo kufanele igwenywe ngesikhathi sokwelashwa. 
• Iziguli ezine multiple sclerosis, isifo senhliziyo, noma isifo sofuba kufanele bazise udokotela wabo ngaphambi kokusebenzisa i-Certolizumab.

Isebenza kanjani i-Certolizumab Tablet

Imithi ye-Certolizumab, i-DMARD yebhayoloji, ikhiyelwa ku-TNF-alpha ngokunemba okumangalisayo. Lesi senzo simisa izimpawu zokuvuvukala ekulimazeni amalunga nezicubu zakho. Umuthi usebenza kangcono ekuvimbeni kokubili amafomu e-TNF ancibilikayo kanye ne-membrane kuneminye imithi efanayo. I-Certolizumab ayibangeli izimpendulo ezithile zokuzivikela komzimba ezingase zibangele imiphumela engemihle eyengeziwe ngoba ayinayo ingxenye ye-Fc etholakala kumasosha omzimba aphelele.

Ngingakwazi yini ukuthatha i-Certolizumab Ngeminye Imithi?

Ungathatha umjovo we-Certolizumab nge:

• Ama-DMARD ajwayelekile afana ne-methotrexate
• Imithi ye-steroid efana ne-prednisolone
• Ukudambisa izinhlungu njenge-paracetamol
• Izidakamizwa ezilwa nokuvuvukala (ama-NSAID)

Akufanele neze uhlanganise i-Certolizumab ne:

• Amanye ama-DMARD ebhayoloji 
• Abavimbeli be-TNF
• Imithi yokugoma ebukhoma njengomgomo we-BCG
• Umuthi wokugomela i-COVID-19 mRNA

Ulwazi Lomthamo

• Iziguli ezine-Crohn's disease zithola ama-400 mg njalo ngemva kwamasonto amane ngemva kwemithamo yazo yokuqala. 
• Iziguli ezine-rheumatoid arthritis, psoriatic arthritis, noma i-ankylosing spondylitis zingathatha ama-200 mg njalo kwelinye isonto noma ama-400 mg nyanga zonke. 
• Odokotela banquma umthamo osuselwa kusisindo wezingane ezine-polyarticular juvenile idiopathic arthritis. 
• Thatha noma yimuphi umthamo ogejiwe ngokushesha lapho ukhumbula, bese uqhubeka neshejuli yakho yasekuqaleni.

Isiphetho

I-Certolizumab iletha ithemba elisha kubantu abazabalaza nezimo zokuvuvukala. Lo muthi onamandla usiza iziguli ezine-Crohn's kanye ne-rheumatoid arthritis lapho ezinye izindlela zokwelapha zingasebenzi. Iziguli eziningi zibona isimo sazo ziba ngcono emasontweni angu-6-12 ngemva kokuqala ukwelashwa.

I-Certolizumab isebenza kahle, kodwa iziguli zidinga ukucabanga ngezinto ezimbalwa ngaphambi kokuba ziqale ukwelashwa. Kumele bahlolwe sofuba futhi batshele udokotela wabo nganoma yiziphi izinkinga zempilo abanazo. Umuthi uhlukile kwamanye ama-blocker e-TNF ngoba unesakhiwo esiyingqayizivele se-PEGylated. Uhlelo olulungile lokudosa luholela emiphumeleni engcono kakhulu. 

Impendulo yesiguli ngasinye ku-Certolizumab ihlukile. Udokotela wakho ubheka ukuqhubeka kwakho futhi ushintsha ukwelashwa kwakho njengoba kudingeka. Umgomo oyinhloko uhlala unjalo-ukuvuvukala okuncane kanye nekhwalithi engcono yokuphila. Lo muthi usiza izinkulungwane zabantu ukuphatha izimo zabo futhi balawule imisebenzi yabo yansuku zonke futhi.

Imibuzo Evame Ukubuzwa

1. Ingabe i-certolizumab isengozini enkulu?

I-Certolizumab iza nezingozi ezibaluleke kakhulu okufanele uxoxe ngazo nodokotela wakho. Ucwaningo lubonisa ukuthi i-certolizumab ingase ibangele izehlakalo ezimbi kakhulu kaningi kuneminye imithi efanayo. 

2. I-certolizumab ithatha isikhathi esingakanani ukusebenza?

Ukuthuthukiswa kokuqala kuvame ukubonakala phakathi kwamaviki angu-2-4 ngemva kokuqala kokwelashwa. Kodwa-ke, iziguli zivame ukubona izinzuzo ezigcwele emasontweni ayi-6-12 ngemuva kokuqala i-Certolizumab. Ukubekezela kwakho kubalulekile ngisho noma ungayiboni imiphumela esheshayo.

3. Kwenzekani uma ngiphuthelwa umthamo?

Isikhathi somthamo wakho olandelayo ohleliwe sibalulekile:

• Phakathi neviki elilodwa—linda umthamo wakho ohleliwe
• Kusele isikhathi esingaphezu kweviki elilodwa—thatha umthamo ogejiwe manje futhi uqhubeke nesimiso sakho esivamile

4. Kwenzekani uma ngiphuza ngokweqile?

Ukunakekelwa kodokotela kubaluleka ngaso leso sikhathi uma weqise. Shayela inombolo ephuthumayo ngokushesha. Ungalindi ukubona izimpawu ngaphambi kokuthola usizo.

5. Ubani ongakwazi ukuthatha i-certolizumab?

I-Certolizumab ingase ingafaneleki kuwe uma:

• Yiba nokutheleleka okusebenzayo
• Awukazami ezinye izindlela zokwelapha
• Ube nokungezwani okukhulu ne-certolizumab

6. Kufanele ngiyithathe nini i-certolizumab?

Isheduli yakho yomjovo we-Certolizumab iqala emasontweni 0, 2, kanye nelesi-4. Ngemva kwalokho, imithamo yesondlo yenzeka njalo emavikini amabili noma amane ngokuya ngesimo sakho. Isikhathi sosuku asinandaba kangako inqobo nje uma unamathela esimisweni sakho.

7. Zingaki izinsuku zokuphuza i-certolizumab?

I-Certolizumab isebenza njengokwelashwa okuhlala isikhathi eside. Izimpawu zingabuya uma uyeka, ngisho nangemva kokuzizwa ungcono. Ukuma kusenesikhathi kuvame ukudala ukuqubuka kwezifo.

8. Ungamisa nini i-certolizumab?

Udokotela wakho kufanele ahlale eqondisa isinqumo sakho sokumisa i-Certolizumab. Yeka ngokushesha uma uba nezifo ezimbi kakhulu, ukungezwani komzimba, noma imiphumela emibi kakhulu. Udokotela wakho angase futhi amise kancane ukwelashwa kwakho ngaphambi kokuhlinzwa.

9. Ingabe kuphephile ukuphuza i-certolizumab nsuku zonke?

I-Certolizumab idinga amashejuli athile womthamo futhi akufanele ithathwe nsuku zonke. Odokotela ngokuvamile banquma noma 200 mg njalo emavikini amabili noma 400 mg ngenyanga. Ingozi yakho yemiphumela emibi iyanda ngaphandle kwezinzuzo ezengeziwe uma uyithatha kaningi kunalokho okushiwo. Imiphumela emihle kakhulu ivela ekulandeleni isimiso esinconywe udokotela wakho.

10. Yisiphi isikhathi esingcono kakhulu sokuthatha i-certolizumab?

Umjovo we-certolizumab usebenza ngempumelelo kungakhathaliseki ukuthi uwuthatha nini phakathi nosuku. Ukugxila kwakho kufanele kube ukungaguquguquki. Khetha isikhathi esifanelana nesimiso sakho sansuku zonke—amahora angaphambi kwesikhathi angaba ngcono uma ungase ukhohlwe kamuva, noma ubusuku bungase bufaneleke kakhulu. Impumelelo ekwelashweni ivela ekugcineni uhlelo olungaguquki.

11. Yini okufanele uyigweme lapho uthatha i-certolizumab?

Iziguli ezisebenzisa i-Certolizumab 200 mg kufanele zigweme:

• Imithi yokugoma ephilayo (okuhlanganisa isifutho samakhala somkhuhlane, isimungumungwane, umvukuzane, irubella)
• Ukuphuza ngokweqile okungase kwandise izinkinga zesibindi
• Xhumana nabantu abanezifo ezisebenzayo, ikakhulukazi phakathi nezinyanga zokuqala zokwelashwa
• Imikhiqizo yobisi engagcotshiwe kanye nenyama engaphekiwe engase ibe namagciwane ayingozi

Khumbula ukutshela udokotela wakho nganoma yimiphi imithi emisha, izithasiselo noma izinguquko ezibalulekile endleleni yokuphila ngesikhathi sokwelashwa kwakho.