I-Clemastine

I-Clemastine

I-Clemastine, i-antihistamine enamandla, inikeza ikhambi kulabo abalwa nokuthimula, ukulunywa, kanye Amehlo amanzi. Amaphilisi e-Clemastine anokusetshenziswa okuningi okungaphezu kokwelapha ukungezwani komzimba nezinkathi ezithile zonyaka. Bangasiza ngokungezwani komzimba unyaka wonke, ukusabela kwesikhumba, kanye nezimpawu zokubanda. Njengoba sihlola umhlaba we-clemastine, sizobheka ukuthi ungayisebenzisa kanjani ngokuphepha, imiphumela yayo engemihle engaba khona, kanye nezinyathelo zokuphepha ezifanele okufanele uzithathe.

Iyini i-Clemastine?

I-Clemastine imithi enamandla ye-antihistamine engeyesizukulwane sokuqala sama-antihistamine. Inemiphumela yokudambisa kanye ne-anticholinergic. Lo muthi unethonya ekuphenduleni komzimba ku-histamine, into ebangela ukungezwani komzimba.

Ukusetshenziswa kwe-clemastine

I-Clemastine, i-antihistamine enamandla egunyazwe i-Food and Drug Administration (FDA), inokusetshenziswa okuningi ekwelapheni izimo ezihlukahlukene. Odokotela bayinikeza ukuze kulawuleke izimpawu zalokhu:

• I-Allergic rhinitis (i-hay fever)
• I-Urticaria (i-hives) ne-angioedema
• I-Allergic conjunctivitis
• Izimo zesikhumba ze-Pruritic (ukuluma okukhulu)
• Ukushisa okuvamile
• Ucwaningo lwakamuva luphakamisa ukuthi ingawela umgoqo wegazi nobuchopho futhi inamandla okusebenza kuma-neurons athile kanye ne-neuroglia, yenza umphumela ovikelayo ohlelweni lwezinzwa olumaphakathi (CNS). Lokhu kuholele ekuphenyweni ngezinzuzo zayo ezingaba khona zezinkinga ezahlukahlukene ze-CNS, okuhlanganisa:
• Izifo ze-Neurodegenerative
• Ukuntuleka kwe-Neurodevelopment
• Ukulimala kwengqondo
• Ukuphazamiseka kwengqondo

Ngaphezu kwalokho, i-clemastine ibonise amandla okuvimbela i-microglia-induced neuroinflammation. Lesi senzo singaba nenzuzo ekulawuleni ukuphazamiseka kwemizwa lapho ukuvuvukala kudlala indima ekuqhubekeleni phambili kwesifo.

Indlela yokusebenzisa i-Clemastine

Ukusetshenziswa ngendlela efanele komuthi we-clemastine wokungezwani komzimba kubalulekile ekusebenzeni kahle nokuphepha kwawo. Lo muthi utholakala kumaphilisi namafomu oketshezi, futhi umthamo uyahluka kuye ngezidingo zomuntu ngamunye kanye nempendulo yakhe.

Lapho uthatha i-clemastine, iziguli kufanele zilandele lezi zinyathelo:

• Funda umhlahlandlela wemithi noma imiyalelo yephakheji kahle.
• Thatha umthamo onqunyiwe noma onconywayo ngesikhathi esifanayo usuku ngalunye.
• Sebenzisa umshini wokulinganisa ofanele ukwenza uketshezi.
• Ungeqi isilinganiso esiphezulu esinconyiwe.
• Uma izimpawu ziqhubeka noma ziqhubeka ziwohloka, thintana nodokotela wakho.

Imiphumela Emibi Yezibhebhe Ze-Clemastine

Njengemithi eminingi, i-clemastine ingaba nemiphumela emibi. Abanye abantu bangase babe nemiphumela engemihle, kuyilapho abanye bengase babhekane nezindaba ezibucayi kakhulu.
Imiphumela emibi evamile ye-clemastine ihlanganisa:

• Ukulala
• isiyezi
• bekhanda
• Umlomo owomile, ikhala, nomphimbo
• ukuqunjelwa
• Isisu sithukuthele
• Umbono ophundlekile
• Ukunciphisa ukusebenzisana
• I-nausea
• Ukuminyana kwesifuba

Kwezinye izimo, i-clemastine ingaba nomthelela esimweni sengqondo, ikakhulukazi ezinganeni nakubantu abadala. Kungase kubangele:

• Ukujabula (ikakhulukazi ezinganeni) noma ukwethuka
• Ukuthukuthela
• Ukudideka

Imiphumela emibi kakhulu, nakuba ingavamile, ihlanganisa:

• Kunzima ukuchama
• Izinguquko embonweni
• Ukushaya kwenhliziyo okusheshayo, ukushaya ngamandla, noma okungajwayelekile
• Ukushintsha kwengqondo/imizwelo (okufana nokubona izinto ezingekho)
• Ukukhala ezindlebeni
• Ukulimala/ ukopha kalula
• ukuquleka
• Ukungezwani komzimba (akuvamile) 

Ukuqapha

Lapho uthatha i-clemastine, kubalulekile ukuqapha futhi uqaphele izingozi ezingaba khona. Lokhu kubandakanya:

1. Izimo Zokwelashwa:

• Izinkinga zokuphefumula (isifuba somoya, i-emphysema)
• I-glaucoma
• Izinkinga zenhliziyo noma umfutho wegazi ophakeme
• Isifo sesibindi
• ukuquleka
• Izinkinga zesisu (izilonda, ukuvaleka)
• I-thyroid engasebenzi ngokweqile
• Izinkinga zokuchama (i-prostate ekhulisiwe, ukugcinwa komchamo)

2. Imithi ethile

3. I-clemastine ingabangela ukozela nesiyezi, okungase kuthinte ikhono lomuntu lokushayela noma ukusebenzisa imishini. 

4. Ukuphuza utshwala 

5. Abesifazane abakhulelwe noma labo abahlela ukukhulelwa noma omama abancelisayo 

6. Abantu abadala kanye nezingane 

7. Iziguli ezihlelelwe ukuhlinzwa,

8. Amalungiselelo oketshezi e-clemastine angase aqukathe ushukela notshwala. Abantu abanesifo sikashukela, abasebenzisa utshwala, noma isifo sesibindi kufanele baqaphele futhi babonane nodokotela wabo mayelana nokusetshenziswa okuphephile.

Isebenza kanjani i-Clemastine

I-Clemastine isebenza ngokubopha ngokukhetha kuma-histamine H1 receptors emzimbeni. Ngokwenza kanjalo, ivimbela ngokuncintisana isenzo se-histamine, ivimbela i-histamine ekubopheni futhi ibangele ukungezwani komzimba, okuholela empumelelweni yezimpawu ezibangelwa ukukhululwa kwe-histamine. Lesi senzo sokuvimbela sinomthelela emiphumeleni ehlukahlukene yomzimba ye-histamine, okuhlanganisa:

• Ukuncipha kwe-capillary permeability kanye nokwenyuka
• Ukuncipha kokwakheka kwe-edema (ukuvuvukala)
• Ukukhululwa ekuphenduleni "ukuqubuka" kanye "nokuluma".
• Ukuphumula kwemisipha ebushelelezi yamathumbu kanye nokuphefumula

Ngaphakathi kwesistimu ye-vascular, i-clemastine ivimbela kokubili imiphumela ye-vasoconstrictor kanye ne-vasodilator ye-histamine. Lesi senzo esikabili sisiza ekudambiseni izimpawu zokungezwani komzimba ngempumelelo. 

Ngingakwazi Ukuthatha I-Clemastine Neminye Imithi?

I-Clemastine isebenzisana nemithi eminingi, futhi kubalulekile ukuqapha lapho uyihlanganisa nezinye izidakamizwa. Eminye yemithi evamile esebenzisana ne-clemastine ihlanganisa:

• Imithi ye-Anticholinergic
• antidepressant
• Ama-Antihistamine
• Ama-Antipsychotics
• CNS depressants
• I-MAO inhibitors
• Imithi yobuhlungu
• Ama-sedative kanye nezinsiza zokulala

Ulwazi Lomthamo

Umthamo we-clemastine usekelwe ezicini eziningana, okuhlanganisa iminyaka, isimo sezokwelapha, kanye nokusabela ekwelashweni. Kubalulekile ukuthi ungakhulisi umthamo noma uphuze imithi kaningi kunokunconywa ngaphandle kokubonana nodokotela. Ukuze ukhulise izinzuzo zayo, kufanele uyisebenzise ngesikhathi esisodwa usuku nosuku.

I-Clemastine itholakala ngezindlela ezahlukene, kuhlanganise amaphilisi kanye nesiraphu. Amandla ethebhulethi angu-1.34 mg no-2.68 mg, kuyilapho isiraphu iqukethe u-0.67 mg we-clemastine ngo-5 mL.

Kubantu abadala kanye nezingane ezineminyaka engu-12 nangaphezulu, umthamo wokuqala onconyiwe uvamise ukuba ngu-1.34 mg kabili ngosuku. Umthamo unganyuswa njengoba kudingeka kodwa akufanele udlule i-2.68 mg kathathu ngosuku. Ezinye iziguli zisabela kahle kumthamo owodwa we-2.68 mg, ongaphindaphindwa njengoba kudingeka, kuze kufike kumaphilisi amakhulu amathathu ngosuku.

Odokotela bangalungisa umthamo wayo ngokusekelwe ezimpendulweni zesiguli ngasinye kanye nezimo.

Isiphetho

I-Clemastine ivimbela i-histamine receptors emzimbeni, ithonya ukuphathwa kwezimo ezihlukahlukene zokungezwani komzimba. Ukusebenza kwayo ekudambiseni izimpawu ezifana nokuthimula, ukulunywa, kanye namehlo agcwele amanzi kuyenza ibe inketho ebalulekile kulabo abalwa nokungezwani komzimba nezinto ezithile. Kodwa-ke, kubalulekile ukukhumbula ukuthi i-clemastine ingabangela imiphumela emva kwemiphumela futhi ihlanganyele neminye imithi, ngakho-ke kubalulekile ukuyisebenzisa njengoba uqondiswa udokotela.

Umthamo ofanele kanye nokuqwashisa ngezinkinga ezingaba khona kuyisihluthulelo sokukhulisa izinzuzo ze-clemastine kuyilapho kunciphisa imiphumela emibi. Noma ngabe ubhekene nezimo zesizini noma zokungezwani okungamahlalakhona, i-clemastine ingaba ithuluzi eliwusizo lezimpawu ezingcono futhi ithuthukise izinga lempilo. 

Imibuzo Evame Ukubuzwa

1. Isetshenziselwani i-clemastine?

I-Clemastine imithi ye-antihistamine enethonya ekulawuleni izimpawu ezihlukahlukene zokungezwani komzimba. Inikeza impumuzo ku-hay fever nezinye izimo zokungezwani komzimba, okuhlanganisa:

• Sneezing
• Iphutha le-Runny
• Amehlo abomvu, ayaluma, namanzi
• Ukuluma nokuvuvukala kwesifuba 
• Ukushisa okuvamile
• Ukuvuvukala ezingxenyeni ezihlukahlukene zomzimba

2. Isebenza ngokushesha kangakanani i-clemastine?

Isivinini i-clemastine eqala ngaso ukusebenza singahluka kumuntu nomuntu. Kodwa-ke, abantu abaningi bathola impumuzo ezimpawini zokungezwani komzimba nezinto ezithile phakathi nesikhashana nje ngemva kokuphuza umuthi. Ngokuvamile, i-clemastine iqala ukusebenza phakathi kwamahora angu-1 kuya kwangu-3 ngemva kokungenisa.

Kuyaphawuleka ukuthi nakuba i-clemastine inganikeza ukukhululeka okusheshayo kwezimpawu ezibucayi, ukusebenza kwayo okugcwele ekulawuleni ukungezwani komzimba okungamahlalakhona kungase kuthathe izinsuku ezimbalwa zokusetshenziswa okuvamile. Iziguli kufanele ziqhubeke nokuthatha umuthi njengoba ziyalelwe, ngisho noma zingakuboni ukuthuthuka okusheshayo.

3. Ingabe i-clemastine ikwenza uzizwe ulele?

Yebo, i-clemastine ingabangela ukozela kubantu abaningi. Njenge-antihistamine yesizukulwane sokuqala, inezinto zokudambisa futhi ingangena emgodleni wegazi nobuchopho, okuholela ekuzwaneni kokulala noma isiyezi, ngisho nalapho ithathwa ngemithamo evamile.

Ngenxa yamandla ayo okubangela ukozela, iziguli kufanele ziqaphe lapho zithatha i-clemastine, ikakhulukazi lapho zibamba iqhaza emisebenzini edinga ukuqapha, njengokushayela noma ukusebenzisa imishini. Utshwala bungakhulisa imiphumela yokulalisa. Kungcono ukugwema ukuphuza utshwala ngenkathi uthatha i-clemastine. 

4. Kuthiwani uma ngisebenzisa ngokweqile i-clemastine?

I-overdose ye-clemastine ingaba yingozi futhi ingaba yingozi empilweni. Ukuthatha imithi ngendlela ebekiwe noma eqondiswe ephaketheni kubalulekile. Imithamo enobuthi ivamise ukwenzeka lapho umuntu ethatha izikhathi ezi-3 kuya kwezi-5 kunenani elivamile.

Uma kusolwa i-overdose, ukungenelela kwezokwelapha ngokushesha kubalulekile. Shayela abezimo eziphuthumayo ngokushesha uma umuntu equlekile, equlekile, enenkinga yokuphefumula, noma equlekile.