I-Colchicine

I-Colchicine

I-Colchicine umuthi othakazelisayo oye wenza amagagasi emhlabeni wezokwelapha. Sekungamakhulu eminyaka isetshenziswa ukwelapha izimo ezihlukahlukene, kodwa amandla ayo akhula njalo. Njengoba singena kulesi sihloko, sizohlola ukusetshenziswa okuningi kwamaphilisi e-colchicine nokuthi asebenza kanjani emizimbeni yethu. Sizophinde sixoxe ngendlela efanele yokusebenzisa amaphilisi e-colchicine, imiphumela engemihle okufanele uyiqaphele, kanye nezinyathelo zokuphepha ezidingekayo okufanele uzikhumbule. 

Yini iColchicine?

I-Colchicine umuthi osekungamakhulu eminyaka usetshenziswa ukwelapha izimo ezahlukahlukene. Kuyasiza kakhulu ekuvimbeleni nasekwelapheni ukuhlasela kwe-gout. I-Gout wuhlobo lwe sokuqaqamba kwamalunga okubangelwa amazinga aphezulu e-uric acid egazini, okuholela ebuhlungu obungalindelekile, obukhulu elunga elilodwa noma ngaphezulu. I-Tablet colchicine isebenza ngokunciphisa ukuvuvukala nokunciphisa ukunqwabelana kwamakristalu e-uric acid abangela ubuhlungu.

I-Colchicine iza ngethebhulethi futhi ithathwa ngomlomo. Kungokwesigaba semithi ebizwa ngokuthi ama-antigout agents. Yehlisa ukuvuvukala futhi inciphise ukunqwabelana kwamakristalu e-uric acid okuholela ekuthini ubuhlungu bamalunga nokuvuvukala ngesikhathi sokuqubuka kwe-gout. Kubalulekile ukuqaphela ukuthi i-colchicine ayisona isidambisi sobuhlungu futhi akufanele isetshenziselwe ubuhlungu obungahlobene ne-gout noma i-Mediterranean fever yomndeni.

Ukusetshenziswa kwethebhulethi ye-Colchicine

Odokotela basebenzisa amaphilisi e-colchicine ngezinjongo ezihlukahlukene, njenge:

• Ukuvimbela nokwelapha i-gout. 
• Ukwelapha i-Mediterranean fever yomndeni, isimo esizuzwe njengefa esidala iziqephu zokushisa, ubuhlungu, nokuvuvukala endaweni yesisu, amaphaphu, namalunga. 
• Ukwelapha isifo sika-Behçet kanye nokunciphisa ingozi yokuhlaselwa yinhliziyo.

Ukusetshenziswa kwe-colchicine okungeyona ilebula:

• I-pericarditis eyingozi futhi ephindaphindiwe (isimo senhliziyo)
• I-cirrhosis yamabhilidi ayisisekelo
• I-hepatic cirrhosis
• I-pseudo gout
• I-Idiopathic pulmonary fibrosis
• I-dermatitis herpetiformis

Ungayisebenzisa kanjani i-Colchicine Tablet

• Kufanele uphuze amaphilisi e-colchicine njengoba nje udokotela wakho ekuyalile. Ukuthatha ngaphezu komthamo onqunyiwe kungase kwandise amathuba okuba nemiphumela emibi kakhulu.
• Ungathatha i-colchicine ngokudla noma ngaphandle kokudla.
• Kubalulekile ukuqaphela ukuthi ijusi ye-grapefruit ne-grapefruit ingase ikhulise imiphumela ye-colchicine, ngakho-ke igweme ngenkathi usebenzisa le mithi.

Imiphumela Emibi Yethebhulethi ye-Colchicine

Amaphilisi e-Colchicine angabangela imiphumela emibi ehlukahlukene, njenge: 

• Uhudo 
• Ukuqhephuka nezinzwa 
• Ubuhlungu besisu
• Ukwehla kwesisu
• Izimpawu zesistimu yezinzwa ezimaphakathi njengokukhathala nekhanda

Imiphumela engemihle engavamile kodwa eyingozi ihlanganisa:

• Ubuthakathaka bemisipha, ubuhlungu, noma ukulimala (rhabdomyolysis).
• Izifo zegazi ezifana ne-leukopenia ne-thrombocytopenia
• Izimpawu zokungezwani nomzimba (ukuphefumula kanzima noma ukuvuvukala komphimbo noma ulimi)
• Izinkinga zesikhumba, njengokuqubuka, i-alopecia, i-maculopapular rash, noma i-purpura
• Izinkinga zokuzala ezifana ne-azoospermia noma i-oligospermia

Ukuqapha

Abantu kufanele baqaphele izinyathelo ezimbalwa zokuqapha lapho besebenzisa amaphilisi e-colchicine. 

• Izimo Zezokwelapha: Kulabo abanezinkinga zezinso noma zesibindi, ukulungiswa komthamo kuyadingeka njengoba lezi zimo zingathinta indlela umzimba owucubungula ngayo lo muthi. Abantu kufanele futhi baqaphele uma benomlando wokuphazamiseka kwegazi, njengoba i-colchicine ingaba nomthelela ekukhiqizeni amangqamuzana egazi.
• Umlando Wezidakamizwa: Kubalulekile ukwazisa udokotela wakho nganoma yimiphi eminye imithi oyithathayo, ikakhulukazi ama-antibiotic athile, ama-antifungal, noma izidakamizwa ze-HIV, njengoba lezi zingasebenzisana ne-colchicine. 
• Utshwala: Abantu kufanele futhi baqaphele ukuphuza kwabo utshwala, njengoba kungandisa ingozi yezinkinga zesisu futhi kuthinte ukusebenza kahle kwe-colchicine ekuvimbeleni ukuhlaselwa yi-gout.
• Abadala: Abantu abadala asebekhulile banengozi enkulu yemiphumela emibi ukuze bangadinga imithamo ephansi. 
• Ukukhulelwa Nokuncelisa: Abesifazane abakhulelwe, abazama ukukhulelwa, noma ibele kufanele baxoxe ngezingozi ezingaba khona kanye nezinzuzo nodokotela wabo ngaphambi kokusebenzisa i-colchicine.
• Umthelela kusidoda: Amaphilisi e-Colchicine anganciphisa ukukhiqizwa kwesidoda, okungase kuthinte ukuzala kwabesilisa. Ngakho-ke, thintana nodokotela wakho mayelana nale mibuzo ngaphambi kokuqala lo muthi. 

Isebenza kanjani ithebhulethi ye-Colchicine

Amaphilisi e-Colchicine asebenza ngendlela eyinkimbinkimbi ehilela ngokuyinhloko izakhiwo zokulwa nokuvuvukala. Umuthi uphazamisa ukusebenza kwe-cytoskeletal ngokuvimbela i-beta-tubulin polymerization ibe ama-microtubules. Le nqubo ivimbela ukusebenza, ukubola, nokufuduka kwama-neutrophils, ahlotshaniswa nokulamula izimpawu ze-gout.

Ngokuthakazelisayo, i-colchicine ayivimbi i-phagocytosis yamakristalu e-uric acid kodwa ibonakala ivimbela ukukhululwa kwe-glycoprotein evuvukalayo kuma-phagocytes. Iphinde ivimbele i-metaphase ngenxa yemiphumela emibili ehlukene ye-antimitotic: ukuphazanyiswa kokwakheka kwe-mitotic spindle kanye nokwakheka kwe-sol-gel.

Kumkhuhlane womndeni waseMedithera, indlela ye-colchicine iqondwa kancane. Ingase iphazamise umhlangano we-intracellular we-inflammasome complex kuma-neutrophils nama-monocytes, oxhumanisa ukusebenza kwe-interleukin-1-beta.

Ngingakwazi Ukuthatha I-Colchicine Ngeminye Imithi?

Imithi ethile ingathinta indlela i-colchicine esebenza ngayo, okungase kuholele emiphumeleni emibi kakhulu, efana nale: 

• Ama-antibiotics afana ne-clarithromycin, i-telithromycin
• Izidakamizwa ze-antifungal ezifana ne-itraconazole, ketoconazole
• Imithi elwa namagciwane ye-HIV, njenge-atazanavir, i-ritonavir
• I-Aprepitant
• I-Cyclosporine
• I-Diltiazem
• Ijusi lamagilebhisi
• Imithi yenhliziyo
• I-Ranolazine
• I-Verapamil

Ulwazi Lomthamo

Umuntu ngamunye kufanele aphuze amaphilisi e-colchicine njengoba eyalelwe odokotela. 

Abantu basebenzisa i-0.6 mg kanye noma kabili ngosuku ukuvimbela i-gout, ngomthamo omkhulu we-1.2 mg ngosuku. 

Ukwelapha i-gout flare eyingozi, abantu bathatha u-1.2 mg esibonakalisweni sokuqala, kulandele u-0.6 mg ihora elilodwa kamuva. 

Umthamo ophelele akufanele udlule i-1.8 mg esikhathini esiyihora elingu-1.

Abantu ngokuvamile bathatha i-1.2 kuya ku-2.4 mg nsuku zonke kumthamo owodwa noma emibili emndenini waseMedithera imfiva. 

Namathela esilinganisweni esinqunyiwe, njengoba kunomehluko omncane kuphela phakathi kwethamo elifanele kanye ne-overdose. Abantu akufanele bashintshe umthamo noma bayeke ukusebenzisa i-colchicine ngaphandle kokubonana nodokotela wabo kuqala.

Isiphetho

Amaphilisi e-Colchicine anomthelela omkhulu ekwelapheni i-gout, imfiva yomndeni yaseMedithera, nempilo yenhliziyo nemithambo yegazi. Ikhono labo lokunciphisa ukuvuvukala nokuvimbela ukuhlaselwa libenze babe inketho yokuya ezigulini eziningi. Nakuba la maphilisi esebenza kahle, kuyadingeka ukukhumbula ukuthi eza nemiphumela engemihle kanye nokusebenzisana neminye imithi. Iziguli kufanele zisebenzisane eduze nodokotela bazo ukuze zisebenzise i-colchicine ngokuphepha nangempumelelo. Umthamo ofanele nokuqapha ngokucophelela kuyisihluthulelo sokuthola okuningi kulo muthi. 

Imibuzo Evame Ukubuzwa

1. Kwenzekani uma ngiphuthelwa umthamo?

Uma ukhohlwa ukuthatha umthamo wakho we-colchicine, kufanele uwuthathe ngokushesha nje lapho ukhumbula khona ngaphandle uma sekusondele isikhathi somthamo wakho olandelayo ohleliwe. Kuleso sibonelo, kufanele weqe umthamo we-colchicine ogejiwe bese uthatha olandelayo ngesikhathi esijwayelekile. 

2. Kwenzekani uma ngiphuza ngokweqile?

Ukuthatha ngaphezu komthamo onqunyiwe we-colchicine kungaba yingozi futhi kungabulala. Izimpawu ze-overdose zingabandakanya isicanucanu, ukuhlanza, ubuhlungu bemisipha, ubuthakathaka, kanye isifo sohudo. Uma usola ukweqisa, funa ukubonisana ngokushesha noma ushayele isikhungo sokulawula ushevu sendawo.

3. Yini okufanele uyigweme lapho uthatha i-colchicine?

Umuntu ngamunye kufanele agweme ukuphuza utshwala obuningi ngenkathi ephuza i-colchicine, njengoba ingase yandise ingozi yezinkinga zesisu futhi ithinte ukusebenza komuthi ekuvimbeleni ukuhlaselwa yi-gout. Abantu ngabanye kufanele futhi bagweme ijusi ye-grapefruit kanye ne-grapefruit njengoba ingakhuphula imiphumela ye-colchicine.