I-Dicyclomine Hydrochloride

I-Dicyclomine Hydrochloride

I-Dicyclomine Hydrochloride iyi-analogue yokwenziwa ye-acetylcholine eyaziwa ngomsebenzi wayo we-antimuscarinic. Iqondise ngokucacile i-muscarinic receptors i-M1, i-M2, ne-M3 etholakala kumsipha obushelelezi wepheshana lesisu. Ngokuphikisana nalawa ma-receptors, i-dicyclomine hydrochloride ivimbela ngokuphumelelayo izenzo ze-acetylcholine, i-neurotransmitter engase ikhuthaze ukufinyela kwemisipha kanye nama-spasms ohlelweni lwe-gastrointestinal.

Lo muthi udlala indima ebalulekile ekwengameleni izinkinga ezihambisana nesifo samathumbu esicasukayo (IBS) ngokunciphisa imvamisa nokuqina kwemisipha yemisipha. Ukwengeza, inomphumela ovimbelayo ongancintisani esenzweni se-histamine ne-bradykinin, enomthelela ekhonweni layo lokunciphisa amandla okufinyela ku-ileum, ingxenye yamathumbu amancane.

I-Dicyclomine itholakala ngezindlela ezihlukahlukene, okuhlanganisa amaphilisi, amaphilisi, nesiraphu, futhi ngokuvamile inikezwa izikhathi ezine ngosuku. Iziguli kufanele zinamathele kumthamo wazo onqunyiwe kanye neshejuli yokwandisa ukusebenza kahle kokwelashwa kuyilapho kunciphisa imiphumela engemihle ye-dicyclomine hcl engaba khona.

Ukusetshenziswa kwe-Dicyclomine Hydrochloride

• I-Dicyclomine hydrochloride inqunyelwe ngokuyinhloko ukuphatha izimpawu ze-Irritable Bowel Syndrome (IBS). 
• I-Dicyclomine hydrochloride nayo inganqunywa kwezinye izifo zamathumbu ezisebenzayo. Idambisa ngokuphumelelayo izimpawu ezicindezelayo ezihambisana nokuphazamiseka kwamathumbu, ithuthukise izinga lempilo yabantu abathintekile ngokuphumuza imisipha ebushelelezi esiswini nasemathunjini.
• I-Dicyclomine ingasiza futhi ekunciphiseni ubuhlungu be-colicky, obufika ngamagagasi futhi ngokuvamile buhlotshaniswa nama-spasms emathunjini noma kwezinye izingxenye zepheshana lesisu.
• I-Dicyclomine futhi inenzuzo kwezinye izinhlobo ze-spasms yamathumbu, kuhlanganise nalezo ezihlobene nezimo ze-GI ezifana ne-diverticulitis noma i-gastroenteritis.

Ungayisebenzisa kanjani i-Dicyclomine Hydrochloride

Ukuze usebenzise i-dicyclomine hydrochloride ngempumelelo, iziguli kufanele zilandele le mihlahlandlela:

• Indlela Yokuphatha: Thatha i-dicyclomine hydrochloride ngomlomo ngengilazi yamanzi. Kungcono ukuphuza lo muthi esiswini esingenalutho, imizuzu engama-30 kuya kwehora eli-1 ngaphambi kokudla.
• Isheduli Yemithamo: Landela izikhombisi-ndlela ezikulebula kadokotela eduze. Iziguli zivame ukuthatha imithi yazo ngezikhathi ezithile, izikhathi ezine ngosuku, ukuze zigcine ukukhululeka okungaguquki. Ungayiphuzi imithi kaningi kunalokho oyalelwe.
• Uphuthelwe Imithamo: Uma weqa umthamo, thatha ngokushesha ngangokunokwenzeka. Kodwa-ke, uma isikhathi somthamo olandelayo sesifikile, yeqa umthamo futhi uqhubeke nohlelo olujwayelekile lokudosa. Ungathathi imithamo ephindwe kabili noma eyengeziwe.
• Isitoreji: Kufanele ugcine i-dicyclomine hydrochloride ekamelweni lokushisa {ububanzi bungu-68°F ukuya ku-77°F (20°C kuya ku-25°C)}. Gwema ukubeka umuthi ekushiseni ngokweqile namakhazeni.
• Izinyathelo Zokuphepha:
  • Ungathathi ama-antacids phakathi kwamahora angu-1 kuya kwangu-2 ngaphambi noma ngemva kwe-dicyclomine hydrochloride, ngoba angaphazamisa ukusebenza kwayo.
  • Lo muthi ungathinta ukuqapha noma ukusebenzisana kanye nembangela umbono ongenalutho, isiyezi, noma ukozela. Gwema ukushayela noma imisebenzi edinga ukuqapha uze wazi ukuthi umuthi ukuthinta kanjani.
  • Gcina i-dicyclomine hydrochloride ikude nezingane, futhi ungabelani ngayo nabanye, ngisho noma benesimo esifanayo.
• Ukucatshangelwa Okukhethekile:
  • Xoxa nodokotela wakho mayelana nokusetshenziswa kwalo muthi ezinganeni, njengoba kungase kudingeke ukunakekelwa okukhethekile.
  • Abantu abadala asebekhulile, ikakhulukazi labo abangaphezu kweminyaka engama-65, bangase basabele ngokuqinile emuthini futhi badinge umthamo omncane.

I-Dicyclomine Hydrochloride Side Effects

Iziguli ezisebenzisa i-dicyclomine hydrochloride ngokuvamile ziba nemiphumela engemihle embalwa, evame ukuxazululeka phakathi kwezinsuku ezimbalwa ukuya emavikini. Imiphumela emibi evamile yalo muthi isiyezi, umlomo owomile, ukungaboni kahle, isicanucanu, ukozela, ubuthakathaka, novalo. Lezi zimpawu zivame ukunyamalala njengoba umzimba ujwayela umuthi.

Imiphumela Emibi Kakhulu:

Imiphumela emibi kakhulu, nakuba ingavamile, idinga ukunakekelwa kwezokwelapha ngokushesha. Lokhu kuhlanganisa ukushaya kwenhliziyo okungavamile noma okusheshayo, ubunzima bokugwinya, ukuqunjelwa okuphawulekayo, nokungezwani okukhulu komzimba, njengokuvuvukala kobuso, izindebe, ulimi, nomphimbo, nobunzima bokuphefumula. Ezinye izimpawu ezinzima ukudideka, ukubona izinto ezingekho, izinkinga zenkumbulo, nezinkinga zokulinganisela noma ukunyakaza kwemisipha.

Ukuqapha

Lapho ucubungula i-dicyclomine hydrochloride yokulawulwa kwezimpawu, iziguli kanye nodokotela kufanele baqaphele izinyathelo ezimbalwa zokuqinisekisa ukusetshenziswa okuphephile, okuhlanganisa: 

• Abantu abanezimo ezifana ne-glaucoma, ikakhulukazi ukuvalwa kwe-engeli i-glaucoma, kufanele igweme i-dicyclomine ngenxa yengozi yokwandisa isimo. 
• Labo abahlushwa i-myasthenia gravis, i-ulcerative colitis enzima, nanoma yiluphi uhlobo lokuvinjelwa kwamathumbu noma umchamo akufanele basebenzise le mithi, ngoba ingaba zimbi kakhulu lezi zimo.
• Iziguli kufanele zazise udokotela wazo ngayo yonke imithi eziyithathayo njengamanje, njengoba i-dicyclomine ingasabela kabi ngemithi ehlukahlukene, kuhlanganise nama-antacid, ama-anticholinergics, nemithi ehlukahlukene kadokotela efana ne-metoclopramide, okungenzeka inciphise ukusebenza kwayo. 
• Kubalulekile futhi ukuxoxa nganoma yimuphi umlando wenhliziyo, isibindi, noma isifo sezinso, njengoba lezi zimo zingadinga ukulungiswa ohlelweni lokwelapha.
• I-Dicyclomine iphikisana ibele omama ngenxa yobukhona balo obisini lwebele, okungaholela emiphumeleni emibi kakhulu ezinganeni. 
• Iziguli esezikhulile kufanele ziqaphe noma zigweme i-dicyclomine ngokuphelele, njengoba zithinteka kakhulu emiphumeleni yayo, njengokulala, ukudideka, nokushisa ngokweqile, okungaholela ekushayweni kokushisa ezindaweni ezishisayo.
• Iziguli kufanele zigweme ukusebenza emishinini esindayo noma ukushayela kuze kube yilapho ziqonda ukuthi i-dicyclomine iwuthinta kanjani umbono nokuqapha kwazo. 
•  Utshwala bungaqinisa ukozela okubangelwa i-dicyclomine, ngakho iziguli kufanele futhi zicabangele lokhu kusebenzisana ukuze zigweme imiphumela ehlanganisiwe.

Isebenza kanjani i-Dicyclomine Hydrochloride

I-Dicyclomine hydrochloride isebenza njenge-ejenti ye-antispasmodic ne-anticholinergic edambisa ngempumelelo imisipha ebushelelezi emgudwini wamathumbu. Ifinyelela lokhu ngokusebenzisa indlela embaxambili. Okokuqala, isebenzisa umphumela othize wokulwa ne-anticholinergic kumasayithi e-acetylcholine-receptor, ivimba i-neurotransmitter acetylcholine, enesibopho sokufinyela kwemisipha. Okwesibili, i-dicyclomine ithinta ngokuqondile imisipha ebushelelezi, inciphisa amandla nokuphindaphinda kwama-spasms.

Le mithi ingeyekilasi elaziwa ngokuthi i-anticholinergics noma i-antispasmodics, ekhulula imisipha ebushelelezi yesisu namathumbu. Ngokuvimbela isenzo se-acetylcholine nokuvimbela ama-receptors i-M1, i-M3, ne-M2, i-dicyclomine inciphisa ukuhamba nokuphuma kwamathumbu emathunjini. Ukwengeza, ayivimbeli ngokuncintisana izenzo ze-bradykinin ne-histamine, iphinde inciphise ukufinyela kwepheshana lesisu, ikakhulukazi ku-ileum.

Ngingakwazi ukuthatha i-Dicyclomine Hydrochloride Neminye Imithi?

Iziguli kufanele zithintane nodokotela wazo ngaphambi kokuhlanganisa i-dicyclomine hydrochloride neminye imithi. I-Dicyclomine hydrochloride ingasebenzisana nemithi ehlukahlukene, engase iguqule ukusebenza kwayo noma imiphumela emibi eyandayo. Isibonelo, ukusetshenziswa kanyekanye kwama-antacid ne-dicyclomine kufanele kulawulwe ngokucophelela, njengoba ama-antacid anganciphisa ukumuncwa kwe-dicyclomine, anciphise ukusebenza kwayo.

Ukwengeza, ukuhlanganisa i-dicyclomine nezinye izidakamizwa ze-anticholinergic kungathuthukisa imiphumela nemiphumela emibi yayo yomibili imithi, okungase kuholele ekwenyukeni kobuthongo, umlomo owomile, noma ukuphazamiseka kokubona. Kubalulekile futhi ukugwema ukusebenzisa i-dicyclomine enemithi yezinhlungu ze-opioid noma ama-antihistamine abangela ukozela, njengoba lokhu kungase kuphazamise ukusebenza kwengqondo nokusebenza kwengqondo.

Ulwazi Lomthamo

I-Dicyclomine hydrochloride iza ngezinhlobo namandla ahlukahlukene, enzelwe ukusetshenziswa kwabantu abadala kanye nezingane. Abantu abadala ngokuvamile baqala nge-dose yokuqala ye-20 mg ethathwe ngomlomo izikhathi ezine ngosuku, okungase kwenyuke ku-40 mg izikhathi ezine ngosuku ngokusekelwe ekuphenduleni nasekubekezeleni.

Umthamo wezingane wezingane ezingaphezu kwezinyanga eziyisithupha uqala ngo-5 mg ngomlomo njalo emahoreni ayisithupha kuya kwayisishiyagalombili futhi akufanele udlule u-20 mg ngosuku. Ezinganeni ezindadlana, umthamo unganyuswa ube ngu-10 mg njalo emahoreni ayisithupha kuya kwayisishiyagalombili, ngesilinganiso esiphezulu esingu-40 mg ngosuku.

Iziguli esezikhulile zidinga ukucatshangelwa ngokucophelela ngenxa yezehlakalo eziphezulu zemiphumela ye-anticholinergic. Ngokuvamile ziqala ngo-10-20 mg ngomlomo njalo emahoreni ayisithupha, ngokuqapha okuseduze ukulungisa umthamo njengoba kudingeka ngaphandle kokudlula i-160 mg nsuku zonke.

Ukwandisa ukumuncwa nokusebenza ngempumelelo, iziguli kufanele ziphuze i-dicyclomine hydrochloride imizuzu engama-30 kuye kwengama-60 ngaphambi kokudla. Ukunamathela ngokuqinile esimisweni somthamo esinqunyiwe kubalulekile ukugwema imiphumela engemihle engaba khona kanye nokusebenzisana neminye imithi.

Imibuzo Evame Ukubuzwa

1. Ingabe i-dicyclomine hydrochloride iyisidambisa-zinhlungu?

I-Dicyclomine hydrochloride ayiyona i-painkiller yendabuko. Ingokwesigaba semithi eyaziwa ngokuthi i-anticholinergics noma i-antispasmodics, esetshenziswa ngokuyinhloko ukuphatha isifo samathumbu esicasulayo (IBS). Ngokubeka amabhuleki ekuhambeni kwemvelo kwamathumbu nokuvimbela izinto ezithile zemvelo, i-dicyclomine hydrochloride ikhulula ngempumelelo imisipha ye-muscle emgudwini wamathumbu, ngaleyo ndlela inciphise ubuhlungu bohlobo lwe-colicky oluhambisana ne-IBS.

2. Isetshenziselwa ini i-Dicycloverine hydrochloride?

Lawa maphilisi anomuthi obizwa nge-dicycloverine hydrochloride, oyingxenye yeqembu le-antispasmodics. Amaphilisi e-Dicyclomine hydrochloride asebenza ngokuphumuza imisipha esiswini namathumbu (amathumbu), amise ukufinyela kwemisipha kungazelelwe (ama-spasms). Lesi senzo sisiza ukukhulula izimpawu ezifana namajaqamba, ubuhlungu, ukuvuvukala, umoya, nokungaphatheki kahle, okwenza kube usizo ikakhulukazi ekwelapheni izinkinga zesisu noma zamathumbu, okuhlanganisa nesifo samathumbu esicasulayo.