I-Domperidone

I-Domperidone

I-Domperidone iyimithi ye-prokinetic ne-anti-nausea. Iphuma ekilasini lemithi eyaziwa ngokuthi abaphikisi be-dopamine. Isetshenziselwa kakhulu ukudambisa izimpawu ezinjengokucanuzela kwenhliziyo, ukuhlanza, izinhlungu nokungaphatheki kahle emzimbeni. isisu kanye ne-upper gastrointestinal (GI) ipheshana, ngokuvamile okubangelwa isisu esihamba kancane kanye nokunyakaza kwepheshana le-GI.

I-Domperidone isebenza ngokuvimbela ama-dopamine receptors atholakala ohlelweni lwamathumbu. Lesi senzo sithuthukisa ukufinyela kwesisu kanye nemisipha yamathumbu, ngaleyo ndlela kube lula ukuhamba okusheshayo nokushelela kokudla ngokusebenzisa umgudu wokugaya ukudla. Ukwengeza, kunomthelela endaweni ye-chemoreceptor trigger zone ebuchosheni, edlala indima ekubangeleni isicanucanu nokuhlanza. Ngokuphawulekayo, le ndawo yobuchopho itholakala ngaphandle komgoqo wokuvikela wegazi nobuchopho. Ngokungafani neminye imithi evimba i-dopamine, i-domperidone ayiweli umgoqo wegazi nobuchopho, inciphisa amathuba okuba nemiphumela engemihle yesistimu yezinzwa emaphakathi.

Mayelana nokusetshenziswa kwayo ekukhuliseni ukukhiqizwa kobisi lwebele, i-domperidone isebenza ngokukhuphula amazinga e-hormone eyaziwa ngokuthi i-prolactin, ekhuthaza ukukhiqizwa kobisi lwebele.

Yiziphi izinkomba zokusetshenziswa kwe-Domperidone?

Izimo eziningi, kuhlanganise okulandelayo, ziphathwa nge-Domperidone:

• Ukudambisa isicanucanu (umuzwa wokugula) nokuhlanza, ikakhulukazi lapho ikhanda elinkenkethayo kuyimbangela eyinhloko.
• Ukumisa ukuhlanza kanye nesicanucanu esibangelwa i-Levodopa ne-Pergolide, izidakamizwa ezimbili ezazisetshenziswa ukwelapha isifo sikaParkinson.
• Siza ekudambiseni ukungaphatheki kahle okulethwa i-Gastroparesis, isimo lapho isisu sinyakaza kancane. 
• I-Dyspepsia (ukuqunjelwa), ukungakwazi ukuqeda ukudla, ukuqunjelwa noma ukusutha ngemva kokudla, ukuphelelwa isifiso sokudla, ukuzizwa ugula, futhi mhlawumbe nokuhlanza noma ukuqunjelwa ngaphandle kokukhululeka ezinye izimpawu ezidanjiswa yilo muthi.

Nini futhi kanjani ukuthatha Domperidone?

Udokotela wakho uzokuchazela ukuthi uwuthatha kanjani futhi nini lo muthi. Thatha i-Domperidone ngokuya ngencwadi kadokotela kuphela.


• Amaphilisi kufanele adliwe wonke, kanye namanzi athile. Ungawahlafuni noma uwaphihlize.
• Sebenzisa inkomishi yokulinganisa yepulasitiki efakiwe uma uthatha ukumiswa ngomlomo.
• Ngenkathi usebenzisa amaconsi omlomo, qiniseka ukuthi usebenzisa i-dropper eza nayo.
• Akudingekile ukuba namanzi ngenkathi uthatha amaphilisi ahlakazayo ngomlomo ngoba ayancibilika emlonyeni.

Iyini imiphumela emibi ye-Domperidone?

Imiphumela emibi ye-dopamine kwesinye isikhathi ingaba mibi kakhulu. Ungaqhubeki uthatha i-Domperidone futhi uthintane nodokotela noma uye ngokushesha esibhedlela uma ubona izimpawu ezilandelayo:

• Uhlangabezana nokuquleka noma ukulingana.
• Uba nokuvuvukala ezandleni, emaqakaleni, ezinyaweni, ebusweni, ezindebeni, noma entanyeni, okungase kwenze kube nzima ngawe ukuhamba, ukuphefumula, noma ukugwinya. Ungase futhi uthole ukulunywa, iqhubu noma i-nettle rash. Lokhu kungase kubonise ukuthi awuzwani nomuthi.
• Ubona noma yikuphi ukunyakaza okungajwayelekile. Kuhlanganisa ukunyakaza kolimi neso okungajwayelekile kanye nokuma okungavamile okufana nentamo esontekile, ukuthuthumela, nokuqina kwemisipha. Izingane zinethuba eliphezulu lokuthola lokhu. 
• Unokushaya kwenhliziyo okusheshayo noma okusheshayo okungajwayelekile. Lokhu kungabonisa isimo esibucayi senhliziyo esingase sibulale.

Lokhu okulandelayo yimiphumela emibi engavamile ye-Domperidone:

• ukukhathazeka
• Ukulala
• Uhudo
• Ukunyakaza kwamehlo okungajwayelekile
• Ukuluma kwesikhumba noma ukuqubuka kwesikhumba
• Amabele abuhlungu noma athambile
• Ukukhiqizwa kobisi lwebele okungajwayelekile kubo bobabili abesilisa nabesifazane
• Ukunciphisa isifiso sobulili besilisa
• Imijikelezo yokuya esikhathini kwabesifazane ingase iguquguquke noma iphele nya.

Le miphumela engemihle ayivamile futhi kwenzeka kuyaqabukela.

Yiziphi izinyathelo zokuphepha ze-Domperidone?    

• Kubalulekile ukuphuza imithi ngaphambi kokudla, njengoba kunconywe umhlinzeki wakho wezempilo, ukuze uqinisekise ukusebenza kahle okuphelele.
• Ungayithathi izinsuku ezingaphezu kweziyisikhombisa ngaphandle kokukhuluma nodokotela wakho kuqala.
• Ungase uzizwe unesiyezi futhi ukhathele ngenxa yalokho. Kuze kube yilapho wazi ukuthi kukuthinta kanjani, ungashayeli noma wenze noma yimiphi eminye imisebenzi edinga ukugxilisa ingqondo.
• Gwema ukuphuza utshwala ngenkathi uthatha i-Domperidone, ngoba ingakwenza uzizwe ulele kakhulu.
• Uma uba nomkhuhlane, ukungaphatheki kahle kwesisu isikhathi eside, noma isifo sohudo esimanzi, tshela udokotela wakho ngokushesha.
• Akukhuthazwa ukusebenzisa lo muthi ezigulini ezingaphansi kweminyaka engu-12 noma ezinesisindo esingaphansi kwama-35 kg njengoba ukuphepha nokusebenza kwawo akukaqinisekiswa ngokwesayensi.
• abesifazane abakhulelwe akufanele isebenzise lesi sidakamizwa ngaphandle kokucela udokotela.
• Ukusetshenziswa kwe-Domperidone kungase kukhuphule ingozi yokungalungi kwesigqi senhliziyo nokuboshwa kwenhliziyo, namathuba aphezulu kubantu abaneminyaka engama-60 noma ngaphezulu kanye nalabo abathatha imithamo engaphezu kuka-30 mg nsuku zonke. Le ngozi iyanda uma ihlanganiswa nemithi ethile. Kubalulekile ukwazisa umhlinzeki wakho wezempilo noma usokhemisi uma usebenzisa izidakamizwa ukwelapha izifo, kungakhathaliseki ukuthi ukhunta noma amagciwane futhi uma unezimo zenhliziyo ezivele zikhona noma amasosha omzimba asengozini njengezimo ezifana ne-HIV/AIDS.
• Kubantu abadala kanye nentsha eneminyaka engu-12 nangaphezulu enesisindo somzimba esingama-35 kg noma ngaphezulu, i-domperidone kufanele inikezwe ngethamo eliphansi kakhulu elisebenza kahle.
• Ngenkathi usebenzisa lo muthi, kubalulekile ukuthintana nodokotela wakho uma uhlangabezana nezinkinga zesigqi senhliziyo, njengokushaya kwenhliziyo, ubunzima bokuphefumula, noma ukulahlekelwa ukwazi. Ezimweni ezinjalo, ukusetshenziswa kwe-domperidone kufanele kuyekwe.

Ukusebenzelana neminye imithi

I-Domperidone akufanele ithathwe uma uthatha imithi yokwelapha:

• Ukutheleleka kwefungal noma Ukutheleleka Ngegciwane
• High Blood Pressure
• Ukucindezeleka
• Ukuphazamiseka kwamathumbu 
• Umalaleveva 
• Cancer
• I-AIDS/HIV (i-protease inhibitors)

Yini okufanele ngiyenze uma ngiphuthelwa umthamo we-Domperidone?

Uma ukhohlwe ukuphuza lo muthi yiphuze ngokushesha nje lapho ukhumbula. Ngakolunye uhlangothi, gwema umthamo ogejiwe futhi uqalise kabusha uhlelo lwakho oluvamile lokudosa uma cishe sekuyisikhathi somthamo wakho olandelayo. Ungalokothi uhlanganise imithamo emibili ibe munye ukuze ugweme ukweqisa.

Yini okufanele uyenze uma i-overdose ye-Domperidone?

Kungase kube yingozi ukuthatha i-Domperidone eningi. Ukushaya kwenhliziyo okusheshayo noma okungajwayelekile kungase kubangele ukuphuza imithi eminingi kunalokho obekuhlosiwe. Endabeni ye-overdose ye-Domperidone, funa usizo lwezokwelapha ngokushesha.

Yiziphi izimo zokugcina i-Domperidone?

• Umuthi udinga ukugcinwa esitsheni esiqinile ekamelweni lokushisa, kude nokushisa, umswakama, nokukhanya okuqinile.
• Umuthi ongasadingeki noma ophelelwe yisikhathi akufanele ugcinwe.
• Gcina imithi lapho izingane zingafinyelela khona ukuze uqinisekise ukuphepha kwazo.

I-Domperidone ibonisa ngokushesha kangakanani imiphumela?

I-Domperidone ibangela ukunyuka kokuqala kwamazinga e-prolactin phakathi nemizuzu engama-60 yokwelashwa. Ngokuvamile, umphumela uqala ukubonakala emaminithini angu-30-40.

I-Domperidone vs Metoclopramide

Imibuzo Evame Ukubuzwa

1. Uyini umehluko phakathi kweDomperidone neMetoclopramide? 

Ngokusekelwe kumshini wesenzo nokusetshenziswa, umehluko phakathi kwe-Domperidone ne-Metoclopramide yilezi:

• Indlela Yesenzo: I-Domperidone ne-Metoclopramide yomibili imithi engasiza ukukhulula izinkinga zokugaya ukudla, kodwa isebenza ngendlela ehlukile. I-Domperidone isebenza ngokuvimbela i-dopamine receptors emathunjini, ithuthukise ukuhamba kwesisu nemisipha yamathumbu, futhi inciphise isicanucanu. Ngakolunye uhlangothi, i-metoclopramide isebenza kuma-dopamine receptors esiswini nangaphezulu emathunjini ukuze kuthuthukiswe ukufinyela kwemisipha futhi kwandise ukuhamba kokudla ngomgudu wokugaya ukudla. Kuphinde kuthinte indawo ye-chemoreceptor trigger zone ebuchosheni, kunciphise isicanucanu nokuhlanza.
• Ukusetshenziswa: Yomibili le mithi isetshenziselwa ukwelapha izimo ezifanayo, njengesicanucanu, ukuhlanza, nokuphazamiseka okuthile kokugaya ukudla, kodwa umhlinzeki wezempilo angase akunikeze i-domperidone, i-metoclopramide, nanoma yimuphi omunye umuthi ofanayo ngokusekelwe esimweni sakho sezempilo sisonke. 

2. Ingabe ithebhulethi ye-domperidone isetshenziselwa i-acidity?

Yebo, i-domperidone ingasetshenziswa ukukhulula izimpawu ezihambisana ne-asidi, njengokucanuzela kwenhliziyo nesilungulela, ikakhulukazi uma lezi zimpawu zihlobene nokubambezeleka kokuphuma kwesisu.

3. Kufanele ithathwe nini i-domperidone?

I-Domperidone ivame ukuthathwa ngaphambi kokudla, njengoba isiza ekukhuthazeni ukuhamba kokudla ngomgudu wokugaya ukudla. Imiyalo eqondile yokudosa kufanele inikezwe uchwepheshe wezempilo ngokusekelwe esimweni sakho esithile.

4. Yimiphi imiphumela emibi engase ibangele i-domperidone?

Imiphumela emibi evamile ye-domperidone ingabandakanya amajaqamba esiswini, isifo sohudo, nekhanda elibuhlungu. Kwezinye izimo, kungase kubangele imiphumela emibi kakhulu, njengokushaya kwenhliziyo okungajwayelekile, okungaba ukukhathazeka, ikakhulukazi ngemithamo ephezulu. Kubalulekile ukusebenzisa lo muthi njengoba uyalelwe umhlinzeki wezempilo futhi ubike noma yimiphi imiphumela emibi engajwayelekile noma enzima ngokushesha.

5. Ingabe i-DOMPERIDONE ingaphumela emlonyeni owomile?

Yebo, umlomo owomile ungaba umphumela we-domperidone. Kubalulekile ukuthi uhlale unamanzi amaningi futhi ubike lokhu nanoma yimiphi eminye imiphumela emibi kumhlinzeki wakho wokunakekelwa kwezempilo uma ihlupha noma iba nzima. Ukulungiswa komuthi noma umthamo kungacatshangelwa uma kunesidingo.

References:

https://www.drugs.com/domperidone.html https://www.mayoclinic.org/drugs-supplements/domperidone-oral-route/description/drg-20063481
https://www.nhs.uk/medicines/domperidone/#:~:text=Taking%20too%20much%20domperidone%20can,a%20fast%20or%20irregular%20heartbeat.

Umshwana wokuzihlangula: Ulwazi olunikezwe lapha alwenzelwe ukufaka iseluleko esivela kuchwepheshe wezokunakekelwa kwempilo. Ulwazi aluhloselwe ukumboza konke ukusetshenziswa okungenzeka, imiphumela engemihle, izinyathelo zokuphepha, nokusebenzisana kwezidakamizwa. Lolu lwazi aluhloselwe ukuphakamisa ukuthi ukusebenzisa umuthi othile kufanelekile, kuphephile, noma kuyasebenza wena noma omunye umuntu. Ukungabi bikho kwanoma yiluphi ulwazi noma isexwayiso mayelana nomuthi akufanele kuhunyushwe njengesiqinisekiso esicacile esivela enhlanganweni. Sikweluleka ngokuqinile ukuthi uthintane nodokotela uma kukhona okukukhathazayo ngomuthi futhi ungalokothi usebenzise umuthi ngaphandle kwencwadi kadokotela.