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I-Duloxetine

I-Duloxetine iyisidakamizwa esinamandla esiza kokubili ubuhlungu kanye nemizwa. Kuwumuthi odumile odokotela abawunikeza abantu abanezinkinga ezahlukene zempilo. Ukusuka ekwehliseni ubuhlungu bezinzwa kuya ekuphakamiseni imizwa ephansi, i-duloxetine inokusetshenziswa okuningi okuyenza igqame emhlabeni wezokwelapha. Lesi sihloko sizobheka ukuthi iyini i-duloxetine nokuthi isebenza kanjani emzimbeni. Sizohlola futhi mayelana nokusetshenziswa okuhlukahlukene kwe-duloxetine nokuthi ungayithatha kanjani ngokuphepha. 

Iyini i-Duloxetine?

I-Duloxetine ingeyesigaba sezidakamizwa esaziwa ngokuthi i-serotonin-norepinephrine reuptake inhibitors (SNRIs). Lo muthi usiza ukubuyisela ibhalansi yezinto ezithile zemvelo ebuchosheni, ikakhulukazi i-serotonin & norepinephrine. Ithebhulethi ye-Duloxetine isetshenziselwa ukwelapha izimo ezihlukahlukene, kuhlanganise nokucindezeleka okukhulu, ukuphazamiseka kokukhathazeka okujwayelekile, kanye Ubuhlungu obungapheliyo izimo ezifana ne-diabetes neuropathy kanye ne-fibromyalgia. I-FDA yaqala ukugunyaza ngo-2004 ngaphansi kwegama lomkhiqizo i-Cymbalta. I-Duloxetine itholakala njengemithi ejwayelekile futhi ithathwa ngomlomo kanye noma kabili ngosuku. Umthamo we-Duloxetine uyahlukahluka kuye ngesimo kanye nempendulo yomuntu emuthini.

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Ukusetshenziswa kwethebhulethi ye-Duloxetine

Izinhlobo ezahlukahlukene zokusetshenziswa kwe-duloxetine yilezi: 

  • Abantu abadala abane-depressive disorder enkulu kanye ne-generalized disorder disorder (GAD)
  • I-GAD ezinganeni ezineminyaka eyisikhombisa nangaphezulu
  • Ubuhlungu nokuluma okubangelwa yi-diabetes peripheral neuropathy
  • I-Fibromyalgia kubantu abadala kanye nezingane ezineminyaka engu-13 nangaphezulu
  • I-Fibromyalgia kubantu abadala 
  • Ubuhlungu obungapheli be-musculoskeletal
  • Ukwelashwa ngamakhemikhali- I-peripheral neuropathy ebangelwayo 
  • Ingcindezi yokungakwazi ukuzithiba komchamo kubo bobabili abesilisa nabesifazane

Ungayisebenzisa kanjani i-Duloxetine Tablet

  • Ukuze uthole inzuzo enkulu kuthebhulethi ye-duloxetine, yithathe njengoba nje udokotela wakho ekuyalela. 
  • Geza i-capsule ebambezelekile ekhishwe lonke ngamanzi noma ngejusi, futhi ungayihlafuni, uyichoboze, noma uyiphule. 
  • Abantu ngabanye bangathatha i-duloxetine ngokudla noma ngaphandle kokudla, kodwa kungcono ukuyithatha ngesikhathi esifanayo usuku ngalunye. 
  • Uma unenkinga yokugwinya, ezinye izinhlobo ze-duloxetine ziyatholakala ukuze zivulwe futhi zifafazwe phezu kwe-appleauce. Nokho, ungakwenzi lokhu ngazo zonke izinhlobo zamaphilisi e-duloxetine. 
  • Kubalulekile ukuqhubeka nokusebenzisa umuthi ngisho noma ungazizwa ungcono ngaso leso sikhathi, njengoba kungathatha amasonto ambalwa ukubona ukuthuthuka. 

Khuluma nodokotela wakho ngaso sonke isikhathi uma unemibuzo mayelana nendlela yokusebenzisa amaphilisi e-duloxetine.

Imiphumela Emibi Yethebhulethi ye-Duloxetine

I-Duloxetine, njengayo yonke imithi, ingaba nemiphumela engemihle. Imiphumela emibi evamile ihlanganisa: 

Imiphumela emibi kakhulu ingenzeka ngezikhathi ezingavamile, njenge: 

  • syncope
  • Izinkinga zesibindi
  • Izinguquko kumfutho wegazi
  • I-Mood iyashintsha
  • I-Serotonin syndrome

Kubalulekile ukufuna usizo lwezokwelapha uma ubona izimpawu ezinzima noma ezingajwayelekile ngenkathi uthatha i-duloxetine.

Ukuqapha

Ngaphambi kokuthatha i-duloxetine, kubalulekile ukwazisa udokotela wakho nganoma yikuphi ukungezwani komzimba, imithi yamanje, noma izimo zempilo onazo. 

  • Ukusebenzisana kwezidakamizwa: Lo muthi ungase uhlanganyele nemithi ethile, okuhlanganisa ama-MAO inhibitors namanye ama-antidepressants. 
  • Ukukhulelwa Nokuncelisa: Okhulelwe noma omama abancelisayo kufanele baxoxe ngezingozi nodokotela wabo. 
  • Isiyezi: I-Duloxetine ingase ibangele isiyezi noma ukozela, ngakho-ke kuhle ukuba uqaphe lapho ushayela noma usebenzisa imishini. Kubalulekile ukugwema utshwala ne-cannabis ngenkathi usebenzisa i-duloxetine, ngoba ingandisa ingozi yemiphumela emibi. 
  • Isimo Sezempilo: Umuthi ungaphinda uthinte umfutho wegazi kanye namazinga kashukela egazini, ngakho ukuqapha njalo kuyadingeka. Abantu abanenkinga yesibindi noma yezinso, i-glaucoma, isifo sikashukela, umlando wokuphazamiseka kwengqondo, noma umlando wokuquleka kufanele usebenzise i-duloxetine ngokuqapha. 

Hlala ulandela imiyalelo kadokotela wakho futhi ubike noma yiziphi izimpawu ezingajwayelekile ngokushesha.

Isebenza kanjani ithebhulethi yeDuloxetine

I-Duloxetine umuthi onamandla othonya amakhemikhali obuchopho. Isebenza ngokumisa ukuphinda kuthathwe amakhemikhali amabili abalulekile: i-serotonin ne-norepinephrine. Kusho ukuthi amaningi alawa makhemikhali asebuchosheni, okusiza ukulinganisa imizwa nokunciphisa ubuhlungu. I-Duloxetine iphinde inyuse amazinga e-dopamine engxenyeni ethile yobuchopho ebizwa ngokuthi i-prefrontal cortex. Lokhu kwenzeka ngoba ivimba amaphampu avame ukususa i-norepinephrine, ephinde ithathe i-dopamine.

Kuyathakazelisa ukuthi i-duloxetine ayiwathinti kakhulu amanye amakhemikhali obuchopho, okwenza igxile ngokuphelele esenzweni sayo. Emgogodleni, i-duloxetine iqinisa izindlela ezisiza ukunciphisa izimpawu zobuhlungu. Yingakho kusiza ukwelapha izimo ezifana nobuhlungu benhliziyo yesifo sikashukela kanye ne-fibromyalgia. Sekukonke, izenzo eziyinkimbinkimbi ze-duloxetine ebuchosheni nasemgogodleni ziyenza iphumelele ekwelapheni kokubili ukuphazamiseka kwemizwelo kanye nezinhlobo ezithile zobuhlungu.

Ngingakwazi ukuthatha i-duloxetine neminye imithi?

I-Duloxetine ingaxhumana nemithi ehlukahlukene, kufaka phakathi: 

  • Utshwala
  • antidepressant
  • Imithi ye-antiplatelet njenge-clopidogrel
  • Ama-Antipsychotics afana ne-thioridazine
  • Izinto ezinciphisa igazi njenge-warfarin
  • I-Cimetidine
  • I-MAO inhibitors
  • Ama-relaxant muscle
  • Ama-NSAID afanayo naproxen, ibuprofen
  • Ukukhwehlela kwe-opioid nokuqeda ubuhlungu
  • John's wort

Ulwazi Lomthamo

Umthamo we-duloxetine uyahlukahluka futhi uncike esimweni sokwelashwa. 

Ngokucindezeleka, umthamo wokuqala ngu-60 mg, othathwa kanye ngosuku, ongakhuphuka ube ngu-120 mg uma kudingeka. 

Ukwelashwa kokukhathazeka kuvame ukuqala ngo-30 mg kanye ngosuku, okungenzeka kukhuphuke kuye ku-60mg. 

Ngobuhlungu bezinzwa, odokotela bavame ukunikeza i-60 mg kanye ngosuku, ngokunyuka okungenzeka kube ngu-60 mg kabili ngosuku. 

Ezimweni zokucindezeleka kokuphazamiseka kokuchama, umthamo wokuqala ngu-20mg kabili ngosuku, ongakhushulwa ku-40mg kabili ngosuku ngemva kwamasonto amabili. 

Isiphetho

I-Duloxetine umuthi oguquguqukayo onomthelela omkhulu kukho kokubili ukuphazamiseka kwemizwelo kanye nezimo zobuhlungu obungapheli. Ikhono layo lokulinganisa amakhemikhali obuchopho lenza libe usizo ekwelapheni ukucindezeleka, ukukhathazeka, nezinhlobo ezihlukahlukene zobuhlungu bezinzwa. Ukusebenza komuthi ekulawuleni lezi zimo ezihlukahlukene kugqamisa ukubaluleka kwawo kwezokwelapha zesimanje. Kodwa-ke, kubalulekile ukukhumbula ukuthi i-duloxetine, njenganoma yimuphi umuthi onamandla, iza nemiphumela engemihle engaba khona kanye nokusebenzisana okudinga ukucatshangelwa ngokucophelela.

Imibuzo Evame Ukubuzwa

1. I-duloxetine ivame ukusetshenziselwa ini?

I-Duloxetine iyindlela yokwelapha evamile yokucindezeleka, ukukhathazeka, ubuhlungu besifo sikashukela, i-fibromyalgia kanye nobuhlungu obungapheli be-musculoskeletal. Odokotela baphinde bayinqumele ingcindezi yokungakwazi ukuzibamba komchamo kwezinye izimo.

2. Ingabe i-duloxetine iphilisi lokulala?

Cha, i-duloxetine ayilona iphilisi lokulala. Nokho, kungathinta amaphethini okulala. Abanye abantu bangase babe nobuthongo, kuyilapho abanye bengase babe nenkinga yokulala lapho bethatha lo muthi.

3. Ubani ongakwazi ukuthatha i-duloxetine?

Abantu abane-glaucoma ye-angle-angle engalawuleki, izinkinga ezinkulu zezinso, noma ukwehluleka kwesibindi akufanele bathathe i-duloxetine. Akunconyelwe futhi kulabo abathatha i-monoamine oxidase inhibitors (MAOIs) noma abane-hypersensitivity eyaziwa emthini.

4. Kungani i-duloxetine ithathwa ebusuku?

Ukuthatha i-duloxetine ebusuku kungasiza ekulawuleni imiphumela engemihle efana nokozela. Nokho, isikhathi esingcono kakhulu sokuyithatha sincike ekutheni ikuthinta kanjani wena siqu.