I-Febuxostat

I-Febuxostat

I-FDA igunyaze i-febuxostat ngo-2009 njengomuthi wesikhathi eside we-gout obangelwa amazinga aphezulu e-uric acid. Umuthi uvimbela ukulimala kwamalunga, umisa ukuhlasela kwe-gout okubuhlungu, futhi unciphisa ubukhulu bezigaxa ezithinta isikhumba. 

Ake singene endleleni yokusebenza ye-febuxostat nemihlahlandlela efanele yemithamo. Abafundi bazothola ulwazi oluningiliziwe mayelana nemiphumela engemihle, izinyathelo zokuphepha, kanye nokusetshenziswa kwe-febuxostat 40mg.

Iyini i-Febuxostat?

I-Febuxostat ingeyesigaba semithi ebizwa ngokuthi i-xanthine oxidase inhibitors. I-Febuxostat isebenza njenge-non-purine selective inhibitor evimba ukukhiqizwa kwe-uric acid. Lo muthi kadokotela usiza ukuphatha i-hyperuricemia engapheli kubantu abadala abane-gout abangakwazi ukusebenzisa i-allopurinol ngempumelelo noma ukuyibekezelela kahle.

Iziguli kufanele zazi ukuthi ukuhlaselwa yi-gout kungase kwande phakathi nezigaba zokuqala zokwelashwa. Odokotela bakhetha phakathi kwamaphilisi angu-40 mg kanye nama-80 mg ukuhlanganisa izidingo ezithile zeziguli.

Ukusetshenziswa kwethebhulethi ye-Febuxostat

Odokotela basebenzisa isidakamizwa i-febuxostat ukuphatha i-hyperuricemia engapheli ezigulini ze-gout. Umuthi unqanda ukuhlasela kwe-gout ngaphambi kokuba ukwelapha izimpawu ezikhona. Ukusetshenziswa njalo kuvimbela ukulimala kwamalunga futhi kunciphisa izigaxa ze-gouty ezithinta isikhumba.

Ungayisebenzisa Kanjani Futhi Nini Ithebhulethi ye-Febuxostat

• Umthamo onconyiwe ithebhulethi eyodwa nsuku zonke, ongayithatha ngokudla noma ngaphandle kokudla. 
• Ukwelashwa kuqala ngo-40mg, futhi udokotela wakho angase andise ibe ngu-80mg ngemva kwamasonto amabili uma kudingeka. 
• Ukuphuza umuthi ngesikhathi esifanayo usuku ngalunye kunikeza imiphumela engcono kakhulu.
• Ungathatha ithebhulethi ngokudla noma ngaphandle kwayo ngokusekelwe kulokho okufanelana nesimiso sakho sansuku zonke.

Imiphumela Emibi Yethebhulethi ye-Febuxostat

Imiphumela emibi kakhulu ye-febuxostat ihlanganisa:

• Izinguquko ekusebenzeni kwesibindi 
• I-nausea 
• Ubuhlungu emalungeni 
• Ukukhwabanisa isikhumba 

Ukuqapha

• Noma ubani onenkinga yenhliziyo kufanele akhulume ngezinye izinketho nodokotela wakhe. 
• Abantu abasengozini yenhliziyo nemithambo yegazi kufanele babonane nodokotela wabo.
• Odokotela abayincomi ukuthi yelaphe i-hyperuricemia ngaphandle kwezimpawu.

Isebenza kanjani i-Febuxostat Tablets

Isebenza njenge-non-purine inhibitor ekhethiwe ye-enzyme xanthine oxidase. Lokhu kuvimbela i-hypoxanthine ekuguquleni ibe yi-xanthine bese iba yi-uric acid. Le nqubo inciphisa ukukhiqizwa kwe-uric acid ngenkathi igcina i-purine synthesis ebalulekile. 

Ngingathatha I-Febuxostat Ngeminye Imithi?

Ezinye zezidakamizwa ezijwayelekile ezingakhombisa ukusabela nge-febuxostat zifaka:

• I-Azathioprine 
• I-Clomipramine
• I-Mercaptopurine 
• I-Methotrexate
• I-Repaglinide
• Theophylline
• I-Topotecan

Ulwazi Lomthamo

Indlela efanele yokuthatha i-febuxostat izokunikeza imiphumela engcono kakhulu yokulawula i-gout. Udokotela wakho uzokuqala ngethebhulethi eyodwa ye-40mg nsuku zonke. Umthamo wakho ungase ukhuphuke ufike ku-80mg nsuku zonke uma i-serum uric acid yakho ihlala ngaphezu kuka-6 mg/dL ngemva kwamasonto amabili.

Ungaphuza iphilisi lakho noma nini lapho likusebenzela kangcono:

• Ngokudla noma ngaphandle kokudla
• Ngama-antacid uma kudingeka
• Ngamanzi

Iziguli ezinenkinga yezinso ezinzima (i-CrCl engaphansi kuka-30 mL/min) akufanele idlule i-40mg nsuku zonke. Kodwa-ke, iziguli ezinezinkinga zezinso ezithambile noma ezimaphakathi azidingi ukulungiswa komthamo.

Udokotela wakho uzohlola igazi lakho minyaka yonke ukuze aqaphe ukusebenza kahle uma amazinga akho e-urate ezinzile. Ukuhlolwa kwegazi kuqala ngemva kwamasonto amabili nje uqale ukwelashwa.

I-Febuxostat idinga isikhathi ukuze isebenze kahle. Qhubeka nokuyithatha ngisho noma uthola ukuhlaselwa yi-gout ekuqaleni noma izimpawu zakho ziphela. Amazinga akho e-urate azokhuphuka uma uyeka maduze. Udokotela wakho uzoqapha amazinga e-uric acid egazini lakho ngesikhathi sokwelashwa ukuze awagcine engaphansi kuka-6 mg/dL. Leli zinga lisiza ukuncibilikisa amakristalu e-urate.

Isiphetho

I-Gout idala izinselele zansuku zonke, kodwa i-febuxostat iletha ithemba ezigulini eziningi ezilwa nalesi simo esibuhlungu. Lo muthi uyisinqumo esisebenzayo, ikakhulukazi uma unenkinga yokubekezelela i-allopurinol. Ukuwuthatha njalo kuletha amazinga e-uric acid ngaphansi kophawu olubalulekile luka-6 mg/dL futhi kusiza ukuncibilikisa lezo zinhlayiya zekristalu ezibuhlungu emalungeni akho.

Qaphela ukuthi i-febuxostat ivimbela ukuhlasela okuzayo kunokwelapha okwamanje. I-gout flares ingase ikhule ngesikhathi sokwelashwa kusenesikhathi njengoba amakristalu eqala ukuncibilika. Iziguli eziningi ziyayeka ukuphuza imithi yazo ngenxa yalokhu kuba kubi kwesikhashana, kodwa labo ababambelele kukho bagcina benokuhlaselwa okumbalwa.

I-Febuxostat inemikhawulo kanye nezingozi zayo kodwa isebenza njengethuluzi elibalulekile lokulawula i-gout engapheli. Wena kanye nodokotela wakho kufanele nikala izinzuzo ngokumelene nezinkinga ezingase zibe khona. Ukuphatha kahle i-gout kuvela ngokusebenzisana nodokotela bakho, ukuphuza imithi njengoba uyalelwe, kanye nokuhlolwa njalo ukuze ulawule i-uric acid.

Imibuzo Evame Ukubuzwa

1. Ingabe i-febuxostat isengozini enkulu?

I-Febuxostat inezingozi eziphakeme zenhliziyo kune-allopurinol. Iziguli ezinesifo esikhulu senhliziyo esivele zikhona akufanele ziwuthathe lo muthi.

2. I-febuxostat ithatha isikhathi esingakanani ukusebenza?

Umuthi uqala ukwehlisa amazinga e-uric acid phakathi nezinsuku. Izimpawu zakho ze-gout zizoba ngcono ngemva kwamasonto ambalwa kuya ezinyangeni.

3. Kwenzekani uma ngiphuthelwa umthamo?

Thatha umuthi uma usukhumbula. Yeqa umthamo ogejiwe futhi uqhubeke nesimiso sakho esivamile uma cishe isikhathi somthamo wakho olandelayo. Ungathathi imithamo ephindwe kabili.

4. Kwenzekani uma ngiphuza ngokweqile?

Thola usizo lwezempilo ngokushesha. Ukwelashwa kwakho kuzobandakanya ukunakekelwa okunezimpawu nokusekelayo.

5. Ubani ongakwazi ukuthatha i-febuxostat?

I-Febuxostat ayifanele:

• Abantu abanezimo ezinzima zenhliziyo
• Iziguli ezinezinkinga ezinzima zezinso noma zesibindi
• Abantu abanezinkinga ze-thyroid
• Noma ubani one-febuxostat hypersensitivity

6. Kufanele ngiyithathe nini i-febuxostat?

Ungathatha ithebhulethi eyodwa nsuku zonke ngokudla noma ngaphandle kokudla. Isikhathi somuthi wakho sibalulekile kunokuwuphuza njalo.

7. Zingaki izinsuku zokuthatha i-febuxostat?

Uzodinga ukwelashwa kwesikhathi eside nge-febuxostat. Udokotela wakho uzonquma ubude besikhathi ngokusekelwe ekuphenduleni komzimba wakho kanye namazinga e-uric acid.

8. Ungamisa nini i-febuxostat?

Khuluma nodokotela wakho ngaphambi kokumisa i-febuxostat. Ukuma kungazelelwe kungalimaza i-gout yakho. Yeka ukuyithatha ngokushesha uma ubona izimpawu ze-hypersensitivity enzima.

9. Ingabe kuphephile ukuthatha i-febuxostat nsuku zonke?

Yebo, odokotela baklama i-febuxostat ukuthi isebenze njengomuthi wesikhathi eside wansuku zonke. Iziguli zesifo senhliziyo kufanele ziqaphele ngoba ucwaningo lukhombisa ubungozi obuphezulu benhliziyo kunezinye izindlela zokwelapha. Ukuhlolwa kwegazi kufanele kuqaphe ukusebenza kwesibindi kulo lonke ukwelashwa.

10. Yisiphi isikhathi esingcono kakhulu sokuthatha i-febuxostat?

Abantu abaningi bathola ukuthi ekuseni kusebenza kangcono kulo muthi. Isikhathi esiqondile sibalulekile kunokungaguquguquki - ukusithatha ngesikhathi esifanayo usuku ngalunye kusiza ekugcineni amazinga egazi azinzile. 

11. Yini okufanele uyigweme lapho uthatha i-febuxostat?

Ungalokothi uhlanganise i-febuxostat ne:

• Utshwala
• Imithamo ephezulu ye-aspirin (inganyusa amazinga e-uric acid)

12. Yikuphi ukudla okufanele ukugweme ngenkathi uthatha i-febuxostat?

Kufanele unciphise uphuzo oludakayo ngoba ludala ukuhlaselwa yi-gout ngokwandisa ukukhiqizwa kwe-uric acid. Ubhiya udala izinkinga eziningi kunezinye iziphuzo ezidakayo. Iziphuzo ezingezona utshwala zisiza ukukhipha i-uric acid, ngakho-ke hlala umanzi.

13. Ingabe i-febuxostat iyayenyusa i-creatinine?

I-Febuxostat ayiwathinti kakhulu amazinga e-serum creatinine. Ucwaningo lwesikhathi eside lukhombisa ukuthi empeleni lungehlisa i-creatinine yegazi cishe ngo-0.3mg/dl.

14. Iyiphi enye indlela ye-febuxostat?

I-Allopurinol imele njengenye indlela eyinhloko esebenza njenge-febuxostat. Ezinye izinketho zifaka:

• I-Benzbromarone noma i-sulfinpyrazone (ukwandisa ukuphuma kwe-urate)
• I-Probenecid (ithuthukisa ukuqedwa kwe-urinary acid)