Fluconazole

Fluconazole

I-Fluconazole umuthi onamandla we-antifungal osuzuze ukuduma ngokusebenza kwawo ekwelapheni izimo eziningi zesikhunta ezingxenyeni ezihlukene zomzimba. Lo muthi oguquguqukayo usuphenduke isixazululo kodokotela abaningi lapho bebhekana nezifo zefungal, kusukela kokujwayelekile. nemvubelo izifo ezifweni ezinzima kakhulu zesistimu.

Lesi sihloko esibanzi sizohlola ukusetshenziswa okuhlukahlukene kwe-fluconazole, indlela yokusebenzisa amaphilisi e-fluconazole ngendlela efanele, imiphumela engemihle engaba khona, kanye nezinyathelo ezibalulekile okufanele uzikhumbule.

Iyini i-Fluconazole?

I-Fluconazole umuthi onamandla we-antifungal womndeni we-triazole. Lo muthi oguquguqukayo uthonya izifo ze-fungal zesistimu nezingaphandle kwezicubu ezihlukahlukene. Ukusetshenziswa kwethebhulethi ye-Fluconazole kubandakanya ukulwa ne-candidiasis, i-cryptococcosis, nezinye izifo zefungal. Imisa ukukhula kwezinhlobo ezithile zesikhunta, ikwenze kube ithuluzi elibalulekile ekwelashweni. I-Fluconazole inezinzuzo eziningi kunezinye izidakamizwa ze-antifungal, okuhlanganisa inketho yokuphathwa ngomlomo kanye nephrofayili yomphumela omncane omncane.

Ukusetshenziswa kwe-Fluconazole

Amaphilisi e-Fluconazole anezinhlobonhlobo zokusetshenziswa ekwelapheni izifo zefungal.

• Amaphilisi e-Fluconazole ayasebenza ngokumelene nezinhlobo ezahlukene zezifo ze-Candida, njengezifo ze-yeast ye-vaginal, izifo ze-Candida ezihleliwe, kokubili i-osophagal kanye i-oropharyngeal candidiasis.
• I-Fluconazole isetshenziselwa ukwelapha i-cryptococcal meningitis kanye ukutheleleka kwe-urinary tract okubangelwa i-Candida.
• Kwezinye izimo, odokotela banquma amaphilisi e-fluconazole e-peritonitis ebangelwa i-Candida.
• Amaphilisi e-Fluconazole nawo asetshenziswa njengesinyathelo sokuvimbela ezigulini ezifakelwa umnkantsha ezithola imiphumela emibi yokwelashwa ngamakhemikhali noma i-radiotherapy ukunciphisa ingozi yokuthuthukisa i-candidiasis.

Isetshenziswa kanjani iFluconazole?

• Abantu bangaphuza amaphilisi e-fluconazole ngokudla noma ngaphandle kokudla.
• Thatha i-fluconazole njengoba uyalelwe udokotela wakho, ngokuvamile kanye ngosuku. Geza ama-capsules wonke ngamanzi ngesikhathi esifanayo usuku ngalunye.
• Nyakazisa ibhodlela kahle ukuze limiswe uketshezi futhi usebenzise idivayisi yokulinganisa enikeziwe ukuze uqinisekise umthamo onembile.
• Umthamo uncike esimweni sakho sohlelo, impendulo ekwelashweni, nesisindo sezingane.
• Ukuze uvimbele ukutheleleka ekubuyeni, qhubeka uphuza imithi ngisho noma izimpawu zakho ziba ngcono.
• Uma ugeje umthamo, yithathe ngokushesha nje lapho ukhumbula khona ngaphandle kwalapho sekusondele isikhathi somthamo wakho olandelayo ohleliwe. Uma kunjalo, yeqa umthamo ogejiwe futhi uqalise kabusha uhlelo lwakho olujwayelekile.

Imiphumela Emibi Yezibhebhe ze-Fluconazole

I-Fluconazole ingabangela imiphumela engemihle ukusuka kokuncane kuye kokuqina.

Imiphumela Emibi Evamile:

• bekhanda
• Ukuvota
• Uhudo
• Ubuhlungu besisu
• I-nausea
• isiyezi
• Izinguquko ekunambithekeni
• Ukuphuza isikhumba

Imiphumela Emibi Kakhulu:

• Izinkinga zesibindi, njengobuhlungu besisu, isicanucanu esinzima, ukuhlanza, nokushintsha kwebala okuphuzi kwesikhumba nokumhlophe kwamehlo.
• Izinkinga zesigqi senhliziyo, okuhlanganisa ukushaya kwenhliziyo okusheshayo/okungajwayelekile.
• Ukungezwani komzimba okunamandla, njengokuqubuka kwesikhumba, ukuvuvukala ebusweni, amehlo, izindebe, ulimi, nomphimbo, ukulunywa, ukuvuvukala kwama-lymph nodes, noma ukuphefumula kanzima.
• Izinkinga ze-adrenal gland, kufaka phakathi ukulahlekelwa ukudla, ukuncipha, nokukhathala okungajwayelekile.

Ukuqapha

Lapho usebenzisa i-fluconazole, kubalulekile ukuthatha izinyathelo zokuphepha, njenge:

• Izimo Zesistimu: Iziguli ezinezinkinga zesibindi nesifo sezinso kufanele zazise udokotela wazo, njengoba i-fluconazole ingathinta isibindi nokusebenza kwezinso.
• Izinyathelo zokuqapha zenhliziyo: I-Fluconazole ingathinta isigqi senhliziyo, ngakho-ke abantu abanezifo zenhliziyo ezivele zikhona kufanele baqaphele.
• Ukukhulelwa Nokuncelisa: Abesifazane abakhulelwe kufanele basebenzise i-fluconazole kuphela uma kunesidingo, ngoba ingase ilimaze ingane engakazalwa. Omama abancelisa ibele kufanele babonane nodokotela wabo njengoba umuthi udlulela obisini lwebele.
• Utshwala: I-Fluconazole ibangela isiyezi. Ngakho-ke, odokotela ngokuvamile bayeluleka iziguli ukuthi zigweme ukusetshenziswa kotshwala nensangu, njengoba lezi zinto zandisa isiyezi.

Njalo wazisa udokotela wakho mayelana nemithi yakho ukuze ugweme ukusebenzisana okungenzeka.

Isebenza kanjani ithebhulethi ye-Fluconazole

I-Fluconazole, i-synthetic triazole antifungal, inethonya kulwelwesi lwamaseli okukhunta. Isebenza ngokuvimbela i-enzyme i-lanosterol 14-α-demethylase, ebalulekile ekukhiqizeni i-ergosterol. I-Ergosterol iyingxenye ebalulekile ye-fungal cell membranes. Ngokuvimbela le enzyme, i-fluconazole imisa ukuguqulwa kwe-lanosterol ku-ergosterol, okuholela ekwandeni kokungena kwe-membrane kanye nokuvuza kwamaseli. Le nqubo ekugcineni iholela ekuboshweni kokukhula kwefungal. Isenzo se-Fluconazole siyi-fungistatic, okusho ukuthi ivimba isikhunta singakhuli kunokuba sibabulale ngokuqondile. Lo mshini wenza i-fluconazole iphumelele ekulweni nezifo ezihlukahlukene zesikhunta, kuhlanganise nalezo ezibangelwa izinhlobo ze-Candida.

Ngingakwazi Ukuthatha I-Fluconazole Neminye Imithi?

I-Fluconazole ingasebenzisana nemithi ehlukahlukene, ngakho-ke kufanele wazise udokotela wakho ngayo yonke imithi eqhubekayo. Eminye imithi akufanele isetshenziswe ne-fluconazole, kanti eminye ingase idinge ukulungiswa komthamo noma ukuqapha ngokucophelela, njenge:

• antidepressant
• I-Carbamazepine
• I-chlorpromazine
• I-Cyclosporine
• Donepezil
• Fentanyl
• I-Lomitapide
• Ama-antibiotic e-Macrolide afana ne-erythromycin
• Imithi engase ithinte isigqi senhliziyo, njenge-pimozole, i-amiodarone, noma i-quinidine
• Phenytoin
• I-Tacrolimus
• Theophylline
• I-Voriconazole
• Warfarin
• I-Zidovudine

Ulwazi Lomthamo

Umthamo we-Fluconazole uyahlukahluka kuye ngohlobo nobukhulu bokutheleleka. Okwe-cryptococcal i-meningitis, umthamo omdala ngu-400 mg ngosuku lokuqala lokwelashwa, bese u-200 mg nsuku zonke amaviki angu-10-12. Imithamo yezingane incike esisindweni.

Nge-oesophagal candidiasis, abantu abadala bavame ukuthatha ama-200 mg ngosuku lokuqala, bese kuba ngu-100 mg ngosuku okungenani amasonto amathathu.

Ukwelashwa kwe-candidiasis ye-Oropharyngeal kubantu abadala kuhilela i-200 mg ngosuku lokuqala, kulandelwa i-100 mg nsuku zonke okungenani amasonto amabili.

Nge-candidiasis yangasese, odokotela ngokuvamile banikeza ithebhulethi eyodwa ye-fluconazole engu-150 mg.

Isiphetho

I-Fluconazole ibonakale ingumuthi oguquguqukayo futhi osebenzayo ekulweni nezifo ezahlukahlukene zefungal. Ukusetshenziswa kwayo okubanzi, kusukela ezifweni ezivamile ze-yeast kuya ezifweni ezinzima kakhulu zesistimu, kugcizelela ukubaluleka kwayo emithini yesimanje. Indlela yokusebenza yomuthi, eqondise ulwelwesi lwamaseli okukhunta, ithonya ikhono layo lokulwa nezinhlobo ezahlukene zesikhunta ngempumelelo.

Njenganoma yimuphi umuthi, kubalulekile ukusebenzisa i-fluconazole ngaphansi kokuqondisa kukadokotela. Ukuqonda izinyathelo zokuphepha nokusebenzisana okungaba khona neminye imithi kubalulekile ukuze kuqinisekiswe ukwelashwa okuphephile nokusebenzayo.

FAQ sika

1. I-fluconazole isetshenziselwa ini ngokuyinhloko?

I-Fluconazole isiza ekwelapheni nasekulawuleni izifo ezihlukahlukene zokukhunta. Ngokuyinhloko isetshenziselwa i-candidiasis, okubandakanya izifo zemvubelo yangasese, i-oral thrush, kanye ne-systemic Candida izifo. I-Fluconazole iphinde yelapha i-cryptococcal meningitis futhi ivimbele ukutheleleka kwefungal ezigulini ezingenawo amandla omzimba.

2. Ngingakwazi ukuthatha amaphilisi e-fluconazole nsuku zonke?

Ukuvama kokusetshenziswa kwe-fluconazole kuncike ekuthelelekeni okulashwayo. Kwezinye izimo, ukusetshenziswa kwansuku zonke kungase kudingeke. Kodwa-ke, ku-thrush yangasese, umthamo owodwa ngokuvamile wanele. Ngaso sonke isikhathi landela imiyalelo kadokotela wakho mayelana nomthamo kanye nobude besikhathi sokwelashwa.

3. Ingabe i-fluconazole iyi-antibiotic noma cha?

I-Fluconazole ayiyona i-antibiotic. Kuwumuthi we-antifungal osebenza ngokumisa ukukhula kwesikhunta. Ngokungafani nama-antibiotics, ahlose amagciwane, i-fluconazole yelapha ngokusobala izifo zesikhunta.