I-Fluticasone

I-Fluticasone

I-Fluticasone iyi-corticosteroid enamandla esiza ukuphatha izimo ezihlukahlukene zokuphefumula. Lo muthi usuthole ukusetshenziswa kabanzi ngenxa yokuphumelela kwawo ekwelapheni i-allergies, ufuba, nezinye izinkinga zokuphefumula. Ukuqonda izinzuzo, ukusetshenziswa kwe-fluticasone, kanye nemiphumela engemihle engaba khona kungasiza iziguli zenze izinqumo ezingcono mayelana nokwelashwa nokuphathwa kwalesi simo.

Iyini i-Fluticasone?

I-Fluticasone iyi-glucocorticoid yokwenziwa enamandla eseklasini lemithi ebizwa ngokuthi i-corticosteroids. Lesi sidakamizwa sidlala indima eyinhloko ekwehliseni ukuvuvukala emzimbeni, okwenza kube ukwelashwa okuphumelelayo kwezimo ezihlukahlukene zokuphefumula. Odokotela baqale bagunyaza i-fluticasone propionate ngo-1990, futhi kusukela lapho, isiphenduke umuthi osetshenziswa kabanzi wokuphatha izinkinga zokuphefumula ezingezwani nezingaguliswanga.

I-Fluticasone isebenza ngokuvimbela ukukhululwa kwezinto ezithile zemvelo ezibangela izimpawu zokungezwani komzimba. Lesi senzo sisiza ekudambiseni ukuvuvukala emigudwini yamakhala kanye nezindlela zomoya, ukukhulula uhla lwezimpawu ezihlobene ne-rhinitis nesifuba somoya.

Ukusetshenziswa kwe-Fluticasone

I-Fluticasone, umuthi oguquguqukayo we-corticosteroid, inezinhlelo eziningi zokusebenza ekwelapheni izimo ezahlukahlukene zokuphefumula nesikhumba. Odokotela banquma i-fluticasone ngezindlela ezahlukene, ngayinye iklanyelwe ukubhekana nezinkinga ezithile zempilo.

• Ezimweni zokuphefumula, i-fluticasone idlala indima ebalulekile ekulawuleni isifuba somoya. I-Food & Drug Administration (FDA) igunyaze i-fluticasone ehogelwe njengomuthi onakekelayo nolawulayo wokwelashwa kwesifuba somoya. 
• I-Fluticasone nayo inezinhlelo zokusebenza ezibalulekile ekwelapheni ikhala kanye izinkinga ze-sinus. I-FDA igunyaze i- nasal fluticasone yakho kokubili i-rhinitis engezwani ne-allergic kanye ne-non-allergic. Lokhu kusho ukuthi kusiza ekudambiseni izimpawu ezifana ukuthimula, ikhala eligijimayo, ikhala eliminyene, nekhala elilumayo okubangelwa izici ezihlukahlukene, kuhlanganise ne-hay fever nezinye izinto ezingezwani nazo. 
• Ngo-2024, i-FDA yandisa ukugunyazwa kwayo ukufaka i-rhinosinusitis engapheli ngaphandle kwama-polyp wamakhala, isebenzisa umkhiqizo omusha wenhlanganisela yezidakamizwa ne-exhalation delivery system (EDS).
• Ezimweni zesikhumba, i-topical fluticasone ifakazele ukuthi isebenza ngempumelelo ekwelapheni i-atopic dermatitis namanye ama-dermatoses asabela nge-corticosteroid. Kuyasiza ukwehlisa ukuvuvukala, ukulunywa, kanye nokubabomvu okuhambisana nalezi zinkinga zesikhumba. 

Isetshenziswa kanjani iFluticasone Tablets

Ukusetshenziswa okufanele kwe-fluticasone kuncike ekubunjweni okuqondile kanye nesimo sokwelashwa, njenge: 

I-Nasal Spray:

• Nyakazisa umuthi ngaphambi kokusetshenziswa ngakunye.
• Vuthela kancane ikhala lakho bese usula amakhala akho.
• Tshekisa ikhanda lakho kancane ulibhekise emuva. Faka ithiphu yekhala ekhaleni lakho.
• Vala ikhala eliphambene ngomunwe.
• Khipha isifutho esisodwa ngenkathi uphefumula ngobumnene ngekhala.
• Bamba umoya wakho imizuzwana embalwa, bese uphefumula kancane ngomlomo wakho.
• Phinda inqubo yekhala eliphambene.
• Gwema ukushaya ikhala lakho noma ukuhlehlisa ikhanda ngemuva kokusebenzisa isifutho.
• Hlanza ithiphu lokufaka isicelo ngethishu bese ubuyisela ikepisi.

I-inhaler:

• Bamba i-inhaler iqonde bese uvule ikepisi ngokugcwele ize ichofoze.
• Phefumula ngokuphelele, uzama ukukhipha amaphaphu akho.
• Beka umlomo emlonyeni wakho womlomo, uvale izindebe zakho nxazonke.
• Phefumula ngokushesha nangokujulile ngomlomo wakho.
• Bamba umoya wakho cishe imizuzwana eyi-10.
• Vala ikepisi ngemva kokuhogela ngakunye.
• Hlanza umlomo wakho ngamanzi ngaphandle kokugwinya ngemva kokusebenzisa i-fluticasone.

Ithebhulethi Yomlomo:

• Thatha ithebhulethi ngesikhathi esifanayo nsuku zonke njengoba uqondiswa udokotela wakho.
• Geza ithebhulethi yonke ngamanzi.
• Ungayichobozi, uyihlafune, noma uyiphule ithebhulethi ye-fluticasone.
• Nge-eosinophilic esophagitis, kusetshenziswa ifomu elikhethekile lapho umuthi ufuthwa khona epharynx futhi ugwinywe.
• Gwema ukudla noma ukuphuza imizuzu engama-30 ngemuva kokuthatha ithebhulethi.

Imiphumela Emibi Yethebhulethi ye-Fluticasone

I-Fluticasone, njengayo yonke imithi, ingabangela imiphumela emibi eminingana, nakuba kungebona bonke abahlangabezana nayo. Lokhu kungase kuhlanganise:

• Ukunambitheka okungemnandi noma iphunga
• Ikhala elomile noma elibuhlungu noma ukopha
• Umphimbo owomile noma obuhlungu noma izwi eliyisihosha
• bekhanda
• Isicanucanu, ukuhlanza, noma isifo sohudo
• isiyezi

Imiphumela Emibi Kakhulu:

Iziguli kufanele ziyothola usizo lwezokwelapha ngokushesha uma zithola:

• Izinkinga zokuphuza
• Ukulimala kwekhala noma izilonda ngaphakathi kwekhala
• Izinguquko emehlweni, njengokufiphala kombono noma ilensi eguqubele (izimpawu ze-glaucoma noma i-cataracts)
• Ukwanda kokungenwa yizifo
• Ukusetshenziswa isikhathi eside kwe-fluticasone kungase kunciphise ukuminyana kwamaminerali amathambo, okungase kuholele emathanjeni abuthaka noma kwamathambo.
• Ukusetshenziswa isikhathi eside noma imithamo ephezulu ye-fluticasone kungaholela ezinkingeni ze-adrenal gland. Izimpawu zayo zihlanganisa ukuba mnyama kwesikhumba, isifo sohudo, isiyezi, ukuquleka, ukulahlekelwa ukudla, ukucindezeleka kwengqondo, isicanucanu, ukuqubuka kwesikhumba, ukukhathala okungavamile, noma ukuhlanza.

Ukuqapha

Iziguli kufanele ziqaphele izinyathelo ezimbalwa ezibalulekile zokuqapha lapho zisebenzisa i-fluticasone ukuze kuqinisekiswe ukwelashwa okuphephile nokuphumelelayo, okuhlanganisa:

• I-Fluticasone ingase ibangele izimbobo noma izilonda ku-cartilage yamakhala futhi ibambezele ukuphulukiswa kwesilonda. 
• Ngaphambi kokusebenzisa i-fluticasone, tshela udokotela wakho mayelana nezinkinga zakamuva zekhala kanye ne-sinus, izifo (ukutheleleka kwamehlo, i-herpes, i-chicken pox, isimungumungwane, umkhuhlane, noma isifo sofuba), nezinkinga zamehlo (i-glaucoma noma i-cataract).
• Abantu abanezinkinga zesibindi bangase baqaphele ngenkathi besebenzisa i-fluticasone.
• abesifazane abakhulelwe 
• I-Fluticasone ingase ibambezele ukukhula kwengane. Abazali kufanele baqaphe ukukhula kwengane yabo futhi bathintane nodokotela ukuze bathole ukukhathazeka.

Isebenza kanjani ithebhulethi ye-Fluticasone

Indlela eyinhloko yokusebenza kwe-fluticasone ihilela ukwenziwa kusebenze kwama-glucocorticoid receptors. Uma sezicushiwe, lawa ma-receptors aqala uchungechunge lwezimpendulo zamaselula ezicindezela izinqubo zokuvuvukala. Lokhu kuvula kuthinta izinhlobo ezihlukahlukene zamaseli ezihilelekile ekuvuvukeni, okuhlanganisa ama-eosinophil, ama-monocyte, amaseli e-mast, ama-macrophages, namaseli e-dendritic. I-Fluticasone ayinciphisi nje kuphela inani lala maseli avuvukalayo kodwa futhi yehlisa ukukhiqizwa kwama-cytokines (ama-molecule abonisa ukuvuvukala).

I-Fluticasone nayo inomphumela wendawo oqondile emigudwini yamakhala kanye nemigudu yomoya. Ibangela i-vasoconstriction, enciphisa imithwalo yegazi futhi isebenze umsebenzi wokulwa nokuvuvukala. Lezi zenzo zisiza ekunciphiseni ukuvuvukala nokuminyana emigudwini yamakhala, ukunciphisa izinkinga zokuphefumula kubantu abane- rhinitis yokungezwani komzimba noma ezinye izimo zekhala.

Ngingakwazi Ukuthatha I-Fluticasone Neminye Imithi?

Ukusebenzisana okuvame ukuhlolwa ne-fluticasone kuhlanganisa:

• I-Acetaminophen
• I-Albuterol
• I-Alprazolam
• Apixaban
• I-Aspirin (kokubili amandla avamile naphansi)
• I-Atorvastatin
• I-Budesonide / Formoterol
• I-Cetirizine
• I-diphenhydramine
• I-Escitalopram
• I-Metoprolol (womabili amafomu e-ER kanye ne-tartrate)
• I-Montelukast
• Levothyroxine
• I-Loratadine

Ulwazi Lomthamo

Kubantu abadala kanye nezingane ezineminyaka engu-12 nangaphezulu abane-rhinitis, umthamo ojwayelekile we-fluticasone furoate nasal spray izifutho ezimbili (27.5 mcg/spray) ekhaleni ngalinye kanye ngosuku. I-Fluticasone propionate nasal spray ngokuvamile isetshenziswa njengesifutho esisodwa noma ezimbili (50 mcg/spray) ekhaleni ngalinye kanye ngosuku njengoba kudingeka.

Isiphetho

I-Fluticasone inomthelela ezimeni ezihlukahlukene zokuphefumula, inikeza impumuzo ezigidini zabantu emhlabeni wonke. Ukuguquguquka kwayo ekwelapheni ukungezwani komzimba nezinto ezithile, isifuba somoya, nezinye izinkinga zokuphefumula kuyenza ibe ithuluzi elibalulekile ekulawuleni impilo yokuphefumula. Njengoba sesibonile, i-fluticasone inciphisa ukuvuvukala emigwaqweni yomoya kanye namakhala, isiza iziguli ziphefumule kalula futhi zijabulele impilo engcono. Nakuba i-fluticasone inikeza izinzuzo ezibalulekile, kubalulekile ukuyisebenzisa njengoba kuyalelwe futhi uqaphele imiphumela engemihle engaba khona nokusebenzisana. 

FAQ sika

1. I-fluticasone isetshenziselwa ini ngokuyinhloko?

I-Fluticasone inomthelela ezimeni ezihlukahlukene zokuphefumula. Odokotela bayinikeza ngokuyinhloko ukwelapha izimpawu zokungezwani komzimba ezifana nokuthimula, ukulunywa, nekhala eligijimayo noma eliminyene. 

2. Ubani okufanele aphuze i-fluticasone?

Odokotela banquma i-fluticasone kubantu abahlangabezana nalokhu:

• Izimpawu ze-Allergic rhinitis
• I-rhinitis engeyona i-allergic
• I-rhinosinusitis engapheli ene-polyps yamakhala noma engenawo
• Isifuba somoya (sokwelashwa kwesondlo)

3. Ingabe kubi ukusebenzisa i-fluticasone nsuku zonke?

Ukusebenzisa i-fluticasone nsuku zonke njengoba kunqunywe udokotela ngokuvamile kuphephile kubantu abaningi. 

4. Ingabe i-fluticasone iphephile?

I-Fluticasone ithinta izimo ezihlukahlukene futhi ngokuvamile ibhekwa njengephephile uma isetshenziswa njengoba kuyaliwe. Kodwa-ke, njengayo yonke imithi, ithwala izingozi ezingase zibe khona kanye nemiphumela engemihle. Abantu abaningi abasebenzisa i-fluticasone nasal spray abanazo imiphumela emibi kakhulu noma yesikhathi eside.

5. Ubani Ongakwazi ukusebenzisa i-fluticasone?

I-Fluticasone ingathinta amasistimu omzimba ahlukahlukene, futhi ayifanele wonke umuntu. Abantu kufanele bakugweme ukusebenzisa i-fluticasone uma:

• Ube nokungezwani ne-fluticasone nanoma yimuphi omunye umuthi
• Yiba nesifo sesikhumba
• Ukuba nezinduna noma ukuguquguquka okukhulu kwesikhumba emakhaleni nazungeze ikhala, izihlathi, isiphongo, nesilevu esifika sidlule (rosacea)
• Yiba nokuluma ngaphansi (indunu) noma indawo yangasese.

6. Ingabe i-fluticasone iphephile ezinso?

Nakuba ulwazi olutholakalayo lungakhulumi ngokusobala ngokuphepha kwe-fluticasone ezinso, kubalulekile ukuthi iziguli zixoxe ngomlando wazo wezokwelapha ophelele, okuhlanganisa noma yiziphi izinkinga zezinso, nodokotela wazo ngaphambi kokuqala ukwelashwa kwe-fluticasone.

Umshwana wokuzihlangula: Ulwazi olunikezwe lapha alwenzelwe ukufaka iseluleko esivela kuchwepheshe wezokunakekelwa kwempilo. Ulwazi aluhloselwe ukumboza konke ukusetshenziswa okungenzeka, imiphumela engemihle, izinyathelo zokuphepha, nokusebenzisana kwezidakamizwa. Lolu lwazi aluhloselwe ukuphakamisa ukuthi ukusebenzisa umuthi othile kufanelekile, kuphephile, noma kuyasebenza wena noma omunye umuntu. Ukungabi bikho kwanoma yiluphi ulwazi noma isexwayiso mayelana nomuthi akufanele kuhunyushwe njengesiqinisekiso esicacile esivela enhlanganweni. Sikweluleka ngokuqinile ukuthi uthintane nodokotela uma kukhona okukukhathazayo ngomuthi futhi ungalokothi usebenzise umuthi ngaphandle kwencwadi kadokotela.