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I-Gefitinib

I-Gefitinib, umuthi onamandla, wenza amagagasi emhlabeni we-oncology, ikakhulukazi ezinhlotsheni ezithile zomdlavuza wamaphaphu. Kule bhulogi, masiqonde ukungena nokuphuma kwe-gefitinib 250, sihlole ukuthi isebenza kanjani nokuthi yini ongayilindela uma uyithatha. Sizophinde sibheke imiphumela engemihle, izinyathelo okufanele sizikhumbule, nokuthi i-gefitinib isebenzisana kanjani neminye imithi. 

Iyini iGefitinib?

I-Gefitinib umuthi onamandla osetshenziselwa ukwelapha nokuphatha umdlavuza wamaphaphu, ikakhulukazi i-metastatic Non-small Cell Lung Cancer (NSCLC) eye yametastase kwezinye izingxenye zomzimba. Ingokwesigaba sezidakamizwa ezibizwa ngokuthi i-kinase inhibitors futhi isebenza ngokuvimbela amaprotheni athile amangqamuzana omdlavuza adinga ukukhula. 

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bhuka i-aphoyintimenti

Ukusetshenziswa kweGefitinib

  • I-Gefitinib ngokuyinhloko yelapha umdlavuza wamaphaphu we-metastatic non-small cell lung (NSCLC). Isebenza kahle kakhulu ezigulini ezinokuguqulwa kwezakhi zofuzo ezithile ku-EGFR gene. 
  • I-Gefitinib ivamise ukunikezwa njengokwelashwa komugqa wokuqala we-NSCLC ethuthukisiwe yasendaweni noma ye-metastatic lapho ezinye izindlela zokwelapha, ezifana ne-platinum-based noma i-docetaxel chemotherapies, zehlulekile.
  • Kuyathakazelisa ukuthi i-gefitinib ibonise isithembiso ekwelapheni i-metastase yobuchopho evela ku-NSCLC. 

Ungayisebenzisa kanjani i-Gefitinib Tablet

  • Ukuthatha umthamo onconyiwe we-gefitinib kubalulekile ekusebenzeni kahle kwawo. 
  • Kungcono ukuthatha lo muthi kanye ngosuku, ngokudla noma ngaphandle kokudla, njengoba uqondiswa udokotela wakho. 
  • Chaza ithebhulethi ku-120 kuya ku-240 millilitha wamanzi uma unenkinga yokuyigwinya. Hlanganisa ingxube cishe imizuzu engu-15, bese uyiphuza ngokushesha. Ukuqinisekisa ukuthi uthola wonke umthamo, hlambulula ingilazi ngenani elifanayo lamanzi futhi uphuze.
  • Ukuthatha i-gefitinib cishe ngesikhathi esifanayo usuku ngalunye kubalulekile.

Imiphumela Emibi Yethebhulethi ye-Gefitinib

Njenganoma yimuphi umuthi, i-gefitinib ingabangela imiphumela ethile engadingeki. Eminye imiphumela emibi ejwayelekile yilena:

Kwezinye izimo, i-gefitinib ingaholela emiphumeleni emibi kakhulu, njenge: 

  • Isifo sesibindi, njenge umchamo omnyama, amehlo aphuzi noma isikhumba, nokuvuvukala ezinyaweni noma emilenzeni engezansi.
  • Izinkinga ezihlobene neso njengokusha, ukoma, noma ukuklebhuka ngokweqile 
  • Izinkinga ezihlobene namaphaphu zihlanganisa ubuhlungu besifuba, ubunzima bokuphefumula, noma ukungakhululeki okuvamile. 
  • Izimpawu zokuphelelwa amanzi emzimbeni, njengokoma kakhulu, ukuncipha kokuphuma komchamo, noma isiyezi.
  • Ukusabela okukhulu kwesikhumba
  • Ubuhlungu obuhlangene noma obunamahloni
  • Izinkinga zesisu njengesilungulela kanye indigestion.

Ukuqapha

Lapho uthatha i-gefitinib, ukulandela izinyathelo ezithile zokuphepha kubalulekile: 

  • Ukuphatha Okufanelekile: Kubalulekile ukunyakazisa ingxube ye-gefitinib cishe imizuzu eyi-15 ngaphambi kokuphuza noma ukuyinikeza ngeshubhu le-nasogastric. Khumbula ukugeza isitsha ngenani elifanayo lamanzi futhi uwasebenzise ukuze uqinisekise umthamo ogcwele. 
  • Ukuqapha: Ukuhlolwa njalo kwezempilo nodokotela wakho kubalulekile ukuze kuqashwe ukusebenza komuthi kanye nemiphumela engemihle engaba khona. Ukuhlolwa kwegazi kungase kudingeke ukuze kutholwe noma yimiphi imiphumela engadingeki. 
  • Ukulawula Ukuzalwa Nokukhulelwa: Kubalulekile ukusebenzisa ukulawulwa kokuzalwa okusebenzayo ngenkathi use-gefitinib futhi okungenani izinsuku eziyi-14 ngemuva komthamo wokugcina, njengoba kungalimaza izingane ezingakazalwa. Uma uhlela ukuba nezingane, xoxa ngalokhu nodokotela wakho kusengaphambili.

Isebenza kanjani ithebhulethi yeGefitinib

I-Gefitinib umuthi onamandla oqondise i-epidermal growth factor receptor (EGFR). Le receptor idlala indima ebalulekile ekukhuleni kwamangqamuzana omdlavuza. Lesi sidakamizwa sisebenza ngokuvimbela umsebenzi we-tyrosine kinase we-EGFR. Uma i-gefitinib ithathwa ngomlomo, imuncwa amaseli omdlavuza futhi ivimbe ukubophezela kwe-ATP kusayithi lokubopha i-ATP ye-EGFR. Lesi senzo simisa i-autophosphorylation ye-EGFR futhi simisa ukusebenza kwezindlela zokusayina ezansi nomfula.

Ngokuphazamisa lezi zindlela, i-gefitinib inomthelela ekwandeni kwamaseli nasekusindeni. Yehlisa ukukhula kwamangqamuzana omdlavuza futhi iwakhuthaze ukuba afe, inqubo eyaziwa ngokuthi i-apoptosis. Lo mshini usebenza ikakhulukazi kumdlavuza wamaphaphu ongewona omncane (NSCLC) onokuguquka okuthile kwe-EGFR, okwenza i-gefitinib ibe ukwelapha okuhlosiwe kwezinhlobo ezithile zomdlavuza wamaphaphu.

Ngingakwazi Ukuthatha I-Gefitinib Ngeminye Imithi?

Ukuthatha i-gefitinib neminye imithi kudinga ukuqapha. Eminye yemithi engase ihlanganyele ne-gefitinib ihlanganisa: 

  • Izinto ezinciphisa igazi njenge-warfarin
  • Corticosteroids 
  • Imikhiqizo yamagilebhisi
  • Ama-NSAID afanayo ibuprofen
  • Ukunciphisa i-asidi yesisu njenge-ranitidine ne-omeprazole
  • IVinorelbine 

Hlala uthintana nodokotela wakho we-oncologist ngaphambi kokuqala, ukuyeka, noma ukushintsha umthamo wanoma yimiphi imithi ngenkathi uthatha amaphilisi e-gefitinib.

Ulwazi Lomthamo

Umthamo ojwayelekile wabantu abadala we-gefitinib womdlavuza wamaphaphu ongewona omncane ungu-250 mg othathwa ngomlomo kanye ngosuku. Lokhu kuyaqhubeka kuze kube yilapho isifo siqhubeka noma imiphumela engemihle ingamukeleki. Ithebhulethi ye-gefitinib ingahlakazwa ku-120 kuya ku-240 ml wamanzi ezigulini ezinenkinga yokugwinya amaphilisi. 

Isiphetho

I-Gefitinib ifakazele ukuthi iguqula umdlalo ekwelapheni umdlavuza wamaphaphu weseli ongewona omncane, ikakhulukazi ezigulini ezinokuguqulwa okuthile kwe-EGFR. Ivimba ukukhula kwamangqamuzana omdlavuza futhi isabalale, iwenze ube yithuluzi elinamandla ekulweni nalesi sifo. Ngaphezu kwalokho, indlela yayo eyingqayizivele yokwenza kanye nendlela ehlosiwe ivule amathuba amasha okwelapha ama-metastases obuchopho avela ku-NSCLC.

Njenganoma yimuphi umuthi, kubalulekile ukuthatha i-gefitinib njengoba kuyalelwe futhi uqaphele imiphumela emibi nokusebenzisana. Uphenyo olwenziwa njalo kanye nokuxhumana okuvulekile nodokotela wakho kuyisihluthulelo sokuthola okuningi kulokhu kwelashwa. 

Imibuzo Evame Ukubuzwa

1. Ingabe i-gefitinib ingawelapha umdlavuza?

I-Gefitinib isetshenziswa ngokuyinhloko ukwelapha umdlavuza wamaphaphu ongewona omncane (NSCLC). Isebenza kakhulu ezigulini ezinezinguquko ezithile ze-EGFR. I-Gefitinib isebenza ngokuvimbela amaprotheni athile amangqamuzana omdlavuza adinga ukukhula, anciphise ukwanda kwawo.

2. Uyithatha nini i-gefitinib?

I-Gefitinib ithathwa kanye ngosuku, ngokudla noma ngaphandle kokudla. Kungcono ukuyithatha ngesikhathi esifanayo nsuku zonke ukuze ugcine amazinga angaguquki emzimbeni wakho. Uma usebenzisa imithi yesisu, yiphuze okungenani amahora angu-6 ngaphambi noma ngemva kwe-gefitinib.

3. Yiziphi izidakamizwa ezifana ne-gefitinib?

I-Erlotinib ingenye i-EGFR tyrosine kinase inhibitor efana ne-gefitinib. Zombili zisebenza ngempumelelo ku-NSCLC ethuthukisiwe, enokusinda okungaqhubeki nokuqhathanisekayo kanye namazinga okusinda ewonke. Nokho, i-gefitinib ivame ukuba nemiphumela engemihle embalwa.

4. Ungathatha isikhathi esingakanani i-gefitinib?

Iziguli zivame ukuqhubeka nokuthatha i-gefitinib kuze kube yilapho isifo siqhubeka noma imiphumela engemihle ingalawuleki. Ubude besikhathi siyahlukahluka kumuntu ngamunye, kuye ngokuthi basabela kanjani ekwelashweni.

5. Isebenza kangakanani i-gefitinib?

Ucwaningo luye lwabonisa ukuthi i-gefitinib inomthelela ekuthuthukiseni izinga lokulawula izifo, ukusinda-mahhala kokuqhubekela phambili, kanye nokusinda okuphelele kweziguli ze-NSCLC. Ukusebenza kwayo kuphawuleka ikakhulukazi ezigulini ezinezinguquko ezithile ze-EGFR.