I-Gliepiride

I-Gliepiride

Umuthi kadokotela uhlala udingeka ukuze uthenge i-Gliepiride. Itholakala njengethebhulethi yomlomo. Ukusetshenziswa kwalo muthi kungahlanganiswa nezinye izindlela zokwelapha. Ngakho-ke uzodinga ukuyiphuza kanye neminye imithi. I-Gliepiride iyaphatha thayipha 2 sikashukela, njengoba kwehlisa amazinga kashukela egazini. Kungathathwa kanye nokudla okunempilo nokuzivocavoca. Ukusiza ekulawuleni izinga likashukela egazini, lo muthi ungasetshenziswa kanye ne-insulin noma ezinye izindlela zokwelapha isifo sikashukela.

Yiziphi izici zokusetshenziswa kwe-glimepiride?

I-Glimepiride isetshenziswa ngokuhlanganiswa neminye imithi ukuphatha isifo sikashukela sohlobo 2. Ingasetshenziswa futhi ngokudla okunempilo kanye nesimiso sokuzivocavoca ukusiza abantu abanesifo sikashukela sohlobo 2 ukulawula amazinga abo kashukela aphezulu. I-Gliepiride yehlisa izinga likashukela egazini ngokushukumisa amanyikwe ukuthi akhiqize i-insulin, umzimba oyidingayo ukuze uhlukanise ushukela futhi wehlise izinga likashukela egazini. Futhi, kwenza kube lula ngomzimba ukusebenzisa i-insulin ngempumelelo. Kodwa-ke, i-Glimepiride ayisetshenziselwa ukuvimbela i-ketoacidosis yesifo sikashukela. Lesi sifo esibucayi singenzeka uma ushukela wegazi ophezulu ungelashwa, noma uthayiphe isifo sikashukela esingu-1, lapho umzimba ungadali i-insulin futhi ungakwazi ukulawula amazinga kashukela egazini.

Ukulawula ushukela wegazi kunciphisa ingozi yesifo sezinso, ubumpumputhe, ukulimala kwezinzwa, ukulahlekelwa izitho zomzimba, kanye nezinkinga ekusebenzeni kocansi. Ngaphezu kwalokho, uma isifo sikashukela silawulwa ngendlela efanele, ingozi yakho yokushaywa unhlangothi noma isifo senhliziyo ingase yehliswe.

Ungayisebenzisa kanjani futhi nini i-Glimepiride?

I-Gliepiride itholakala njengethebhulethi yomlomo. Ivamise ukudliwa kanye ngosuku, ngesidlo sasekuseni noma ngokudla kokuqala okunomsoco. Isimo sakho sezempilo kanye nempendulo yokwelashwa kuyacatshangelwa ngenkathi kunqunywa umthamo. Thatha i-Gliepiride njengoba kukhonjisiwe. Ungathathi ngaphezulu noma ngaphansi komthamo wayo noma kaningi kunalokho okuyalelwe ngudokotela wakho. Udokotela wakho cishe uzokunikeza umthamo omncane we-Gliepiride; uma kunesidingo, leyo mali izokhula kancane kancane. Udokotela wakho angase futhi ashintshe umthamo odingekayo ukuze aqinisekise ukuthi umuthi uyasebenza. Ukuze uthole okuningi kulo muthi, thatha njengoba uyalelwe.

Yimiphi imiphumela emibi ye-glimepiride?

Okulandelayo eminye yemiphumela emibi evame kakhulu ye-Glimepiride:

• bekhanda
• I-nausea
• isiyezi
• Ushukela Wegazi Ophansi
• Ukukhula kwesisindo okungachazeki

Uma imiphumela engemihle imincane, kufanele iphele ezinsukwini ezimbalwa noma amasonto. Kodwa-ke, bona udokotela wakho noma usokhemisi uma ziba nzima kakhulu noma zingasuki.

Okulandelayo yizibonelo zemiphumela emibi kakhulu nezimpawu:

• Ushukela ophansi wegazi
• Ukusabela kwe-Hypersensitivity (i-allergic).
• Ubumhlophe besikhumba namehlo kuba phuzi.
• Umchamo onombala omnyama 
• Indle ephaphathekile noma indle enombala wetiyela
• Amagciwane, kanye nemihuzuko noma ukopha okunganqamuki ngokushesha njengoba kufanele.
• Amazinga e-sodium aphansi.

Yiziphi izinyathelo zokuphepha okufanele zithathwe?

• Ungaba nokungaboni kahle, ukuwozela, noma ukozela ngenxa yeshukela eliphansi kakhulu noma eliphakeme kakhulu. Ungasebenzisi noma yimuphi umshini noma wenze noma yimiphi eminye imisebenzi edinga ukuphaphama noma ukubona kahle ngaphandle uma uqinisekile ukuthi ungakwenza ngokuphepha.
• Gwema utshwala. Yehlisa ushukela egazini futhi ingavimbela imithi yakho yesifo sikashukela ukuthi isebenze.
• Gwema ukusebenzisa imibhede yokushuka noma ukuba selangeni. I-Glimipiride ingakhuphula ukushiswa yilanga. Ngenkathi ungaphandle, gqoka izinto zokuzivikela futhi usebenzise i-sunscreen.
• Kuphela lapho kudingekile kufanele lo muthi uthathwe ngenkathi ukhulelwe.
• Izixwayiso ze-Glimepiride (umuthi wesifo sikashukela) zifaka ubungozi boshukela wegazi ophansi (hypoglycemia), ukungezwani komzimba okungaba khona, ukukhathazeka kwesibindi nezinso, ukuzwela ilanga, ukusebenzisana kotshwala, ukuqapha ngesikhathi sokukhulelwa nokuncelisa kanye nengozi yokusebenzisana nezidakamizwa. Hlala ulandela isiqondiso sezokwelapha futhi uqaphe impilo yakho ngenkathi usebenzisa lo muthi.

Kuthiwani uma uphuthelwa umthamo we-Gliepiride?

Thatha umthamo ogejiwe walo muthi ngokushesha nje lapho ukhumbula. Uma kusondela umthamo wakho olandelayo, yeqa ongawugeja bese uqala kabusha uhlobo lwakho oluvamile lokudosa. Gwema imithamo ephindwe kabili.

Kuthiwani uma kune-overdose ye-glimepiride?

Ngenkathi usebenzisa i-Gliepiride eningi, kufanele uhlole ushukela wakho wegazi njalo futhi uqale ukwelashwa lapho wehla ngaphansi kuka-70 mg/dL. Esimweni esinjalo, thatha 15-20 amagremu glucose. Bese uqapha izinga likashukela egazini imizuzu eyi-15 ngemuva kokwelapha ukusabela okuphansi koshukela. Phinda ukwelashwa kokugcina uma ushukela wakho usephansi.

Uma uquleka noma ungakwazi ukugwinya ngenxa yokusabela koshukela omncane, kufanele unikezwe umjovo weglucagon ukuze welaphe ukusabela koshukela ophansi. Ungase udinge ukuvakashela izimo eziphuthumayo zesibhedlela esiseduze.

Yiziphi izimo zokugcina ze-Glimipiride?

• I-Gliepiride kufanele igcinwe ekamelweni lokushisa. Yigcine phakathi kuka-20 - 25°C (68 kanye no-77F) ngaso sonke isikhathi.

• Gcina le mithi kude nokukhanya.

• Gcina lo muthi kude nezindawo ezimanzi noma ezimanzi njengezindlu zangasese.

Ukuqapha neminye imithi

Lapho isetshenziswa neminye imithi, i-Gliepiride ingase ingasebenzi kahle. Imithi ethile ingase ibe nomthelela emazingeni egazi ezinye izidakamizwa ozithathayo, okungase kwandise imiphumela emibi noma kwenze imithi ingasebenzi kahle. Uma uthatha i-colesevelam, kufanele uthathe umthamo wakho we-Gliepiride okungenani amahora ama-4 ngaphambili.

Imithi eyahlukene, okuhlanganisa nemithi kanye nemithi ethengwayo, amavithamini, nezithako zemithi, ingasebenzisana ne-Gliepiride. I-Metoprolol, i-propranolol, namaconsi e-glaucoma njenge-timolol yizibonelo zezidakamizwa ze-beta-blocker ezingase zehlise ukushaya kwenhliziyo okusheshayo, okushaya ngamandla ovame ukukuzwa lapho amazinga kashukela egazini ehla kakhulu. Nokho, le mithi ayizinciphisi kakhulu ezinye izimpawu zokwehla ushukela egazini, njengobuthakathaka, indlala, noma ukujuluka. Yazisa udokotela wakho ngayo yonke imithi yakho ekhona kanye nanoma yimiphi imithi emisha noma eyekiwe.

I-Gliepiride ikhombisa ngokushesha kangakanani imiphumela?

Emahoreni ama-2 kuye kwangama-3, umthamo owodwa we-glimepiride wehlisa ushukela wegazi.

IGlimepiride vs Vildagliptin

Imibuzo Evame Ukubuzwa

1. Isetshenziselwa ini i-glimepiride kanye nemiphumela yayo emibi?

Ukusetshenziswa: I-Gliepiride isetshenziselwa ukwelapha isifo sikashukela sohlobo 2, esiza ukulawula amazinga kashukela egazini uma kuhlanganiswa nokudla okunempilo nokuzivocavoca.
Imiphumela Emibi: Imiphumela emibi evamile ingase ihlanganise ushukela wegazi ophansi (hypoglycemia), ukukhuluphala, kanye nezinkinga zokugaya ukudla. Imiphumela engemihle engavamile kodwa embi kakhulu ingase ihlanganise ukungezwani okukhulu komzimba, izinkinga zesibindi, nokuphazamiseka kwegazi. Xhumana nomhlinzeki wakho wokunakekelwa kwezempilo ukuze uthole uhlu olubanzi lwemiphumela engemihle engaba khona.

2. Uyini umehluko phakathi kwe-glimepiride ne-Vildagliptin?

I-Glimipiride umuthi we-sulfonylurea okhuthaza ukukhululwa kwe-insulin, kuyilapho i-Vildagliptin iyi-dipeptidyl peptidase-4 (DPP-4) inhibitor esiza ukulawula ushukela wegazi ngokuvimbela ukuwohloka kwamahomoni e-incretin. Bangamakilasi ahlukene emithi elwa noshukela futhi basebenza ngezindlela ezihlukene zokwenza. Udokotela wakho uzonquma ukuthi isiphi esifanele isimo sakho esithile.

3. Ingabe i-glimepiride iphephile kubantu abanesifo sikashukela?

I-Gliepiride ingaba ephephile futhi isebenze kahle kubantu abaningi abanesifo sikashukela sohlobo 2 uma isetshenziswa njengoba kuyaliwe futhi ngaphansi kokuqondisa komhlinzeki wezempilo. Nokho, ukuphepha nokufaneleka kwayo kuncike ezintweni ezingazodwana, okuhlanganisa umlando wezokwelapha, eminye imithi, kanye nempilo iyonke. Xhumana nochwepheshe bezokunakekelwa kwempilo ukuze uthole ukuthi ikufanele yini.

4. Uyini umthamo we-glimepiride?

Umthamo othize we-Gliepiride uyahlukahluka kuye ngezidingo zomuntu ngamunye kanye nokusabela komuthi. Ngokuvamile, umthamo wokuqala uphansi futhi ungase unyuswe kancane kancane. Kubalulekile ukulandela izincomo zikadokotela wakho mayelana nesilinganiso esifanele kanye nesikhathi, esingaba kusukela ku-1 mg kuya ku-8 mg ngosuku.

References:

https://www.webmd.com/drugs/2/drug-12271/Glimepiride-oral/details

https://www.healthline.com/health/drugs/Glimepiride-oral-tablet#about
https://my.clevelandclinic.org/health/drugs/19079-Glimepiride-tablets

Umshwana wokuzihlangula: Ulwazi olunikezwe lapha alwenzelwe ukufaka iseluleko esivela kuchwepheshe wezokunakekelwa kwempilo. Ulwazi aluhloselwe ukumboza konke ukusetshenziswa okungenzeka, imiphumela engemihle, izinyathelo zokuphepha, nokusebenzisana kwezidakamizwa. Lolu lwazi aluhloselwe ukuphakamisa ukuthi ukusebenzisa umuthi othile kufanelekile, kuphephile, noma kuyasebenza wena noma omunye umuntu. Ukungabi bikho kwanoma yiluphi ulwazi noma isexwayiso mayelana nomuthi akufanele kuhunyushwe njengesiqinisekiso esicacile esivela enhlanganweni. Sikweluleka ngokuqinile ukuthi uthintane nodokotela uma kukhona okukukhathazayo ngomuthi futhi ungalokothi usebenzise umuthi ngaphandle kwencwadi kadokotela.