golimumab

golimumab

I-Golimumab iyi-antibody ye-monoclonal yomuntu ebalulekile esebenza njengomuthi we-immunosuppressive ezimeni eziningana ezingelapheki. Lokhu kwelashwa kuqondise i-tumor necrosis factor alpha (TNF-alpha), i-molecule evuselela ukuvuvukala, okuyenza i-TNF inhibitor.

I-World Health Organization ibone umjovo we-golimumab njengomuthi obalulekile. Iziguli zingathola umuthi we-golimumab ngomjovo ongaphansi kwesikhumba, okwenza utholakale kulabo abadinga ukunakekelwa okuqhubekayo. I-European Medicines Agency kanye ne-US Food & Drug Administration igunyaze i-golimumab ukwelapha izimo ze-autoimmune.

Lesi sihloko sihlanganisa konke iziguli okufanele zazi ngalo muthi-kusukela endleleni yokusebenza kuya ekudoseni okufanele kanye nemiphumela engemihle engaba khona.

Iyini i-Golimumab?

I-Golimumab ingeyesigaba semithi ebizwa ngokuthi i-TNF blockers. Lokhu kwelashwa kwebhayoloji kubophezela kuma-molecule e-TNF-alpha emzimbeni wakho futhi kuwavimbele ukuthi anamathele kuma-receptors. Amasosha akho omzimba akhiqiza i-TNF-alpha, engabangela ukuvuvukala nobuhlungu lapho kukhiqizwa ngokweqile. I-Golimumab isiza ukunciphisa lezi zimpawu ngokuvimbela le nqubo yokuvuvukala.

I-Golimumab Isebenzisa

Odokotela banikeza i-golimumab ikakhulukazi yezimo ze-autoimmune. Umuthi welapha okumaphakathi kuya kokunzima rheumatoid arthritis (kuhlanganiswe ne-methotrexate), i-psoriatic arthritis esebenzayo, i-ankylosing spondylitis, kanye izilonda emathunjini. Izingane ezineminyaka engu-2 noma ngaphezulu ezine-polyarticular juvenile idiopathic arthritis esebenzayo nazo zingazuza kulokhu kwelashwa.

Ungayisebenzisa Kanjani Futhi Nini Ithebhulethi ye-Golimumab

Umthamo ojwayelekile umjovo ongaphansi kwesikhumba ongu-50 mg kanye ngenyanga. Ukwelashwa kwe-ulcerative colitis kuqala ngomthamo we-200 mg, kulandelwa ngu-100 mg ngesonto lesi-2, bese kuba ngu-100 mg njalo emavikini angu-4. Umuthi udinga isiqandisi phakathi kuka-36°F no-46°F. Wena noma ilungu lomndeni ninganikeza umjovo ekhaya nisebenzisa isirinji esele igcwaliswe noma ipeni lomjovo ozenzakalelayo ngemva kokuqeqeshwa okufanele.

Imiphumela Emibi Yethebhulethi ye-Golimumab

Okulandelayo yimiphumela emibi evamile yalo muthi:

• Izifo zepheshana lokuphefumula eliphezulu 
• Ukusabela kwendawo yomjovo njengokubomvu noma ubuhlungu 
• Ama-enzyme esibindi aphakanyisiwe

Imiphumela emibi kakhulu ihlanganisa:

• Izifo ezinzima
• Lymphoma
• Umdlavuza wesikhumba
• Izinkinga zenhliziyo
• Ukuphendula kwe-allergen

Ukuqapha

• Udokotela wakho uzokuhlolela isifo sofuba kanye ne-hepatitis B ngaphambi kokuba ukwelashwa kuqale. Akufanele uthathe i-golimumab ngokutheleleka okusebenzayo. Imithi yokugoma ephilayo ayinconywa ngesikhathi sokwelashwa. 
• Odokotela baqikelela kakhulu lapho benikeza le mithi ezigulini ezinezifo zenhliziyo noma ezithola izifo njalo.
• Gcina i-golimumab yakho esiqandisini, kodwa ungalokothi uyifrize.

Isebenza kanjani ithebhulethi yeGolimumab

I-Golimumab iqondise futhi ivimbe iphrotheni ebizwa ngokuthi i-TNF-alpha edlala indima ebaluleke kakhulu ezimweni zokuvuvukala. Amasosha akho omzimba ahlasela izicubu ezinempilo ngenxa ye-TNF-alpha eyeqile. I-Golimumab imisa le nqubo eyingozi ngokubopha ngezinhlobo ezimbili ze-TNF-alpha ezindaweni eziningi. Lokhu kwelashwa kwebhayoloji okulwa ne-TNF kuqeda ukuvuvukala emthonjeni wako esikhundleni sokufihla izimpawu.

Ngingakwazi ukuthatha i-Golimumab Ngeminye Imithi?

I-Golimumab isebenza ngempumelelo ngemithi eminingana:

• Ungayithatha nayo ngokuphepha imethotrexate, ama-NSAID afana ibuprofen, namaphilisi ezinhlungu njenge paracetamol
• Odokotela bavame ukuyinikeza nge-methotrexate ukwelapha isifo samathambo
• Akufanele neze uyihlanganise neminye imithi ye-biologic noma i-Janus kinase inhibitors

Hlola nodokotela wakho ngaphambi kokuqala noma yimiphi imithi emisha. Yazisa bonke odokotela abangaphandle kwethimba lakho le-rheumatology mayelana nokwelashwa kwakho kwe-golimumab.

Ulwazi Lomthamo

Isimo sakho sinquma umthamo:

• I-Rheumatoid arthritis, i-psoriatic arthritis, i-ankylosing spondylitis iziguli zidinga ama-50 mg kanye ngenyanga (i-subcutaneous)
• Ukwelashwa kwe-ulcerative colitis kuqala ngo-200 mg, kulandelwa ngu-100 mg ngesonto lesi-2, bese kuba ngu-100 mg njalo emavikini amane.
• Uchwepheshe kufanele anqume umthamo wezingane

Isiphetho

I-Golimumab iletha izinzuzo ezinkulu ezigulini ezilwa nezimo ezingapheli zokuvuvukala. Umuthi uvimba amaprotheni e-TNF-alpha aqala ukuvuvukala okubuhlungu futhi anikeze ukukhululeka lapho ezinye izindlela zokwelapha zingasebenzi. Iziguli eziningi zithola ishejuli yazo yanyanga zonke yokudosa ilula njengoba yenza indlela yazo yokwelashwa ibe lula kunemithi okudingeka iyiphuze kaningi.

Inkululeko yokuthatha izithombe ze-golimumab ekhaya yenza umehluko omkhulu ezigulini eziningi. Uma sebefunde indlela efanele, iziguli zingakwazi ukulawula uhlelo lwazo lokwelashwa ngaphandle kokuya emitholampilo ngaso sonke isikhathi. Lokhu kuzimela kusiza ngempela abantu abanezinkinga zokuhamba noma amashejuli agcwele.
I-Golimumab isebenza kahle neminye imithi efana ne-methotrexate ukuze idale inhlanganisela enamandla yokwelapha izimo ezifana ne-rheumatoid arthritis.

Imibuzo Evame Ukubuzwa

1. Ingabe i-golimumab isengozini enkulu?

Ama-blocker e-TNF afana ne-golimumab angandisa ingozi yakho yokutheleleka, okuma njengomphumela omubi kakhulu. Inani elincane leziguli lingase libe ne-lymphoma noma umdlavuza wesikhumba. Udokotela wakho uzolinganisela ngokucophelela lezi zingozi nezinzuzo ozozithola ekulawuleni isimo sakho sokuvuvukala.

2. I-golimumab ithatha isikhathi esingakanani ukusebenza?

Kufanele uqaphele ukuthuthuka phakathi kwamaviki angu-8-12. Ezinye iziguli zizizwa zingcono ngeviki lokuqala, nakuba izinzuzo ngokuvamile zivela ngemva kwamaviki angu-6.

3. Kwenzekani uma ngiphuthelwa umthamo?

Thatha umthamo ogejiwe ngokushesha nje lapho ukhumbula. Ishejuli yakho yasekuqaleni ingaqhubeka uma ukubambezeleka kungaphansi kwamaviki angu-2. Ishejuli entsha kufanele iqale kusukela ngedethi yomjovo uma ukubambezeleka kudlula amaviki angu-2. Akufanele neze kabili umthamo wakho.

4. Kwenzekani uma ngiphuza ngokweqile?

Thola usizo lwezokwelapha ngokushesha ngokushayela abezimo eziphuthumayo.

5. Ubani ongakwazi ukuthatha i-golimumab?

Lo muthi awufaneleki uma unezifo ezisebenzayo, ukuhluleka kwenhliziyo okumaphakathi kuya kokunzima, noma i-multiple sclerosis. Iziguli ezinesifo sofuba esingalashwa kufanele futhi zigweme le mithi.

6. Kufanele ngiyithathe nini i-golimumab?

Thatha umthamo wakho kanye ngenyanga noma njengoba udokotela wakho ekuyalela.

7. Zingaki izinsuku zokuthatha i-golimumab?

Ukwelashwa kwakho kufanele kuqhubeke ngisho nangemva kokuba usuqale ukuzizwa ungcono. Izimpawu zingase zibuye uma uyeka kusenesikhathi.

8. Imiswa nini i-golimumab?

Yeka ukuthatha i-golimumab uma uba negciwane eliyingozi. Kufanele futhi ume cishe amasonto amahlanu ngaphambi kwanoma yikuphi ukuhlinzwa okuhleliwe. Njalo hlola nodokotela wakho ngaphambi kokuqeda ukwelashwa kwakho.

9. Ingabe kuphephile ukuphuza i-golimumab nsuku zonke?

Odokotela abancomi ukuthatha i-golimumab nsuku zonke. Umuthi ufika ngesirinji esigcwaliswe ngaphambilini noma ipeni lomjovo othomathikhi elakhelwe ukusetshenziswa nyanga zonke. Iziguli eziningi zidinga ukujova umthamo owodwa we-50 mg njalo emavikini ama-4. Lolu hlelo lusiza ukugcina amazinga emithi efanele egazini lakho.

10. Yisiphi isikhathi esingcono kakhulu sokuthatha i-golimumab?

Ngaphandle kokungabaza, asikho "isikhathi esingcono kakhulu" sokujova i-golimumab. Ungazifaka umjovo noma nini phakathi nosuku. Naphezu kwalokho, odokotela basikisela ukunamathela cishe ngesikhathi esifanayo kumthamo ngamunye ohleliwe. Umzimba wakho ugcina amazinga emithi engaguquki ngale ndlela.

11. Yini okufanele uyigweme lapho uthatha i-golimumab?

Lezi zinyathelo zokuphepha zibalulekile:

• Hlala kude nemithi yokugoma ephilayo (isifutho somkhuhlane wamakhala, umuthi wokugomela inkukhu, umuthi wokugomela i-shingles, izikhuthazi zesimungumungwane)
• Ungahlanganisi nabanye abavimbeli be-TNF 
• Gcina kude nabantu abanezifo
• Khuluma nodokotela wakho ngaphambi kwanoma yikuphi ukuhlinzwa