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I-Griseofulvin

izifo fungal kuthinta izigidi emhlabeni wonke, kubangela ukungakhululeki nokukhathazeka kulabo ababhekana nakho. Odokotela bavame ukutusa i-griseofulvin, umuthi osusungulwe kahle we-antifungal, ukwelapha izifo ezihlukahlukene zesikhunta, izinwele nezinzipho. Lo mhlahlandlela obanzi uchaza konke iziguli okudingeka ziyazi mayelana ne-griseofulvin, okuhlanganisa ukusetshenziswa kwe-griseofulvin 500mg, ukuphatha ngendlela efanele, imiphumela engemihle engaba khona, kanye nezinyathelo zokuphepha ezidingekayo. 

Iyini i-Griseofulvin?

I-Griseofulvin iwumuthi kadokotela kuphela we-antifungal ophuma kukhunta enhlabathini ebizwa ngokuthi i-Penicillium griseofulvum Iwumuthi ophuzwayo osetshenziselwa ukwelapha izifo zefungal. 

Ukusetshenziswa kwethebhulethi ye-Griseofulvin

Umuthi weGriseofulvin ukhombisa ukusebenza kahle okukhethekile ekwelapheni izimo ezithile ezithile. Lokhu kubandakanya:

  • Izifo zesikhumba ezifana ne-jock itch kanye nezikelemu
  • Unyawo lomdlali
  • Ukutheleleka kwesikhumba
  • Uzipho lweminwe nozipho lwesikhunta
  • Izimo zesikhunta ezihlobene nezinwele

Ungayisebenzisa kanjani i-Griseofulvin Tablet

Ukuthatha i-griseofulvin ngendlela efanele kubalulekile ukuze umuthi usebenze ngempumelelo. Iziguli kufanele ziphuze ithebhulethi ngengilazi yamanzi, okungcono ngesikhathi noma ngemva kokudla okunamafutha. 

Ukudla okunjengobisi oluphelele, u-ayisikhilimu, noma i-cheeseburger kusiza umzimba ukuthi umunce umuthi kangcono.

Umuthi ungaphuzwa kanye ngosuku noma uhlukaniswe ngemithamo emibili, kuye ngemiyalelo kadokotela. Ukuyithatha kabili ngosuku kungase kubonakale kusebenza kakhulu ezigulini ezingaphenduli kahle kumthamo owodwa wansuku zonke.

Imihlahlandlela Yesikhathi Sokwelashwa:

  • Izifo zesikhumba (Tinea corporis): 2-4 amaviki
  • Ukutheleleka kwesikhumba (i-tinea capitis): amaviki angu-4-8
  • Izifo ezinyaweni (tinea pedis): amaviki angu-4-8
  • Ukutheleleka kwezinzipho (tinea unguium): izinyanga ezingu-6-12

Iziguli kufanele ziphuze i-griseofulvin ye-antifungal ngezikhathi ezilinganayo usuku lonke. Labo abaphuthelwa umthamo kufanele bawuphuze ngokushesha nje lapho bekhumbula, ngaphandle uma sekusondele isikhathi somthamo olandelayo ohleliwe.

Imiphumela Emibi ye-Griseofulvin Tablet

Iziguli eziningi ziba nemiphumela engemihle evame ukuzixazulula ngokwazo:

Imiphumela Emibi Kakhulu: 

  • Ukusabela okukhulu kwesikhumba ngezimpawu ezifana nalezi:
  • Isikhumba esibhayizayo noma esixebukayo
  • Fever
  • Ukuvuvukala kobuso noma ulimi

Ukukhathazeka Okuhlobene Nesibindi: Iziguli kufanele zibheke izimpawu zezinkinga zesibindi, ikakhulukazi lapho zithatha imithamo ephezulu noma zisebenzisa umuthi isikhathi eside. Izimpawu eziyisixwayiso zihlanganisa:

Ukuqapha

Iziguli ezithatha i-griseofulvin zidinga ukulandela izinyathelo ezithile zokuphepha ukuze kuqinisekiswe ukwelashwa okusebenzayo. 

  • Izimo Ezihlelekile: Yazisa udokotela mayelana nokungezwani komzimba noma izimo zezokwelapha, ikakhulukazi isifo sesibindi, i-lupus, noma i-porphyria.
  • Utshwala: Gwema utshwala ngenkathi uphuza umuthi, ngoba kungabangela ukushaya kwenhliziyo okusheshayo nokushaya ngamandla. Iziguli ezishayela noma ezisebenzisa imishini nazo kufanele ziqaphele.
  • Ukuhlela Komndeni: Sebenzisa izindlela ezithembekile zokulawula inzalo, njengoba lo muthi unganciphisa ukusebenza kahle kwezivimbela-nzalo ezingamahomoni. Abesifazane akufanele bakhulelwe ngenkathi bethatha i-griseofulvin. Amadoda ahlela ukuba obaba bezingane kufanele alinde okungenani izinyanga eziyisithupha ngemva kokuqeda ukwelashwa ngaphambi kokuzama ukukhulelwa.
  • Ukuvikela Ilanga: Hlala uvikelekile ekukhanyeni kwelanga, njengoba imithi yandisa ukuzwela kwelanga. Lapho uchitha isikhathi ungaphandle, ukugqoka izingubo zokuzivikela kanye ne-sunscreen ene-SPF okungenani engu-15 kubalulekile. Kubantu abanebala elimhlophe, kungase kudingeke i-SPF ephakeme.

Isebenza kanjani i-Griseofulvin Tablet

Lapho isiguli sithatha i-griseofulvin, iqala ingene egazini bese ingena emangqamuzaneni akhiqiza i-keratin. I-Keratin iphrotheni eyakha isikhumba, izinwele nezinzipho. Umuthi ubophezela kulawa maseli, udale umgoqo ovikelayo osiza ukuvimbela ukukhula kwesikhunta esikhathini esizayo.

I-Griseofulvin ingena kumaseli esikhunta ezingeni lamaselula ngokusebenzisa izinqubo zokuthutha ezincike emandleni. Uma isingaphakathi, ibophezela kuma-microtubules okukhunta abalulekile ekuhlukaneni kwamaseli. Lesi senzo esibophayo sivimbela isikhunta ukuthi singaziphindaphindi kahle, sinqande ngempumelelo ukusabalala kwezifo.

Okwenza i-griseofulvin isebenze ngokukhethekile yikhono layo lokugxila ku-keratin esanda kwakheka. Njengoba umzimba ukhiqiza amangqamuzana esikhumba amasha, izinwele, nezinzipho, ngokwemvelo amelana nokuhlasela kwesikhunta. Le nqubo ichaza ukuthi kungani ngokuvamile ukwelashwa kudingeka kuqhubeke kuze kube yilapho isicubu esinegciwane sesithathelwe indawo ngokuphelele ukukhula okusha, okunempilo.

Ngingakwazi Ukuthatha I-Griseofulvin Ngeminye Imithi?

Ukusebenzisana kwemithi kudinga ukunakwa ngokucophelela lapho uthatha i-griseofulvin. 

Ukusebenzisana Kwemithi Okubalulekile:

  • Ama-antacid kanye nama-H2 blockers 
  • Imithi yokwehlisa igazi njenge-warfarin ingase ingasebenzi kahle
  • Ukusebenza kokulawula ukuzalwa kwama-hormone kungase kwehle
  • Inhlanganisela ye-griseofulvin notshwala ingabangela ukusabela okubi, okuhlanganisa isicanucanu nokuhlanza. 
  • Abesifazane abasebenzisa izivimbela-nzalo ezingamahomoni kufanele basebenzise izindlela zokulawula inzalo ezengeziwe ngesikhathi sokwelashwa, njengoba i-griseofulvin ingase yehlise ukusebenza kwayo. 

Ulwazi Lomthamo

Imithi yomlomo ye-Griseofulvin iza ngezinhlobo ezimbili: amaphilisi ama-microsize kanye ne-ultra microsize, anezidingo zomthamo ezihluka ngokuya ngeminyaka, isisindo, kanye nohlobo lokutheleleka.

Imihlahlandlela Yokudoswa Kwabantu Abadala:

  • Ukwakhiwa kwe-Microsize: 500 mg nsuku zonke ngezifo ezivamile, kuze kufike ku-1000 mg nsuku zonke ngezifo ezisabalele
  • Ukwakhiwa kwe-Ultra microsize: 375 mg nsuku zonke, okungase kwenyuswe ku-750 mg ngezifo ezinzima

Odokotela babala umthamo wezingane ezineminyaka engaphezu kwengu-2 ngokusekelwe kwesisindo somzimba. Ukwakhiwa kosayizi omncane ngokuvamile kudinga u-10 mg/kg/ngosuku, kuyilapho ukwakhiwa kosayizi omncane kakhulu kudinga cishe u-7.3 mg/kg/ngosuku. Izingane ezinesisindo esingu-13.6-22.7 kg zithola i-125-250 mg nsuku zonke.

Isiphetho

I-Griseofulvin ime njengendlela yokwelapha enokwethenjelwa ezigulini ezinenkinga yokutheleleka kwefungal okuqhubekayo. Lo muthi ubonakala ubalulekile ikakhulukazi lapho ukwelapha ngetopic kungalethi imiphumela, okunikeza ithemba kulabo ababhekene nezifo zesikhumba ezinenkani, izinwele, nezinzipho.

Ukwelashwa okuphumelelayo kuncike ekulandeleni ishejuli yemithamo enqunyiwe kanye nokuqeda yonke inkambo yemithi. Iziguli kufanele zikhumbule ukuthi izifo ezihlukene zidinga ubude bokwelashwa obuhlukene - kusukela emasontweni ambalwa ezimweni zesikhumba kuya ezinyangeni ezimbalwa zokutheleleka kwezinzipho. Ukuthatha umuthi ngokudla okunamafutha kusiza ukukhulisa ukusebenza kahle kwawo.

Ukuphepha kuhlala kubalulekile ngesikhathi sokwelashwa. Iziguli kufanele zibheke imiphumela emibi engaba khona futhi zigcine ukuxhumana njalo nodokotela bazo. Nakuba imiphumela engemihle ingase ibe khona, abantu abaningi baqeda ukwelashwa kwabo ngempumelelo lapho belandela imihlahlandlela efanele kanye nezinyathelo zokuphepha.

Imibuzo Evame Ukubuzwa

1. I-griseofulvin ithatha isikhathi esingakanani ukusebenza?

I-Griseofulvin iqala ukusebenza ngokushesha, kodwa ukuthuthukiswa okubonakalayo kungase kuthathe izinsuku ezimbalwa noma amasonto. Ukusebenza komuthi kuyabonakala njengoba izicubu ezintsha ezinempilo zikhula zithatha indawo yezindawo ezithelelekile.

2. Kwenzekani uma ngiphuthelwa umthamo?

Iziguli kufanele zithathe umthamo ngokushesha nje lapho zikhumbula uma zigeje owodwa. Kodwa-ke, uma sekusondele isikhathi somthamo olandelayo ohleliwe, kufanele beqe umthamo ogejiwe futhi baqhubeke neshejuli yabo evamile. 

3. Kwenzekani uma ngiphuza ngokweqile?

Esimeni se-griseofulvin overdose, kufanele ufune ukungenelela kwezokwelapha ngokushesha noma uthinte isikhungo sangakini sokulawula ushevu. Nakuba kungenakwenzeka ukuthi kubangele umonakalo omkhulu ngomthamo owodwa owengeziwe, ukuqapha kwezokwelapha kungase kudingeke.

4. Ubani ongakwazi ukuthatha i-griseofulvin?

I-Griseofulvin ayifaneleki:

  • Abantu abanenkinga yesibindi
  • Labo abane-porphyria
  • Abesifazane abakhulelwe noma labo abahlela ukukhulelwa
  • Izingane ezingaphansi kweminyaka eyi-2

5. Zingaki izinsuku okufanele ngiphuze i-griseofulvin?

Ubude besikhathi sokwelashwa buhluka ngokwemibandela:

  • Ukutheleleka kwesikhumba: amaviki angu-2-4
  • Ukutheleleka kwezinyawo: amaviki angu-4-8
  • Izifo zezinwele/ekhanda: amaviki ama-4-6
  • Ukutheleleka kweminwe: izinyanga ezi-3-4
  • Ukutheleleka kwezinzwane: Okungenani izinyanga eziyisi-6

6. Kungani i-griseofulvin ithathwa ebusuku?

Odokotela bavame ukutusa i-griseofulvin ngobisi noma ngemva kokudla ukuze kuthuthukiswe ukumuncwa nokunciphisa ukucasuka kwesisu. Ukuyithatha ebusuku kusiza ukuqinisekisa ukumuncwa okungaguquki ngokusebenzisa isikhathi esifanele sokudla.

7. Ngingakwazi yini ukuthatha i-itraconazole ne-griseofulvin ndawonye?

Nakuba kungekho ukusebenzisana okuqondile okukhona phakathi kwe-itraconazole ne-griseofulvin, odokotela ngokuvamile batusa ukuphuza imithi eminingi ye-antifungal kanyekanye. Abantu kufanele babonane nodokotela wabo ngaphambi kokuhlanganisa le mithi.

8. Ingabe i-griseofulvin iyasebenza?

Ucwaningo lubonisa ukuthi i-griseofulvin iphumelela kakhulu ekulweni nezifo ezihlukahlukene zesikhunta, ikakhulukazi lapho ezinye izindlela zokwelapha eziphathwayo zehlulekile. Amazinga empumelelo aphezulu lapho iziguli ziphothula sonke isifundo esinqunyiwe.

9. Ingabe i-griseofulvin iyi-steroid?

Cha, i-griseofulvin ayiyona i-steroid. Kungokwesigaba semithi ye-antifungal. Nakuba kungase kuthinte amazinga e-hormone, isebenza ngokuphazamisa ukukhula kwamangqamuzana esikhunta kunokuba ngokusebenzisa izindlela ezisekelwe ku-steroid.