Inositol

Inositol

I-Inositol, evame ukungaziwa njengevithamini B8, ayilona ivithamini kodwa iwuhlobo lukashukela olusebenza imisebenzi eminingi ebalulekile emzimbeni. Kuvela ngokwemvelo ekudleni okuhlukahlukene njengezithelo, ubhontshisi, okusanhlamvu, namantongomane; umzimba ungawukhiqiza futhi kuma-carbohydrate adliwe. Ngokwesakhiwo, i-inositol iyingxenye ebalulekile yolwelwesi lwamangqamuzana ethu futhi idlala indima ebalulekile ezenzweni ze- insulin, i-hormone ebalulekile yokulawula ushukela wegazi. Ngaphezu kwalokho, ithonya ama-neurotransmitters afana ne-serotonin ne-dopamine, abalulekile ekusebenzeni kobuchopho.

I-Inositol ikhona ngezinhlobo eziningana, okuhlanganisa i-myo-inositol, i-D-chiro-inositol, ne-inositol hexaphosphate, futhi iyatholakala njengesengezo sokudla. Le nhlanganisela ayibalulekile nje kuphela ekuthuthukisweni nasekukhuleni kwamangqamuzana kodwa futhi ithinta impilo ye-metabolic nengqondo ngokubandakanyeka kwayo ekudluliselweni kwesignali yamangqamuzana nokusabela kwehomoni. Inani eliphakeme kakhulu le-inositol litholakala egazini Ubuchopho, lapho isiza emisebenzini ye-neurotransmitter kanye ne-hormone receptor, ebalulekile empilweni yengqondo nezinqubo zokuqonda.

Ukusetshenziswa kwe-Inositol

I-Inositol, into eyenzeka ngokwemvelo emzimbeni, inikeza inqwaba yezinzuzo zezempilo ezihlanganisa kodwa ezingagcini nje:

• I-Metabolic Syndrome: I-Metabolic syndrome ihlanganisa iqoqo lezici eziyingozi ezikhulisa amathuba okuba nezifo ezingelapheki njenge sikashukela, isifo senhliziyo, kanye unhlangothi. Lezi zici zihlanganisa isisu ukukhuluphalaamazinga aphezulu e-triglyceride, ancishisiwe okuhle (i-HDL) amazinga e-cholesterol, phezulu ukushaya kwegazi, kanye noshukela ophezulu. Izithako ze-Inositol zingasiza ukuphatha lezi zici eziyingozi, ezingase zithuthukise umfutho wegazi, i-triglycerides, i-cholesterol, namazinga kashukela egazini.
• I-Polycystic Ovary Syndrome (PCOS): I-PCOS yisifo sehomoni esibonakala ngokuthi ukungazali, ukuya esikhathini okungajwayelekile, izinduna, ukukhuluphala, nokukhula kwezinwele ngokweqile. I-Inositol, ehlangene ne-folic acid, ingadambisa izimpawu eziningi ze-PCOS, ithuthukise ukulawula ushukela wegazi, inciphise umfutho wegazi, amazinga e-triglyceride aphansi, ikhuthaze ukuvuthwa kweqanda, futhi andise ukukhulelwa amanani.
• Isifo sikashukela sokukhulelwa kanye nokuzalwa ngaphambi kwesikhathi: Ukwengezwa kwe-Inositol ngesikhathi sokukhulelwa kungase kunciphise ingozi yesifo sikashukela sokukhulelwa (amazinga aphezulu eglucose ngesikhathi sokukhulelwa) kanye nokuzalwa ngaphambi kwesikhathi. Ucwaningo lubonisa ukuthi i-inositol, ene-folic acid, ingavimbela lezi zimo lapho ithathwa ngesikhathi sokukhulelwa.
• Izimo Zezempilo Yengqondo: I-Inositol ingase futhi inikeze izinzuzo zezimo zempilo yengqondo ezifana ukucindezeleka kanye ne-bipolar disorder ngokuthonya ama-neurotransmitters afana ne-serotonin kanye i-dopamine. Olunye ucwaningo lubonisa ukuthi i-inositol supplementation ingasiza ekulinganiseni lawa makhemikhali obuchopho, okungenzeka kudambise izimpawu zokucindezeleka nokunciphisa ubunzima be-bipolar disorder.

Ungayisebenzisa kanjani i-Inositol?

Ukuze ufake ngempumelelo i-inositol ohlelweni lwakho lwezempilo, landela le mihlahlandlela ngokusekelwe ohlotsheni nenjongo yokusetshenziswa:

• Isilinganiso Esijwayelekile se I-PCOS:
  • I-Myo-inositol: Thatha i-4,000 mg ngosuku, ihlukanise ngemithamo emibili.
  • I-D-chiro-inositol: Yidla phakathi kuka-600 - 1,000 mg nsuku zonke.
  • I-Myo ehlanganisiwe ne-D-chiro-inositol: Khetha umthamo ohlangene we-4,000 mg we-Myo-inositol kanye ne-100 mg ye-D-chiro-inositol nsuku zonke, ihlukaniswe ngemithamo emibili.
• Amathiphu okuphatha:
  • Thatha izithasiselo ze-inositol ngesikhathi sokudla, kuhle ngemva kokudla kokuqala nokokugcina kosuku, ukuze uthuthukise ukulawulwa kwe-insulin nokulinganisela kwehomoni.
  • Gcina okungenani isikhawu samahora ayisithupha phakathi kwemithamo emibili ukuze uthuthukise ukumuncwa.
• Ukucatshangelwa Kwezithako Ezengeziwe:
  • Qaphela izithasiselo eziqukethe izinto ezinoshukela noma izithasiselo ezeqile, njengoba lokhu kungase kuphazamise ukumuncwa kwe-inositol.

I-Side Effects ye-Inositol Tablet

Izithako ze-Inositol zivame ukubekezelelwa kahle kodwa zingadala imiphumela engemihle, ikakhulukazi ngemithamo ephezulu. Abantu abaningi baba nemiphumela engemihle kuphela, engabandakanya isicanucanu, igesi, nobunzima bokulala. Abanye bangase futhi babike izinhlungu zekhanda, isiyezi, kanye nokukhathala lapho udla imithamo ye-12 amagremu ngosuku noma ngaphezulu. 
Ukwengeza, imithamo ephezulu ye-inositol hexaphosphate ingase ibangele ukumuncwa okulinganiselwe kwamaminerali abalulekile njenge-zinc ne-iron, okungase kuholele ekuntulekeni komsoco. Njalo thintana nodokotela ngaphambi kokuqala noma yisiphi isithasiselo esisha, ikakhulukazi uma unezimo eziyisisekelo zesistimu noma uthatha eminye imithi.

Ukuqapha

Ngaphambi kokufaka izithako ze-inositol ohlelweni lwakho, khuluma nodokotela wakho, ikakhulukazi uma uthatha eminye imithi, njengoba i-inositol ingasebenzisana nayo, njenge: 

• Abantu abanesifo sikashukela kufanele babhekisise amazinga kashukela egazini ngoba i-inositol ingaholela ku-hypoglycemia. 
• Labo abanakho i-bipolar ukuphazamiseka kufanele kuqaphele; i-inositol eningi ingase ibangele iziqephu ze-manic noma ze-hypomanic. 
• Abantu abakhulelwe nabancelisayo kufanele bagweme i-inositol. 
• Imithamo ephezulu ye-inositol hexaphosphate ingase ibangele ukumuncwa okungaphansi kokuvamile kwamaminerali abalulekile njenge-zinc ne-iron, okungase kubangele ukuntuleka komsoco. Ngaso sonke isikhathi sebenzisa izithasiselo ze-inositol ngaphansi kokuqondisa kwezokwelapha hhayi esikhundleni sokwelashwa okuqinisekisiwe.

Isebenza kanjani i-Inositol?

I-Inositol isebenza njengengxenye ebalulekile ezinqubweni ezihlukahlukene zebhayoloji emzimbeni, ikakhulukazi emigudwini yokudlulisela isignali ehlanganisa i-insulin nama-neurotransmitters. Itholakala ngezindlela eziningi, njenge-myo-inositol ne-inositol hexakisphosphate (IP6), ngayinye idlala indima ehlukile ekuphathweni kwezempilo.

I-Myo-inositol, uhlobo oluvelele lwe-inositol, ibamba iqhaza kumjikelezo we-phosphatidylinositol, obalulekile ekuhlanganiseni kwe-neurotransmitter. Lo msebenzi ulingisa ukwenziwa kusebenze kwama-postsynaptic receptors, alawula umsebenzi we-neurotransmitter ngaphandle kokucupha ama-receptors ngokuqondile, ngaleyo ndlela abe nomthelela ezimeni zempilo yengqondo njengokucindezeleka nesifo sokuphazamiseka kwengqondo okuguquguqukayo.

I-Inositol phosphates, ikakhulukazi i-IP6, ithuthukisa ukuzwela kwe-insulin ngokugqugquzela ukunsundu kwama-adipocyte amhlophe kanye nokwenza ngcono ukusayina kwe-insulin. I-IP6 yehlisa izinga likashukela egazini futhi ilibazise ukugayeka nokumuncwa kwama-carbohydrate, okubonisa izinzuzo zayo ezingaba khona zokulawula isifo sikashukela. Iphinde ilingise imiphumela ye-insulin ngokunciphisa izinga lokubhalwa kwezakhi zofuzo ezibandakanyeka ku-gluconeogenesis, njengofuzo lwe-phosphoenolpyruvate carboxykinase (PEPCK).

Ngaphezu kwalokho, i-inositol isekela i-lipid metabolism ngokuthonya umsebenzi wama-enzyme namaprotheni afana ne-perilipin1, elawula i-lipolysis kuma-adipocytes. Lokhu kuguqulwa kusiza ukuphatha izimo ezihambisana nokungalingani kwe-lipid, njenge ukukhuluphala kanye ne-metabolic syndrome.

Ngingathatha i-Inositol Neminye Imithi?

Uma ucabangela ukwengeza izithasiselo ze-inositol ohlelweni lwakho, ukuxoxa ngalokhu nodokotela kubalulekile, ikakhulukazi uma okwamanje uthatha eminye imithi. I-Inositol ngokuvamile inephrofayili yokuphepha enhle kodwa ingasebenzisana nemithi ethile, okungenzeka iguqule imiphumela yayo. Isibonelo, njengoba i-inositol ithonya i-insulin namazinga e-serotonin, ingase ithinte ukusebenza kwemithi yesifo sikashukela kanye nama-antidepressants. Njalo qinisekisa ukuthi udokotela ubuyekeza imithi yakho yamanje ukuze ugweme ukusebenzisana okungekuhle.

Ulwazi Lomthamo

Ukunquma umthamo ofanele we-inositol kubalulekile ekwandiseni izinzuzo kanye nokunciphisa izingozi. Umthamo wokuqala ojwayelekile we-myo-inositol (MI) wokwesekwa kwezempilo yengqondo usukela ku-2,000 kuya ku-4,000 mg ngosuku. Ukulungisa umthamo ngokusekelwe ezidingweni ezingokwenyama zomuntu ngamunye kanye nemigomo yezempilo kubalulekile.

Imibuzo Evame Ukubuzwa

1. Ingabe KULUNGILE ukuphuza i-inositol nsuku zonke?

Izivivinyo zomtholampilo ziphakamisa ukuthi ukwesekwa kwansuku zonke kwe-myo-inositol ngokuvamile kuphephile, okuyenza ifanelekele ukudla kwansuku zonke. Ukubonana nodokotela ukuze uthole iseluleko esiqondene nawe kanye nokuthatha umthamo ofanele kubalulekile.

2. Ngingakwazi ukuthatha i-Inositol ngaphandle I-PCOS?

Yebo, i-myo-inositol ihlolelwe ukusebenza kahle kubo bobabili abesifazane be-PCOS nabangewona ama-PCOS, ebonisa izinzuzo ekukhulelweni kwemvelo nangesikhathi sezinqubo zobuchwepheshe ezisizwayo zokuzala.

3. Ingabe i-inositol ilungele inzalo?

I-Myo-inositol idlala indima ebalulekile ekuzaleni, ikakhulukazi ngokwenza i-ovulation kanye nokwandisa amazinga okukhulelwa kokubili i-PCOS kanye nabesifazane abangewona i-PCOS.

4. Ingabe i-inositol izongisiza ngiye esikhathini?

Kwabesifazane abane-PCOS, i-Myo-inositol supplementation iboniswe ukusiza ukubuyisela okuvamile imijikelezo yokuya esikhathini, evame ukuphazanyiswa ukushintshwa kwesignali ye-gonadotropin.

5. Ubani okufanele agweme i-inositol?

Nakuba i-inositol ngokuvamile iphephile, abantu kufanele babonane nodokotela ngaphambi kokuqala ukwesekwa, ikakhulukazi uma ukhulelwe, umhlengikazi, noma unezimo zempilo ezingaphansi.