I-Lansoprazole

I-Lansoprazole

I-Lansoprazole, umuthi onamandla, ingaba ikhambi lesilungulela noma i-acid reflux. Lo muthi oshiwo kabanzi ungowesigaba semithi ebizwa ngokuthi i-proton pump inhibitors (PPIs). I-Lansoprazole iguqule ukwelashwa kwezinkinga ezihlukahlukene zokugaya ukudla njenge-GERD, izilonda zesisu, nezinye izifo ezihlobene nokukhiqizwa kwe-asidi yesisu ngokweqile. Masiqonde izinzuzo, ukusetshenziswa okufanele, kanye nemiphumela engemihle engaba khona yephilisi le-lansoprazole.

Iyini i-Lansoprazole?

Iphilisi leLansoprazole liwumuthi onamandla osesigabeni esibizwa nge-proton pump inhibitors (PPIs). Lo muthi udlala indima ebalulekile ekwehliseni ukukhishwa kwe-asidi esiswini, okuwenza ube ukwelashwa okusebenzayo kwezinhlobonhlobo izingqinamba zokugaya ukudla.

Lokhu kuncipha kwe-asidi yesisu kuthinta kakhulu izimo eziningana zesisu. I-Lansoprazole iphumelela kakhulu ekukhuliseni ukuphulukiswa ezimweni ze-ulcerative kanye nokwelapha isifo se-reflux ye-gastroesophageal (GERD). Kuyasiza futhi ukuphatha amanye ama-pathologies abangelwa ukukhishwa kwe-asidi ngokweqile.

Ukusetshenziswa kwe-Lansoprazole Tablet

Odokotela banquma i-lansoprazole ngezimo ezihlukahlukene, njenge:

• Ukungakhululeki nokushiswa okuhambisana nokungagayeki kahle kokudla
• I-reflux ye-Acid
• Isifo se-Gastroesophageal Reflux (GORD)
• I-Lansoprazole ivimbela izilonda zesisu ngokuvikela ulwelwesi lwesisu ekulimaleni kwe-asidi ngokweqile. Kulabo asebevele benezilonda zesisu, isiza ekwelapheni, ikhuthaza ukululama ngokushesha futhi inciphise ukungakhululeki.
• Kwezinye izimo, odokotela banquma i-lansoprazole ukwelapha isimo esingavamile esibizwa ngokuthi i-Zollinger-Ellison syndrome. Lokhu kuphazamiseka, okubangelwa isimila ku-pancreas noma emathunjini, kubangela ukukhiqizwa ngokweqile kwe-asidi esiswini. I-Lansoprazole isiza ukuphatha lesi simo ngokunciphisa inani le-asidi ekhiqizwayo.

Ungayisebenzisa kanjani iLansoprazole

Ukusetshenziswa okufanele kwe-lansoprazole kubalulekile ekusebenzeni kwayo. Iziguli kufanele ziwuphuze lo muthi njengoba ziyalelwe udokotela wazo, ungadluli umthamo obekiwe, imvamisa, noma ubude besikhathi sokwelashwa.

• Gweba i-capsule ngokuphelele ngaphandle kokuyichoboza, ukuyihlephula, noma ukuyihlafuna.
• Noma, hlanganisa okuqukethwe kwe-capsule no-60 mL we-apula, i-orange, noma ijusi katamatisi.
• Phuza ingxube ngokushesha futhi uphinde ugcwalise inkomishi kabili ngejusi ukuze uqinisekise ukuthi wonke umuthi uyathathwa.

Ukusebenzisa i-lansoprazole ene-nasogastric (NG) tube:

• Vula i-capsule bese uxuba okuqukethwe kwayo no-40 mL wejusi ye-apula.
• Jova noma uthele le ngxube epayipini le-nasogastric.

Imiyalo yethebhulethi ye-Lansoprazole yokuhlakaza ngomlomo:

• Qinisekisa ukuthi izandla zakho zomile ngaphambi kokuphatha ithebhulethi echithwa ngomlomo. Ivumele ukuba incibilike ibe yizinhlayiya futhi igwinye ngokushesha.

Imiphumela Emibi Yethebhulethi yeLansoprazole

I-Lansoprazole, njenganoma yimuphi umuthi, ingaba nemiphumela engemihle. Imiphumela emibi evame kakhulu ihlanganisa:

• Uhudo
• Ubuhlungu besisu
• I-nausea
• ukuqunjelwa

Nakuba kungavamile, eminye imiphumela emibi kakhulu ingase ibe khona futhi idinga ukunakekelwa kwezokwelapha ngokushesha:

• Izinkinga Zezinso: I-acute tubulointerstitial nephritis ingakhula nganoma yisiphi isikhathi phakathi nokwelashwa. Iziguli kufanele zibheke ukwehla kokukhishwa komchamo noma igazi emchameni futhi zithinte udokotela wazo ngokushesha uma lezi zimpawu zenzeka.
• Isifo sohudo esihambisana nama-antibiotic: Ukugcwala ngokweqile kwe-Clostridioides difficile (C. diff) emathunjini kungenzeka ngesikhathi sokwelashwa kwe-lansoprazole. Izimpawu zihlanganisa isifo sohudo esiManzi esingasuki, amajaqamba esiswini, umkhuhlane, noma igazi esitulweni.

Ukusabela Okubi Kwesikhumba: Imithi ye-Lansoprazole ingabangela ukusabela kwesikhumba okunamandla njenge-Stevens-Johnson Syndrome (SJS) kanye ne-Toxic Epidermal Necrolysis (TEN). Izimpawu zihlanganisa:

• Isikhumba esibuhlungu esibomvu noma esinsomi esixebukayo
• Umqubuko obomvu oyisicaba noma amabhamuza esikhumbeni, emlonyeni, ekhaleni, nasezithweni zangasese
• Okubomvu, kubuhlungu, Amehlo amanzi
• I-Allergic Reaction Enzima noma i-anaphylaxis

Eminye imiphumela emibi kakhulu:

• I-Lupus: Ubuhlungu obusha noma obuba bubi bamalunga noma ukuqubuka ezingalweni noma ezihlathini
• Ukushoda kwe-Vitamin B-12: Ulimi olubuhlungu, ubuthakathaka, ukunkenketha ezandleni noma ezinyaweni
• I-Hypomagnesemia: Izinguquko ekushayeni kwenhliziyo, isiyezi, ukugoqa kwemisipha, ukuquleka
• Ukulahleka kwamathambo nokuphuka: Ingozi ephezulu kubantu abadala kanye nabasebenzisi besikhathi eside
• Ukungezwani komzimba kakhulu: Izinkinga zokuphefumula, inhliziyo egijima, ukuvuvukala kobuso noma umphimbo

Ukuqapha

Nakuba iphumelela, i-lansoprazole idinga ukucatshangelwa ngokucophelela ngaphambi kokusetshenziswa. 

• Abantu abane-allergies kunoma yiziphi izithako zayo kufanele bagweme lo muthi. Kubalulekile ukwazisa odokotela ngayo yonke imithi yamanje, okuhlanganisa nezidakamizwa ezithengwayo, amavithamini, amaminerali, nezithako zemithi, njengoba imithi ye-lansoprazole ingase ihlangane nayo.
• Odokotela batusa ukuthatha i-lansoprazole imizuzu engama-30-60 ngaphambi kokudla ukuze bakhulise ukusebenza kahle kwayo futhi banciphise ukusebenzisana okungenzeka.
• Izimo ezithile zezokwelapha zidinga ukunakwa okukhethekile lapho usebenzisa i-lansoprazole. Iziguli kufanele zazise udokotela wazo uma zine:
  • Izinga legazi eliphansi le-potassium, i-magnesium, i-calcium, noma i-sodium
  • Izinkinga zesibindi
  • I-Phenylketonuria
• Abesifazane abakhulelwe noma labo abahlela ukukhulelwa nomama abancelisayo kufanele bagweme le mithi.

Isebenza kanjani iLansoprazole

I-Lansoprazole inomthelela ekwehliseni ukukhishwa kwe-asidi esiswini ngendlela ehlosiwe. Lo muthi ungowesigaba sezidakamizwa ezibizwa ngokuthi i-proton pump inhibitors (PPIs) futhi usebenza ngokugxila ku-enzyme ethile esiswini.

Isihluthulelo sempumelelo ye-lansoprazole sisemandleni ayo okukhomba i-H+, K+-ATPase, i-enzyme ebalulekile esinyathelweni sokugcina sokuphuma kwe-asidi kumaseli e-parietal. Ngokuvimbela le enzyme, i-lansoprazole inciphisa ngempumelelo i-asidi ekhiqizwa esiswini. Lokhu kubophezela kunomphumela ohlala isikhathi eside, okuchaza ukuthi kungani ama-PPI afana ne-lansoprazole anganikeza ukuvinjelwa okunwetshiwe kokuphuma kwe-asidi.

Ngingathatha I-Lansoprazole Neminye Imithi?

I-Lansoprazole, umuthi onqunyelwe kabanzi, unamandla okuxhumana nezinye izidakamizwa eziningi. 

Eminye yemithi evame ukusetshenziswa engase ihlanganyele ne-lansoprazole ihlanganisa: 

• Amphetamine
• Apixaban
• aspirin (amandla aphansi)
• I-Atorvastatin
• Calcium supplements
• I-Carbamazepine
• I-Celecoxib
• I-Clopidogrel
• I-diphenhydramine
• I-Duloxetine
• I-Escitalopram
• I-Rosuvastatin

Ulwazi Lomthamo

Umthamo we-Lansoprazole uyahlukahluka kuye ngesimo sokwelashwa kanye neminyaka yesiguli. Odokotela banquma umthamo ofanele ngokusekelwe ezidingweni zomuntu ngamunye kanye nomlando wezokwelapha.

Umthamo ojwayelekile wokuqunjelwa kanye ne-acid reflux isukela ku-15mg kuya ku-30mg ngosuku. Uhla lwemithamo efanayo lusebenza ekwelapheni izilonda zesisu. Kodwa-ke, ku-Zollinger-Ellison syndrome, umthamo wokuqala uvame ukuphakama ku-60mg ngosuku, ongakhuphuka ube ngu-120mg ngosuku uma kunesidingo. Umthamo uncike ekutheni isiguli sisabela kahle kangakanani ekwelashweni.

Umthamo wezingane we-GERD kanye ne-erosive esophagitis kuyahlukahluka ngeminyaka nesisindo:

• Izingane ezineminyaka engu-1 kuya ku-11:
• Isisindo esingu-30 kg noma ngaphansi: 15 mg kanye ngosuku
• Isisindo esingaphezu kwama-30 kg: 30 mg kanye ngosuku
• Isikhathi sokwelashwa: Kufika emavikini ayi-12
• Izingane ezineminyaka engu-12 nangaphezulu:
• I-Erosive esophagitis: 30 mg kanye ngosuku kuze kube amasonto angu-8
• I-GERD: 15 mg kanye ngosuku kuze kube amasonto ayisishiyagalombili

Isiphetho

I-Lansoprazole ithonya kakhulu ukuphathwa kwezinkinga ezihlukahlukene zokugaya ukudla, kusukela ezinkingeni ezivamile ezifana nesilungulela kuya ezimweni ezimbi kakhulu ezifana nezilonda kanye ne-GERD. Ikhono layo lokunciphisa ukukhishwa kwe-asidi esiswini kwenza kube usizo ekuthuthukiseni izinga lempilo yeziguli eziningi. Ukuguquguquka komuthi, kuhlangene nokubekezelelwa kwawo kahle, kuholele ekusetshenzisweni kwawo kabanzi ekwelapheni ukuphazamiseka kwesisu.

Nakuba i-lansoprazole iphumelela, kubalulekile ukuyisebenzisa ngaphansi kokuqondisa kwezokwelapha futhi uqaphele imiphumela engemihle engase ibe khona nokusebenzisana. Iziguli kufanele zilandele imiyalelo yomthamo ngokucophelela futhi zazise udokotela wazo ngayo yonke imithi eqhubekayo ukuze kuqinisekiswe ukwelashwa okuphephile nokusebenzayo.

FAQ sika

1. Isetshenziselwa ini i-lansoprazole?

I-Lansoprazole isiza ukunciphisa inani le-asidi ekhiqizwa yisisu. Isetshenziselwa ukwelapha izinkinga ezihlukahlukene zokugaya ukudla, okuhlanganisa:

• Ukuqunjelwa kanye nesilungulela
• I-Acid Reflux kanye nesifo se-reflux ye-gastroesophageal (GERD)
• I-Erosive esophagitis 
• Izilonda zesisu (izilonda zesisu) kanye nezilonda ze-duodenal
• Ukuvimbela izilonda zesisu ezibangelwa ama-NSAID
• I-Zollinger-Ellison syndrome
• Ukutheleleka kwe-Helicobacter pylori, kuhlanganiswe nama-antibiotics

2. Ubani okungafanele aphuze i-lansoprazole?

Abantu abathile kufanele bakugweme ukuthatha i-lansoprazole noma bayisebenzise ngokuqapha. Lokhu kubandakanya:

• Abantu abangezwani ne-lansoprazole noma amanye ama-proton pump inhibitors
• Abanenkinga yesibindi
• Abesifazane abakhulelwe noma labo abazama ukukhulelwa
• Ibele omama
• Abantu abahlelelwe i-endoscopy

Kubalulekile ukwazisa udokotela mayelana ne-allergies, izimo zezokwelapha, noma imithi ngaphambi kokuqala ukwelashwa kwe-lansoprazole. 

3. Ungayithatha isikhathi esingakanani i-lansoprazole ngokuphepha?

Ubude besikhathi sokwelashwa kwe-lansoprazole buncike esimweni sokwelashwa kanye nezici zesiguli ngasinye. Kubalulekile ukukhumbula ukuthi ukusetshenziswa kwesikhathi eside kwe-lansoprazole kungase kube nezingozi ezithile, njengamazinga aphansi e-magnesium egazini, ukuphuka kwamathambo, izifo zamathumbu, kanye nokuntuleka kukavithamini B12.

4. Ingabe i-lansoprazole iphephile ukusetshenziswa nsuku zonke?

I-Lansoprazole ingavikeleka ukusetshenziswa nsuku zonke uma ithathwa njengoba kuyalelwe udokotela. Kodwa-ke, ukusetshenziswa kwansuku zonke isikhathi eside kufanele kube ngaphansi kwesiqondiso sezokwelapha esiseduze ngenxa yezingozi ezingaba khona ezihlobene nokusetshenziswa kwesikhathi eside kwe-proton pump inhibitor. 

5. Ngingakwazi yini ukuthatha i-lansoprazole ebusuku?

Ungathatha i-lansoprazole ebusuku, kodwa isikhathi somthamo singathinta ukusebenza kwayo. Ucwaningo luye lwabonisa ukuthi ukuphuza i-lansoprazole ekuseni ngokuvamile kuphumelela kakhulu ekulawuleni i-acidity usuku lonke, ikakhulukazi ngezikhathi ezihlobene nokudla. Ngaleso sikhathi, umthamo wakusihlwa ungase uzuze iziguli ezinezimpawu ikakhulukazi zasebusuku.

Ucwaningo oluqhathanisa nomthamo wasekuseni nakusihlwa we-lansoprazole luthole ukuthi umthamo wasekuseni wehlise i-acidity ye-intragastric yamahora angu-24 kuya ku-36% yenani le-placebo, uma kuqhathaniswa no-42% womthamo wakusihlwa. Ngakho-ke, thintana nodokotela wakho ukuze uthole isiqondiso esifanele ohlelweni lwakho lwe-dosing.