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UMbendazole

Ubuwazi ukuthi ithebhulethi eyodwa ingaphatha izifo eziningi ezinamagciwane? I-Mebendazole, umuthi onamandla we-antiparasitic, isiphenduke ikhambi lokuxazulula izinkinga ezihlukahlukene zezikelemu. Lesi sidakamizwa esisebenziseka ngezindlela eziningi siye saduma ngenxa yokuphumelela kwaso ekwelapheni izifo ezivamile ezithinta izigidi emhlabeni wonke.

Ake sihlole ukuthi iyini i-mebendazole, ukusetshenziswa kwayo, indlela yokuyisebenzisa kahle, imiphumela engemihle, kanye nezinyathelo zokuphepha ezidingekayo okufanele uzikhumbule. Sizophinde sixoxe ngokuthi i-mebendazole isebenza kanjani emzimbeni kanye nokusebenzisana kwayo neminye imithi.

Iyini iMebendazole?

I-Mebendazole iyimithi enamandla ye-anthelmintic esetshenziselwa ukwelapha izifo ezihlukahlukene zezikelemu. Lo muthi obanzi ubulokhu usetshenziswa iminyaka engaphezu kwengama-40 futhi uthole imvume ye-FDA ezigulini ezindala kuneminyaka emibili. Amaphilisi e-Mebendazole ayasebenza ezinhlotsheni ezimbalwa zezikelemu zamathumbu, okuhlanganisa izikelemu, izikelemu, izikelemu, nezikelemu.

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bhuka i-aphoyintimenti

Ukusetshenziswa kwethebhulethi ye-Mebendazole

Amaphilisi e-Mebendazole anokusetshenziswa okuningi, okuwenza abe yingxenye ebalulekile yezinhlelo eziningi zokwelapha. Kusukela ku-pinworm kuya kuma-hookworms, umuthi we-mebendazole uqondise izimuncagazi ezahlukene ezikwazi ukudala izinkinga zempilo ezingathi sína uma ziyekwa zingalashwa. 

Ngaphezu kokusetshenziswa okugunyaziwe, i-mebendazole inezicelo ezimbalwa ezingekho kulebula. Lokhu kuhlanganisa ukwelapha izifo ze-nematode zamathumbu ezibangelwa i-capillariasis, i-cystic echinococcosis, i-toxocariasis, i-trichinellosis, ne-trichostrongyliasis. 

Ucwaningo lwakamuva luphinde lwabonisa ukuthi i-mebendazole ingaba namandla ku-oncology, ikakhulukazi ekwelapheni amaseli amelana nemithi yokwelapha egunyaziwe. Ibonise umsebenzi we-cytotoxic kanye nokubambisana nemisebe ye-ionizing kanye nama-chemotherapeutic agents, okuvuselela ukusabela komzimba kwamasosha omzimba.

Isetshenziswa kanjani i-Mebendazole Tablets

Abantu kufanele baphuze amaphilisi e-mebendazole njengoba eyalelwe udokotela wabo. Umthamo uncike ekuqhubekeleni phambili kwesifo kanye nokusabela ekwelashweni. 

  • Abantu ngabanye bangathatha i-mebendazole ngokudla noma ngaphandle kokudla. 
  • Endabeni yamaphilisi ahlafunwayo, abantu bangahlafuna futhi bagwinye ithebhulethi lonke noma bayichoboze futhi bayixube nokudla. 
  • Kulabo abanenkinga yokugwinya, faka ithebhulethi kusipuni bese wengeza u-2 kuya ku-3 mL wamanzi. Ithebhulethi izomunca amanzi futhi yakhe isisindo esithambile okulula ukusigwinya.
  • Odokotela bavame ukunikeza umthamo owodwa we-mebendazole ezifweni zesikelemu. Ezinye izifo ezivamile zezikelemu, njengezikelemu eziyindilinga noma izikelemu, ngokuvamile zidinga ukuthatha i-mebendazole kabili ngosuku (ekuseni nakusihlwa) izinsuku ezintathu. 
  • Ukuze uvimbele ukutheleleka ukuthi kungabuyeli, qeda yonke inkambo yokwelashwa, ngisho noma izimpawu ziba ngcono. Udokotela wakho angase ancome ukwelashwa kwesibili ngemva kwamasonto ambalwa uma kunesidingo.

Imiphumela Emibi Yezibhebhe ze-Mebendazole

Amaphilisi e-Mebendazole angabangela imiphumela ethile engemihle, nakuba kungebona bonke ababhekana nayo. Imiphumela emibi evamile ihlanganisa: 

Imiphumela emibi kakhulu, nakuba ingavamile, yilezi: 

  • Izinkinga zesibindi, njengokuphuzi kwamehlo noma isikhumba 
  • Ukulingana noma ukuquleka
  • Izimpawu zokutheleleka (umkhuhlane, amakhaza, noma umphimbo obuhlungu)
  • Ukungezwani nomzimba okungathi sína (i-anaphylaxis) kuhlanganisa izindebe ezingazelelwe, umlomo, umphimbo, noma ukuvuvukala kolimi, ubunzima bokuphefumula, nokushintsha kwesikhumba. 

Ukuqapha

Amaphilisi e-Mebendazole adinga ukucatshangelwa ngokucophelela ngaphambi kokusetshenziswa, okuhlanganisa: 

  • Umlando Wezokwelapha: Abantu ngabanye kufanele bazise udokotela wabo mayelana nokungezwani komzimba nezinto ezithile, imishanguzo eqhubekayo, nezithako zemithi noma zamavithamini. Ngenxa yezifundo ezilinganiselwe, umuthi awunconyelwe izingane ezingaphansi kweminyaka emibili ubudala. 
  • Isimo Sesibindi: Iziguli ezinesifo sesibindi kufanele ziyisebenzise ngokuqapha, njengoba isibindi sigaya i-mebendazole. Labo abane-biliary obstruction badinga ukunakwa okukhethekile, njengoba imithi ikhishwa ngokuyinhloko ngohlelo lwe-biliary.
  • Ukukhulelwa Nokuncelisa: abesifazane abakhulelwe kufanele baxoxe ngezingozi nodokotela wabo, njengoba i-mebendazole ihlukaniswa njengomuthi wesigaba C. I-Mebendazole ikhona obisini lwebele, ngakho-ke abesifazane abancelisayo kufanele baqaphele.
  • Ukunakekelwa Kwenhlanzeko: Ukuze uvimbele ukuphinda utheleleke, gcina imikhuba emihle yenhlanzeko. Geza izandla njalo, ikakhulukazi ngaphambi nangemuva kwezimo ezifana nokudla nangemuva kokusebenzisa indlu yangasese. Hlanza izingubo zokulala nezingubo zokulala njalo. Lezi zinyathelo zisiza ukunciphisa ingozi yokubuya kwezifo eziwumshayabhuqe.

Isebenza kanjani i-Mebendazole Tablet

I-Mebendazole, i-benzimidazole anthelmintic, ithinta izikelemu eziyizinambuzane ngokuphazamisa ukwakheka kwazo kweglucose. Isebenza ngokunamathela endaweni ezwela i-colchicine ye-tubulin, evimba ukubola kwama-microtubules kumaseli amathumbu ezinambuzane. Lesi senzo siholela ekulahlekelweni kwama-cytoplasmic microtubules, okwenza kube nzima ukuthi izikelemu zimunce i-glucose nezinye izakhi.

Ngenxa yalokho, izitolo ze-glycogen zezimuncagazi ziyaphela, futhi ukukhiqizwa kwawo kwamandla kuyehla. Lokhu kuntuleka kwamandla kwenza izikelemu zinganyakazi futhi ekugcineni zife. I-Mebendazole iphinde ivimbele amandla ezikelemu ukukhiqiza amaqanda, futhi ivimbele ukusabalala kwezifo.

Umuthi awumuncwe kahle emgudwini wokugaya ukudla komuntu, ngaleyo ndlela uwenze ube indlela yokwelapha ephumelelayo yezifo zezikelemu zamathumbu ezinemiphumela engemihle emincane. Nokho, izinguquko kuphrotheni ye-β-tubulin zingabangela ukumelana, okunganciphisa ukusebenza kwe-mebendazole.

Ngingakwazi Ukuthatha I-Mebendazole Neminye Imithi?

I-Mebendazole ingasebenzisana nemithi ethile, njenge: 

Ulwazi Lomthamo

Umthamo we-Mebendazole uyahlukahluka futhi uncike ohlotsheni lwe-parasitic infection. 

Abantu abadala kanye nezingane ezineminyaka engaphezu kwemibili ubudala ngokuvamile bathatha 100 mg kabili ngosuku izinsuku ezintathu ezilandelanayo ukuze bathole izifo ezivamile zezikelemu, njengezikelemu, izikelemu, nezikelemu. 

Odokotela bavamise ukunikeza umthamo owodwa ongu-100 mg wezifo zezikelemu. Kodwa-ke, uma ukutheleleka kuqhubeka ngemva kwamasonto amathathu, inkambo yesibili yokwelashwa ingase idingeke.

Izinhlobo ezahlukene zomthamo ziyanconywa ezifweni ezinzima kakhulu noma ezingajwayelekile kakhulu. Ukwelashwa kwe-capillariasis kuhilela u-200 mg kabili ngosuku izinsuku ezingu-20, kuyilapho i-trichinosis ingase idinge u-200 kuya ku-400 mg kathathu ngosuku izinsuku ezintathu, kulandele 400 kuya ku-500 mg kathathu ngosuku izinsuku eziyishumi. 

Isiphetho

Amaphilisi e-Mebendazole athinta kakhulu ekwelapheni izifo ezihlukahlukene zezimuncagazi, enikeza ikhambi eliguquguqukayo lokuhlasela kwezikelemu ezivamile. Lo muthi oguquguqukayo uqondise izinhlobo ezihlukene zezimuncagazi, kusukela kuma-pinworm kuya kuma-hookworm, okuwenza ube yithuluzi elibalulekile ekunakekelweni kwezempilo. Ukusebenza kwayo, okuhambisana nemiphumela engemihle emincane ngenxa yokumunca kahle emgudwini wokugaya ukudla, kuqinise indawo yayo njengendawo yokwelapha izifo ze-helminthic zamathumbu.

Nakuba ngokuyinhloko isetshenziselwa ukwelapha izifo zezikelemu, i-mebendazole ibonise isithembiso kwezinye izindawo, okuhlanganisa ukusetshenziswa okungenzeka i-oncology. Njenganoma yimuphi umuthi, ukulandela imiyalelo efanele yomthamo kanye nokwazi ngemiphumela engemihle engase ibe khona kanye nokusebenzisana neminye imithi kubalulekile ukuze kuqinisekiswe ukwelashwa okuphephile nokusebenzayo.

Imibuzo Evame Ukubuzwa

1. Isetshenziselwa ini i-mebendazole?

I-Mebendazole iyasebenza ekwelapheni izifo ezihlukahlukene zezikelemu zamathumbu, okuhlanganisa izikelemu, izikelemu, izikelemu, nezikelemu. Isebenza ngempumelelo ekwelapheni izifo ezibangelwa izikelemu zamathumbu emgudwini wamathumbu.

2. I-mebendazole kufanele ithathwe izinsuku ezingaki?

Ubude besikhathi sokwelashwa kwe-mebendazole buncike ohlotsheni lokutheleleka. Ngezikelemu, umthamo owodwa wanele. Kwezinye izifo ezivamile zezikelemu ezifana nezikelemu noma izikelemu, ngokuvamile zithathwa kabili ngosuku izinsuku ezintathu. Udokotela wakho uzokweluleka ngeshejuli yemithamo efanele.

3. Ingabe i-mebendazole iphephile?

Amaphilisi e-Mebendazole ngokuvamile abekezelelwa kahle uma ethathwa njengoba kuyalelwe. Kodwa-ke, njengayo yonke imithi, ingabangela imiphumela engemihle njenge ubuhlungu besisu, isicanucanu, kanye nesifo sohudo.

4. Ngingakwazi ukuthatha i-mebendazole kabili?

Ngezinye izikhathi, inkambo yesibili ye-mebendazole ingadingeka. Uma ukutheleleka kuqhubeka ngemva kwamasonto amathathu, udokotela wakho angase atuse ukuphinda ukwelashwa. Kubalulekile ukubonana nodokotela wakho ngaphambi kokuthatha imithamo eyengeziwe.

5. Kufanele ngiyiphuze kanjani i-mebendazole?

Amaphilisi e-Mebendazole angahlafunwa, agwinywe aphelele, achotshozwe futhi ahlanganiswe nokudla. Abantu bangayithatha ngokudla noma ngaphandle kokudla. Labo abanenkinga yokugwinya bangabeka ithebhulethi kusipuni, bayixube no-2 kuya ku-3 mL wamanzi ukuze benze isisindo esithambile futhi bayithathe ngokushesha.

6. Kwenzekani uma ngiphuthelwa umthamo?

Uma weqa umthamo we-mebendazole, yithathe ngokushesha nje lapho ukhumbula. Ungaphindi umthamo ukuze uvale ogejiwe.

7. Kwenzekani uma ngiphuza ngokweqile?

Uma kwenzeka u-overdose, ungase ube nezimpawu ze-gastrointestinal (isicanucanu, ukuhlanza nobuhlungu besisu). Nakuba ubuthi obunzima bungavamile, kubalulekile ukuvakashela esibhedlela ngokushesha uma usola ukuthi ungaphezu kwe-dose. Xhumana nabezimo eziphuthumayo noma udokotela wakho ukuze uthole isiqondiso.