I-Methylprednisolone

I-Methylprednisolone

I-Methylprednisolone, i-synthetic steroid, ilingisa izenzo zamahomoni emvelo akhiqizwa izindlala ze-adrenal. Lezi zinhlayiya ezincane zihlala phezu kwezinso zakho futhi zikhiqize amahomoni asiza ukulawula ukugayeka kokudla emzimbeni wakho. I-Methylprednisolone isetshenziselwa ngokuyinhloko ukunciphisa ukuvuvukala nokwelapha izimo ezihlukahlukene, kuhlanganise nokungezwani komzimba, sokuqaqamba kwamalunga, isifuba somoya, nokuphazamiseka kwesikhumba. Nakuba ngokuvamile iphephile, lesi sidakamizwa singaba nemiphumela emibi, njengokuzuza isisindo, ukushintsha kwemizwelo, nomfutho wegazi ophakeme, ikakhulukazi uma isetshenziswa isikhathi eside. Umthamo kanye nesikhathi salo muthi kufanele kuqashelwe ngokucophelela uchwepheshe wezempilo ukuze kugwenywe ukweqisa izidakamizwa nezinye izinkinga.

Yiziphi izinzuzo ze-Methylprednisolone?

I-Methylprednisolone isebenza njengengxenye ye-hormone ekhiqizwa izindlala ze-adrenal futhi isetshenziselwa ukwenza imisebenzi yayo elindelekile, njengokunciphisa ukuvuvukala nokwelapha izimo ezihlukahlukene zezokwelapha. Izicelo zayo zihlanganisa:

• Izimo Zokuvuvukala: I-Methylprednisolone isetshenziselwa ukwelapha izimo ezihlukahlukene zokuvuvukala, okuhlanganisa i-rheumatoid arthritis, i-osteoarthritis, i-lupus, i-psoriasis, nezifo zamathumbu ezivuthayo ezifana nesifo sika-Crohn kanye ne-ulcerative colitis.
• Ukungezwani komzimba: Inganqunywa ukuphatha ukungezwani okunamandla, okubandakanya lezo ezibandakanya isikhumba, amehlo, nohlelo lokuphefumula.
• Isifuba Somoya: I-Methylprednisolone ingasetshenziswa ekwelapheni i-asthma exacerbations.
• Izifo ze-Autoimmune: Isetshenziselwa ukucindezela impendulo yokuzivikela komzimba ezifweni ezizimele njenge-multiple sclerosis kanye ne-systemic lupus erythematosus.
• Izinkinga Zokuphefumula: I-Methylprednisolone ngezinye izikhathi isetshenziswa ezimweni ezingapheli zokuphefumula njengesifo esingenasifo se-pulmonary obstructive (COPD) ukunciphisa ukuvuvukala nokuthuthukisa ukuphefumula.
• Ukufakelwa kwezitho: Isetshenziswa njenge-immunosuppressant kwabamukeli bokufakelwa isitho ukuvimbela ukwenqatshwa kwesitho esitshaliwe.
• AmaCancer athile: Kwezinye izimo, isetshenziswa ekwelapheni umdlavuza ukunciphisa ukuvuvukala nokuphatha imiphumela emibi ye-chemotherapy.
• Izimo ze-Dermatological: I-Methylprednisolone ingasetshenziswa ekwelapheni izifo zesikhumba njenge-eczema kanye nezimo ezinzima ze-hives (urticaria).
• Izimo Zemizwa: Ezimweni ezithile zezinzwa, njengokulimala okunzima komgogodla, umthamo ophezulu we-Methylprednisolone usetshenziselwa ukunciphisa ukuvuvukala nokunciphisa ukulimala kwezinzwa.

Kanjani futhi nini ukuthatha Methylprednisolone?

I-Methylprednisolone ivamise ukunikezwa ngomlomo njengethebhulethi, umthamo kanye nohlelo olunqunywa udokotela ngokusekelwe esimweni sesiguli. Njengoba umuthi uthinta ibhalansi ye-hormonal, kubalulekile ukulandela uhlobo olunqunyiwe ngokunembile futhi ungalungisi umthamo ngaphandle kokubonana nodokotela. Nakuba umuthi ungaveza impumuzo ezinsukwini ezimbalwa, kubalulekile ukuqhubeka uphuza imithi kuze kube yilapho udokotela eyala okunye. 

Ukuyeka umuthi kungazelelwe kungabangela ukusabela okungekuhle njengokungathandi ukudla, ukudideka, ukuhlanza, ukozela, ikhanda elibuhlungu, ubuhlungu bamalunga nemisipha, nokuxebuka kwesikhumba. Ngakho-ke, kubalulekile ukufuna isiqondiso ku-a umhlinzeki wezempilo ngaphambi kokuyeka lo muthi.

Iyini imiphumela emibi ye-Methylprednisolone?

Lesi sidakamizwa singadala imiphumela engemihle evamile, njengoba ibalwe ngezansi. 

• bekhanda
• Ukuvota
• isiyezi
• Insomnia
• induna
• ukukhathazeka
• Ukucasuka kwesisu
• Ukuphumula
• Umzimba uba ntekenteke
• Ukucindezeleka
• Ukwanda kwezinwele

Nakuba imiphumela emibi ye-methylprednisolone ngokuvamile ingeyesikhashana, kubalulekile ukwazisa udokotela uma izimpawu ziqhubeka noma ziba nzima.

Yiziphi izinyathelo zokuphepha okufanele zithathwe?

Ngaphambi kokuthatha i-Methylprednisolone, kubalulekile ukugcina lezi zinyathelo zokuphepha engqondweni:

• Dalula noma yikuphi ukungezwani komzimba ne-Methylprednisolone, i-aspirin, i-tartrazine, noma ezinye izidakamizwa.
• Yazisa udokotela nganoma yimiphi imithi kadokotela noma engeyona ekadokotela ethathwayo njengamanje, ikakhulukazi ama-anticoagulants, i-arthritis, i-aspirin, i-clarithromycin, i-cyclosporine, nama-diuretics.
• Gwema ukuthatha i-Methylprednisolone uma uhlushwa ukutheleleka kwefungal kunoma iyiphi ingxenye yomzimba ngaphandle kwesikhumba.
• Dalula noma yimuphi umlando wangaphambili wesibindi, izinso, inhliziyo, noma isifo samathumbu, isifo sikashukela, indlala yegilo engasebenzi kahle, ukugula ngengqondo, noma umfutho wegazi ophakeme.
• Yazisa udokotela nodokotela wamazinyo uma uhlela ukuhlinzwa amazinyo ngenkathi uthatha i-Methylprednisolone.
• Nciphisa ukuphuza utshwala ngenkathi uthatha i-Methylprednisolone, njengoba ingandisa ingozi yokopha kwesisu nezinye izinkinga.

Kuthiwani uma uphuthelwa umthamo we-Methylprednisolone?

Uma umthamo we-Methylprednisolone weqiwa ngenkathi uyithatha kanye ngosuku, ingase ithathwe ngokushesha njengoba ukhunjulwa, kodwa ukuthatha imithamo emibili ngesikhathi esisodwa ukuze kunxephezele lowo ophuthelwe akunconywa. Uma sekusondele isikhathi somthamo olandelayo, kuyatuseka ukuthi weqe umthamo futhi uqhubeke neshejuli evamile. Kubalulekile ukubonana nodokotela ngaphambi kokuqala i-Methylprednisolone ukuthola ukuthi yini okufanele uyenze uma umthamo weqiwe.

Kuthiwani uma uthatha i-overdose ye-Methylprednisolone?

Ukweqisa kwe-Methylprednisolone kungase kubangele ukukhuphuka komfutho wegazi, ukugcinwa kukasawoti namanzi, kungase kubangele ukuvuvukala ezingalweni zakho, imilenze, noma ezinyaweni. Kungehlisa futhi amazinga e-potassium egazini, okuholela ekubeni buthaka, amajaqamba emisipha, ukukhathala, njll. 

Yiziphi izimo zokugcina i-Methylprednisolone?

• Lesi sidakamizwa kufanele sigcinwe ekamelweni lokushisa. Ukuyigcina phakathi kuka-20 - 25C (68 - 77F) kufaneleka kakhulu. 

• Gcina umuthi ebhokisini ofike kuwo futhi kude nalapho izingane zingafinyeleleki khona. Akufanele igcinwe ezindaweni ezimanzi noma ezimanzi.

Isexwayiso ngeminye imithi

Imithi elandelayo ingaphazamisa ukusebenza kweMethylprednisolone: 

• Igazi elincane
• Izidakamizwa ezingezona ukuvuvukala (ama-NSAID)
• Imithi yesifo sikashukela
• I-Ketoconazole
• Phenytoin futhi Phenobarbital
• I-Paxlovid
• Imithi ethile yokugoma ephilayo.

I-Methylprednisolone ibonisa ngokushesha kangakanani imiphumela?

I-Methylprednisolone isebenza ngokushesha. Ngokuvamile ifinyelela umphumela wayo omkhulu ngemva kwehora. Umphumela omkhulu ugcinwa cishe amahora amabili. 

I-Methylprednisolone vs Prednisone 

Imibuzo Evame Ukubuzwa

1. Ingabe i-methylprednisolone izobangela ukukhuluphala?

I-Methylprednisolone ingabangela ukuzuza kwesisindo njengenye yemiphumela yayo emibi. Ukuzuza isisindo kuwumphumela ovamile oseceleni wemithi ye-corticosteroid efana ne-Methylprednisolone, ikakhulukazi uma isetshenziswa isikhathi eside noma ngemithamo ephezulu.

2. Ingabe i-methylprednisolone iyi-antibiotic?

I-Methylprednisolone ayiyona i-antibiotic. Kuyimithi ye-corticosteroid esetshenziselwa ukunciphisa ukuvuvukala ezimeni ezihlukahlukene zezokwelapha.

3. Ngingakwazi yini ukuphuza utshwala ngenkathi ngithatha i-methylprednisolone?

Ngokuvamile kuhle ukugwema utshwala ngenkathi uthatha i-Methylprednisolone, njengoba utshwala bungandisa ingozi yemiphumela ethile engathandeki, okuhlanganisa ukucasuka kwesisu kanye nethuba lezilonda zesisu. Utshwala bungaphazamisa nokusebenza komuthi.

4. Iyini imiphumela emibi ye-methylprednisolone?

Imiphumela emibi ye-Methylprednisolone ingabandakanya ukuzuza kwesisindo, ukwanda kwesifiso sokudla, ukushintsha kwemizwelo, ukuphazamiseka kokulala, ukucindezelwa kwegazi okwandayo, ukugcinwa kwamanzi, kanye nesimiso sokuzivikela esibuthakathaka, phakathi kwabanye. Imiphumela emibi kakhulu ingase yenzeke ngokusetshenziswa isikhathi eside noma umthamo ophezulu, ngakho-ke kubalulekile ukusebenzisa lo muthi ngokweseluleko sikadokotela.

5. Yiziphi ukusetshenziswa kwe-methylprednisolone?

Ukusetshenziswa kwe-Methylprednisolone kuhlanganisa ukwelapha izimo eziningi zezokwelapha ezibandakanya ukuvuvukala, njenge-rheumatoid arthritis, i-allergies, isifuba somoya, izifo ezizimele, izifo zesikhumba, izimo zokuphefumula, nezinye izinhlobo zomdlavuza, phakathi kwabanye. Ukusetshenziswa okuqondile kwe-Methylprednisolone kuncike esimweni sesiguli kanye nesincomo sikadokotela.

References:

https://www.mayoclinic.org/drugs-supplements/Methylprednisolone-oral-route/description/drg-20075237 https://my.clevelandclinic.org/health/drugs/4812-corticosteroids
https://www.uptodate.com/contents/Methylprednisolone-drug-information/print#:~:text=Day%201%3A%2024%20mg%20on,regardless%20of%20time%20of%20day

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