I-Minoxidil

I-Minoxidil

I-Minoxidil isidakamizwa esiyingxenye yezidakamizwa ezibizwa ngokuthi ama-vasodilators. Ama-Vasodilator yizidakamizwa ezinwebekayo futhi ngaleyo ndlela zikhulule imithambo yegazi, okwenza uketshezi lugeleze kalula kuyo. Ekuqaleni yayisetshenziselwa ukwelapha umfutho wegazi ophakeme, kodwa ukusetshenziswa kwayo kuye kwanda ngokuhamba kwesikhathi.

Ukusetshenziswa kwe-Minoxidil njenge-vasodilator kubangele umphumela owodwa obalulekile okuthiwa i-Hypertrichosis. I-Hypertrichosis idala izinwele ezinde ngokweqile ukuthi zikhule noma kuphi emzimbeni wabesilisa nabesifazane. Lokhu kwaholela ekusetshenzisweni kwe-topical Minoxidil ukwelapha impandla yephethini yabesilisa kanye ukukhula kwezinwele.

Yiziphi izici zokusetshenziswa kwe-Minoxidil?

I-Minoxidil isetshenziselwa ukulawula umfutho wegazi. I-Minoxidil itholakala ngomlomo njengethebhulethi futhi iyatholakala njengokhilimu we-topical kanye namagwebu phezu kwekhawunta. I-Minoxidil inokusetshenziswa okulandelayo:

• I-topical minoxidil ikhonjiswe ukuthi isetshenziselwe i-androgenetic alopecia futhi ivunyelwe yi-FDA. Ingase futhi isetshenziselwe ngaphandle kwelebula ekwelapheni ezinye izimo ezihlobene nokulahlekelwa izinwele njenge-alopecia areata, ukuthuthukiswa kwentshebe, i-alopecia ebangelwa ngamakhemikhali, ukuthuthukiswa kwamashiya, i-frontal fibrosing alopecia, kanye ne-alopecia enezibazi.

• Isixazululo se-Minoxidil kanye negwebu zisetshenziselwa ukwelapha impandla yamadoda. Isixazululo se-Minoxidil esingu-2% singaba yinzuzo ekwelapheni ukuncipha kwezinwele kwabesifazane.

• Amaphilisi e-Oral Minoxidil angamiselwa udokotela ukwelapha umfutho wegazi ophakeme noma umfutho wegazi ophezulu njengoba ephumuza imithambo yegazi futhi ehlisa nomfutho wegazi.

Ungayithatha kanjani futhi nini iMinoxidil?

Amaphilisi e-Oral Minoxidil

Amaphilisi e-Oral minoxidil kufanele asetshenziswe kuphela lapho eyalelwe ngudokotela. Amaphilisi e-Minoxidil angathathwa ngokudla noma ngaphandle kokudla njengoba eyalelwe udokotela. Amaphilisi angagwinywa ngamanzi. Odokotela bavame ukunikeza umthamo owodwa noma emibili ngosuku. Kungcono uma amaphilisi athathwa ngesikhathi esifanayo nsuku zonke.

I-Minoxidil ye-topical

I-Minoxidil itholakala ngendlela yesisombululo noma igwebu. Ingasetshenziswa ngqo esikhumbeni ukukhuthaza ukukhula kwezinwele kwabesilisa nabesifazane. Faka umthamo njengoba unqunywe udokotela endaweni ethintekile kanye noma kabili ngosuku.

Ungayisebenzisa kanjani i-minoxidil?

Nansi inkomba yesinyathelo ngesinyathelo sendlela yokusebenzisa i-minoxidil ekukhuleni kwezinwele:

• Lungiselela Ikhanda Lakho: Geza izinwele zakho nge-shampoo emnene bese usomisa ngobumnene ngethawula. Qinisekisa ukuthi isikhumba sakho somile ngokuphelele ngaphambi kokufaka i-minoxidil.
• Hlukanisa Izinwele Zakho: Sebenzisa ikamu noma iminwe yakho ukuze uhlukanise izinwele zakho ukuze uveze izindawo zesikhumba lapho ufuna ukufaka khona i-minoxidil.
• Faka i-Minoxidil: Sebenzisa isifakeli esihlinzekiwe noma i-dropper ukuze usebenzise inani elinconyiwe lesisombululo se-minoxidil noma igwebu ngqo esikhumbeni sekhanda ezindaweni zokuncipha noma ukulahleka kwezinwele. Umthamo ojwayelekile ngu-1 ml osetshenziswa kabili ngosuku (ekuseni nakusihlwa).
• Ukubhucunga Ufake Ekhanda: Gcoba kancane i-minoxidil ekhanda lakho usebenzisa iminwe yakho. Qinisekisa ukuthi usakaza isisombululo ngokulinganayo phezu kwezindawo ezihlosiwe.
• Vumela Ukoma: Vumela i-minoxidil yome ngokuphelele ngaphambi kokupenda izinwele zakho noma ukulala. Gwema ukusebenzisa umshini wokomisa izinwele ukusheshisa inqubo yokomisa.
• Ungazigezi Noma Izinwele Ezimanzi Ngokushesha: Ungagezi izinwele zakho noma isikhumba sekhanda okungenani amahora angu-4 ngemva kokufaka i-minoxidil. Lokhu kuvumela imithi ukuthi ingene kahle esikhumbeni sekhanda.
• Faka isicelo kabili ngosuku: i-Minoxidil iphumelela kakhulu uma isetshenziswa kabili ngosuku, kanye ekuseni nakanye kusihlwa. Ukungaguquguquki kuyisihluthulelo sokubona imiphumela.
• Yiba Nesineke: Ukukhula kabusha kwezinwele nge-minoxidil kungase kuthathe izinyanga ezimbalwa zokusetshenziswa okuqhubekayo. Imiphumela iyahlukahluka kumuntu nomuntu, ngakho yiba nesineke futhi uqhubeke usebenzisa njengoba uyalelwe.
• Gwema Ukuthintana Namehlo Nezinye Izindawo: Qaphela ukuthi ugweme ukufaka i-minoxidil emehlweni akho, emlonyeni, noma kwezinye izindawo ezibucayi. Uma kwenzeka ukuthintana ngephutha, hlambulula kahle ngamanzi.
• Gada Imiphumela Eseceleni: Buka noma yiziphi izimpawu zokucasuka kwesikhumba, ububomvu, noma ukulunywa. Uma uhlangabezana nanoma yikuphi ukusabela okungekuhle, yeka ukusebenzisa futhi uxhumane nomhlinzeki wakho wokunakekelwa kwezempilo.
• Qhubeka Sebenzisa Njengoba Kuqondiswe: Ukuze ugcine izinwele zikhula, qhubeka usebenzisa i-minoxidil njalo njengoba kunconywe umhlinzeki wakho wezempilo noma imiyalelo yomkhiqizo.

Yimiphi imiphumela emibi ye-Minoxidil?

Yonke imithi ingase ibe nemiphumela ethile engemihle. Imiphumela emibi ye-Minoxidil ihlanganisa:

• Isiyezi noma ikhanda elikhanyayo.
• Ukuphelelwa amandla
• Ukushaya kwenhliziyo okusheshayo
• Ukukhula noma ukufiphala kwezinwele ezinhle zomzimba
• Ukuphelelwa umoya
• Ukuvuvukala emaqakaleni/ezinyaweni
• Ukukhathala
• Ukuzuza kwesisindo okungajwayelekile/okuzumayo

 Amagwebu ajwayelekile nezisombululo zingaba nemiphumela engemihle elandelayo:

• Ukuvutha
• ubuhlungu besifuba
• Ukuphefumula kanzima, ikakhulukazi lapho ulele
• isiyezi
• Itching
• Ukuphelelwa amandla
• Ukushaya kwenhliziyo okusheshayo noma okungajwayelekile
• ububomvu
• Ukuvuvukala kwezandla nezinyawo
• Ukukhathala
• Ukuzuza kwesisindo okungajwayelekile
• Uboya obungafunwa ebusweni noma bomzimba

Nakuba kungavamile, imiphumela emibi kakhulu ye-oral minoxidil iye yabikwa, njengokuhluleka kwenhliziyo ehlangene, isifo senhliziyo ye-ischemic, i-pulmonary hypertension, kanye nokugcinwa kwe-sodium noketshezi, ukusabela okungathi sína kwe-allergic ku-minoxidil akuvamile. Kodwa-ke, uma ukungezwani okukhulu komzimba kwenzeka noma eminye imiphumela emibi iphikelela, thintana nodokotela wakho ngokushesha.

Isebenza kanjani i-minoxidil ukuze ikhuthaze ukukhula kwezinwele?

I-Minoxidil isebenza ukukhuthaza ukukhula kwezinwele ngalezi zindlela ezilandelayo:

• Ukwandisa Imithambo yegazi (Vasodilation): I-Minoxidil ivula imithambo yegazi esikhumbeni, ithuthukise ukugeleza kwegazi ezimpandeni zezinwele. Lokhu kuletha umoya-mpilo owengeziwe, izakhi, kanye nezici zokukhula ku-follicles, okubalulekile ekukhuleni kwezinwele okunempilo.
• Ukuthuthukisa Ukujikeleza Kwegazi: Ngokwandisa ukugeleza kwegazi ekhanda, i-minoxidil idala indawo engcono yokukhula kwezinwele zezinwele. Ukujikeleza okuthuthukisiwe kondla ama-follicle futhi kusekela umjikelezo wabo wokukhula.
• Ukuvula Iziteshi zePotassium: I-Minoxidil ivula iziteshi ezithile kumaseli ezinwele zezinwele, ezithinta ulwelwesi lwamaseli. Le nqubo ingaba nomthelela ekwandeni komsebenzi wokukhula kwezinwele.
• Ukwandisa Isigaba Sokukhula Kwezinwele (Isigaba Se-Anagen): I-Minoxidil isiza ukunweba isigaba sokukhula esisebenzayo somjikelezo we-follicle yezinwele. Lokhu kusho ukuthi izinwele zihlala esigabeni sokukhula isikhathi eside, okuholela emicu yezinwele ezinde futhi eziminyene ngokuhamba kwesikhathi.
• I-Stimulating Dermal Papilla Cells: I-Minoxidil ingashukumisa amangqamuzana e-dermal papilla, abalulekile ekuthuthukiseni i-follicle yezinwele nokukhula. Lokhu kugqugquzela kusiza ukuqalisa nokugcina izinwele zikhula.
• Ukuvuselela Umsebenzi We-Follicle Yezinwele: Ezimweni ezifana ne-androgenetic alopecia (impandla yephethini), izimpande zezinwele zingashwabana noma zingasebenzi. I-Minoxidil ingasiza ukuvuselela la ma-follicle, okuholela ekukhuleni kwezinwele eziqinile neziqinile.

Izixwayiso ze-Minoxidil

I-Minoxidil inamandla okubangela ukusabela okunamandla kwe-allergic. Izimpawu zihlanganisa:

• Ubunzima bokuphefumula
• Ukuvuvukala emphinjeni noma olimini
• Ukuthuthukiswa kwesifuba.

Yiziphi izinyathelo zokuphepha okufanele zithathwe ngenkathi usebenzisa i-Minoxidil?

Gcina izinkomba ezilandelayo engqondweni lapho uthatha i-Minoxidil:

• Funda leli pheshana ngokucophelela ngaphambi kokusebenzisa umuthi.
• Sebenzisa i-minoxidil kuphela ngokweseluleko sikadokotela.
• Yazisa udokotela nganoma yikuphi ukungezwani komzimba okukhona ngaphambili noma izimo zempilo.
• Landela umthamo oshiwo udokotela.
• Abesifazane abakhulelwe kanye/noma abancelisayo kufanele baxoxe nodokotela wabo uma benikezwe iMinoxidil ukuze belaphe isimo esithile.
• Okwamanje alukho ucwaningo noma ulwazi mayelana nokuthi i-minoxidil ithuthukisa kanjani ukukhula kwezinwele. Ngakho-ke, akufanele isetshenziselwe ukwelapha ukulahleka kwezinwele okungazelelwe noma ukulahleka kwezinwele kwangemva kokubeletha.
• Abantu abangaphansi kweminyaka engu-18 nangaphezulu kweminyaka engama-65 kufanele bakhulume ngobungozi nezinzuzo nodokotela wabo uma benikezwe iMinoxidil.

Kuthiwani uma uphuthelwa umthamo we-Minoxidil?

Uma weqa umthamo, ungaweqa futhi uqhubeke nomthamo ojwayelekile. Ukugcina isikhawu sesikhathi esifanelekile phakathi kwemithamo emibili Uma kuyisikhathi sethamo elilandelayo, kuhle ukweqa umthamo ogejiwe we-Minoxidil. Kunoma yikuphi, ungathathi imithamo emibili ndawonye ukuze ulinganise umthamo ogejiwe.

Kuthiwani uma usebenzisa i-Minoxidil ngokweqile?

Umthamo we-minoxidil kufanele uqashwe ngokucophelela. Thatha umthamo kuphela njengoba kunqunywe udokotela. Uma kwenzeka weqile, phuthuma esibhedlela esiseduze.

Yiziphi izimo zokugcina zeMinoxidil?

Kumelwe igcinwe ekamelweni lokushisa kude nokushisa ngokweqile, umswakama nokukhanya kwelanga. Izixazululo ze-Minoxidil namagwebu kufanele zivalwe ngokuqinile futhi zigcinwe kude nezingane nezilwane ezifuywayo. Ungalokothi uwushaye phansi endlini yangasese noma uwuthululele emseleni. Funda imiyalelo epheshaneni ukuze ulahle umuthi ngokucophelela.

Izixwayiso nokucatshangelwa ngaphambi kokusebenzisa i-minoxidil

Ngaphambi kokusebenzisa i-minoxidil ekukhuleni kwezinwele, kubalulekile ukuqaphela izexwayiso nokucatshangelwa okuningana:

• Ukubonisana Nochwepheshe Wezokunakekelwa Kwezempilo: Ngaphambi kokuqala ukwelashwa kwe-minoxidil, thintana nodokotela wesikhumba noma umhlinzeki wezempilo, ikakhulukazi uma unezimo zempilo ezicashile noma uthatha eminye imithi. Bangahlola isimo sakho esithile futhi batuse ukwelashwa okufanele.
• Qonda Imbangela Yokulahleka Kwezinwele: I-Minoxidil iphumelela kakhulu ezinhlotsheni ezithile zokulahlekelwa izinwele, njengempandla yesilisa nesesifazane (i-androgenetic alopecia). Angase angafaneleki ukulahlekelwa izinwele okubangelwa ezinye izici ezifana nokuntuleka kokudla okunomsoco, ukungalingani kwamahomoni, noma izimo zezokwelapha. Ukuqonda imbangela eyinhloko yokulahlekelwa izinwele kubalulekile ekukhetheni ukwelashwa okufanele.
• Imiyalelo yohlelo lokusebenza: Landela imiyalelo enikezwe umhlinzeki wakho wokunakekelwa kwezempilo noma kulebula yemithi yokufaka i-minoxidil. Ngokuvamile, isetshenziswa esikhumbeni kanye noma kabili ngosuku. Sebenzisa kuphela inani elinconyiwe futhi ugweme ukulisebenzisa kwezinye izingxenye zomzimba.
• Ukusetshenziswa Okungaguquki Nesineke: I-Minoxidil idinga ukusetshenziswa okungaguquki nesikhathi eside ukuze ubone imiphumela. Ukukhula kwezinwele kungase kungabonakali izinyanga ezimbalwa, futhi ukusetshenziswa okuqhubekayo kuyadingeka ukuze kugcinwe imiphumela. Yiba nesineke futhi ulandele uhlobo lokwelashwa njengoba uqondiswa.
• Imiphumela Engase Engase Ibizwe: Imiphumela emibi evamile ye-minoxidil ihlanganisa ukucasuka kwesikhumba, ukoma, ukulunywa, nokucwayiza. Kwezinye izimo, kungase kubangele ukukhula kwezinwele okungafunwa ezindaweni ezingaphandle kwesikhumba. Imiphumela engemihle engavamile kodwa eyingozi ingase ihlanganise isiyezi, ukushaya kwenhliziyo okusheshayo, nobuhlungu besifuba. Yeka ukusebenzisa i-minoxidil futhi ufune usizo lwezokwelapha uma uhlangabezana nemiphumela emibi kakhulu.

Ngingakwazi ukuthatha i-Minoxidil neminye imithi?

I-Minoxidil ingasebenzisana ne-guanethidine, i-disulfiram, ne-metronidazole. Uma uthatha noma yimiphi eminye imithi engase ikukhulise ukushaya kwegazi, yazisa udokotela wakho ngaphambi kokuthatha i-Minoxidil nayo. I-Minoxidil yaziwa nangokuthi ithebhulethi yomfutho wegazi. Ungathintana nodokotela uma kudingekile ukuthatha le mithi noma eminye imithi enqunyiwe nge-Minoxidil. Odokotela banganikeza enye indlela ephephile kulesi simo.

Umthamo we-Minoxidil

Ngesixazululo sesihloko (2% noma 5%):

• Faka i-1 ml yesisombululo ezindaweni ezithintekile ze-scalp kabili ngosuku.
• Umthamo wansuku zonke ophelele akufanele udlule u-2 mL kungakhathaliseki ukuthi kugxilwe kangakanani.

I-Minoxidil izokhombisa ngokushesha kangakanani imiphumela? 

Ukuze ukwelashwa kokulahlekelwa izinwele, i-minoxidil yomlomo ingathatha izinyanga ezi-6-12 ukukhombisa imiphumela.

I-Minoxidil vs Redensyl

Isiphetho

I-Minoxidil isetshenziselwa kabanzi ukwelapha izimo eziningana ngezindlela zayo ezihlukahlukene. Kodwa-ke, kufanele kuqashelwe ukuthi indlela eqondile yokusebenza ye-minoxidil ayikaqondwa ngokugcwele ezimweni ezihlukahlukene. Nakuba i-topical minoxidil itholakala ngaphandle kwencwadi kadokotela, kutuswa kakhulu ukuthi yonke imithi isetshenziswe kuphela ngemva kokubonisana nodokotela.

References:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691938/ https://www.webmd.com/drugs/2/drug-3503/minoxidil-topical/details https://www.mayoclinic.org/drugs-supplements/minoxidil-topical-route/side-effects/drg-20068750?p=1 https://medlineplus.gov/druginfo/meds/a689003.html