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I-Nortriptyline

I-Notriptyline, isidakamizwa esisebenza ngezindlela eziningi, ibilokhu yenza amagagasi emhlabeni wezokwelapha. Le mithi enamandla ingeyesigaba sezidakamizwa ezaziwa ngokuthi ama-tricyclic antidepressants futhi ibonakale iwusizo ekucindezelekeni nasezinhlungwini ezingapheli. 

Masiqonde ukuthi iyini i-nortriptyline yesidakamizwa nokuthi ingakusiza kanjani. Sizofaka ukusetshenziswa kwayo, kusukela ekwelapheni ukudangala kuya ekulawuleni ubuhlungu bezinzwa, imiphumela engemihle engase ibe khona, izinyathelo zokuphepha ezibalulekile, nokuthi i-nortriptyline isebenza kanjani emzimbeni wakho.  

Iyini i-Notriptyline?

I-Notriptyline imithi enamandla esesigabeni sezidakamizwa esibizwa ngokuthi i-tricyclic antidepressants (TCAs). Isetshenziselwa ukwelapha ukucindezeleka, kodwa odokotela babuye bayinikeze ezinye izimo. Uzothola isidakamizwa i-nortriptyline sitholakala njengamaphilisi noma uketshezi, oluthathwe ngomlomo. Lo muthi oguquguqukayo unyusa amazinga amakhemikhali athile emvelo ebuchosheni bakho, ikakhulukazi i-norepinephrine ne-serotonin, esiza ukugcina ukulinganisela kwengqondo.

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Ukusetshenziswa kwethebhulethi ye-Notriptyline

  • Amaphilisi e-Notriptyline anezinhlobonhlobo zokusetshenziswa, ikakhulukazi ekwelapheni ukuphazamiseka okukhulu kokucindezeleka. 
  • Odokotela banikeza lo muthi ukusiza ukubuyisela ukulingana kwamakhemikhali ebuchosheni, ukuthuthukisa isimo sengqondo nokuziphatha. 
  • I-Notriptyline nayo iyasebenza ekulawuleni izimo ezibuhlungu ezingapheli. 
  • I-Notriptyline nayo iyasiza ekudambiseni ubuhlungu be-neuropathic, kuhlanganise ne-diabetic neuropathy kanye ne-postherpetic neuralgia.

Kwezinye izimo, odokotela bangase batuse i-nortriptyline ukuze isetshenziswe ngaphandle kwelebula, njenge: 

Isetshenziswa kanjani i-Notriptyline Tablets

  • Kufanele uphuze amaphilisi e-nortriptyline njengoba nje esho udokotela wakho. Ngokuvamile, uzoyithatha kanye ngosuku, okungcono ngaphambi kokulala, ngoba ingakwenza ulale. Uma kuthinta ukulala kwakho, zama ukukuthatha kusenesikhathi kusihlwa. 
  • Abantu bangaphuza amaphilisi ngokudla noma ngaphandle kokudla. Zigwinye ziphelele ngamanzi; ungawahlafuni njengoba enambitha okubabayo.
  • Uma ukhohlwa umthamo we-nortriptyline, yithathe ngokushesha nje uma ukhumbula ngaphandle uma sekusondele isikhathi sakho esilandelayo. Uma kunjalo, yeqa okugejiwe futhi uqhubeke nesimiso sakho esivamile. Ungalokothi uphindwe kabili umthamo ukuze wenze lowo okhohliwe.
  • Gcina amaphilisi e-nortriptyline esitsheni esivalwe ngci ekamelweni lokushisa.

Imiphumela Emibi Yezibhebhe ze-Notriptyline

Amaphilisi e-Notriptyline angaba nemiphumela engemihle esukela kokumaphakathi ukuya kokuqina. Imiphumela emibi evamile ihlanganisa:

Imiphumela emibi kakhulu, nakuba ingajwayelekile, ihlanganisa:

  • Ukungezwani komzimba okukhulu
  • Imicabango yokuzibulala
  • Ukudideka
  • Ukwanda komfutho wamehlo
  • Izinguquko kusigqi senhliziyo
  • Izinguquko kumfutho wegazi
  • Izimpawu ze-serotonin syndrome- Uma ubona izimpawu ezifana nobunzima bokuphefumula, ubuhlungu besifuba, ukudideka, noma izinguquko ezinzima zemizwa, funa usizo oluphuthumayo ngokushesha.

Ukuqapha

Lapho uthatha i-nortriptyline, udinga ukuqaphela izinyathelo ezimbalwa ezibalulekile, okuhlanganisa: 

  • Ukuqapha Kwemithi: Abantu ngabanye kufanele bagweme ukusebenzisa i-nortriptyline ngemithi ethile, ikakhulukazi i-monoamine oxidase (MAO) inhibitors. Kudingeka kube negebe okungenani lamasonto amabili phakathi kokumisa eyodwa nokuqala enye. Yazisa udokotela wakho ngayo yonke imithi eqhubekayo, amavithamini, nezithako zemithi.
  • Izinkinga Zenhliziyo: I-Notriptyline ingase futhi yandise ingozi yezinkinga zenhliziyo, ngakho tshela udokotela wakho uma unezinkinga zenhliziyo nemithambo yegazi. 
  • Izinkinga Zokuqwashisa: Qaphela lapho ushayela noma wenza imisebenzi edinga ukuqapha, njengoba i-nortriptyline ingabangela ukozela.
  • Izinkinga zamehlo: I-Notriptyline ingase ikhulise ukucindezeleka kwamehlo, ngakho tshela udokotela wakho uma unomlando we-glaucoma.
  • Abadala: Abantu abadala bangase bazwele kakhulu emiphumeleni engemihle, ikakhulukazi ukudideka kanye nezinguquko zomfutho wegazi.
  • Ukuqapha Okuvamile: Udokotela wakho kufanele ahlole ukuqhubeka kwakho njalo futhi angase acele ukuhlolwa kwegazi ukuze aqaphe noma yimiphi imiphumela engadingeki. Kuyisibopho ukwazisa udokotela wakho uma uhlangabezana nanoma yiziphi izinguquko esimweni sakho sengqondo, njengokwanda kokucindezeleka noma imicabango yokuzilimaza. Lokhu kubaluleke kakhulu kubantu abadala abasebasha, njengoba i-nortriptyline ingandisa amathuba okuba nemicabango yokuzibulala.

Isebenza kanjani ithebhulethi ye-Notriptyline

Amaphilisi e-Notriptyline asebenza ngokuthonya amazinga amakhemikhali athile ebuchosheni bakho. Le mithi ingeyeqembu elibizwa ngokuthi i-tricyclic antidepressants. Ithinta isimiso sezinzwa esimaphakathi, ikhuphule izinga le-serotonin ne-norepinephrine ebuchosheni. Lawa makhemikhali alawula imizwa nokuziphatha.

Uma uthatha i-nortriptyline yokucindezeleka, isiza ukuphakamisa isimo sakho sengqondo ngokukhuphula amazinga e-serotonin. Ukunciphisa ubuhlungu, kushintsha indlela izinzwa zakho ezithola ngayo izimpawu zobuhlungu, ukunciphisa ukungakhululeki. I-Notriptyline iphinde ithinte amanye amakhemikhali obuchopho, kuhlanganise ne-histamine ne-acetylcholine.

Umphumela womuthi ku-norepinephrine unamandla ikakhulukazi, okunomthelela ekusebenzeni kwawo. Kuyathakazelisa ukuthi i-nortriptyline ingase futhi isize ngokulala ngenxa yomphumela wayo kuma-receptors athile ebuchosheni. Umthamo ojwayelekile wokudangala usukela ku-75 kuye ku-100 mg nsuku zonke, namazinga egazi aphakathi kuka-50 no-150 ng/mL ngokuvamile ahambisana nomthelela we-antidepressant.

Ngingakwazi Ukuthatha I-Notriptyline Neminye Imithi?

Udinga ukuqapha lapho uthatha i-nortriptyline neminye imithi. I-Notriptyline ingasebenzisana nemithi eminingi, njenge:

  • Ama-Antihistamine 
  • I-Buspirone
  • Imithi ethile yesigqi senhliziyo, njenge-propafenone noma i-quinidine
  • Lithium
  • Imithi ebangela isiyezi nokulala
  • I-Monoamine oxidase inhibitors (MAOIs) noma phakathi kwamaviki amabili wokumisa i-MAOI
  • Imithi ye-opioid, efana ne-oxycodone, i-morphine, i-codeine, i-tramadol, noma i-fentanyl
  • Ukukhetha i-serotonin reuptake inhibitors (ama-SSRIs)
  • John's wort
  • Imithi ye-thyroid 
  • I-Triptans, njenge-sumatriptan, i-eletriptan

Ulwazi Lomthamo

Amaphilisi e-Notriptyline eza ngamandla ahlukene: 10mg, 25mg, kanye no-50mg. 

Ukwelapha ubuhlungu bezinzwa kubantu abadala, uvame ukuqala ngo-10mg nsuku zonke, okungandiswa uma kunesidingo. Umthamo omkhulu wezinhlungu ngu-75 mg nsuku zonke, kodwa kuphela ngaphansi kokuqondisa kukachwepheshe. 

Ukwelapha ukucindezeleka kubantu abadala, odokotela kancane kancane bakhulisa umthamo ube phakathi kuka-75 mg no-100mg ngosuku. Kwezinye izimo, ingakhuphukela ku-150 mg nsuku zonke uma kunqunywe uchwepheshe. 

Entsha enokucindezeleka, umthamo uqala ngaphansi futhi ukhuphuka kancane kancane usuka ku-30mg ukuya ku-50 mg ngosuku. 

Khumbula, thatha njalo i-nortriptyline njengoba uyalelwe udokotela wakho. 

Imibuzo Evame Ukubuzwa

1. Kwenzekani uma ngiphuthelwa umthamo?

Uma ukhohlwa umthamo we-nortriptyline, yithathe ngokushesha lapho ukhumbula. Kodwa-ke, uma sekusondele isikhathi somthamo wakho olandelayo we-nortriptyline, yeqa ogejiwe futhi uqhubeke neshejuli yakho evamile. I-alamu yesikhumbuzi ingakusiza ukuthi uphuze imithi yakho ngesikhathi.

2. Kwenzekani uma ngiphuza ngokweqile?

I-overdose ye-nortriptyline ingaba yingozi. Uma uphuze ngaphezu komthamo owunqunyiwe, funa usizo lwezokwelapha ngokushesha. Izimpawu zokweqisa izidakamizwa zingabandakanya ukushaya kwenhliziyo okungajwayelekile, ukozela okukhulu, izinkinga zokubona, ukudideka, kanye ukuhlukunyezwa. Kubalulekile ukugcina i-nortriptyline ikude nezingane, njengoba ngisho nephilisi elilodwa noma amabili angababulala.

3. Yini okufanele uyigweme lapho uthatha i-nortriptyline?

Gwema uphuzo oludakayo, njengoba lungandisa imiphumela emibi. Ungayeki ngokushesha ukuthatha i-nortriptyline ngaphandle kokubonisana nodokotela wakho. Gwema ukusebenzisa imishini noma ukushayela imoto ngenkathi ungaphansi komphumela womuthi. 

4. Ingabe i-nortriptyline iphephile?

I-Notriptyline ngokuvamile iphephile uma ithathwa njengoba kushiwo. Nokho, njengayo yonke imithi, ingaba nemiphumela engemihle kanye nezingozi. Kubalulekile ukuthi uyisebenzise ngaphansi kokuqondisa kukadokotela wakho, ikakhulukazi kulabo abanezimo zenhliziyo, i-glaucoma, noma umlando wokuquleka.

5. Isidakamizwa se-nortriptyline sivame ukusetshenziselwa ini?

I-Notriptyline isetshenziselwa ukwelapha ukucindezeleka. Odokotela baphinde bayinikeze izimo ezibuhlungu ezingapheli, kuhlanganise nobuhlungu be-neuropathic kanye ne-migraines. Abanye odokotela bayisebenzisa ngaphandle kwelebuli yokuphazamiseka kokukhathazeka, ukuchama ezinganeni, nokusiza ekuyekeni ukubhema.

6. Ubani ongakwazi ukuthatha i-nortriptyline?

I-Notriptyline ivinjelwe kubantu abasanda kuhlaselwa isifo senhliziyo, labo abane-hypersensitivity eyaziwa emuthini, kanye neziguli ezithatha i-monoamine oxidase inhibitors (MAOIs). Kufanele isetshenziswe ngokuqapha ezigulini esezikhulile kanye nalabo abanezimo ezithile zezokwelapha.

7. Kungani i-nortriptyline ithathwa ebusuku?

I-Notriptyline ivame ukuthathwa ebusuku ngaphambi kokuyolala ngoba ingabangela ukozela. Ukuyithatha ngaphambi kokulala kusiza ukunciphisa ukulala kwasemini kanye neminye imiphumela engemihle. Iphinde ihambisane namandla omuthi okuthuthukisa izindlela zokulala kwezinye iziguli ezinokucindezeleka.

8. Ingabe i-nortriptyline ilungele ukukhathazeka?

Nakuba ngokuyinhloko i-antidepressant, i-nortriptyline ingasebenza kwezinye izinhlobo zokukhathazeka, ikakhulukazi uma kwenzeka kanye nokucindezeleka. Kodwa-ke, akuyona indlela yokwelapha yokuqala yezinkinga zokukhathazeka. Ukusebenza kwayo kokukhathazeka kungahluka phakathi kwabantu.

9. Ngingakwazi ukuthatha i-nortriptyline zonke izinsuku?

I-Notriptyline ivame ukunqunywa ukusetshenziswa kwansuku zonke. Ukuyithatha zonke ezinye izinsuku akunconywa ngaphandle uma uyalwe udokotela wakho ngokuqondile. Umthamo wansuku zonke ongaguquguquki usiza ukugcina amazinga egazi aqinile omuthi, okubalulekile ekusebenzeni kwawo.