I-Olanzapine

I-Olanzapine

I-Olanzapine iyisidakamizwa esinamandla esiguqule izimpilo zabantu abaningi ababhekene nezinkinga ezithile zempilo yengqondo. Lo muthi, otholakala njengamaphilisi e-olanzapine, udlala indima enkulu ekwelapheni izimo ezinjenge-schizophrenia kanye ne-bipolar disorder.

Kulesi sihloko, sizohlola ukusetshenziswa kwethebhulethi ye-olanzapine. Sizobheka indlela yokusebenzisa amaphilisi e-olanzapine, imiphumela engemihle engenzeka, izinyathelo zokuphepha ezidingekayo okufanele uzikhumbule, ukusebenzisana kwayo neminye imithi, kanye nolwazi lomthamo. Ekugcineni, uzowuqonda kangcono lo muthi obalulekile nokuthi ubasiza kanjani labo abawudingayo.

Iyini i-Olanzapine?

I-Olanzapine iyisidakamizwa esivamile sesizukulwane sesibili se-antipsychotic esinomthelela omkhulu kuzithunywa zamakhemikhali zobuchopho futhi sisetshenziselwa kakhulu ukwelapha i-schizophrenia & ukucindezeleka kwe-bipolar kubantu abangaphezu kweminyaka engu-13 ubudala. Lesi sidakamizwa sisebenza ngokushintsha ukusebenza kwezinto ezithile ebuchosheni, ikakhulukazi i-dopamine ne-serotonin. Nakuba ingazelaphi lezi zimo, i-olanzapine ithuthukisa kakhulu izimpawu kanye nezinga lempilo ezigulini eziningi. Kubalulekile ukuqaphela ukuthi i-olanzapine ingathatha izinsuku ezimbalwa noma amasonto ukukhombisa imiphumela yayo egcwele.

Ukusetshenziswa kwethebhulethi ye-Olanzapine

Amaphilisi e-Olanzapine anomthelela omkhulu ekulawuleni izimo zempilo yengqondo ehlukahlukene, njenge: 

• Amaphilisi e-Olanzapine ngokuyinhloko asetshenziselwa ukwelapha i-schizophrenia kubantu abangaphezu kweminyaka engu-13 ubudala, esiza ekudambiseni izimpawu ezifana nokubona izinto ezingekho, ukukhohlisa, nemicabango ephithizelayo. 
• I-Olanzapine ithinta i-bipolar disorder, ikakhulukazi ekulawuleni iziqephu ze-manic noma ezixubile. 
• I-Olanzapine ingasiza ekwehliseni imizwa yokuyaluza, ukuba matasatasa, kanye nokuthatheka okuhambisana nokusangana.
• Ngokuhambisana ne-fluoxetine, amaphilisi e-olanzapine asetshenziselwa ukwelapha ukudangala okuxhumene nohlobo 1 lwe-bipolar disorder kanye nokucindezeleka okumelana nokwelashwa ezigulini ezingaphezu kweminyaka eyishumi ubudala. 
• I-Olanzapine futhi inokugunyazwa ukusetshenziswa ne-lithium noma i-valproate yokulawula noma yokwelapha i-acute manic noma iziqephu ezixubile ku-bipolar I disorder.

Ungayisebenzisa kanjani i-Olanzapine Tablet

• Amaphilisi e-Olanzapine athathwa kanye ngosuku, ngokudla noma ngaphandle kokudla. 
• Geza ithebhulethi yonke ngengilazi yamanzi. 
• Uma usebenzisa amaphilisi ahlakazeka ngomlomo, wabeke olimini lwakho futhi uwayeke ahlakazeke. Ungaphuza ngemva kwalokho uma kudingeka. 
• Udokotela wakho uzokhipha umthamo ofanele kuwe, ongase usuke ku-2.5mg kuya ku-20mg, ngokusekelwe ebukhulwini besifo sakho kanye nempendulo yokwelashwa. 
• Imijovo ye-olanzapine inikezwa udokotela kuphela esibhedlela noma emtholampilo.

Kubalulekile ukulandela imiyalelo kadokotela wakho ngokuqondile futhi ungashintshi umthamo wakho ngaphandle kokubonisana. 

Imiphumela Emibi Yethebhulethi ye-Olanzapine

Amaphilisi e-Olanzapine angabangela imiphumela emibi ehlukahlukene. Imiphumela emibi evamile ihlanganisa: 

• Ukuzizwa ubuthongo emini
• Inzuzo yesisindo
• Ukwandisa ukudla
• isiyezi
• Ukukhathala okungajwayelekile
• ukuqunjelwa
• Umlomo omile
• ukundindizela
• Ubuhlungu ezingalweni nasemilenzeni

Le miphumela ngokuvamile ayidingi ukunakekelwa kwezokwelapha futhi ingase iphele njengoba umzimba wakho ujwayela umuthi.

Kodwa-ke, i-olanzapine ingabangela nemiphumela emibi kakhulu, kuhlanganise: 

• Ushukela ophakeme wegazi
• Ukwandisa amazinga e-cholesterol ne-triglyceride
• ukuquleka
• Izinkinga zokunyakaza njenge-tardive dyskinesia
• Ukuphazamiseka kwegazi njenge-leukopenia, i-neutropenia, i-agranulocytosis
• Ukuqapha okuncishisiwe
• Ukwehla kungazelelwe kweBP uma usukuma kungaholela ekuweni. 
• I-Neuroleptic malignant syndrome (engavamile)

Ukuqapha

• Ukusebenzisana kwezidakamizwa: Ngaphambi kokuthatha amaphilisi e-olanzapine, hlala wazisa udokotela wakho mayelana nezinto ezingakuphathi kahle, izimo zezokwelapha, noma imithi oyisebenzisayo. Lokhu kufaka phakathi izidakamizwa ezithengwayo kanye nezithasiselo zemithi. 
• Amapharamitha Egazi: I-Olanzapine ingase yenyuse amazinga kashukela egazini, ngakho ukuqapha njalo kubalulekile, ikakhulukazi kubantu abanesifo sikashukela. Kungase futhi kuthinte amazinga e-cholesterol kanye ne-triglyceride, edinga ukuhlolwa okwengeziwe. 
• Izimo Zezokwelapha: Yazisa udokotela wakho ngomlando wakho wezokwelapha, ikakhulukazi umfutho wegazi ophakeme noma ophansi, isifo sikashukela, amazinga aphezulu e-cholesterol, Isifo i-Alzheimer, unhlangothi, ukuquleka, izifo zesibindi, noma i-glaucoma.
• Ukozela: I-Olanzapine ingadala ukozela futhi ithinte ikhono lakho lokushayela noma ukusebenzisa imishini. Gwema ukuphuza utshwala uma uthatha lo muthi, ngoba ungaqinisa umphumela wobuthongo. 
• Ukubhema: Ababhemayo bangase badinge imithamo ephezulu ngenxa yokuthi ukubhema kuwuthinta kanjani umzimba womuthi. 

Hlala ukhuluma nodokotela wakho ngaphambi kokushintsha, ukuqala noma ukuyeka imithi ngenkathi usebenzisa i-olanzapine.

Isebenza kanjani ithebhulethi ye-Olanzapine

Amaphilisi e-Olanzapine athinta izithunywa zamakhemikhali zobuchopho, ezaziwa ngokuthi ama-neurotransmitters. Lo muthi uvimba ama-receptors athile ebuchosheni, ikakhulukazi i-dopamine ne-serotonin. Ngokwenza lokhu, i-olanzapine inomthelela ekulinganiseni kabusha lawa ma-neurotransmitters, okusiza ukuthuthukisa isimo sengqondo nokuziphatha.

Isenzo esiyinhloko somuthi ukuvimba ama-dopamine receptors, okunomthelela omkhulu ekwehliseni izimpawu ezinjengokubona izinto ezingekho kanye nokukhohlisa. Iphinde isebenze kuma-serotonin receptors, esiza ukubhekana nezindaba ezifana ne-anhedonia nokunganakwa kahle. Umthelela we-Olanzapine kwamanye ama-receptors, okuhlanganisa i-histamine nama-muscarinic receptors, uchaza imiphumela ethile engemihle, njengokulala nomlomo owomile.

Kubalulekile ukuqaphela ukuthi nakuba i-olanzapine ithinta kakhulu izimpawu, kungase kuthathe amasonto ambalwa ukuze imiphumela yayo egcwele ibonakale.

Ngingayithatha I-Olanzapine Neminye Imithi?

I-Olanzapine ingasebenzisana nemithi eminingi, izithasiselo, nokudla, okufana nalokhu:

• Utshwala
• Imithi ye-Anticholinergic
• Caffeine  
• I-Carbamazepine 
• I-Diazepam 
• I-Dopamine agonists, njenge-pramipexole, i-ropinirole
• I-fluvoxamine 
• Imithi ye Isifo sikaParkinson
• Imithi yokulala nokukhathazeka

Ulwazi Lomthamo

Umthamo wamaphilisi we-olanzapine uyahlukahluka kuye ngesimo sokwelashwa. 

Kubantu abadala abane-schizophrenia, umthamo wokuqala ngu-5 kuya ku-10 mg kanye ngosuku, ngomthamo ohlosiwe wamamiligremu ayi-10 nsuku zonke. 

Ku-bipolar disorder, abantu abadala bavame ukuqala ngo-10 noma 15 mg kanye ngosuku, okungahle kulungiswe njengoba kudingeka. 

Ezinganeni ezineminyaka engu-13 kuya ku-17 ezine-schizophrenia noma i-bipolar disorder, umthamo wokuqala uphansi, kusukela ku-2.5 kuya ku-5 mg nsuku zonke. 

Umthamo omkhulu onconyiwe wabantu abadala kanye nentsha ngu-20 mg ngosuku. 

Uma isetshenziswa ne-fluoxetine ye-bipolar depression, umthamo wokuqala i-olanzapine 5mg kubantu abadala kanye no-2.5 ​​mg wezingane ezineminyaka engu-10 kuya ku-17. 

Ukulungiswa komthamo kufanele kwenziwe kancane kancane, ngokuvamile ngezikhathi ezithile okungenani amahora angama-24 kubantu abadala kanye nesonto elilodwa entsheni.

Isiphetho

I-Tablet olanzapine iyithuluzi elinamandla ekwelapheni nasekulawuleni izinkinga ezithile zempilo yengqondo. Kubalulekile ukukhumbula ukuthi lo muthi usebenza kahle kakhulu njengengxenye yohlelo lokwelapha olubanzi, olungase luhlanganise ukwelashwa kanye nezinguquko zendlela yokuphila. Njenganoma yimuphi umuthi, ukuxhumana okuvulekile nodokotela wakho kuyisihluthulelo sokuqinisekisa ukusetshenziswa okuphephile nokusebenzayo kwamaphilisi e-olanzapine.

Imibuzo Evame Ukubuzwa

1. Isetshenziselwa yiphi i-olanzapine? 

I-Olanzapine umuthi we-antipsychotic ongakwazi ukulawula izimo zempilo yengqondo ehlukahlukene, njenge-schizophrenia kubantu abangaphezu kweminyaka engu-13 ubudala kanye nesifo sokuphazamiseka kwengqondo okuguquguqukayo, okuhlanganisa ukuhlanya noma iziqephu ezixubile. Amaphilisi e-Olanzapine abuye asetshenziswe ne-fluoxetine ukwelapha ukucindezeleka okuhlobene nohlobo 1 lwe-bipolar disorder kanye nokucindezeleka okumelana nokwelashwa ezigulini ezingaphezu kweminyaka eyishumi ubudala. 

2. Ingabe i-olanzapine iyithebhulethi yokulala?

I-Olanzapine ayiyona ithebhulethi yokulala. Kuyisidakamizwa esinamandla se-antipsychotic esisetshenziswa ngokuyinhloko ukwelapha i-schizophrenia nesifo se-bipolar. Nakuba kungase kubangele ukozela njengomphumela omubi, akufanele kumiselwe kuphela ukuphazamiseka kokulala. I-Olanzapine isebenza ngokuthinta amakhemikhali obuchopho, ikakhulukazi i-dopamine ne-serotonin, ukuze ilawule izimpawu ezifana nokubona izinto ezingekho, ukukhohlisa, nokushintshashintsha kwemizwelo.

3. Kungani uthatha i-olanzapine ebusuku?

I-Olanzapine ivame ukuthathwa ebusuku ngoba ingabangela ukozela. Ukuwuthatha kusihlwa kusiza iziguli ukuthi zilawule lo mphumela ongase ube nawo futhi ulale kahle ebusuku. Kubalulekile ukuthatha i-olanzapine ngesikhathi esifanayo nsuku zonke ukuze ulondoloze amazinga angaguquki emzimbeni. Nokho, isikhathi esiqondile somthamo kufanele kuxoxwe ngaso nodokotela, njengoba izidingo zomuntu ngamunye zingahluka.

4. Ubani odinga i-olanzapine?

I-Olanzapine inqunyelwe abantu abane-schizophrenia engapheli noma i-bipolar disorder. Ngokuvamile inikezwa abantu abaneminyaka engu-13 nangaphezulu ngenxa ye-schizophrenia kanye nabantu abadala abane-bipolar disorder. Ngokuhambisana neminye imithi, kuyasiza ekwelapheni ukucindezeleka okuhlobene nesifo sokuphazamiseka kwengqondo ezigulini ezingaphezu kweminyaka eyishumi ubudala. Udokotela unikeza i-olanzapine ngokusekelwe ezimpawini ezithile zomuntu kanye nomlando wezokwelapha.