I-Paroxetine

I-Paroxetine

Ukucindezeleka nokukhathazeka kuthinta izigidi zabantu emhlabeni wonke, okwenza izinketho zokwelashwa ezisebenzayo zibe zibalulekile ekulawuleni lezi zimo. I-Paroxetine ingenye yemithi enqunywe kakhulu ekilasini layo yokwelapha izimo ezihlukahlukene zempilo yengqondo. Lo mhlahlandlela obanzi uchaza konke iziguli okudingeka ziyazi ngemithi ye-paroxetine, okuhlanganisa ukusetshenziswa kwayo, umthamo ofanele, imiphumela engemihle kanye nolwazi olubalulekile lokuphepha. 

Iyini i-Paroxetine?

I-Paroxetine iyi-serotonin reuptake inhibitor enamandla ekhethiwe (SSRI) esebenza ngokwandisa inani le-serotonin ebuchosheni. 

Okwenza i-paroxetine ihluke kwamanye ama-SSRI isici sayo esiyingqayizivele sokuba namandla amakhulu nokukhetha ekuvimbeleni ukuphindwa kwe-serotonin, okunomthelela omncane kwamanye amakhemikhali obuchopho. Umuthi ngokuvamile uthatha cishe amaviki angu-6 ukukhombisa imiphumela yawo egcwele, usebenza ngokusiza ukugcina ibhalansi yengqondo ngokulawula ngokucophelela amazinga e-serotonin ebuchosheni.

Ukusetshenziswa kwethebhulethi ye-Paroxetine

Ukusetshenziswa okuyinhloko okuvunyelwe kwamaphilisi e-paroxetine kufaka:

• Ukucindezeleka Nokukhathazeka: Yelapha i-depressive disorder enkulu kanye nokukhathazeka okujwayelekile
• I-Panic and Social Disorders: Isiza ukuphatha i-panic disorder kanye nokukhathazeka komphakathi
• I-Obsessive-Compulsive Disorder (OCD): Yehlisa imicabango exakile nokuziphatha okuyimpoqo
• I-Post-traumatic Stress Disorder (PTSD): Isiza ekulawuleni izimpawu ezihlobene nokuhlukumezeka
• Izinkinga Zempilo Yabesifazane: Yelapha i-premenstrual dysphoric disorder (PMDD) kanye nezimpawu zokunqamuka kokuya esikhathini njengokushisa okushisayo

Ungayisebenzisa kanjani ithebhulethi yeParoxetine

Iziguli kufanele zithathe le mithi ngomlomo ngengilazi yamanzi, futhi kungcono ukuthi ungayithathi esiswini esingenalutho ukuvimbela ukuphazamiseka kwesisu.

• Thatha amaphilisi e-paroxetine kanye ngosuku ekuseni
• Gcina ishejuli engaguquki ngesikhathi esifanayo usuku ngalunye
• Ungalokothi uchofoze noma uhlafune amaphilisi
• Thatha nokudla ukuze ugweme ukuphazamiseka kwesisu
• Sebenzisa amadivaysi okulinganisa afanele ohlobo lwe-liquid

Imiphumela Emibi Yethebhulethi ye-Paroxetine

Abantu abaningi baba nemiphumela engemihle evame ukuba ngcono njengoba umzimba wabo ujwayela umuthi:

• Ukuzizwa ugula noma isicanucanu
• Ukozela noma ukukhathala
• Umlomo omile
• Ukulala kuyashintsha
• Ukunciphisa ukudla
• Ukuphoqa
• Umsebenzi wocansi uyashintsha
• Ikhanda elibuhlungu elithambile

Abanye abantu bangase babe nemiphumela emibi kakhulu edinga ukunakwa ngokushesha. Lokhu kubandakanya:

• Ukulimala noma ukopha okungajwayelekile
• Imizwa iyashintsha
• Imicabango ngokuzilimaza
• Isiyezi esinzima
• Izinkinga zembono
• Ukungezwani komzimba okukhulu

Iziguli kufanele zibheke izimpawu ze-serotonin syndrome, isimo esingavamile kodwa esibucayi esingenzeka lapho kuthathwa i-paroxetine. Izimpawu zihlanganisa ukushisa okukhulu, ukudideka, ukushaya kwenhliziyo okungajwayelekile, nesiyezi esinzima.

Ukuqapha

Ukucatshangelwa kokuphepha kudlala indima ebalulekile lapho uthatha umuthi i-paroxetine. 

Ukucatshangelwa Okubalulekile Kokuphepha:

• Imishini Enzima: Gwema ukushayela noma ukusebenzisa imishini phakathi nezinsuku ezimbalwa zokuqala zokwelashwa uze uqonde ukuthi imithi ikuthinta kanjani.
• Ukusebenzisa kabi Izidakamizwa: Qaphela ukusetshenziswa kotshwala njengoba kungase kwandise ukozela. Gwema ukusetshenziswa kwe-cannabis ngoba kungadala ukushaya kwenhliziyo okusheshayo.
• Qaphela ukopha okungavamile lapho uthatha i-aspirin noma amanye ama-NSAID
• Hlala uqaphile ukuze uthole izimpawu zokuvala i-engeli i-glaucoma, ikakhulukazi uma kucatshangelwe kusengaphambili

Isebenza kanjani ithebhulethi yeParoxetine

I-Paroxetine isebenza ngokuvimbela ukutholwa kabusha kwe-serotonin, into engokwemvelo etholakala ebuchosheni esiza ukugcina ukulinganisela kwengqondo. Uma ithathwa njalo, ithatha cishe u-88% wabathuthi be-serotonin ku-prefrontal cortex, okuyenza iphumelele kakhulu emsebenzini wayo.

Imiphumela yomuthi kukhemikhali yobuchopho ihlanganisa:

• Ukwandisa ukugxila kwe-serotonin kuma-synapses wobuchopho
• Ukulinganisa amazinga e-serotonin receptor
• Inikeza ithonya elithile ekuthatheni kabusha kwe-norepinephrine
• Ibonisa ukuhlobana kwama-receptors obuchopho amaningi, okuhlanganisa izinhlobo ze-muscarinic ne-dopaminergic

Ngingathatha I-Paroxetine Neminye Imithi?

Ukusebenzisana kwemithi kudinga ukunakwa ngokucophelela lapho uthatha i-paroxetine. Imithi ebalulekile okufanele uyigweme:

• Amphetamine
• aspirin
• Imithi yesigqi senhliziyo
• Lithium
• I-Monoamine oxidase inhibitors (MAOIs) esetshenziselwa ukucindezeleka noma isifo sika-Parkinson
• Izidakamizwa ezingezona ukuvuvukala (ama-NSAID)
• Ama-opioid pain relievers
• Amanye ama-serotonin reuptake inhibitors akhethiwe (SSRIs)
• I-Pimozide (esetshenziselwa i-Tourette syndrome)
• Tamoxifen
• I-Thioridazine (esetshenziselwa izimo zempilo yengqondo)
• Ama-anticepressants e-Tricyclic
• I-Triptans
• Warfarin
• John's wort supplements

Ulwazi Lomthamo

Iziguli eziningi ziqala ukwelashwa ngomthamo wokuqala we-10mg noma 20mg nsuku zonke. Ngokucindezeleka nokukhathazeka, odokotela ngokuvamile banikeza:

Isiphetho

I-Paroxetine imile njengomuthi onamandla osiza izigidi ukuphatha ukudangala, ukukhathazeka, nezinye izimo zempilo yengqondo. Izici ezihlukile zemithi ziyenza iphumelele kakhulu ekuqondiseni amazinga e-serotonin ebuchosheni, nakuba iziguli zidinga amasonto ambalwa ukuze zithole izinzuzo zayo ezigcwele.

Impumelelo nge-paroxetine incike ekusetshenzisweni okufanele kanye nokunaka imihlahlandlela yokuphepha ngokucophelela. Iziguli kufanele zikhumbule ukuthi izidingo zomthamo ziyahlukahluka kuye ngesimo sazo esithile, ubudala, kanye nesimo sezempilo sisonke. Ukuxhumana okuvamile nodokotela kuhlala kubalulekile kuyo yonke inqubo yokwelashwa.

Imibuzo Evame Ukubuzwa

1. Ingabe i-paroxetine iyisidakamizwa esiyingozi kakhulu? 

I-Paroxetine iphephile uma ithathwa njengoba kushiwo. Ucwaningo lukhombisa ukuthi akuvamile ukuthi libulale uma lithathwa lilodwa, kanti iziguli zisinda ekusetshenzisweni ngokweqile okufika ku-3600 mg. Nokho, ukuqapha ngokucophelela kuyadingeka, ikakhulukazi phakathi namasonto ambalwa okuqala okwelashwa.

2. I-paroxetine ithatha isikhathi esingakanani ukusebenza? 

Iziguli eziningi zibona ukuthuthukiswa ngemva kwamaviki angu-4-6 okusetshenziswa okungaguquki. Umuthi udinga isikhathi ukuze wakhe ohlelweni futhi uzuze umphumela wawo ophelele wokwelapha.

3. Kwenzekani uma ngiphuthelwa umthamo?

Uma ukhunjulwa ngaphambi kokulala, thatha umthamo ophuthelwe ngokushesha. Uma ukhunjulwa ngakusasa, yeqa umthamo we-paroxetine ogejiwe futhi uqhubeke nohlelo olujwayelekile. 

4. Kwenzekani uma ngiphuza ngokweqile? 

Ukweqisa okumaphakathi (okufika izikhathi ezingama-30 kunomthamo ojwayelekile wansuku zonke) ngokuvamile kubangela izimpawu ezincane. Izimpawu ezijwayelekile ze-overdose zihlanganisa:

• Ukozela nokundindizela
• I-nausea nokuhlanza
• Ukuhlwitha ebusweni
• Isiyezi nokujuluka

5. Ubani ongakwazi ukuthatha i-paroxetine? 

Umuthi contraindicated for:

• Abantu abathatha ama-MAOI
• Izingane ezingaphansi kweminyaka eyi-18
• Abesifazane abakhulelwe (ngenxa yezingozi ezingaba khona)
• Labo abane-hypersensitivity eyaziwayo

6. Zingaki izinsuku zokuphuza i-paroxetine? 

Ubude besikhathi sokwelashwa buyahlukahluka ngezimo kodwa ngokuvamile buqhubeka izinyanga ezimbalwa ngemva kokuthuthuka kwezimpawu. Isinqumo sincike kokuthi:

• Ukuqina kwezimpawu
• Umlando wangaphambilini
• Impendulo ekwelashweni

7. Ungamisa nini i-paroxetine? 

Ungayeki ukuthatha i-paroxetine ngokuzumayo. Odokotela ngokuvamile batusa ukunciphisa umthamo kancane kancane emasontweni ambalwa ukuze kuvinjelwe izimpawu zokuhoxa.

8. Ingabe i-paroxetine iphephile ezinso? 

Ucwaningo lubonisa ukuthi i-paroxetine idinga ukulungiswa komthamo ezigulini ezinezinkinga ezinkulu zezinso. Ukuqapha njalo kunconywa ezigulini ezine isifo sezinso.

9. Kungani uphuza i-paroxetine ebusuku? 

Ezinye iziguli zithatha i-paroxetine ebusuku ukuze zilawule imiphumela engemihle, nakuba ingaphuzwa nganoma yisiphi isikhathi sosuku ngokudla.

10. Ingabe i-paroxetine ibangela ukukhuluphala? 

Ukushintsha kwesisindo kuyehluka kumuntu ngamunye. Ezinye iziguli zingase zithole ukuncipha kwesisindo sokuqala ngenxa yokuncipha kwesifiso sokudla, okulandelwa ukuzuza kwesisindo esincane njengoba isifiso sokudla sibuya.