I-Piroxicam

I-Piroxicam

I-Piroxicam iyisidakamizwa esingezona ukuvuvukala (i-NSAID) esiyingxenye ye-oxicam. Ivimbela ukukhiqizwa kwe-endogenous prostaglandin, elamula ubuhlungu, ukuqina, ubumnene, futhi ukuvuvukala.

Ukusetshenziswa kwethebhulethi yePiroxicam

Amaphilisi e-Piroxicam asetshenziswa ngokuyinhloko ukwelapha izinhlungu, ukuvuvukala kwamalunga, ukuthamba, nokuqina okubangelwa i-osteoarthritis kanye ne-rheumatoid. sokuqaqamba kwamalunga. Lezi zimo zibandakanya ukuvuvukala nokuwohloka kwamalunga, okuholela ekuphathekeni kabi nokuncipha kokuhamba.

Ukwengeza, i-Piroxicam ithola izinhlelo zokusebenza ekuphatheni:

• Ubuhlungu obuhlangene nokuvuvukala kwe-gouty arthritis
• I-ankylosing spondylitis
• Ubuhlungu bemisipha nokuvuvukala
• Ubuhlungu bokuya esikhathini
• Ubuhlungu ngemva kokuhlinzwa noma ngemva kokubeletha

Indlela yokusebenzisa i-Piroxicam

I-Piroxicam itholakala ngamaphilisi noma amaphilisi futhi ingathathwa ngomlomo. Ngokuvamile kuthathwa kanye noma kabili ngosuku, kuye ngomthamo onqunyiwe. Kufanele ulandele imihlahlandlela elandelayo ukuze usebenzise ngokuphephile nangempumelelo:

• Imiyalelo Yemithamo: Landela izikhombisi-ndlela ezikulebula yakho yemithi ngokucophelela, futhi uthathe i-Piroxicam ngokuqondile njengoba udokotela wakho ekuqondisa. 
• Isikhathi Nobude besikhathi: Thatha i-Piroxicam ngesikhathi esifanayo nsuku zonke ukuze ugcine amazinga angashintshi omuthi emzimbeni wakho. Sebenzisa i-Piroxicam isikhathi esifushane ngangokunokwenzeka, njengoba kunconywe udokotela wakho, ngokusekelwe ezinhlosweni zakho zokwelashwa ngazinye.

Imiphumela emibi yethebhulethi ye-piroxicam

Njenganoma yimuphi omunye umuthi, i-Piroxicam nayo ingabangela imiphumela emibi. Imiphumela emibi ye-Piroxicam ingaba kusuka komnene kuye kokuqina, njenge:

• Ukuvimbela
• Indle enegazi noma emnyama
• Ukuvutha ubuhlungu besisu esingenhla
• Umchamo uguqubele
• ukuqunjelwa
• Ukuncipha kokukhishwa komchamo
• bekhanda
• isilungulela
• Ukuzithoba
• Ukuluma kwesikhumba noma ukuqubuka
• Ukulahlekelwa kwesifiso
• Ukudabuka noma ukuhlanza
• Isikhumba esiphezulu
• Ubuhlungu obukhulu besisu, i-cramping, noma ukushisa
• Isicanucanu esinamandla nesiqhubekayo
• Ukuvuvukala kobuso, iminwe, izinyawo, noma imilenze engezansi
• Ukuphefumula kanzima
• Ukusuka okungavamile noma ukulimaza
• Ukukhathala okungavamile noma ubuthakathaka
• Ukuphalaza kwegazi noma izinhlayiya ezibukeka njengesisekelo sekhofi
•  Izinguquko zesisindo

Ukuqapha

Lapho uthatha i-Piroxicam, kubalulekile ukulandela izinyathelo ezithile zokunciphisa ubungozi bemiphumela emibi futhi uqinisekise ukusetshenziswa okuphephile nokusebenza kahle. Nazi ezinye izinto ezibalulekile:

• Ingozi yenhliziyo: Izidakamizwa ezingezona ukuvuvukala (ama-NSAID) njengePiroxicam zingandisa ingozi ye-thrombotic yenhliziyo nemithambo yegazi, ukwehluleka kwenhliziyo okuhlanganayo (CHF), ukuhlaselwa yinhliziyo (i-myocardial infarction), kanye unhlangothi, okungaba yingozi. Le ngozi ingase ikhule ngokusetshenziswa isikhathi eside. Iziguli ezinesifo senhliziyo esikhona (CVDs) zingase zibe sengozini enkulu. 
• Ingozi Yama-Gastrointestinal: I-Piroxicam namanye ama-NSAID akhulisa ingozi yezehlakalo ezimbi kakhulu zesisu (GI), okuhlanganisa kodwa kungagcini nje ukopha, izilonda, nokubhobozwa kwesisu noma amathumbu, okungaba yingozi empilweni. 
• Ingozi Yesifo Sezinso: Ukuphathwa kwesikhathi eside kwama-NSAID njengePiroxicam kungabangela izinkinga zezinso ikakhulukazi ezigulini ezisengozini enkulu, njengabantu abadala, labo abanokukhubazeka kwezinso, i-hypovolemia, ukuhluleka kwenhliziyo, isibindi ukungasebenzi kahle, ukuncipha kukasawoti kanye nabantu abathatha ama-diuretics, ama-ACE inhibitors, noma ama-ARB.
• Izimo Zesikhumba: Ama-NSAID, kuhlanganise ne-Piroxicam, angabangela izehlakalo ezimbi kakhulu zesikhumba ezifana ne-Stevens-Johnson Syndrome (SJS), i-exfoliative dermatitis & ne-toxic epidermal necrolysis (TEN), engasongela ukuphila.
• Ingozi Yezinye Izimo Zezokwelapha: I-Piroxicam ingase ikhulise ingozi ufuba, ukukhubazeka kwesibindi, umfutho wegazi ophakeme (i-hypertension), nokukhubazeka kwezinso. Odokotela ngokuvamile abayincomi i-Piroxicam ezigulini eziye zabhekana nokusabela kwe-aspirin anaphylactoid. Ama-NSAID afana ne-Piroxicam angabangela i-anemia futhi andise isikhathi sokopha, ngakho ukuqapha kuyadingeka.
• Ukukhulelwa Nokuncelisa: I-Piroxicam kufanele isetshenziswe ngokuqapha ku-trimester yokuqala neyesibili yokukhulelwa uma izinzuzo zidlula ubungozi, njengoba izifundo zezilwane zibonisa ubungozi obungaba khona kanye nezifundo zabantu. Phakathi ne-trimester yesithathu, i-Piroxicam kufanele isetshenziswe kuphela ezimweni eziphuthumayo ezisongela ukuphila lapho kungekho okunye okuphephile okutholakalayo, njengoba kungase kubangele ukuvala ngaphambi kwesikhathi kwe-ductus arteriosus, kubangele ingozi ku-fetus.

Isebenza kanjani i-Piroxicam

I-Piroxicam isebenza ngokunciphisa amazinga egazi amahomoni abangela ukuvuvukala nobuhlungu emzimbeni. Umphumela wokulwa nokuvuvukala we-piroxicam uvela ekuvinjweni okubuyiselekayo kwe-cyclooxygenase, i-enzyme ehilelekile ekukhiqizeni i-prostaglandin.

Indlela Yokusebenza

I-Prostaglandin yizinto ezinjenge-hormone ezikhiqizwa i-enzyme ebizwa ngokuthi i-cyclooxygenase-1 (COX-1). I-Piroxicam ivimba i-enzyme ye-COX-1, iphazamisa ukukhiqizwa kwe-prostaglandin. Lokhu kuvinjelwa kwe-prostaglandin synthesis kunciphisa ukuvuvukala nobuhlungu.

Ukwengeza, i-Piroxicam ivimbela ukufuduka kwe ama-leukocytes (amangqamuzana egazi amhlophe) abe kumasayithi okuvuvukala futhi avimbele ukwakheka kwe-thromboxane A2, i-aggregating agent ekhiqizwa amaplatelet. Ngokuqondisa lezi zindlela, i-Piroxicam inciphisa ngempumelelo ukuvuvukala, ubuhlungu nokuvuvukala okuhambisana nezimo ezifana ne-rheumatoid arthritis kanye osteoarthritis.

Ngingakwazi Ukuthatha I-Piroxicam Neminye Imithi?

Kunezidakamizwa ezingama-386 ezaziwa ukuthi zisebenzisana ne-Piroxicam; kukho konke ukusebenzisana kwezidakamizwa, ezingama-95 zinkulu, ezingama-280 zisesilinganisweni, kanti eziyi-11 zincane.
Kubalulekile ukwazisa udokotela wakho nganoma yimiphi imithi kadokotela noma ye-over-the-counter (OTC), amavithamini noma amaminerali, imikhiqizo yamakhambi, kanye nezithasiselo ozisebenzisayo ngaphambi kokuthatha i-Piroxicam. Imithi ethile ingasebenzisana ne-Piroxicam, okungase kwandise amathuba okuba nemiphumela engemihle noma iguqule ukusebenza kokwelashwa.

Imibuzo Evame Ukubuzwa

1. Uyini umehluko phakathi kwePiroxicam ne-diclofenac?

I-Piroxicam ne-diclofenac zombili izidakamizwa ezilwa nokuvuvukala (ama-NSAID), kodwa ziyehluka ngesakhiwo sazo samakhemikhali kanye ne-pharmacokinetics. I-Piroxicam inohhafu wempilo ende, evumela ukudoswa kanye ngosuku, kuyilapho i-diclofenac ngokuvamile idinga umthamo ovamile ngenxa yesigamu sempilo yayo emfushane. Zombili zisetshenziselwa ukwelapha ubuhlungu kanye ukuvuvukala.

2. Ubani okungafanele asebenzise i-Piroxicam?

I-Piroxicam kufanele igwenywe noma isetshenziswe ngokuqapha kubantu abathile, okuhlanganisa:

• Isifo senhliziyo sakamuva
• Ukuphazamiseka kokuphuza
• Umlando we izilonda zesisu noma ukopha
• Isifo sesibindi, njengoba iPiroxicam ingabangela ukulimala kwesibindi (i-hepatotoxicity)
• Isifo sezinso esithuthukile noma esinzima
• Isifuba somoya sibangelwa i-aspirin
• Ukukhulelwa nokuncelisa
• Iziguli esezikhulile

3. Ingabe i-Piroxicam iyisidambisa-zinhlungu esinamandla?

Yebo, iPiroxicam ithathwa njengesidambisi sezinhlungu esinamandla. Ifakwa ngaphansi kwezidakamizwa ezingezona ukuvuvukala (ama-NSAID) futhi iyasebenza ekudambiseni ubuhlungu obumaphakathi kuya kobunzima nokuvuvukala okuhambisana nezimo ezimbalwa, njenge rheumatoid arthritis, i-osteoarthritis, nezinye izifo ezivuthayo.

4. Ingabe i-piroxicam inamandla kune-diclofenac?

Kokubili i-Piroxicam ne-diclofenac zingama-NSAID anamandla okunciphisa ubuhlungu nokunciphisa ukuvuvukala. Nakuba zombili zisebenza kahle, amandla abo ahlobene namandla angahluka futhi ancike esimweni esithile kanye nezici zesiguli ngasinye. Ngokuvamile, i-diclofenac inamandla kancane kune-Piroxicam yokunciphisa ubuhlungu kanye nemiphumela eqeda ukuvuvukala. 

5. Ingabe i-Piroxicam ilungele ubuhlungu bezinso?

Odokotela ngokuvamile abayincomi i-Piroxicam ekwelapheni ubuhlungu bezinso noma izimo ezihlobene nezinso. I-Piroxicam nezinye izidakamizwa ezingezona ukuvuvukala (ama-NSAID) zingadala ukulimala kwezinso, ikakhulukazi ngokusetshenziswa isikhathi eside noma umthamo omkhulu.

6. Ingabe i-Piroxicam iyingozi esibindini?

Yebo, i-Piroxicam ingaba yingozi esibindini, nakuba amathuba okulimala kwesibindi ephansi uma kuqhathaniswa nezinye izidakamizwa ezingezona ukuvuvukala (ama-NSAID). I-Piroxicam, njengamanye ama-NSAID, iye yahlotshaniswa namacala okulimala kwesibindi okubangelwa izidakamizwa (DILI), okungaba kusuka ekuphakameni kwe-enzyme yesibindi kuya ekulimaleni okukhulu kwesibindi noma ngisho nokuhluleka kwesibindi.