I-progesterone, i-hormone ebalulekile emzimbeni womuntu, idlala indima ebalulekile empilweni yokuzala nangale kwalokho. Le nhlanganisela enamandla ithinta kakhulu imisebenzi ehlukahlukene yomzimba, kusukela ekulawuleni imijikelezo yokuya esikhathini ekusekeleni ukukhulelwa. Ukusetshenziswa kwamaphilisi e-progesterone ekukhulelwe sekuthole ukunakwa kwamandla ayo okusekela ukukhulelwa kusencane kanye nokunciphisa ingozi yezinkinga ezithile. Lesi sihloko sihlola imisebenzi ebalulekile ye-progesterone, izinzuzo zayo, kanye nezingozi ezingaba khona.
I-progesterone iyi-hormone ye-steroid ebalulekile edlala indima ebalulekile empilweni yokuzala. Umzimba ukhiqiza le hormone ngokwemvelo ku-adrenal cortex, ama-ovari, nama-testes. Ngesikhathi sokukhulelwa, i-ovarian corpus luteum ikhiqiza i-progesterone emasontweni ayishumi okuqala, ngemva kwalokho placenta ithatha ukukhiqiza. I-progesterone itholakala ku- cholesterol ebophezela kuma-receptors e-progesterone kuwo wonke umzimba, elawula ukubonakaliswa kofuzo futhi ibe nomthelela emisebenzini ehlukahlukene yomzimba, ikakhulukazi ngaphakathi kwesistimu yokuzala.
Amaphilisi e-progesterone anezinhlobonhlobo zezicelo empilweni yokuzala, okuhlanganisa:
Odokotela banikeza amaphilisi e-hormone ye-progesterone eneziqondiso ezithile, njenge:
Amaphilisi e-hormone ye-progesterone angaba nemiphumela emibi evamile futhi engavamile. Imiphumela emibi evamile ihlanganisa:
Imiphumela engavamile ingase ihlanganise:
Amaphilisi e-progesterone asebenza ngokulingisa imiphumela ye-progesterone ekhiqizwa ngokwemvelo emzimbeni. Zithonya imisebenzi ehlukahlukene yomzimba, ikakhulukazi leyo ehlobene nempilo yokuzala. Uma ethathwa, amaphilisi e-progesterone asiza ukulawula amazinga e-hormone, okungaba nomthelela empilweni yesikhumba nokubukeka. Ngesikhathi sokukhulelwa, amazinga e-progesterone ayanda, okunomthelela ekushintsheni umbala wesikhumba futhi okungase kubangele i-melasma. Ekunqamukeni kokuya esikhathini, njengoba amazinga e-estrogen ne-progesterone ehla, isikhumba singase silahlekelwe yi-collagen, okuholela ekushwabaneni nokoma. Amaphilisi e-progesterone angasiza ekuxazululeni lezi zinkinga ngokwengeza ukukhiqizwa kwehomoni yemvelo yomzimba.
I-progesterone isebenzisana nemithi eminingi, njenge:
Hlala uthintana nodokotela wakho ngaphambi kokuhlanganisa i-progesterone neminye imithi ukuze uqinisekise ukwelashwa okuphephile nokuphumelelayo.
Umthamo we-progesterone uyahlukahluka futhi uncike esimweni esithile sezokwelapha esiphathwayo.
Ukuvimbela i-endometrial hyperplasia kwabesifazane abangemva kokuya esikhathini abathola ukwelashwa kwe-estrogen, umthamo ojwayelekile ngu-200 mg othathwa ngomlomo ngaphambi kokulala izinsuku eziyi-12 ezilandelanayo ngomjikelezo wezinsuku ezingama-28.
Ukwelapha i-amenorrhea, abantu abadala ngokuvamile bathatha ama-400 mg ngomlomo ngesikhathi sokulala izinsuku eziyishumi.
Kubalulekile ukulandela imiyalelo kadokotela noma ilebula izikhombisi-ndlela ngokunembile. Umthamo, imvamisa, kanye nobude besikhathi sokwelashwa kuncike endabeni ethile yezokwelapha yesiguli kanye nempendulo yomuthi. Iziguli akufanele ziguqule umthamo wazo ngaphandle kokubonisana nodokotela wazo.
I-progesterone idlala indima ebalulekile empilweni yokuzala kanye nempilo enhle. Le hormone ithonya ngokuphawulekayo imisebenzi ehlukahlukene yomzimba, kusukela ekusekeleni ukukhulelwa kuya ekulawuleni imijikelezo yokuya esikhathini. Ukusetshenziswa kwamaphilisi e-progesterone sekuphenduke ithuluzi elibalulekile ekubhekaneni nokungalingani kwamahomoni kanye nezindaba zokuzala.
Ukuqonda ukusetshenziswa okufanele, imiphumela emibi engaba khona, kanye nezinyathelo zokuphepha ezihlobene nemithi ye-progesterone kubalulekile ukuze kuqinisekiswe ukwelashwa okuphephile nokuphumelelayo. Njenganoma yimuphi umuthi, kubalulekile ukubonana nodokotela ngaphambi kokuqala ukwelashwa kwe-progesterone. Banganikeza izeluleko ezenziwe ngokwezifiso ezisekelwe ezimeni zezempilo ngazinye kanye nokusebenzisana kwezidakamizwa okungaba khona.
I-progesterone idlala indima ebalulekile empilweni yokuzala. Ilawula umjikelezo wokuya esikhathini, ilungiselela ulwelwesi lwesibeletho sokukhulelwa, futhi isekela ukukhulelwa. Le hormone iqinisa ulwelwesi lwesibeletho, inciphise ukufinyela kwe-myometrial, futhi ivimbele ukuncelisa ngesikhathi sokukhulelwa. Iphinde ibe nomthelela ekukhiqizeni abalamuli abavuvukalayo ngaphakathi kwesibeletho.
I-progesterone ingathinta ukuya esikhathini. Uma uthatha i-progesterone njengengxenye yokwelashwa kokuzala, isikhathi sakho singase sibambezeleke. Ngokuvamile, ukuya esikhathini kuqala izinsuku ezingu-2-5 ngemva kokuyeka ukwelashwa. Ukuhlolwa okwengeziwe kungadingeka uma isikhathi singekho phakathi kwezinsuku eziyi-10-14. Umthelela we-progesterone kumjikelezo wakho uncike kunqubo yokwelashwa ethile.
Ukusetshenziswa kwe-progesterone kwansuku zonke kuncike esimweni sezokwelapha esiphathwayo. Abantu abadala ngokuvamile bathatha 200 mg nsuku zonke ngesikhathi sokulala izinsuku eziyi-12 ngomjikelezo wezinsuku ezingama-28 ukuvimbela i-endometrial hyperplasia. Ngokwelashwa kwe-amenorrhea, umthamo ojwayelekile ngu-400 mg nsuku zonke ngaphambi kokulala izinsuku eziyishumi. Ngaso sonke isikhathi landela imiyalelo kadokotela wakho mayelana nomthamo kanye nobude besikhathi.
Ukuthatha i-progesterone ebusuku kuvame ukutuswa ngoba kungabangela ukozela. Lo mphumela ungase ube nenzuzo yokulala, ikakhulukazi kwabesifazane abanqamula ukuya esikhathini abanenkinga yokulala. I-progesterone inomthelela omuhle ekulaleni emiphakathini ethile, okuhlanganisa abantu abangemva kokuya esikhathini kanye nabantu abane-apnea yokulala.
Ucwaningo nge-progesterone nesisindo somzimba aluhambisani. Ezinye izifundo ziphakamisa ukuxhumana phakathi kokwelashwa okusekelwe ku-progesterone kanye nokuzuza kwesisindo; abanye ababonisi umphumela obalulekile. Ukushintsha kwesisindo kungase kube ngenxa yezinye izici, njengamazinga ancishisiwe omsebenzi noma izinguquko zamahomoni.
I-progesterone kadokotela ngokuvamile iphephile uma isetshenziswa njengoba kuyalelwa udokotela. Nokho, ingase ingafaneli wonke umuntu. I-progesterone kufanele igwenywe yilabo abanomdlavuza webele, isifo sesibindi, noma engaxilongwanga ukopha kwesitho sangasese sowesifazane.
I-progesterone ibalulekile ekuzaleni nasekugcineni ukukhulelwa. Isiza ukulungiselela isibeletho ukuze sifakwe, isekela ukukhula kombungu, futhi ivimbele ukufinyela kwangaphambi kwesikhathi. Amazinga aphansi e-progesterone angenza ukukhulelwa kube nzima futhi andise ingozi yokuphuphuma kwesisu. Izithako ze-progesterone zivame ukusetshenziswa ekwelashweni kwenzalo, okuhlanganisa i-IVF, ukuthuthukisa amathuba okukhulelwa okuphumelelayo nokuvimbela ukuzalwa ngaphambi kwesikhathi ezimweni ezisengozini enkulu.