I-Sunitinib

I-Sunitinib

I-Sunitinib, isidakamizwa esinamandla, yenze amagagasi emhlabeni wezokwelapha ngekhono layo lokulwa nomdlavuza wezinso nezinye izimo ezinzima. Lo muthi uvimbela amangqamuzana omdlavuza ekukhuleni nasekusakazeni, okunikeza ithemba kubantu abaningi ababhekene nokuxilongwa okunzima.

I-Sunitinib iza ngethebhulethi, futhi odokotela bayisebenzisa ngezizathu ezimbalwa. Akuwona umdlavuza wezinso kuphela - ungasiza nangomdlavuza wamaphaphu nezinye izimila ezingandile. Lesi sihloko sizohlola i-sunitinib, indlela yokuyithatha, nokuthi yimiphi imiphumela emibi okufanele uyiqaphele. 

Iyini i-Sunitinib?

I-Sunitinib umuthi onamandla wokulwa nomdlavuza onomthelela ezinhlotsheni eziningi zamathumba. Iyingxenye yesigaba esibizwa ngokuthi ama-kinase inhibitors futhi ivimba isenzo samaprotheni angavamile abonisa amangqamuzana omdlavuza ukuthi aphindaphindeke. Lo muthi unomthelela omkhulu ekumiseni noma ekubambezeni ukusabalala kwamangqamuzana omdlavuza futhi ungasiza ekushwabaneni kwamathumba.

Ukusetshenziswa kwe-Sunitinib

I-Sunitinib inomthelela omkhulu ekwelapheni izinhlobo ezahlukene zomdlavuza, njenge: 

• I-Advanced-stage renal cell carcinoma (RCC)
• Izimila ze-Gastrointestinal stromal (GIST) ezingakaphenduli kahle kwezinye izindlela zokwelapha
• Amaphilisi e-Sunitinib aphinde avimbele ukubuya kwe-RCC ezigulini ezikhishwe izinso futhi zisengozini enkulu yokuphindaphinda.
• Izimila ze-pancreatic neuroendocrine (pNET) ezithuthukisiwe ezingelapheka ngokuhlinzwa. 
• I-Sunitinib iphinde ibambezele ukuthuthukiswa kwemithambo yegazi emisha ngaphakathi kwesimila, okudingekayo ekwelapheni umdlavuza.

Ungayisebenzisa kanjani ithebhulethi ye-Suninib

• I-Sunitinib ifika ngama-capsules angathathwa ngomlomo, ngokudla noma ngaphandle kokudla. 
• Umthamo nohlelo luncike esimweni esiphathwayo. 
• Kubalulekile ukuthatha i-sunitinib ngesikhathi esifanayo nsuku zonke. 
• Landela imiyalelo kadokotela wakho ngokucophelela, futhi uthintane nabo ngaphambi kokushintsha umthamo wakho. 
• Gwema ama-capsules ngokuphelele; ungawahlukanisi, uwahlafune, noma uwachoboze. 
• Udokotela wakho we-oncologist angase alungise umthamo wakho ngokusekelwe endleleni umuthi osebenza ngayo kuwe nanoma yimiphi imiphumela emibi, obhekana nayo. 
• Hlala ukhuluma nodokotela wakho mayelana nendlela ozizwa ngayo ngesikhathi sokwelashwa kwethebhulethi ye-sunitinib.

Imiphumela Emibi Yethebhulethi ye-Sunitinib

I-Sunitinib ingabangela uhla lwemiphumela emibi, eminye yayo engase ibe nzima. Imiphumela emibi evamile ihlanganisa: 

• Ukukhathala
• Uhudo
• I-nausea
• Ukulahlekelwa kwesifiso
• Ukushintsha kombala wesikhumba
• Umfutho wegazi ophezulu

Ukuqapha umfutho wegazi njalo kanye nokubika izimpawu ezifana nekhanda elibuhlungu noma isiyezi kudokotela wakho kubalulekile.

Imiphumela emibi kakhulu ingenzeka, njenge: 

• Izinkinga zokuphuza
• Izinkinga zesibindi
• Izinkinga zenhliziyo njengobuhlungu besifuba, ukuphelelwa umoya, noma izinyawo ezivuvukele namaqakala. 
• Ukungasebenzi kahle kwe-thyroid, okungabangela ukukhathala, ukushintsha kwesisindo, noma ukushintshashintsha kwemizwelo
• Imiphumela engathandeki ehlobene nesikhumba, ehlanganisa ukuqubuka, amabhamuza, noma izinguquko embala wezinwele

Ukuqapha

Ukuthatha i-sunitinib kudinga ukunakwa ngokucophelela ezinyathelweni eziningana, njenge: 

• Ukuqapha: Ukuhlolwa njalo kwezempilo nodokotela wakho kubalulekile ukuze uqaphe ukuqhubeka kwakho futhi ubuke noma yimiphi imiphumela engadingeki. Ukuhlolwa kwegazi nomchamo kungase kudingeke ukuze kuqinisekiswe ukuthi umuthi usebenza kahle.
• Izinkinga zokuzala: I-Sunitinib ingalimaza izingane ezingakazalwa, ngakho kubalulekile ukuba abesilisa nabesifazane basebenzise ukulawulwa kokuzalwa okuphumelelayo phakathi nokwelashwa kanye namasonto ambalwa ngemva komthamo wokugcina. Ezinye iziguli zingase zibe nezinkinga zokuzala.

Isebenza kanjani ithebhulethi ye-Sunitinib

I-Sunitinib iyi-multitargeted tyrosine kinase inhibitor enamandla ethinta ukukhula kwesimila nokwakheka kwemithambo yegazi. Isebenza ngokuvimbela amaprotheni amaningana abonisa amangqamuzana omdlavuza ukuthi aphindaphindeke futhi akhe imithambo yegazi emisha. Lo muthi unomthelela omkhulu ekumiseni ukukhula kwamathumba futhi ungasiza ukuwashwabanisa.

Isidakamizwa sihlose ama-receptors abalulekile abandakanyeka ekukhuleni komdlavuza, njenge-Vascular Endothelial Growth Factor Receptors (VEGFR) kanye ne-platelet-derived growth factor receptors (PDGFR). Ngokuvimbela la ma-receptors, i-sunitinib ibambezela ukukhula kwamangqamuzana omdlavuza futhi inqamule ukutholakala kwegazi lawo, okubalulekile ukuze aphile.

Ngingakwazi Ukuthatha I-Sunitinib Neminye Imithi?

I-Sunitinib isebenzisana neminye imithi eminingi, ngakho ukutshela udokotela wakho ngayo yonke imithi eqhubekayo kubalulekile. Eminye yemithi evamile engase ihlanganyele ne-sunitinib ihlanganisa: 

• I-Amitriptyline
• Apixaban
• Izinto ezinciphisa igazi njenge-heparin
• Ama-antibiotic athile, njenge-levofloxacin
• Imithi yesigqi senhliziyo

Ulwazi Lomthamo

Umthamo onconyiwe we-sunitinib uyahlukahluka kuye ngesimo sokwelashwa. 

Kumathumba e-gastrointestinal stromal (GIST) kanye ne-advanced renal cell carcinoma (RCC), odokotela banquma amamiligremu angu-50 kanye ngosuku amasonto amane, okulandelwa ikhefu lamasonto amabili. Lo mjikelezo wamaviki angu-6 uyaphindwa kuze kube yilapho isifo siqhubeka noma imiphumela engemihle ingalawuleki.

Umthamo ojwayelekile we-sunitinib wamathumba e-pancreatic neuroendocrine (pNET) ngu-37.5 mg othathwa nsuku zonke ngaphandle kwekhefu. 

Your i-oncologist ingase ilungise umthamo wakho ngokusekelwe ekutheni uwubekezelela kahle kangakanani umuthi kanye nempumelelo yawo.

Isiphetho

I-Sunitinib ithonya kakhulu ukwelashwa komdlavuza ohlukahlukene, inikeza ithemba ezigulini ezibhekene nokuxilongwa okunzima. Ivimbela amangqamuzana omdlavuza ukuthi angakhuli futhi asabalale, aqondise amaprotheni athile ayisihluthulelo sokuthuthukiswa kwesimila. Lo muthi ukhombise ukusebenza kahle ekwelapheni umdlavuza wezinso, izimila ze-stromal zesisu, kanye nezimila ze-pancreatic neuroendocrine, okuwenza ube yithuluzi elisebenza ngezindlela eziningi ekulweni nomdlavuza.

Imibuzo Evame Ukubuzwa

1. Ingabe i-sunitinib ingawelapha umdlavuza?

I-Sunitinib inomthelela ekwelapheni izinhlobo ezahlukene zomdlavuza, okuhlanganisa i-advanced renal cell carcinoma, izimila ze-stromal zamathumbu, kanye nezimila ze-pancreatic neuroendocrine. Kuvimba ukukhula nokusabalala kwamangqamuzana omdlavuza futhi kungasiza ekunciphiseni amathumba. Amaphilisi e-Sunitinib asetshenziswa lapho ezinye izindlela zokwelapha zingasebenzanga noma zingenakuphuzwa.

2. Uyithatha nini i-sunitinib?

I-Sunitinib ithathwa kanye ngosuku, ngokudla noma ngaphandle kokudla. 

3. Yiziphi izidakamizwa ezifana ne-sunitinib?

I-Sunitinib ingeyomndeni wezidakamizwa ze-tyrosine kinase inhibitors. Ezinye izidakamizwa kuleli klasi zihlanganisa i-sorafenib ne- pazopanib. Le mithi isebenza ngokufanayo ngokuvimbela amaprotheni athile abonisa ukuthi amangqamuzana omdlavuza aphindaphindeka. Nokho, umuthi ngamunye ungase ube nokusetshenziswa okuhlukile kanye nemiphumela engemihle.

4. Ungathatha isikhathi esingakanani i-sunitinib?

Ubude besikhathi sokwelashwa kwe-sunitinib buncike ekutheni isebenza kahle kangakanani nokuthi uyibekezelela kahle kangakanani. Ezinye iziguli zingase zithathe i-sunitinib isikhathi eside, ngisho neminyaka, uma iqhubeka isebenza kahle futhi imiphumela engemihle iyalawuleka. Udokotela wakho uzoqapha ukubikezela kwakho futhi alungise ukwelashwa njengoba kudingeka.

5. Isebenza kangakanani i-sunitinib?

I-Sunitinib ibonise ukusebenza okuphawulekayo ekwelapheni imidlavuza ethile. Ezivivinyweni zomtholampilo, kubonise ukusinda-mahhala okuthuthukisiwe kanye namazinga okusinda jikelele ezigulini ezine-advanced renal cell carcinoma. Amazinga okuphendula ayahluka kuye ngohlobo lomdlavuza kanye nezici zomuntu ngamunye. 

6. Isebenza isikhathi esingakanani i-sunitinib?

Ubude besikhathi sokusebenza kwe-sunitinib siyahlukahluka phakathi kweziguli. Abanye bangase bathole izinzuzo izinyanga ezimbalwa noma ngisho neminyaka, kanti abanye bangase babe nesikhathi esifushane sokuphendula. Ukuqapha njalo nokuskena kusiza ukunquma ukuthi umuthi uqhubeka isikhathi esingakanani usebenza. Uma umdlavuza uqhubeka, udokotela wakho angase acabangele ezinye izindlela zokwelapha.

7. Ingabe i-sunitinib ingathinta izinso?

I-Sunitinib ingaba nomthelela ekusebenzeni kwezinso. Ezinye iziguli zingase zibe ne-proteinuria (iphrotheni emchamweni) noma izinguquko ekusebenzeni kwezinso. Ukuqapha njalo ukusebenza kwezinso nokuhlolwa komchamo kubalulekile ngesikhathi sokwelashwa. Uma kwenzeka izinkinga ezinkulu zezinso, udokotela wakho angase alungise umthamo noma acabangele ezinye izindlela zokwelapha.

8. Kuyini umthamo we-sunitinib?

Umthamo we-sunitinib uyahlukahluka kuye ngohlobo lomdlavuza. Ngomdlavuza wezinso kanye nezimila ze-stromal zamathumbu, umthamo ojwayelekile ngu-50 mg nsuku zonke amasonto amane, okulandelwa ikhefu lamaviki amabili. Kumathumba e-pancreatic neuroendocrine, kuvame ukuba ngu-37.5 mg nsuku zonke ngaphandle kokuphumula.

9. Kufanele ngimise nini i-sunitinib ngaphambi kokuhlinzwa?

Uma ukuhlinzwa kuyelulekwa, udokotela wakho cishe uzokweluleka ukuthi uyeke ukuthatha i-sunitinib okungenani amasonto amathathu ngaphambi kwenqubo. Lokhu kungenxa yokuthi i-sunitinib ingathinta ukuphulukiswa kwesilonda. Udokotela wakho uzokunikeza imiyalelo yokuthi uyeke nini nokuthi ungawuqala nini kabusha umuthi ngokuphepha ngemva kokuhlinzwa.