I-Tolterodine, isidakamizwa esinqunywa kabanzi, sinikeza impumuzo kubantu abaningi abadonsa kanzima ukuphuthuma komchamo kanye nemvamisa. Lo muthi udlala indima ebalulekile ekuthuthukiseni izinga lempilo yalabo ababhekene nezinkinga zokulawula esinyeni, okwenza kube isihloko esibalulekile okufanele sihlolwe.
Ake sihlole izici ezihlukahlukene ze-tolterodine, okuhlanganisa ukusetshenziswa kwayo, ukuphatha okufanele, kanye nemiphumela emibi engaba khona. Sizohlola umthamo ojwayelekile we-tolterodine 2 mg futhi sixoxe ngokuthi ithebhulethi ye-tolterodine isebenza kanjani ukuze kudambise izimpawu.
I-Tolterodine ingeyeqembu lezidakamizwa ezibizwa ngokuthi i-antimuscarinics. Idlala indima ebalulekile ekwelapheni isinye esisebenza ngokweqile (OAB), ukugula lapho imisipha yesinye ifinyela ngokungalawuleki. Lesi sifo ngokuvamile sibonakala njengokuchama njalo, isidingo esiphuthumayo sokuchama, nokungakwazi ukulawula ukuchama. I-Tolterodine itholakala ekuqanjweni okukhishwe ngokushesha kanye nokukhishwa okunwetshiwe.
I-Tolterodine ingeyesigaba sezidakamizwa ezibizwa ngokuthi i-antimuscarinic, enesenzo esithile ekusebenzeni kwesinye. I-Tolterodine iphatha ngokuyinhloko esinyeni esisebenza ngokweqile (OAB). Lesi sidakamizwa sisebenza ngokuphumuza imisipha yesinye, okuvimbela ukufinyela kwesinye futhi kwandise amandla okugcina umchamo.
Abantu abane-OAB bavame ukuzwa isifiso esinamandla, esisheshayo sokuchama, ngisho noma esinyeni sabo singaphelele. I-Tolterodine inciphisa ukuvakasha kwamagumbi okugeza futhi isiza ukulawula izingozi zokumanzisa, ithuthukisa kakhulu izinga lempilo yalabo abathintwe yilezi zimpawu.
I-Tolterodine iza ngezinhlobo ezimbili: amaphilisi kanye namaphilisi okukhululwa okunwetshiwe. Iziguli ziphuza amaphilisi kabili ngosuku, kuyilapho amaphilisi akhishwa isikhathi eside edinga umthamo kanye ngosuku. Ukulandela ilebula kadokotela ngokucophelela nokubonana nodokotela nganoma yimiphi imibuzo kubalulekile. Iziguli kufanele zithathe i-tolterodine ngokuqondile njengoba kuqondiswe ngaphandle kokushintsha umthamo noma imvamisa.
I-Tolterodine ingabangela imiphumela emibi, nakuba kungeyena wonke umuntu ohlangabezana nayo. Imiphumela emibi evamile ihlanganisa:
I-Tolterodine isebenza ngokuphumuza imisipha yesinye futhi ikhulise inani lomchamo isinye esingawubamba. Lesi senzo sisiza ukwehlisa izimpawu ezifana nokuchama njalo, isidingo esiphuthumayo sokuchama, kanye nezingozi zokumanzisa ezihambisana nokusebenza ngokweqile kwesinye.
I-Tolterodine isebenzisana nemithi eminingi, njenge:
Ukwengeza, i-tolterodine inokusebenzisana notshwala nokudla okuthile. Iziguli kufanele zidalule yonke imithi kadokotela, imithi ethengwayo, amavithamini, nezithako ezingeziwe kudokotela wazo ngaphambi kokuthatha i-tolterodine.
I-Tolterodine itholakala ngamaphilisi akhishwa ngokushesha kanye nama-capsules akhululiwe.
Kubantu abadala, umthamo ojwayelekile wamaphilisi akhishwa ngokushesha ngu-2mg kabili ngosuku, athathwe amahora angu-12 ngokuhlukana. Amaphilisi okukhululwa okunwetshiwe ngokuvamile anqunywa njenge-4mg kanye ngosuku.
Umthamo wezingane usukela ku-1 kuye ku-4mg nsuku zonke, kuye ngesimo nempendulo.
I-Tolterodine yelapha izimpawu zesinye esisebenza ngokweqile, okuhlanganisa isidingo esiphuthumayo sokuchama, ukuchama njalo, nokungakwazi ukuzithiba. Ikhulula imisipha yesinye, ikhulise amandla okugcina umchamo.
I-Tolterodine ayifaneleki kulabo abanokugcinwa komchamo, ukugcinwa kwesisu, i-glaucoma ye-angle-angle engalawuleki, noma ukungezwani nezithako zayo. Iphinde inqatshelwe iziguli ezine-myasthenia gravis, ukuqunjelwa kakhulu, isifo sokuqaqamba kwamathumbu, noma ukuvinjwa kokuphuma kwesinye isinye.
I-Mirabegron iyi-β-adrenoceptor agonist futhi ibekezelelwa kangcono kune-tolterodine. Ibonisa ukukhululeka kwezimpawu okuthuthukisiwe kanye nokuthandwa okuphezulu kwesiguli. I-Tolterodine inemiphumela emibi kakhulu ye-anticholinergic uma iqhathaniswa ne-mirabegron.
I-Tolterodine ibonisa ukugxila okuphezulu ezigulini ezinokukhubazeka kwezinso. Odokotela batusa ukunciphisa umthamo weziguli ezinezinkinga zezinso ukuze kuvinjelwe izinkinga ezingaba khona.
Yebo, amaphilisi e-tolterodine akhishwa ngokushesha ngokuvamile athathwa kabili ngosuku, amahora angu-12 ngokuhlukana. Umthamo ojwayelekile wabantu abadala ngu-2mg kabili ngosuku.
Ucwaningo lwezokwelapha luye lwabonisa ukuthi ukuhlanganisa i-tolterodine ne-alpha-blocker efana ne-tamsulosin kuthuthukisa kakhulu izimpawu kubantu abanazo zombili isinye esisebenza ngokweqile kanye ne-benign prostatic hyperplasia.