I-Venlafaxine

I-Venlafaxine

I-Venlafaxine, i-antidepressant enamandla, ithole ukunakwa ngesenzo sayo esimbaxa-mbili mayelana nemizwa nengcindezi. Lesi sidakamizwa sisebenza ngokuthinta amakhemikhali obuchopho axhumene nempilo yengqondo, enikeza ithemba kulabo abanenkinga yokudangala kanye ukukhathazeka.

Ake sihlole ukuthi iyini i-venlafaxine nokuthi isetshenziswa kanjani. Sizobheka izinhlobo ezahlukene zamaphilisi e-venlafaxine, ukusetshenziswa kwe-venlafaxine 75 mg kanye nokusetshenziswa kwe-venlafaxine 150 mg, kanye nendlela efanele yokuwathatha. 

Iyini i-Venlafaxine?

I-Venlafaxine iyi-antidepressant enamandla eseklasini lemithi eyaziwa ngokuthi i-serotonin ekhethiwe kanye ne-norepinephrine reuptake inhibitors (SNRIs). Lo muthi ukhulisa amazinga e-serotonin kanye ne-norepinephrine ebuchosheni, esiza ukugcina ibhalansi yengqondo.

Umuthi uza ngezinhlobo ezimbili: amaphilisi akhishwa ngokushesha namaphilisi akhululiwe. Inguqulo yokukhishwa okunwetshiwe yethulwa ngo-1997 futhi ivame ukunqunyelwa ukwelashwa kwesikhathi eside. I-Venlafaxine ingasetshenziswa njengendlela yokwelapha ezimele noma njengengxenye yokwelapha okuhlangene neminye imithi, kuye ngezidingo nesimo sesiguli esithile.

Ukusetshenziswa kwethebhulethi ye-Venlafaxine

Amaphilisi e-Venlafaxine anohlu lokusetshenziswa okugunyaziwe nokungafakwa ilebula. Ukusetshenziswa kwe-venlafaxine okugunyazwe yi-FDA yilezi: 

• Isifo esikhulu sokucindezeleka
• I-Generalized Anxiety Disorder (GAD)
• Ukuphazamiseka kokukhathazeka komphakathi
• Isifo se-panic 

Okulandelayo okunye ukusetshenziswa ngaphandle kwelebula ye-venlafaxine: 

• Ukukhathazeka ngokweqile
• fibromyalgia
• I-syndromes yobuhlungu obuyinkimbinkimbi
• Ukushisa okushisayo okuhambisana nokunqamuka kokuya esikhathini
• Ukuvimbela Migraine
• I-post-traumatic stress disorder
• Isifo esibhekene nokuqapha
• Isifo se-premenstrual dysphoric
• Ubuhlungu be-neuropathic

Isetshenziswa kanjani i-Venlafaxine Tablet

• Amaphilisi e-Venlafaxine kufanele aphuzwe kanye nokudla ekuseni noma kusihlwa cishe ngesikhathi esifanayo nsuku zonke. 
• Umthamo we-Venlafaxine usekelwe esimweni sezokwelapha kanye nempendulo yokwelashwa. 
• Kubalulekile ukulandela imiyalelo kadokotela wakho ngokucophelela futhi uxhumane nabo ngaphambi kokumisa noma ukushintsha umthamo wakho. 
• Qhubeka uthatha i-venlafaxine njalo, ngisho noma uzizwa uphilile, njengoba kungase kuthathe amasonto ambalwa ukuqaphela izinzuzo ezigcwele. 
• Uma weqa umthamo, yithathe ngokushesha ngangokunokwenzeka, kodwa weqe uma sekusondele isikhathi somthamo wakho olandelayo. Ungalokothi uphindwe kabili kumithamo.

Imiphumela Emibi Yethebhulethi ye-Venlafaxine

I-Venlafaxine, njengayo yonke imithi, ingabangela imiphumela emibi kwabanye abantu. Imiphumela emibi evamile ihlanganisa:

• I-nausea
• Ukuphoqa
• Ukuphathwa yikhanda
• Umlomo omile
• isiyezi
• Ukulala 
• Umbono ophundlekile
• ubuhlungu besifuba
• Izinguquko ekushayeni kwenhliziyo
• Ukuzamula njalo

Akuvamile, imiphumela emibi kakhulu ingenzeka, njenge: 

• I-hallucination
• ukuquleka
• Ukulahlekelwa kokuxhumana
• Ukuhlanza kakhulu noma isifo sohudo
• Ukukhwehlela okungapheli
• Fever
• Ukuqina kwemisipha okukhulu
• Izinkinga zokuchama
• Izinguquko ekusebenzeni kocansi
• Izinguquko zesisindo 
• ukuqunjelwa 

Ukuqapha

• Umlando Wemithi: Ngaphambi kokuthatha i-venlafaxine, yazisa udokotela wakho nganoma yikuphi ukungezwani komzimba noma imithi oyisebenzisayo. Lokhu kufaka phakathi izidakamizwa ezithengwayo kanye nezithasiselo zemithi. I-Venlafaxine ingase ihlanganyele nemithi ethile, ikakhulukazi i-monoamine oxidase inhibitors (MAOIs). 
• Utshwala: Kubalulekile ukugwema utshwala ngenkathi uthatha lo muthi, njengoba kungandisa ukozela futhi kuthinte ikhono lakho lokucabanga ngokucacile. 
• Izimo Zezokwelapha: Yazisa udokotela wakho okwelaphayo ngomlando wakho wezokwelapha, ikakhulukazi uma unomlando we-glaucoma, isifo sokuwa, ukuphazamiseka kwegazi, izifo zenhliziyo, isifo sesibindi, noma isifo sezinso. I-Venlafaxine ingakhuphula umfutho wegazi, ngakho-ke kuyadingeka ukuhlola njalo. Kungase futhi kwandise ingozi yokopha, ikakhulukazi uma uthatha izidakamizwa zegazi noma ama-NSAID. 
• Isiyezi: Gwema ukushayela noma ukusebenzisa imishini ngaphansi komphumela womuthi, njengoba umuthi ungadala isiyezi. 
• Ukukhulelwa Nokuncelisa: Omama abakhulelwe noma abancelisa ibele kufanele baxoxe ngezingozi nezinzuzo nodokotela wabo. 
• Abadala: Abantu abadala asebekhulile bangase bazwele kakhulu emiphumeleni engathandeki, ikakhulukazi amazinga aphansi e-sodium egazini.

Isebenza kanjani i-Venlafaxine Tablet

I-Venlafaxine, i-serotonin-norepinephrine reuptake inhibitor (SNRI), isebenza ngokukhuphula amazinga e-serotonin ne-norepinephrine ebuchosheni. Ivimbela amaprotheni ezokuthutha avame ukumunca kabusha lawa ma-neurotransmitters, ashiye amaningi awo etholakala ku-synapse. Le nqubo ithinta ukulawulwa kwemizwelo kanye nokuphila kahle kwengqondo.

Ngemithamo ephansi, i-venlafaxine ithinta ngokuyinhloko ukutholwa kabusha kwe-serotonin. Njengoba umthamo ukhula, nawo uqala ukuba nomthelela ekuthatheni kabusha kwe-norepinephrine. Ngemithamo ephezulu, ingaba nomthelela obuthakathaka ekuthatheni kabusha kwe-dopamine. Lesi senzo esithweswe iziqu sivumela ukwelashwa okufanelana nezimo ezihlukahlukene.

Indlela ye-Venlafaxine idlula nje ukulawulwa kwe-neurotransmitter. Kuphinde kuthinte izici ze-neurotrophic ezitholakala ebuchosheni, ukukhuthaza i-neuroplasticity nokunciphisa i-neuroinflammation. Le miphumela ingase ibe nomthelela ekusebenzeni kwayo ekwelapheni ukudangala nokukhathazeka.

Ngingakwazi Ukuthatha I-Venlafaxine Ngeminye Imithi?

I-Venlafaxine ingasebenzisana nemithi ehlukahlukene, okuhlanganisa: 

• antidepressant
• Ama-Antihistamine afana ne-cetirizine, i-diphenhydramine
• Izidakamizwa ze-antiplatelet ezifana ne-clopidogrel
• Izinto ezinciphisa igazi njenge-warfarin
• Izidakamizwa zokulala nokukhathazeka, njenge-alprazolam, i-zolpidem, ne-lorazepam
• I-Monoamine oxidase inhibitors (MAOIs) 
• Izidakamizwa ezingezona ukuvuvukala ezifana ne-naproxen, ibuprofen
• Ukukhwehlela kwe-opioid nokuqeda ubuhlungu
• I-Triptans
• John's wort

Ukwengeza, abantu kufanele bagweme utshwala ngenkathi besebenzisa i-venlafaxine ngoba ingaqinisa ukozela. Hlala ukhuluma nodokotela wakho ngaphambi kokuqala noma ukuyeka noma yimuphi umuthi ngenkathi uthatha i-venlafaxine ukuze uqinisekise ukwelashwa okuphephile nokusebenzayo.

Ulwazi Lomthamo

Umthamo we-Venlafaxine uyahlukahluka kuye ngesimo kanye nempendulo yesiguli. 

Ngokucindezeleka, abantu abadala baqala ngo-75 mg nsuku zonke, kungaba njengomthamo owodwa noma ohlukaniswe. Umthamo unganyuswa kancane kancane, ngenani eliphakeme lama-225 mg nsuku zonke ezigulini ezingaphandle kanye nama-375 mg nsuku zonke ezigulini ezicindezeleke kakhulu. 

Ngezinkinga zokukhathazeka, udokotela angase aqale ngomthamo wama-milligrams angu-75 kanye ngosuku, ngenani eliphakeme lama-225 mg nsuku zonke.

Isiphetho

I-Venlafaxine igqama njengomuthi oguquguqukayo, onikeza impumuzo kulabo abanenkinga yokucindezeleka nokukhathazeka. Indlela yayo eyingqayizivele, ehilela ukukhulisa amazinga e-serotonin ne-norepinephrine ebuchosheni, ithonya ukulawulwa kwemizwelo kanye nokuhlala kahle kwengqondo. Yize kuyindlela yokwelapha esebenzayo, kubalulekile ukukhumbula ukuthi i-venlafaxine, njenganoma yimuphi umuthi, iza nemiphumela engemihle engaba khona kanye nokusebenzisana okudinga ukucatshangelwa ngokucophelela.

Kunoma ubani ocabanga noma osebenzisa i-venlafaxine njengamanje, ukuxhumana okuvulekile nodokotela kubalulekile. Banganikeza isiqondiso mayelana nomthamo ofanele, basize ukuqapha imiphumela emibi, futhi benze izinguquko ezidingekayo ohlelweni lokwelapha. Ngokuqonda ukuthi i-venlafaxine isebenza kanjani kanye nokulandela imihlahlandlela enqunyiwe, iziguli zingakwazi ukwandisa izinzuzo zayo kuyilapho zinciphisa ubungozi, okungase kuholele ekuthuthukisweni kwempilo yengqondo kanye nezinga lempilo.

Imibuzo Evame Ukubuzwa

1. Ubani ongakwazi ukuthatha i-venlafaxine?

I-Venlafaxine ayifanele wonke umuntu. Abantu abangalawulwa nomfutho wegazi ophezulu, ingozi enkulu ye-ventricular engathi sína i-arrhythmia, noma labo abangaphansi kweminyaka engu-18 ubudala kufanele bagweme lo muthi. Abantu abanomlando wokuquleka noma i-glaucoma noma labo abasanda kusebenzisa i-monoamine oxidase inhibitors (MAOIs) nabo akufanele bathathe i-venlafaxine. Abesifazane abakhulelwe abancelisayo kufanele babonane nodokotela babo ngaphambi kokusebenzisa le mithi.

2. Ingabe i-venlafaxine iyiphilisi lokulala?

Cha, i-venlafaxine ayilona iphilisi lokulala. Kuyi-antidepressant esetshenziselwa ukwelapha ukudangala nokukhathazeka. Nakuba kungase kubangele ukozela kwabanye abantu, inhloso yakho enkulu akukhona ukuyenga ubuthongo.

3. Ingabe KULUNGILE ukuphuza i-venlafaxine ebusuku?

I-Venlafaxine ingaphuzwa ebusuku, ikakhulukazi uma ibangela ukozela. Nokho, abantu abaningi bakhetha ukuyiphuza ekuseni. Inguqulo yokukhishwa okunwetshiwe ithathwa kanye ngosuku, kungaba ekuseni noma kusihlwa. 

4. Yini okungafanele idliwe ne-venlafaxine?

Yize ingekho imikhawulo ethile yokudla nge-venlafaxine, kungcono kakhulu ukugwema utshwala njengoba kungandisa ukozela kanye neminye imiphumela emibi. Kufanele futhi ugweme i-St. John's Wort herbal supplement ngenxa yengozi ye-serotonin syndrome. Kunconywa ukuthatha i-venlafaxine nokudla ukuze usize ukuvimbela isicanucanu, umphumela ovamile.

5. Ingabe i-venlafaxine ayilungile esibindini sakho?

I-Venlafaxine ingabangela ukuphakama kwesikhashana okungabonakali emazingeni e-serum aminotransferase futhi iye yahlotshaniswa nezimo ezingavamile zokulimala kwesibindi okubonakala emtholampilo. Kodwa-ke, lezi zimo zivame ukuzibekela umkhawulo futhi zixazululwe phakathi nezinyanga ezimbalwa. Iziguli ezinezimo zesibindi ezivele zikhona kufanele zazise udokotela wazo ngaphambi kokuqala i-venlafaxine.

6. Kwenzekani uma ngiphuthelwa umthamo?

Uma ugeja umthamo we-venlafaxine, yiphuze ngokushesha nje lapho ukhumbula, kodwa hhayi ngethamo elihleliwe elilandelayo. Ungalokothi uphindwe kabili umthamo ukuze wenze umthamo ogejiwe.

7. Yini okufanele ngiyigweme ngenkathi ngithatha i-venlafaxine?

Ngenkathi uthatha i-venlafaxine, gwema utshwala ne-cannabis. Qaphela lapho ushayela imoto, njengoba lo muthi ungabangela isiyezi noma ukozela. Gwema ukumisa kungazelelwe i-venlafaxine ngaphandle kokubonisana nodokotela wakho, njengoba lokhu kungaholela ezimpawini zokuhoxa. Futhi, qaphela ukuthi i-venlafaxine ingase ikhulise ithuba lokopha, ngakho-ke yazisa udokotela wakho uma uthatha izinto ezinciphisa igazi noma ama-NSAID.