I-Vildagliptin

I-Vildagliptin

I-Vildagliptin umuthi othathwa ngomlomo osetshenziswa lawula uhlobo 2 sikashukela. Ingowomndeni wezidakamizwa we-dipeptidyl peptidase-4 (DPP-4) inhibitors, edlala indima ebalulekile ekulawuleni amazinga kashukela egazini. Ngokungafani nemithi yendabuko yesifo sikashukela egxile kakhulu ekukhiqizweni kwe-insulin, i-Vildagliptin iqondise ohlelweni lwe-incretin, inethiwekhi eyinkimbinkimbi yamahomoni anesibopho sokulawula i-glucose homeostasis.

Ukusetshenziswa kweVildagliptin

I-Vildagliptin iboniswa ngokuyinhloko ekwelapheni isifo sikashukela sohlobo 2, isimo esibonakala ngokungakwazi komzimba ukusebenzisa i-insulin noma ukuyikhiqiza ngokwanele ngokuphumelelayo. Ngokuqondisa uhlelo lwe-incretin, iVildagliptin isiza:

• Thuthukisa Ukulawulwa Kwe-Glycemic: I-Vildagliptin ithuthukisa ukusabela kwemvelo komzimba ekuphakameni amazinga kashukela, okuholela ekulawuleni okuthuthukisiwe kanye nokuncipha kokuguquguquka kweglucose yegazi.
• Yehlisa i-Hyperglycemia: I-Vildagliptin isiza ukwehlisa izinga likashukela egazini, okuwuphawu lwesifo sikashukela sohlobo 2, ngokuvuselela ukukhiqizwa kwe-insulin futhi icindezele ukukhiqizwa kwe-glucagon, ihomoni enyusa ushukela wegazi.
• Phatha i-Postprandial I-Hyperglycemia: I-Vildagliptin ilawula ngempumelelo ukukhuphuka kukashukela egazini ngokuvamile okwenzeka ngemva kokudla, iphethini evamile kubantu abanesifo sikashukela sohlobo 2.
• Gcwalisa Izindlela Zokwelashwa Ezikhona: I-Vildagliptin ingasetshenziswa kanye nezinye izidakamizwa zesifo sikashukela (i-metformin noma i-sulfonylureas) ukuhlinzeka ngendlela ebanzi futhi ehambisanayo yokulawula isifo sikashukela.

Ungayisebenzisa kanjani iVildagliptin

IVildagliptin imvamisa ithathwa ngomlomo, ngokudla noma ngaphandle kokudla, njengokuyalelwa ngudokotela wakho.

Ulwazi lomthamo ku-Vildagliptin

Umthamo onconyiwe we-Vildagliptin uyahlukahluka futhi uncike emlandweni wezokwelapha womuntu, impilo iyonke, kanye nendlela asabela ngayo emuthini. Ngokuvamile, okulandelayo yimihlahlandlela yomthamo wayo:

• I-Monotherapy: Umthamo ojwayelekile we-Vildagliptin njengomuthi ozimele ngu-50 mg kabili ngosuku, ophuzwa kanye nokudla.
• Ukwelashwa Okuhlanganisiwe: I-Vildagliptin ingu-50 mg kanye ngosuku lapho ihlanganiswa neminye imithi yesifo sikashukela, njenge-metformin noma i-sulfonylureas.
• Ukukhubazeka Kwezinso: Kubantu abanokukhubazeka okumaphakathi kuya kokuqina kwezinso, umthamo we-Vildagliptin ungadinga ukuhlelwa ngokulandela izincomo zikadokotela.

Imiphumela Emibi Yethebhulethi ye-Vildagliptin

Ngenkathi i-Vildagliptin ivame ukubekezelelwa kahle, njenganoma iyiphi enye imithi, kungase kubangele imiphumela emibi. 

• Ikhanda elibuhlungu: Abanye abantu bangase babhekane nakho izinhlungu zekhanda (okuncane kuye komaphakathi) ngenkathi uthatha i-Vildagliptin.
• Isiyezi: Iphesenti elincane leziguli lingase libike imizwa yesiyezi noma ikhanda elilula.
• Isicanucanu: Isicanucanu esincane sibikwe yinani elincane labantu abathatha i-Vildagliptin.
• I-Hypoglycemia: Ezimweni ezingavamile, i-Vildagliptin ingaholela eziqephuni zoshukela wegazi ophansi, ikakhulukazi uma isetshenziswa ngokuhlangana nezinye. imithi yesifo sikashukela.
• Ukuthuthumela: Ukundindizela okuncane kubikwe ngabantu abathatha i-Vildagliptin.

Ukuqapha

Nakuba i-Vildagliptin ngokuvamile ibhekwa njengephephile futhi ibekezelelwa kahle, kunezinyathelo ezithile zokuphepha okufanele iziguli ziziqaphele:

• Ukukhubazeka Kwezinso: Abantu abanokukhubazeka okumaphakathi kuya kanzima kwezinso bangadinga ukulungiswa komthamo noma okunye ukwelashwa, njengoba i-Vildagliptin ihlanzwa ngokuyinhloko izinso.
• Ukukhubazeka Kwesibindi: Iziguli ezinesifo sesibindi esivele zikhona noma ezinenkinga yokusebenza kwesibindi kufanele zisebenzise i-Vildagliptin ngokuqapha nangaphansi kokuqondisa kukadokotela wazo.
• I-Pancreatitis: Imibiko engavamile ye-acute i-pancreatitis Okuhlobene nokusetshenziswa kwe-Vildagliptin kuye kwabikwa. 
• Ukusabela kwe-Hypersensitivity: Ezimweni ezingavamile, umuthi we-Vildagliptin ungadala ukungezwani komzimba noma i-hypersensitivity, njengokuqubuka, ukuqubuka, noma i-angioedema. Iziguli ezinomlando owaziwayo wezimpendulo ezinjalo kufanele zigweme ukusebenzisa i-Vildagliptin.

Isebenza kanjani iVildagliptin

Indlela yokusebenza ye-Vildagliptin igxile ekhonweni layo lokuvimbela i-enzyme dipeptidyl peptidase-4 (DPP-4). Le enzyme ihlukanisa amahomoni amabili abalulekile e-incretin- i-glucagon-like peptide-1 (GLP-1) ne-glucose-dependent insulinotropic polypeptide (GIP).

Ngokuvimbela i-DPP-4, i-Vildagliptin ithuthukisa umsebenzi walawa mahomoni e-incretin, adlala indima ebalulekile ekulawuleni amazinga kashukela egazini. Ngokuqondile:

• Ukuthuthukiswa kwe-GLP-1: I-Vildagliptin inyusa ukutholakala kwe-GLP-1, i-hormone ebangela ukukhishwa kwe-insulin kumanyikwe ukuze ilawule ukukhuphuka kwamazinga kashukela egazini. Le nqubo isiza ukwehlisa ushukela wegazi futhi ithuthukise ukulawulwa kwe-glycemic.
• Ukuthuthukiswa kwe-GIP: I-Vildagliptin iphinde ithuthukise imiphumela ye-GIP, enye i-hormone ye-incretin ekhuthaza ukukhiqizwa kwe-insulin futhi icindezele ukukhiqizwa kwe-glucagon, iphinde ibe nomthelela ekulawuleni ushukela wegazi.

Ngingakwazi ukuthatha i-Vildagliptin neminye imithi?

I-Vildagliptin ingasetshenziswa ngokuhlanganiswa neminye imithi yesifo sikashukela, njenge-metformin, insulin, kanye ne-sulfonylureas. Kodwa-ke, kubalulekile ukubonana nodokotela ngaphambi kokuqala uhlobo lomuthi olusha noma ukushintsha olukhona, njengoba inhlanganisela ethile nemithamo ingase idinge ukulungiswa ukuze kuqinisekiswe ukuphepha nokusebenza ngempumelelo okuphelele.

Kubalulekile ukukhumbula ukuthi i-Vildagliptin ingahlangana neminye imithi, okuhlanganisa:

• Imithi elwa nesikhunta: Imithi ethile elwa nesikhunta, njenge-ketoconazole, ingakhuphula ukugcwala kwe-Vildagliptin emzimbeni, okudinga ukulungiswa komthamo.
• Ama-antibiotics: Amanye ama-antibiotics, njenge-rifampicin, anganciphisa ukusebenza kwe-Vildagliptin.
• Imithi ye-antiseizure: Eminye imishanguzo ye-antiseizure, njenge-carbamazepine, ingase yehlise ukugcwala kwe-Vildagliptin emzimbeni.

I-Vildagliptin vs Sitagliptin

I-Vildagliptin ne-Sitagliptin womabili ama-DPP-4 inhibitors asetshenziswa ekwelapheni isifo sikashukela sohlobo 2. Ngenkathi behlanganyela ngendlela efanayo yokusebenza, kunomehluko oyinhloko phakathi kwemithi emibili:

• Umthamo: Umthamo onconyiwe ophephile we-Vildagliptin ngu-50 mg kabili ngosuku, kanti i-Sitagliptin ivamise ukuthathwa kanye ngosuku ngethamo elingu-100 mg.
• I-Metabolism: I-Vildagliptin ngokuyinhloko yenziwa isibindi. Ngaleso sikhathi, izinso zidlala indima ebalulekile ekuqedeni iSitagliptin.
• Ukusebenza kahle: Ucwaningo lwezokwelapha lubonise ukuthi i-Vildagliptin ne-Sitagliptin zisebenza ngendlela efanayo ekwehliseni i-HbA1c (isilinganiso sikashukela osegazini wesikhathi eside) kubantu abanesifo sikashukela sohlobo 2.
• Imiphumela Emibi: Yomibili le mithi inephrofayili yomphumela ofanayo, enekhanda elibuhlungu, isiyezi, kanye izimpawu zesisu ngokuba phakathi kwezivame ukubikwa.
• Ukukhubazeka Kwezinso: I-Sitagliptin ingadinga ukulungiswa komthamo kubantu abanokukhubazeka kwezinso, kuyilapho i-Vildagliptin ingasetshenziswa ngokunganaki kangako ngezinkinga eziphathelene nezinso.

Imibuzo Evame Ukubuzwa

1. Ingabe i-Vildagliptin iphephile?

Yebo, i-Vildagliptin imvamisa ithathwa njengomuthi ophephile uma usetshenziswa njengokuyalelwa ngudokotela wakho. Nokho, njengeminye imithi, imiphumela yayo engemihle engaba khona kufanele iqashwe. Kubalulekile ukuxoxa ngobungozi kanye nezinzuzo ze-Vildagliptin nodokotela wakho ukuze unqume ukuthi iyindlela yokwelapha efanele yini kuwe.

2. Kufanele ngiyithathe nini i-Vildagliptin?

IVildagliptin ithathwa kabili ngosuku, kanye ekuseni nakanye kusihlwa. Ingathathwa ngokudla noma ngaphandle kokudla, kodwa kubalulekile ukuyithatha ngesikhathi esifanayo usuku ngalunye ukuze isebenze kahle.

3. Ingabe i-Vildagliptin ne-metformin ziyefana?

Cha, i-Vildagliptin ne-metformin azifani. I-Vildagliptin umuthi we-DPP-4 inhibitor osetshenziselwa ukuphatha isifo sikashukela sohlobo 2. Ngakolunye uhlangothi, i-metformin iwuhlobo oluhlukile lwemithi yesifo sikashukela eyehlisa ukwakheka kweglucose esibindini futhi ithuthukise ukusabela komzimba ku-insulin.

4. Ingabe i-Vildagliptin iphephile ezinso?

I-Vildagliptin ngokuvamile ithathwa njengephephile kubantu abanokukhubazeka kwezinso okumaphakathi kuya komaphakathi. Kodwa-ke, ezimeni ezinzima zesifo sezinso, umthamo ungadinga ukulungiswa. Ukuxoxa nodokotela wakho ngokuphepha kwe-Vildagliptin ekusebenzeni kwezinso kubalulekile.