I-Voglibose

I-Voglibose

I-Voglibose iyi-alpha-glucosidase inhibitor, uhlobo lwemithi yomlomo ye-antidiabetic esetshenziselwa ukuphatha uhlobo 2 sikashukela i-mellitus. Kuyinhlanganisela yokwenziwa evimbela ukugaya kwama-carbohydrate ayinkimbinkimbi, ngaleyo ndlela kunciphise umthelela wawo amazinga kashukela.

Isebenza kanjani iVoglibose

Ama-carbohydrate ayinkimbinkimbi, njengesitashi, ngokuvamile ahlukaniswa abe ushukela olula (ama-monosaccharides) ngesikhathi. ukugaya, ezivumela ukuthi zimunceke emathunjini futhi zingene egazini. I-Voglibose ivimbela ama-enzyme e-alpha-glucosidase anesibopho sale nqubo yokuwohloka, ibambezele ngempumelelo ukumuncwa kwama-carbohydrate ayinkimbinkimbi futhi yehlise izinga likashukela wegazi wangemva kokudla (ngemuva kokudla).

Ukusetshenziswa kweVoglibose

Ukusetshenziswa okuyinhloko kwe-Voglibose ukulawula amazinga eglucose wegazi we-postprandial (ngemuva kokudla) ezigulini ezine-postprandial thayipha 2 ngesifo sikashukela. Ukusetshenziswa kwayo kuhlanganisa:

• Ku-Type 2 Diabetes Mellitus:
  • I-Voglibose isetshenziswa kanye nohlelo lokudla kanye nohlelo lokuzivocavoca ukuze kuthuthukiswe ukulawulwa kokushukela egazini kubantu abadala abanesifo sikashukela sohlobo 2.
  • Odokotela bayikhombisa njengokwelashwa okuhambisanayo lapho ukudla, ukuvivinya umzimba, namanye ama-oral hypoglycemic agents (OHAs) noma amalungiselelo e-insulin akubangeli ukulawula okwanele kwe-glycemic.
• Kusifo sikashukela esingancikile ku-insulini (NIDDM):
  • I-Voglibose ikhonjiswa njengesengezo kuhlelo lokudla nokuzivocavoca ukuze kuthuthukiswe ukulawulwa kwe-glycemic ezigulini ezine-NIDDM, lapho i-normoglycemia ingenakufinyelelwa ngokudla kuphela.
• Ngokuhlanganisa ne insulin:
  • Kubantu abanesifo sikashukela esincike ku-insulin (IDDM) kanye nokulawulwa kwe-glycemic okuphazamisekile, i-Voglibose ingafakwa ekwelashweni kwe-insulin ukuze kuthuthukiswe ukukhuphuka kweglucose yegazi ngemuva kokudla nokunciphisa i-glycosylated. amazinga e-hemoglobin (HbA1c)..
• Okunye Ukusetshenziswa:
  • Ezigulini esezikhulile noma ezigulini ezinenkinga yokungasebenzi kahle kwesibindi noma ukukhubazeka okuncane kuya kokulinganisela kwezinso, lapho amanye ama-OHA ephikiswa khona noma adinga ukusetshenziswa ngokuqapha, iVoglibose ingaba enye indlela ewusizo.
  • I-Voglibose ingasiza ekuvimbeleni ukuqhubekela phambili kokubekezelelana kwe-glucose ku-compromised (IGT) ukuze kuthayiphe isifo sikashukela sohlobo 2 kubantu abasengozini enkulu.
  • Kungaba usizo ekuvimbeleni i-hypoglycemia ezigulini ezinesifo sokugcina i-Ib glycogen kanye ne-non-diabetesic hyperinsulinemia.
  • I-Voglibose ingase futhi ibe wusizo ku-steroid-induced diabetes mellitus, nakuba idatha yomtholampilo kulesi silungiselelo inomkhawulo.

Ungayisebenzisa kanjani iVoglibose

Umthamo onconyiwe weVoglibose uyahlukahluka kuye ngezinto ezingazodwana njengobunzima besimo, iminyaka, neminye imithi ethathwayo. Nayi eminye imihlahlandlela ejwayelekile yokusebenzisa i-Voglibose:

Iziqondiso Zomthamo

• Kubantu abadala abanesifo sikashukela sohlobo 2 (i-DM Type 2), umthamo ojwayelekile ngu-0.2 mg weVoglibose othathwa kathathu ngosuku ngaphambi kokudla ngakunye.
• Kwezinye izimo, odokotela bangase banyuse umthamo ube ngu-0.3 mg kathathu ngosuku, kodwa kufanele ube ngaphakathi kwesilinganiso esiphezulu esinconywa nsuku zonke esingu-0.6 mg.
• Ezigulini ezinesifo sikashukela esingathembele ku-insulin (NIDDM), umthamo we-0.2 mg othathwa kathathu ngosuku ngaphambi kokudla uvame ukusebenza kahle.
• Ezigulini ezinesifo sikashukela esithembele ku-insulin (IDDM), i-Voglibose ingangezwa ekwelashweni kwe-insulin ngo-0.2 kuya ku-0.3 mg ophuzwa kathathu ngosuku ngaphambi kokudla.

Izimo Eziqondile

• Kwabanganesifo sikashukela i-hyperinsulinemia nesifo sikashukela esibangelwa i-steroid, umthamo onconywayo ngu-0.2 mg, othathwe kathathu nsuku zonke ngaphambi kokudla.
• Esifweni sokugcinwa kwe-glycogen, odokotela bangancoma ukuthatha umthamo ophansi we-0.1 mg we-Voglibose ngesikhathi sasemini nakusihlwa ukuze kwehliswe ubungozi beziqephu ze-hypoglycemic.

Administration

• I-Voglibose kufanele ithathwe ngomlomo ngokushesha ngaphambi kokudla ngakunye.
• Itholakala ngamafomu avamile nawe-oral disintegrating (ODT), kanye nokwakheka kwe-ODT okungase kube ngcono ukuthobela imithi.

Imiphumela emibi yeVoglibose

Njengemithi eminingi, i-Voglibose ingabangela imiphumela ethile engemihle. Imiphumela emibi evame kakhulu ehlobene ne-Voglibose ihlanganisa:

• Imiphumela Emibi Yesisu:
  • Uhudo
  • I-flatulence (igesi)
  • Ubuhlungu besisu noma ukungakhululeki
  • Ukuvimbela
  • Ukugcwala kwesisu
  • I-nausea nokuhlanza
• Imiphumela emibi ye-Hepatic:
  • Kufika ku-20% weziguli ezithatha i-Voglibose zingase zibe nokukhuphuka kwama-enzyme esibindi. Ezimweni ezingavamile, i-Voglibose iye yaxhunyaniswa nokusabela kwe-hypersensitivity, okuholela ku-cholestasis enzima (ukuvinjelwa kwe-bile duct) kanye ne-hepatitis (ukuvuvukala kwesibindi).
• I-Hypoglycemia:
  • Iziqephu ze-Metabolic hypoglycemic (amazinga aphansi kashukela egazini) azivamile ezigulini ezelashwa nge-voglibose, ikakhulukazi uma kuhlanganiswa neminye imithi ye-antidiabetic noma i-insulin.k
• Isiyezi:
  • I-Voglibose ingadala isiyezi, ikakhulukazi ezigulini esezikhulile noma lezo ezine-micro- noma i-macroangiopathies (ukuphazamiseka kwemithambo yegazi). Lo mphumela ungase ube phakathi kwemizuzu engu-10-20 ngemva kokuthatha i-Voglibose ngomlomo futhi kucatshangwa ukuthi ubangelwa ukuncipha kwesikhashana kwevolumu yoketshezi olujikelezayo ngenxa yokuguquguquka koketshezi lwamathumbu emathunjini okubangelwa ama-oligosaccharides angagayeki.
• Eminye I-Side Effects
  • Ukukhwabanisa isikhumba
  • I-Pneumatosis intestinal (ukuba khona kwegesi odongeni lwamathumbu)

Kubalulekile ukuqaphela ukuthi nakuba le miphumela emibi ngokuvamile imnene futhi iyalawuleka, ezinye iziguli zingase zibe nokusabela okubi kakhulu. Uma kuphakama noma yiziphi izimpawu, kubalulekile ukufuna usizo lwezokwelapha ngokushesha.

Isebenza kanjani iVoglibose

I-Voglibose iyi-alpha-glucosidase inhibitor. Ibambezela ukugayeka kokudla kanye nokumuncwa kwama-carbohydrate ayinkimbinkimbi emathunjini amancane. Nansi indlela esebenza ngayo:

• Ukuvimbela Ukugaya I-Carbohydrate: Isenzo se-anti-hyperglycaemic se-voglibose siphumela ekuvinjweni okubuyiselekayo kwama-enzyme e-alpha-glucosidase emathunjini aboshwe ulwelwesi. Lawa ma-enzyme e-hydrolyse (aphule) ama-oligosaccharides nama-disaccharides abe yi-glucose namanye ama-monosaccharides emngceleni webhulashi wamathumbu amancane. Ngokuvimbela lawa ma-enzyme, i-Voglibose ibambezela ukugaya kwama-polysaccharides okudla njenge-sucrose, i-maltose, nesitashi.
• Ibambezela Ukumuncwa Kwe-Carbohydrate: I-Voglibose ivimbela ngokuphindiselayo ama-enzyme okugaya ama-carbohydrate njenge-sucrase, i-maltase, ne-isomaltase, ngaleyo ndlela yehlise izinga lapho ama-carbohydrate ayinkimbinkimbi ehlukaniswa abe ama-monosaccharides. Lokhu ukubambezeleka kokugaya yehlisa i-postprandial hyperglycemia (PPHG), noma ukwenyuka okungavamile kwamazinga eglucose egazini ngemva kokudla.
• I-Modulating I-Incretin Hormones: I-Voglibose ingase futhi isize ukuhlanganisa ama-hormone e-endogenous incretin afana ne-glucagon-like peptide-1 (GLP-1), ivimbele ukuphuma kwesisu kanye nokukhishwa kweglucagon, ngaleyo ndlela yehlise amazinga eglucose asheshayo.
• Thuthukisa Ukulawulwa Kwe-Glycemic: Ngokubambezela ukugaya nokumuncwa kwama-carbohydrate ayinkimbinkimbi, i-Voglibose isiza ukwehlisa i-postprandial. i-hyperglycemia, ngaleyo ndlela kuthuthukisa ukulawulwa okuphelele kwe-glycemic kubantu abanesifo sikashukela sohlobo 2.

Ngingakwazi ukuthatha i-Voglibose Neminye Imithi?

I-Voglibose ingaxhumana nemithi ethile, ngakho-ke ibalulekile thintana nodokotela ngaphambi kokuyithatha ihlanganiswe nezinye izidakamizwa. Nazi ezinye izinto ezibalulekile:

• Imithi ye-Antidiabetic: I-Voglibose ingathuthukisa umphumela wokwehlisa ushukela wegazi weminye imishanguzo ye-antidiabetes, efana ne-sulfonylureas (isb, i-glimepiride, i-glyburide), i-metformin, ne-insulin, ngaleyo ndlela kwandise amathuba e-hypoglycemia (ushukela ophansi wegazi).
• Izithasiselo Ze-Enzyme Yokugaya: I-Voglibose ingase iphazamise ukusebenza kwezithasiselo ze-enzyme yokugaya, njengamalungiselelo e-pancreatic enzyme noma amanye ama-alpha-glucosidase inhibitors.
• I-Cholestyramine: I-Cholestyramine, i-bile acid sequestrant eyayisetshenziswa yehlisa amazinga e-cholesterol, inganciphisa ukumuncwa kweVoglibose lapho ithathwa kanyekanye.
• Ama-Anticoagulants: I-Voglibose ingathuthukisa umphumela we-anticoagulant we-warfarin nezinye izinto eziphuma ku-coumarin, ngaleyo ndlela yandise ingozi yokopha okuzenzakalelayo.
• I-Cyclosporine: I-Voglibose ingakhuphula ukumuncwa kanye ne-bioavailability ye-cyclosporine. Kuwumuthi ovikela ukuzivikela komzimba osetshenziswa kwabamukeli bokufakelwa izitho zomzimba.

Ulwazi Lomthamo

Odokotela benza ngokwezifiso umthamo weVoglibose ngokusekelwe ekubekezeleleni kwesiguli kanye nempumelelo ebonwayo. Isilinganiso esiphezulu esinconywayo se-0.6 mg, esithathwe kathathu ngosuku, akufanele sidlule.

Isiphetho

I-Voglibose umuthi osebenzayo osetshenziswa ngokuyinhloko ukulawula amazinga kashukela egazini ezigulini ezinohlobo 2 lwe-DM. Yehlisa ukumuncwa kwe-carbohydrate emathunjini, ngaleyo ndlela ivimbele ukukhuphuka koshukela wegazi ngemuva kokudla. Lapho uthatha i-Voglibose, unamathela kumthamo onqunyiwe futhi wazi ngemiphumela engemihle engaba khona, njenge ukungakhululeki emathunjini, kubalulekile. Hlala uthintana nodokotela ukuze uqinisekise ukuthi i-Voglibose iyisinqumo esifanele sezidingo zakho zempilo ngayinye futhi uqonde ukuthi ungayihlanganisa kanjani ngokuphepha nezinye izindlela zokwelapha.

Imibuzo Evame Ukubuzwa

1. Ingabe i-Voglibose ibangela ukuncipha kwesisindo?

I-Voglibose, i-alpha-glucosidase inhibitor, ngokuvamile ayihlotshaniswa nayo ukuncipha okukhulu kwesisindo. Kodwa-ke, ezinye izifundo zibike umehluko omkhulu ngokwezibalo ekwehliseni isisindo somzimba phakathi kweziguli ezithatha inhlanganisela ye-Voglibose ne-metformin uma kuqhathaniswa nalezo ezithatha i-metformin kuphela. 

2. Ingabe i-Voglibose iphephile ezinso?

I-Voglibose ngokuvamile ibhekwa njengephephile ukuthi isetshenziswe ezigulini ezinokukhubazeka okuncane kuya kokumaphakathi kwezinso. Kodwa-ke, kufanele kugwenywe ezigulini ezinesifo sezinso esingamahlalakhona (CKD) izigaba 4 & 5 kanye nalezo ezine-end-stage renal disease (ESRD).

3. Ingabe i-Voglibose ne-metformin ziyefana?

Cha, iVoglibose ne-metformin azifani. I-Voglibose iyi-alpha-glucosidase inhibitor. Kubambezela ukumuncwa kwama-carbohydrate asuka emathunjini amancane, ngaleyo ndlela kunciphise amazinga eglucose egazini ngemuva kokudla (ngemuva kokudla). Ngakolunye uhlangothi, i-metformin iyi-biguanide esebenza ngokuyinhloko ngokunciphisa ukukhiqizwa kwe-glucose esibindini futhi ikhulise ukuzwela kwe-insulin ezicutshini zangaphandle, ngaleyo ndlela yehlise ukuzila ukudla kweglucose yegazi.

4. Kufanele ithathwe nini iVoglibose?

I-Voglibose kufanele ithathwe ngomlomo, ngokushesha ngaphambi kokudla ngakunye, kathathu ngosuku.