Intuthuko Ekwelashweni komdlavuza wePancreatic

Inyanga Yokuqwashisa Ngomdlavuza We-pancreatic ka-2023: Umdlavuza we-pancreatic ungenye yezinhlobo zomdlavuza obulala kakhulu, ovame ukutholakala ezigabeni ezithuthukile ngezinketho zokwelashwa ezilinganiselwe. Kodwa-ke, eminyakeni yamuva nje kube nentuthuko enkulu emkhakheni wokwelashwa komdlavuza we-pancreatic, ikakhulukazi ngokuvela kwezindlela zokwelapha ezihlosiwe. NgokukaDkt. Deepak Koppaka, Umxhumanisi - I-Medical Oncology, Izibhedlela ze-CARE, Idolobha lase-HITEC, i-Hyderabad, lezi zindlela ezintsha zithembisa ukuthuthukisa imiphumela yesiguli futhi zilungise kabusha isimo sokunakekelwa komdlavuza we-pancreatic.

Ukuqonda Umdlavuza We-Pancreatic

Umdlavuza we-pancreatic ubonakala ngokukhula okungavamile kwamaseli ku-pancreas, isitho esibalulekile esibhekele ukukhiqiza ama-enzyme okugaya kanye ne-insulin. Idume ngemvelo yayo enolaka, ukuxilongwa kwesigaba sekwephuzile, kanye nokusabela okulinganiselwe ekwelashweni okujwayelekile njengokuhlinzwa, i-chemotherapy, nokwelashwa ngemisebe. Ukuntuleka kwezimpawu zakuqala ngokuvamile kuholela ekubambezelekeni kokutholwa, okunomthelela ekuqaguleni okudabukisayo okuhambisana nalesi sifo.

Izindlela zokwelapha ezihlosiwe

I-Molecular Profile and Personalized Medicine: Enye yempumelelo ebalulekile ekwelashweni komdlavuza we-pancreatic ukufika kwephrofayili yamangqamuzana, okuvumela ukuqonda okujulile kwezinguquko zofuzo namangqamuzana aqhuba ukukhula komdlavuza. Lolu lwazi seluvule indlela yokwelashwa komuntu siqu, lapho amasu okwelapha enziwa afanele ukwakheka kofuzo oluthile lwesimila somuntu. Izindlela zokwelapha ezihlosiwe zigxile ekuphazamiseni izindlela ezithile zamangqamuzana ekuqhubekeni komdlavuza, zinikeza indlela enembe kakhudlwana nesebenzayo.

I-PARP Inhibitors: Ama-poly (ADP-ribose) polymerase (PARP) inhibitors abonise isithembiso ekwelapheni umdlavuza wamaphaphu, ikakhulukazi ezigulini ezinokuguquguquka okuthile kofuzo, njengalezo ezisezakhini zofuzo ze-BRCA. Izivivinyo zemitholampilo zibonise imiphumela ekhuthazayo, zivula izindlela ezintsha zokuhlanganisa ama-PARP inhibitors ezinhlotsheni ezijwayelekile zokwelapha umdlavuza we-pancreatic.

I-Angiogenesis Inhibitors: Ukukhomba i-angiogenesis sekugxilwe ekwelapheni umdlavuza, futhi kuye kwaphenywa ama-angiogenesis inhibitors amaningana ngomdlavuza we-pancreatic.

Immunotherapies

I-Immune Checkpoint Inhibitors: I-Immunotherapy iye yavela njengendlela yokuguqula ekwelashweni komdlavuza, futhi umdlavuza we-pancreatic nawo unjalo. Ama-immune checkpoint inhibitors afana ne-pembrolizumab kanye ne-nivolumab block amaprotheni afana ne-PD-1 ne-PD-L1 avimbela impendulo yokuzivikela komzimba evumela amaseli e-T ukuthi abone futhi abhubhise amaseli omdlavuza. Nakuba kusacutshungulwa ukusebenza kwe-immune checkpoint inhibitors kumdlavuza we-pancreatic, izivivinyo zakuqala zomtholampilo zibonise imiphumela ethembisayo, enikeza ithemba ezigulini okungenzeka zingaphenduli kahle ekwelashweni kwendabuko.

Imithi Yokwelapha Yeseli Etholwayo: Ukwelashwa kwamaseli okutholwa kuhilela ukuphatha amasosha omzimba esiguli, njengama-T cell, angaphandle komzimba futhi awabuyisele ukuze aqondise futhi abhubhise amangqamuzana omdlavuza. I-Chimeric Antigen Receptor T-cell therapy (CAR-T) iyisibonelo esiphawulekayo sokwelashwa kweseli lokutholwa. Nakuba izindlela zokwelapha ze-CAR-T zibonise impumelelo ephawulekayo kumdlavuza othile wegazi, ukusetshenziswa kwazo kumathumba aqinile njengomdlavuza we-pancreatic kuyindawo esebenzayo yocwaningo. Ukunqoba izinselelo ezihambisana ne-pancreatic tumor microenvironment kusalokhu kugxilwe ekuthuthukiseni ukusebenza kahle kokwelashwa kwamaseli okutholwa.

Isixhumanisi Esiyisethenjwa

https://www.thehealthsite.com/diseases-conditions/pancreatic-cancer/advancements-in-pancreatic-cancer-treatment-targeted-therapies-and-immunotherapies-1035515/