Ukusuka ekudleni kuye ekucindezelekeni: Yazi ukuthi izici zemvelo zingayithinta kanjani ingozi yomdlavuza

I-New Delhi: Iminyaka eminingi, abantu babebheka umdlavuza njengesici sofuzo. Nokho, ucwaningo lwakamuva lwesayensi elawula izakhi zethu zofuzo, olwaziwa ngokuthi i-epigenetics, lubonisa ukuthi ikusasa lethu lingase libe nezimo kakhulu kunalokho esasikucabanga ekuqaleni. I-Epigenetics, inkambu ecwaninga ukuthi izakhi zofuzo zishintsha kanjani ngaphandle kokushintsha ukulandelana kwekhodi yazo, isifundisa ukuthi izici zangaphandle zingashintsha ukushintsha kofuzo—njengaleyo ehlobene nomdlavuza wamabele—ivuleke futhi ivale. Amathonya emvelo, njengokudla, ukungcola, kanye nengcindezi, angenza kusebenze noma kungasebenzi izakhi zofuzo ezihilelekile kumdlavuza. Ngakho-ke, ukuvimbela kubaluleke kakhulu njengokwelashwa, njengoba kungakacaci ukuthi yiziphi izici ezizobonakala njengabahlanganyeli abacacile lapho kuchazwa imingcele yokunquma ukuthi ubani osengozini yalesi sifo.

Ekusebenzelaneni ne-News9Live, uDkt. Sumanth Kumar M, Umxhumanisi - I-Medical Oncology, Izibhedlela ze-CARE, i-Banjara Hills, i-Hyderabad, ukhulume ngendima ye-epigenetics ekuxilongweni komdlavuza.

Ukuqonda i-Epigenetics kuCancer

Ngokungafani nokuguqulwa kofuzo okushintsha unomphela i-DNA, ukuguqulwa kwe-epigenetic kuyahlehliswa futhi kuthonywa ukukhetha kwendlela yokuphila. Izindlela ezintathu eziyinhloko ziqhuba lezi zinguquko:

1. I-DNA Methylation: Ukwengezwa kwamaqembu e-methyl kuma-molecule e-DNA kungathulisa izakhi zofuzo ezicindezela isimila, ziwavimbele ekumiseni ukukhula kwamaseli okungalawuleki.
2. Ukuguqulwa kwe-Histone: Amaprotheni abizwa ngokuthi ama-histones asiza ukupakisha i-DNA kuma-chromosome. Izinguquko zamakhemikhali kuma-histones zingaqinisa noma zixegise ukujikajika kwe-DNA, kuthinte ukufinyeleleka kwezakhi zofuzo.
3. I-RNA engafaki ikhodi: Amangqamuzana amancane e-RNA alawula ukubonakaliswa kwezakhi zofuzo, okuthonya ukuthi izakhi zofuzo ezikhuthaza umdlavuza zicushiwe noma ziyekiswa ukusebenza.

Iqhaza Lezinto Ezithinta Imvelo

Ucwaningo oluningi lugqamisa ukuthi amathonya angaphandle akuthinta kanjani ukulawulwa kwe-epigenetic. Ukuqonda lezi zici kunganika abantu amandla okwenza izinqumo ezinolwazi ezithuthukisa impilo futhi zivikele izifo.

1. Ukudla nokudla okunomsoco: Ukudla okunomsoco kudlala indima ebalulekile ekulawuleni izinguquko ze-epigenetic. Izakhamzimba ezifana ne-folate, uvithamini B12, nama-polyphenols (atholakala etiyeni eliluhlaza, i-turmeric, namajikijolo) asekela i-DNA methylation enempilo, enciphisa ingozi yokukhula kwamangqamuzana okungavamile. Ngokuphambene, ukudla okuphezulu ekudleni okugayiwe, inyama ebomvu, notshwala obudlulele kungaholela ekuguqulweni okuyingozi kwe-epigenetic.
2. Ukungcola kanye Nobuthi: Ukungcoliswa komoya, izinsimbi ezisindayo, nokuchayeka emagciwaneni anjengogwayi nezibulala-zinambuzane kwaziwa ngokuletha izinguquko ze-epigenetic eziholela kumdlavuza. Ucwaningo luye lwabonisa ukuthi abantu abasendaweni engcoliswe kakhulu babonisa ukungavamile kwe-DNA methylation, ngaleyo ndlela bandise izinga labo lokuba sengozini yomdlavuza.
3. Ukucindezeleka Nempilo Yengqondo: Ukucindezeleka kuphakamisa amazinga e-hormone, i-cortisol, yona eshintsha i-DNA methylation kanye nokuguqulwa kwe-histone, okungase kuvule ama-oncogenes. Ukucindezeleka kwengqondo kuhlobene nokuziphatha kwesimila esinolaka kanye nezimpendulo ezimbi ekwelashweni.

Ithemba Ngekusasa: I-Epigenetics kanye Nokwelashwa Komdlavuza

Njengoba izinguquko ze-epigenetic zibuyiselwa emuva, lokhu kunikeza isithembiso sokuvimbela umdlavuza kanye nokwelashwa. Manje abacwaningi benza izidakamizwa ze-epigenetic, njenge-DNA methylation inhibitors kanye ne-histone deacetylase inhibitors, engabuyisela izakhi zofuzo ekusebenzeni okuvamile. Umuthi oqondene nawe oqondiswa iphethini ye-epigenetic yomuntu ngamunye kufanele uholele ekwelashweni okusebenzayo kanye nobuthi obuncane.

Isixhumanisi Esiyisethenjwa

https://www.news9live.com/health/health-conditions/does-blood-type-influence-ageing-and-longevity-2833387