Izivivinyo Zokuvuselela I-ACTH

Ukuhlolwa Kokuvuselela Kwe-ACTH e-Hyderabad

 I-Adrenocorticotropic Diagnosis noma i-ACTH ingenye yamahomoni akhiqizwe indlala ye-pituitary etholakala ngemuva kobuchopho. 

Umsebenzi oyinhloko we-ACTH ukukhuthaza izindlala ze-adrenal zezinso ukuthi zikhiphe amahomoni amabili abizwa ngokuthi i-cortisol ne-adrenaline. Lezi zaziwa nangokuthi i-epinephrine futhi zisiza umuntu ukuba aphendule ekucindezelekeni. Nakuba impendulo yenziwa ngendlela enempilo ezosekela amasosha omzimba. I-Cortisol yaziwa ngokuthi i-hormone ye-steroid ethinta izingxenye eziningi nezinhlelo zomzimba njenge-

• Uhlelo lokujikeleza kwegazi

• izivikeli mzimba

• Uhlelo lwezinzwa

• I-Bone metabolism

• I-Metabolism yezakhi ezinjengama-carbohydrate, amafutha, namaprotheni

Izinzwa kanye nezinhlelo zokujikeleza kwegazi zigcinwa yi-adrenaline hormone ehambisana ne-norepinephrine engasiza umuntu ukulwa nesimo esicindezelayo. Inikeza impendulo evame ukwaziwa njengokulwa noma ukusabela kwendiza.

Ukuhlolwa kwe-ACTH kwenziwa ukuze kwahlulele imisebenzi efanayo; lokho kusho ukusebenza kwezindlala ze-adrenal. Ingxenye yokwenziwa ye-ACTH ebizwa ngokuthi i-cosyntropin iyajovwa ngesikhathi sokuhlaziywa bese kuthathwa amasampula egazi ama-2: eyodwa ngaphambi kwe-cosyntropin neyodwa ngemva komjovo. 

Ukuhlola kwakuzokwahlulela izinga le-cortisol egazini elingasiza odokotela base-CARE Hospitals ukuba baxilongwe kahle (ukwazi izimbangela) kanye nokwelashwa.

Ukuhlola okubizwa ngokuthi i-ACTH stimulation tests kungakala izindlala ze-adrenal kanye nokusabela kwazo nge-ACTH egazini futhi odokotela bazokwazi amazinga e-cortisol. 

Kungani kwenziwa izivivinyo zokuvuselela i-ACTH?

Ukuhlolwa Kokuvuselela I-ACTH (Adrenocorticotropic Hormone) kwenziwa ukuze kuhlolwe ukuthi izindlala ze-adrenal zisebenza kahle kangakanani. Ngokukhethekile, kusiza ukuhlonza izinkinga ezihlobene nokungasebenzi kahle kwezindlala ze-adrenal, njengesifo sika-Addison noma ukungasebenzi kahle kwezindlala ze-adrenal. Nakhu ukuthi kungani ukuhlolwa kuthathwa:

• Ukuhlola ukusebenza kwezindlala ze-adrenal: Ukuhlola kuhlola ukuthi izindlala ze-adrenal zikhiqiza i-cortisol eyanele yini, ihomoni ebalulekile esiza ukulawula ukugaya, umfutho wegazi, nezimpendulo zengcindezi.
• Ukuxilonga ukungasebenzi kahle kwezindlala ze-adrenal: Kuyasiza ekunqumeni ukuthi izindlala ze-adrenal azikhiqizi yini i-cortisol eyanele ngenxa yomonakalo (isifo sika-Addison) noma ngenxa yenkinga ye-pituitary gland noma i-hypothalamus (ukungasebenzi kahle kwezindlala ze-adrenal).
• Ukuqapha ukusabela ekwelashweni: Ukuhlolwa kungasetshenziswa ukuqapha iziguli ezinokuphazamiseka kwe-adrenal okwaziwayo ukuze kuqinisekiswe ukuthi ukwelashwa kusebenza ngendlela efanele.
• Ukuhlola ukugcinwa kwezindlala ze-adrenal: Ezimeni lapho umzimba ungase ucindezeleke khona (njengalapho ugula noma uhlinzwa), lokhu kuhlola kuhlola ukuthi izindlala ze-adrenal zingasabela yini ngokukhiqiza i-cortisol eyanele.

Izimpawu ze-Addison's Disease kanye ne-Hypopituitarism  

Izimo ezifana nesifo sika-Addison (ukungasebenzi kahle kwezindlala ze-adrenal), kanye ne-hypopituitarism (i-pituitary engasebenzi) zingahlulelwa ngosizo lwe-ACTH Stimulation Test. Izimpawu nezimpawu zihlanganisa; 

• Ukwehla kwesisindo kungazelelwe

• Umfutho wegazi ophansi

• Ukulahlekelwa kwesifiso

• Ubuthakathaka bemisipha

• Ubuhlungu besisu nobuhlangene

• Ukukhathala

• Ukuba mnyama noma ukushintsha kombala kwesikhumba

• Imodi iyashintsha

• Ukucindezeleka

• Ukuthukuthela

Kukhona ezinye izimpawu ezingase zibe khona uma umuntu ene-cortisol ephuma ngokweqile.

• induna

• Ubuso obuyindilinga

• Ukukhuluphala

• Izinwele zobuso ezandayo

• Izinwele eziningi zomzimba 

• Ukungahambi kahle kokuya esikhathini kwabesifazane

• Umfutho ophansi wocansi emadodeni

Ukungasebenzi kahle kwezindlala ze-adrenal kwahlulelwa ngesisekelo sokuhlolwa kokuvuselela i-ACTH futhi kuphinde kuxilongwe ukuze zelashwe.

Izingozi Ezihambisana Nokuhlolwa

Kukhona ubungozi obuthile obuhambisana nokuhlolwa ngesikhathi kukhishwa igazi- 

• Lightheadedness

• Ukutheleleka

• Ukuphuma ngokweqile

• Ukuphelelwa amandla

• IHematoma

• Ukuvuvukala komthambo lapho kukhishwe khona igazi

Abantu bangase bezwe ubuhlungu obuncane endaweni yomjovo noma ukubhoboza okuhlabayo endaweni. Umhuzuko omncane ungabonwa kodwa awukwazi ukushiya imiphumela emibi ehlala isikhathi eside.

Ukuthi Ukuhlolwa Kokulingisa Kwe-ACTH Kwenziwa kanjani 

Ukuxilongwa Ngokuhlolwa Kokuvuselela Kwe-ACTH e-Hyderabad kwenzeka ngale ndlela elandelayo.

• Ukuhlolwa komzimba okunjengomfutho wegazi, ukuhlolwa kweglucose, okubalulekile njengomkhuhlane, izinga lokushaya kwenhliziyo, ukuminyana kwesifuba, nokuhlolwa kwesisindo kwenziwa ngaphambi kokuhlolwa kokugcina.

• Lokhu kubizwa ngokuthi ukuhlola kokuqala okuthi ngemva kwalokho kuhlolwe igazi le-ACTH ukuze kuhlolwe ezinye izimo zezokwelapha- isibindi, izinso kanye nemisebenzi ehlobene nayo.

• Ngemuva kwezimo zomzimba, umlando wezokwelapha womuntu waziwa ngokubheka noma yisiphi isici sofuzo esithinta izimpawu zabo.

• Uma usulungile futhi ucelwa ukuxilonga Ukuhlolwa Kokuvuselela Kwe-ACTH, kuzodingeka ukuthi ulethe isampula yegazi.

• Kuthathwa ukukala amazinga e-cortisol egazini futhi kuphinde kusetshenziswe njengesisekelo lapho ezinye iziqhathaniso zingenziwa khona. Iqhutshwa kabili ngesizathu esifanayo.

• Ingxenye yokwenziwa ye-ACTH ebizwa ngokuthi i-cosyntropin inikezwa njengomjovo emgudwini wegazi lapho izoheha izindlala ezikhiqiza i-cortisol. 

• Kudingeka ihora ukuze udokotela ahlulele ukusabela futhi ngokuqhubekayo, uzothatha isampula yegazi lesibili. Lokhu kunganikeza amazinga e-cortisol egazini. Kwahlulelwa ngesikhathi umzimba osithathile ukuze usabele. 

• Amasampula okuhlolwa kokuvuselela kwe-ACTH aphinde ahlolelwe amazinga e-cortisol futhi imiphumela ingavela lingakapheli isonto noma amabili.

• Udokotela wakho angakwazi ukwenza ukuhlolwa kwe-insulin-induced hypoglycemia, kanye nokuhlolwa kwezithombe ukuze aqinisekise ukuxilongwa.

• Odokotela bazokwazi ukuthi unesifo sika-Addison noma i-hypopituitarism.

Indlela Yokulungiselela Ukuhlolwa

• Kungase kudingeke unciphise umsebenzi wakho womzimba futhi udle ukudla okunothe ngama-carbohydrates emahoreni ayi-12 kuye kwangama-24 ngaphambi kokuhlolwa. 
• Kwezinye izimo, ukuzila ukudla amahora angu-6 ngaphambi kokuhlolwa kungase kudingeke. Nokho, akukho ukulungiselela okuqondile okudingekayo ezimweni ezithile. 
• Ungase futhi uyalwe ukuthi ume isikhashana imithi efana ne-hydrocortisone, njengoba ingathinta imiphumela yokuhlolwa kwegazi kwe-cortisol.

Isivivinyo sizozizwa kanjani

• Lapho inaliti ishuthelwa ukuze kudonswe igazi, abanye abantu baba nobuhlungu obusesilinganisweni, kuyilapho abanye bezwa kuphela ukuhlaba noma ukulunywa kancane. Ukulimala okuncane noma ukushaywa kungase kwenzeke ngemva kwalokho, kodwa ngokuvamile kuncipha ngokushesha.
• Umjovo ehlombe ungabangela ukungakhululeki okumaphakathi noma ukuzwa okuhlabayo.
• Ngemva kokuthola umjovo we-ACTH, abanye abantu bangase bazizwe bekhathele, bekhathazekile, noma benesicanucanu.

Imiphumela Ejwayelekile Nengajwayelekile

• Imiphumela Evamile: Ngemva kokukhuthazwa kwe-ACTH, ukukhuphuka kwamazinga e-cortisol kulindeleke. Ngokuvamile, amazinga e-cortisol kufanele akhuphuke ngaphezu kuka-13 kuya ku-14 mcg/dL (358 kuya ku-386 nmol/L), kuye ngokuhlolwa kwe-cortisol kanye nomthamo we-ACTH osetshenzisiwe. Ububanzi obujwayelekile bungase buhluke kancane phakathi kwamalabhorethri, njengoba amanye amalebhu esebenzisa amayunithi ahlukene noma ahlole amasampula ahlukene. Kubalulekile ukuxoxa ngemiphumela yakho ethile nomhlinzeki wakho wokunakekelwa kwezempilo ukuze uthole incazelo enembile.
• Imiphumela Engavamile: Imiphumela engavamile evela kulokhu kuhlolwa ingabonisa izimo ezifana nalezi:
  • I-acute adrenal crisis, isimo esisongela ukuphila ngenxa ye-cortisol enganele.
  • Isifo sika-Addison, lapho izindlala ze-adrenal zikhiqiza i-cortisol encane kakhulu.
  • I-Hypopituitarism, lapho i-pituitary gland ingakhiqizi amahomoni anele, okuhlanganisa i-ACTH.

Ukwelashwa 

• Ukwelashwa kunikezwa futhi ukulungisa izinga lamahomoni amahomoni e-steroid.

• Uma amazinga e-cortisol yegazi engaphansi kwebanga, ukukhuthazwa kunikezwa njengokuphansi. 

• Abantu bangase baphathwe yizimo ezinjenge-acute adrenal crisis, isifo sika-Addison, noma i-hypopituitarism.

• Nakuba lokhu kuhlolwa kunconywa ikakhulukazi odokotela ukuba banikeze ukwelashwa okufanele.

Ukwelashwa okuvamile kuhilela

Imithi 

• I-Hydrocortisone (Cortef), i-prednisone noma i-methylprednisolone esikhundleni se-cortisol enikezwe ngendlela yomjovo.

• I-Fludrocortisone acetate esikhundleni se-aldosterone.

• I-Corticosteroids inikezwa ngendlela ye-hydrocortisone (Cortef) noma i-prednisone (i-Rayos). Lezi zizothatha indawo ye-adrenal ngenxa yokushoda kwehomoni ye-adrenocorticotropic (ACTH).

• I-Levothyroxine (Levoxyl, Synthroid, abanye) inikezwa ukwelapha amazinga aphansi e-hormone yegilo.

• Ama-hormone ocansi

• Amahomoni okukhula 

• Amahomoni enzalo 

Ukuhlinzwa

I-CT ngezikhathi ezithile noma i-MRI scan ingenziwa ukuze kwaziwe isimo sesimila se-pituitary (uma sitholakala ekuhlolweni) futhi kuzokwazi ezinye izizathu ezihlobene.
Kungase kuhlanganise ukuhlinzwa ukuze kususwe ukukhula okunjalo ngosizo lwemithi yokwelapha ngemisebe.

Kungani ukhethe Izibhedlela ze-CARE eNdiya?

I-CARE Hospitals ingesinye sezaseNdiya izibhedlela ezingcono kakhulu ezinemisebenzi eminingi, ezinikele ekuhlinzekeni ukwelashwa kwezempilo okungenakuqhathaniswa nokusekelwe ebufakazini. 

Siyisikhungo esivelele nesididiyelwe sokunakekelwa kwezempilo esineZikhungo Ezinhle Kakhulu zobuchwepheshe obukhethekile njengokuhlinzwa kwenhliziyo, ukuhlinzwa kwe-CT, i-neurology, umdlavuza, isibindi, ukufakelwa kwezitho eziningi, amathambo namalunga, i-nephrology, ukuhlinzwa komgogodla, umama nengane, nokuzala.

Isibhedlela sethu sithathwa njengesinye sezibhedlela ezihamba phambili eNdiya ngenxa yezinsiza nezinsiza zesimanje. Sinezibhedlela ezisebenza ngochwepheshe abahlukahlukene ezihlome ngemibhede yezokwelapha esebenza ngokugcwele, iyunithi yokunakekela abagula kakhulu/ithiyetha yokusebenza, i-ultrasound ehambayo, i-X-ray, i-2D echo, nokunye. izinsiza zokunakekelwa okubucayi ezigulini ezigula kakhulu.