Dicyclomine plus Mefenamic acid : Uses, Side Effects, Dosage, Precautions & More

Dicyclomine + Mefenamic acid

Dicyclomine + Mefenamic acid

Dicyclomine + Mefenamic acid is a tablet used to relieve menstrual pain and cramps. It blocks the chemical messenger cyclooxygenase enzymes, or COX, thereby relaxing the inflammation of muscles. It basically helps relax muscles due to its anti-inflammatory properties.

What are the uses of Dicyclomine + Mefenamic acid?

Dicyclomine works as an antispasmodic to reduce muscle contractions in the stomach by relieving them. Mefenamic acid blocks COX enzymes and stops the chemical messenger so that fewer prostaglandins are produced, which in turn reduces pain and inflammation. Some dicyclomine uses and mefenamic acid uses are the following:

  • Menstrual cramps, nausea, bloating, muscle spasms, and discomfort 

  • Abdominal and Stomach pain

  • Fever

  • Fracture-related injuries

  • Minor Surgeries

  • Tooth Decay

  • Soft Tissue Swellings

  • Irritable Bowel Syndrome

  • Joint Pain

How and when to take Dicyclomine + Mefenamic acid?

Dicyclomine + Mefenamic acid should be taken after eating food and swallowed with water, otherwise, it may upset your stomach. It should be taken in all at once, without breaking, chewing, or crushing it.

The dosage and duration of administration will depend upon your doctor’s advice based on your symptoms and health condition. 

What are the side effects of Dicyclomine + Mefenamic acid?

Some dicyclomine side effects are

  • Blurred vision

  • Acidity 

  • Dryness in the mouth

  • Dizziness

  • Visual hallucinations 

  • Indigestion

  • Itching 

  • Increased sweating

  • Nausea

  • Nervousness

  • Sleepiness

  • Weakness

  • Increase in blood pressure

  • Skin rash & swelling

  • Vomiting 

What precautions should be taken while using Dicyclomine + Mefenamic acid?

You should increase your water intake while taking Dicyclomine + Mefenamic acid. Also, rinse your mouth regularly and follow oral hygiene. Sugarless candies can help with increased dryness caused by this medicine. Other precautions include the following:

  • Pregnant and breastfeeding women should not take it without consulting the doctor.

  • As the medicine causes drowsiness and dizziness, it is not advisable to drive if you are taking it.

  • Do not consume alcohol along with it, as it may further increase drowsiness. The risk of stomach-related problems increases.

  • Patients with pre-existing liver conditions must not take it without the doctor’s advice. Caution must be taken while taking it. The medicine is not recommended for those with severe liver diseases.

  • Patients with kidney diseases are advised to take Dicyclomine + Mefenamic acid with caution. The dose can be adjusted by the doctor if the medicine is needed. Those with terminal kidney disease must avoid it.

  • People with glaucoma, high blood pressure, enlarged prostate, problems with the heart, liver, or kidneys, and thyroid problems must not consume the medicine without a doctor’s consultation.

  • A blood clotting test is suggested if Dicyclomine + Mefenamic acid medicine is taken for a prolonged time. It can also cause a false positive reaction for the urinary bile test.

What should I do if a dose of Dicyclomine + Mefenamic acid is missed?

In case you miss the prescribed dosage of Dicyclomine + Mefenamic acid, you can take it as and when you recall it. However, you should avoid the missed dose if the next dose is due soon (at least maintain the 4-hour gap in between doses). Follow the dosages as per the set timings without doubling them to avoid any mishaps.

What happens in case of an overdose of dicyclomine + mefenamic acid?

If someone overdoses, then they might pass out because of the ill effects it may cause on the brain. Many individuals might experience difficulty breathing. These are some serious signs calling for instant medical help without losing time. Hence, it is always advised to contact your medical doctor when you overdose on Dicyclomine + Mefenamic acid.

What are the storage conditions of dicyclomine + mefenamic?

Dicyclomine + Mefenamic acid should be stored at room temperature, in a clean and dry place, away from heat and sunlight. Storing it in the bathroom is not suggested. Avoid places with moisture and keep them away from children.

Can I take dicyclomine + mefenamic with other medications?

The list of medicines with it may interact and cause problems, including:

  • Painkillers like Aspirin

  • Antipsychotic medicines - Quinidine, Lithium, Phenothiazine 

  • Diuretic-Furosemide

  • Blood thinning medicines -Warfarin 

  • Anti-diabetic-Glimiperide, Glibenclamide, Gliclazide

  • Anti-rheumatoid-Methrotrexate

  • Antibiotics-Amikacin, Gentamicin, Tobramycin, Cyclosporine 

  • Antiemetic-Metoclopramide

  • Antiplatelet-Clopidogrel

  • Steroids

  • Immunosuppressant-Tacrolimus 

  • Anti-HIV-Zidovudine

  • Cardiac glycoside-Digoxin

However, you should always consult your doctor if you are taking any of the medications, including the ones mentioned above, and whether it’s necessary to take Dicyclomine + Mefenamic acid as well. Your doctor or pharmacist might prescribe you a better alternative if necessary.

How quickly will dicyclomine + mefenamic show results? 

It becomes effective on the same day when you take it, or it might show results within 2 hours itself. It differs from person to person for the medicine to work. If a dose is missed, the results will be delayed until the next dose. In any case, the dose should not be doubled to get faster results.

Comparison of Dicyclomine + Mefenamic acid with Dicyclomine, Dextropropoxyphene and Paracetamol


Dicyclomine + Mefenamic acid

Dicyclomine, Dextropropoxyphene and Paracetamol


To relieve abdominal and menstrual cramps, stomach discomfort, and pain due to gas, infection, acidity and other gastrointestinal diseases

It reduces cramps, fever and pain in the stomach and abdomen. 


Dicyclomine (10mg),  Simethicone (40mg)

Dicyclomine (20mg), Dextropropoxyphene (500mg), Paracetamol 500 mg

Storage Instructions

Room temperature 10-30C

Room temperature 

15-30 C


People who are already taking other medicines or have other pre-existing medical conditions must exercise precautions in order to avoid complications. It is always better to consult your doctor when taking Dicyclomine + Mefenamic acid or even for any other drug. The medicine is used for treating several symptoms. However, being wary and having all the information in advance is always safe for your health.


TATA 1mg




Disclaimer: The information provided here is not meant to substitute an advice from a healthcare professional. The information is not intended to cover all the possible uses, side-effects, precautions, and drug interactions. This information is not intended to suggest that using a specific drug is suitable, safe, or efficient for you or anyone else. The absence of any information or warning regarding the drug should not be interpreted as an implicit guarantee from the organisation. We strongly advise you to consult a doctor if you have any concerns about the drug and never use the medication without a doctor’s prescription.