Methylcobalamin : Uses, Side Effects, Dosage, Precautions



Methylcobalamin is the activated form of Vitamin B12, available as an oral medicine. It is prescribed for people suffering from a deficiency of vitamin B12. The aim of this vitamin is to help with the proper functioning of the brain and nerves as well as the production of red blood cells.

Methylcobalamin helps treat the deficiency of vitamin B12 by producing a substance known as "myelin". This substance is responsible for covering nerve fibres and protecting them. Without inadequate amounts of methylcobalamin in the body, the myelin sheath cannot develop well or stay healthy.

What are the uses of methylcobalamin?

Some of the uses of methylcobalamin are

  • Methylcobalamin is prescribed for treating certain nerve problems and anaemia by restoring the levels of vitamin B12 in the body.

  • Replenishment of the vitamin helps in the regeneration and improvement of damaged and irritated nerves, which can be caused by medical conditions like pernicious anaemia, neuropathy, and neuralgia.

  • It is also prescribed for people who experience back pain, anaemia, or other problems related to the nervous system that can be caused by a deficiency of vitamin B12.

  • Methylcobalamin also works as a painkiller for people with diabetes.

How and when to take methylcobalamin?

Methylcobalamin is available as tablets and injections as well. The tablets are to be consumed orally. Do not try to swallow or chew an entire tablet or lozenge. 

  • Methylcobalamin is a water-soluble vitamin. It is better absorbed in the body when taken on an empty stomach. So, you can take one in the morning, at least 30 minutes before eating, or 2 hours after you have eaten.

  • Methylcobalamin injections are injected into a muscle. The administration is usually done 1 to 3 times a week. Follow the instructions given by your doctor. 

  • Do not increase or decrease the dose without consulting your doctor.

What are the side effects of methylcobalamin?

Get immediate medical assistance in case you notice signs of an allergic reaction like difficulty in breathing, hives (itchy red bumps on the skin), or swollen lips, face, tongue, or throat. Certain common side effects of Methylcobalamin include:

  • Vomiting

  • Diarrhoea

  • Nausea

  • Headache

  • Loss of appetite

If you face any of the mentioned (or other) side effects for a persistent period, stop taking the medicine and contact your doctor for help immediately. 

What precautions are to be taken while using Methylcobalamin?

Certain precautions must be taken before any medicines are prescribed or taken by a person. In the case of methylcobalamin

  • Avoid drinking alcohol in large amounts since it makes it difficult for your body to absorb methylcobalamin.

  • Do not buy or consume expired tablets.

  • Do not give methylcobalamin to a child without proper medical advice.

Other than the precautions mentioned above, make sure to mention the following details to your doctor before taking Methylcobalamin:

  • If you are allergic to vitamin B12 or cobalt

  • If you are taking any other vitamins

  • If you have or used to suffer from Leber’s disease, folic acid or iron deficiency, or low levels of potassium in the blood

  • If you are pregnant, breastfeeding, or trying for a baby

  • If you are taking any other medicines, especially chloramphenicol, colchicine, antibiotic medicines, oral diabetes medicines containing metformin, medicines that reduce stomach acid, or medicines that do not require a prescription, like Ayurvedic or herbal.

What if I miss a dose of Methylcobalamin?

There is no need to worry if you miss a dose. Take the dose as soon as you remember, but leave out the missed dose if it is almost time for your next dose. Do not try to take two doses together to make up for the missed dose as it might lead to side effects.

What if you overdose on Methylcobalamin?

If you or someone you know overdoses on Methylcobalamin, immediately go to the emergency department of the nearest hospital. Take the container or sachet of the medicine with you for reference.

What are the storage conditions for methylcobalamin?

  • Store methylcobalamin in a dry and cool place, preferably at room temperature between 20°C and 25°C.

  • Keep it away from direct contact with light, heat, and air.

  • Keep it safely in a place that is away from children’s reach.

Can I take Methylcobalamin with other medications?

Unless prescribed by your medical practitioner or pharmacist, do not consume methylcobalamin with any other medicine. If it is prescribed to be taken with some other medicine, do not go beyond the prescribed dosage for either of the medicines.

How quickly will the Methylcobalamin tablet show results?

Typically, results can be observed within 48 to 72 hours after taking Methylcobalamin.

Comparison of Methylcobalamin with Vitamin B complex



Vitamin B complex


Prescribed for persons with deficiency of vitamin B12.

Prescribed for preventing or treating the deficiency of vitamin B.

Class of Drugs

It is a vitamin tablet.

It is a supplement for all major B vitamins. 

Common Side Effects

Vomiting, Nausea, Loss of Appetite, Diarrhoea, Headache.

Nausea, excessive urination, vomiting, diarrhoea, and nerve damage.


It is wise to always follow the instructions provided by your doctor when consuming any medications. Keep all the medications out of reach and sight of children to avoid any mishaps.


TATA 1mg



Disclaimer: The information provided here is not meant to substitute an advice from a healthcare professional. The information is not intended to cover all the possible uses, side-effects, precautions, and drug interactions. This information is not intended to suggest that using a specific drug is suitable, safe, or efficient for you or anyone else. The absence of any information or warning regarding the drug should not be interpreted as an implicit guarantee from the organisation. We strongly advise you to consult a doctor if you have any concerns about the drug and never use the medication without a doctor’s prescription.