Ukufakelwa kwe-Bone Marrow

Ukufakelwa kwe-Bone Marrow

Ukufakelwa komnkantsha kuyinqubo yezokwelapha. Lolu wuhlobo lwe ukwelashwa lapho umnkantsha emzimbeni wakho kuthathelwa indawo amaseli anempilo. Amaseli asetshenziselwa ukushintshwa athathwa emzimbeni wakho noma athathwe kumnikeli. 

Ukufakelwa kwe-stem cell elinye igama elisetshenziselwa ukubhekisela ekufakweni komnkantsha. Ngokuqondile, kwaziwa ngokuthi ukudluliswa kwe-hematopoietic stem cell. Kunezinhlobo ezithile zomdlavuza njenge-myeloma, i-leukemia, Futhi i-lymphoma engelashwa ngokufakelwa komnkantsha. Ezinye izifo zegazi nezivikeli mzimba ezithinta umnkantsha nazo ziphathwa ngokufakelwa komnkantsha.  

Inqubo yokufakelwa komnkantsha wethambo ihilela ukufaka ama-stem cells akha igazi emzimbeni wakho. Lawa ma-stem cells anempilo athatha indawo yawo wonke umnkantsha olimele noma onesifo emzimbeni wakho. Uma umnkantsha wakho uyeka ukusebenza ngesizathu esithile futhi umisa ukukhiqizwa kwamangqamuzana abomvu egazi anempilo, khona-ke kudingeka ukufakelwa komnkantsha. Ngakho-ke, izibhedlela ze-CARE zihlinzeka ngesibhedlela sokufakelwa komnkantsha eHyderabad nge odokotela abangcono kakhulu bezokwelapha.

Isingeniso Semnkantsha kanye Nezinhlayiya Zesiqu

Kunamaseli akhethekile emzimbeni wethu aziwa ngokuthi ama-stem cell. Lawa maseli angakwazi ukwenza amakhophi awo futhi abe nekhono lokushintshela ezinhlotsheni eziningi zamaseli adingwa umzimba wakho. Kunezinhlobo eziningi ezahlukene zama-stem cell. Uhlobo ngalunye lwe-stem cell lutholakala ezingxenyeni ezihlukene zomzimba wakho ngezikhathi ezahlukene. 

Ukwelashwa komdlavuza nomdlavuza kuqondise kumaseli emzimbeni wakho. Bangalimaza ngokuqondile amaseli akho e-hematopoietic stem. Amaseli we-stem anamandla okuphenduka abe amaseli egazi aziwa ngokuthi ama-hematopoietic stem cell.

Izicubu ezithambile, eziyisipontshi emzimbeni wethu eziqukethe amaseli we-hematopoietic aziwa ngokuthi umnkantsha. Indawo yomnkantsha phakathi nendawo yethambo ngalinye. Igazi elihamba kuwo wonke umzimba wethu liqukethe namaseli e-hematopoietic stem. 

Amangqamuzana egazi abomvu, amaseli egazi amhlophe, Futhi ama-platelet awakhiwe kusuka kumaseli we-hematopoietic stem uma wonakalisiwe. Izinhlobo ezintathu zamangqamuzana egazi zibaluleke kakhulu ohlelweni lwethu futhi ngayinye yazo inomsebenzi ohlukile. Zimi kanje:-

Amaseli abomvu egazi- Umsebenzi wabo oyinhloko ukuthwala umoya-mpilo kuwo wonke umzimba. Kanye nokuthutha umoya-mpilo, ziphinde zihambise i-carbon dioxide emaphashini akho ukuze ikhishwe. 

Amangqamuzana amhlophe egazi- Ziyizici eziyinhloko zamasosha ethu omzimba. Umsebenzi wabo oyinhloko ukulwa namagciwane. Amagciwane angamagciwane namagciwane anamandla okukugulisa. 

Amapulatifomu- Ama-platelet ahlobene nokwakheka amahlule igazi. 

Ngenqubo yezokwelapha yomnkantsha wamathambo noma ukufakelwa kwe-stem cell, amaseli e-stem anempilo adluliselwa emnkantsheni noma egazini. Lokhu kusiza ekubuyiseleni ikhono lomzimba lokudala amangqamuzana egazi abomvu, amangqamuzana amhlophe egazi, namaplatelet noma nini lapho kudingeka.

Izinhlobo Zokufakelwa Kwethambo Lamathambo

Kukhona ikakhulukazi izinhlobo ezimbili zokufakelwa komnkantsha. Zimi kanje:-

Ukufakelwa kwe-Allogeneic stem cell- Inqubo yokufakelwa i-allogeneic stem cell ihlanganisa ukusetshenziswa kwamaseli egazi anempilo atholakala kumnikeli ukuze athathele indawo yomnkantsha ogulayo noma owonakele. I-allogeneic stem cell transfer ibizwa nangokuthi i-allogeneic bone marrow transplant. 

Onikelayo kungaba yinoma ngubani, kungaba yilungu lomndeni, umuntu amaziyo, noma kungaba yinoma yimuphi umuntu ongamazi. Lezi yizinhlobo zamangqamuzana egazi asetshenziswa ekufakelweni kwe-allogeneic stem cell: - 

• Igazi liqoqwa kumnikeli.

•  I-stem cell yaqoqwa emnkantsheni we-hipbone yomnikeli. 

• Ama-stem cells aqoqwa kunoma iyiphi inkaba enikelwe. Kuqoqwe egazini lenkaba enikelwe

Umzimba udinga ukulungiswa kuqala ngaphambi kokufakelwa kwe-allogeneic stem cell. Imithamo ephezulu ye imiphumela emibi yokwelashwa ngamakhemikhali kanye nemisebe itholwa isiguli ngaphambi kokufakelwa i-allogeneic stem cell. Lokhu kwenzelwa ukulimaza amangqamuzana agulayo ngaphambi kokuba umzimba ulungele ukwamukela amangqamuzana anikelayo

Ukufakelwa kwe-Autologous stem cell- Ku-autologous stem cell transplant, ama-blood stem cell anempilo avela emzimbeni wesiguli asetshenziselwa ukufaka esikhundleni somnkantsha wethambo olimele futhi onesifo emzimbeni wakho. I-autologous stem cell transplant yaziwa nangokuthi i-autologous bone marrow transplant. 

Indlela yokufakelwa i-autologous stem cell inikeza izinzuzo ezithile phezu kokufakelwa kwe-allogeneic stem cell. Lokhu kungenxa yokuthi ama-stem cell asetshenziswa emzimbeni wakho. Lokhu kungenxa yokuthi, kulokhu, awudingi ukukhathazeka ngokungahambisani phakathi kwamaseli omnikeli nomamukeli.  

Uma umzimba wakho uqhubeka ukhiqiza amangqamuzana omnkantsha anempilo anele, ungakwazi kalula ukufakelwa i-autologous stem cell transplant. Ama-stem cells anempilo emzimbeni wakho angaqoqwa, aqandiswe, bese egcinwa ukuze asetshenziswe kamuva. 

Kungani Kudingeka Ukufakelwa Kwe-Bone Marrow?

Ukusetshenziswa kokufakelwa komnkantsha kungase kuhlotshaniswe nalokhu:-

• Lokhu kuvumela ukwelashwa okuphephile kwesimo sakho ngokusebenzisa imisebe noma i-chemotherapy. Khona-ke ukwelashwa kokubuyisela umnkantsha esikhundleni sawo wonke amangqamuzana alimele ngenxa yemisebe. 

• Ama-stem cells amasha athatha indawo yawo wonke umnkantsha wamathambo owonakele futhi onesifo.

• Ama-stem cells amasha anikezwayo angasiza ukubulala amangqamuzana omdlavuza ngokuqondile. 

Abantu bangazuza ekufakweni komnkantsha ngezindlela ezihlukahlukene. Abantu abanazo zombili izifo eziwumdlavuza nezingezona umdlavuza bangazuza ekufakweni komnkantsha. Lezi ngezinye zezifo ezingahlomula ngokufakwa komnkantsha:- 

• I-leukemia enamandla

• I-Adrenoleukodystrophy

• I-aplastic anemia

• I-Bone marrow syndromes

• I-leukemia engapheli

• I-Hemoglobinopathies

• I-Hodgkin's lymphoma

• Ukushoda kwamasosha omzimba

• Amaphutha azalwa nawo we-metabolism

• I-myeloma eminingi

• Ama-syndromes we-Myelodysplastic

• I-neuroblastoma

• I-Non-Hodgkin's lymphoma

• Izinkinga ze-plasma cell

• IZIBONGO I-syndrome

• I-amyloidosis eyinhloko

Ziyini Izingozi Zokufakelwa Kwethambo Lomnkantsha?

Izingozi eziningi zidalwa ukufakelwa komnkantsha. Abanye abantu bayasinda ngokufakelwa komnkantsha okunezinkinga ezincane noma okungenazo izinkinga futhi abanye abantu babhekana nezinkinga ezinkulu. Ezimweni ezingavamile, lezi zinkinga zingase zibeke ukuphila engozini. Izingozi ezithile umuntu abhekana nazo zincike ezintweni eziningi ezahlukene. Lokhu kuhlanganisa uhlobo lwesifo noma isimo esikwenza udinge ukufakelwa, iminyaka yakho, kanye nomlando wakho wezokwelapha. 

Izinkinga ezingenzeka ngenxa yokufakelwa komnkantsha zihlanganisa:

• I-Graft-versus-host disease (ukufakelwa kwe-allogeneic kuphela)

• Ukuhluleka kwe-stem cell (graft).

• Ukulimala komzimba

• Izifo

• Lolu ngwengwezi lwakheka

• ukungazali

• Umdlavuza omusha

• Ukufa

Udokotela wakho uzochaza izingozi ongase ubhekane nazo uma ufakwa umnkantsha. Ungaxoxa ngezingozi zokufakelwa komnkantsha wakho nodokotela wakho bese unquma ngakho. 

Zingasiza Kanjani Izibhedlela Ze-CARE?

Ezibhedlela ze-CARE, sinobuchwepheshe obuphambili namathuluzi akamuva okuxilonga isimo sakho ngokunembile futhi sikunikeze izinhlelo zokwelashwa ezingcono kakhulu. Uzoba sezandleni ezingcono kakhulu uma ungaphansi kokunakekelwa kwezibhedlela ze-CARE njengoba singesinye sezibhedlela Izibhedlela ezihamba phambili zokufakelwa komnkantsha eHyderabad. Chofoza Lapha ukuze uthole Izindleko Zokufakelwa Kwemathambo imininingwane eNdiya.